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  1. The ongoing novel coronavirus disease 2019 (COVID-19) pandemic has a significant mortality rate of 3–5%. The principal causes of multiorgan failure and death are cytokine release syndrome and immune dysfunctio...

    Authors: Indranill Basu-Ray, Kashinath Metri, Dibbendhu Khanra, Rishab Revankar, Kavitha M. Chinnaiyan, Nagaratna Raghuram, Mahesh Chandra Mishra, Bhushan Patwardhan, Manjunath Sharma, Ishwar V. Basavaraddi, Akshay Anand, Shrinath Reddy, K. K. Deepak, Marian Levy, Sue Theus, Glenn N. Levine…
    Citation: BMC Complementary Medicine and Therapies 2022 22:191
  2. Atherosclerosis (AS) is the greatest contributor to pathogenesis of atherosclerotic cardiovascular disease (ASCVD), which is associated with increased mortality and reduced quality of life. Early intervention ...

    Authors: Zheng Jin, Huanyi Zhao, Yuan Luo, Xiushen Li, Jiayan Cui, Jing Yan and Pingzhen Yang
    Citation: BMC Complementary Medicine and Therapies 2022 22:190
  3. hyperlipidemia acute pancreatitis (HTG-AP) is a major hidden danger affecting human health, however, whether there is a protective effect of resveratrol on HTG-AP is unclear. Therefore our study was aimed to i...

    Authors: Xiaoying Zhang, Guodong Yang, Yulin Chen, Zhao Mu, Haiyue Zhou and Luoyao Zhang
    Citation: BMC Complementary Medicine and Therapies 2022 22:189
  4. Ginsenoside Rg3 (GRg3) is one of the main active ingredients in Chinese ginseng extract and has various biological effects, such as immune-enhancing, antitumour, antiangiogenic, immunomodulatory and anti-infla...

    Authors: Shangbin Lv, Xiaodong Chen, Yu Chen, Daoyin Gong, Gang Mao, Caifei Shen, Ting Xia, Jing Cheng, Zhaoliang Luo, Yu Cheng, Weihong Li and Jinhao Zeng
    Citation: BMC Complementary Medicine and Therapies 2022 22:188
  5. Rheumatoid arthritis (RA) is a chronic, progressive, systemic autoimmune inflammatory disease. Bi Zhong Xiao decoction (BZXD) performs multiple functions for rheumatoid arthritis (RA) treatment for decades. In...

    Authors: Cailin He, Yang Wang, Yuqi Wen, Teng Li, En Hu, Siqing Zeng and Xingui Xiong
    Citation: BMC Complementary Medicine and Therapies 2022 22:186
  6. As an original traditional Chinese medicinal formula, Qin Huang formula (QHF) is used as adjuvant therapy for treating lymphoma in our hospital and has proven efficacy when combined with chemotherapy. However,...

    Authors: Weili Li, Lingling Lv, Ming Ruan, Jiayue Xu, Wenhua Zhu, Qiong Li, Xufeng Jiang, Lan Zheng and Weirong Zhu
    Citation: BMC Complementary Medicine and Therapies 2022 22:185
  7. H. brasiletto is used in popular culture due to its therapeutic properties, including antioxidant, anti-inflammatory and antiproliferative properties, although little is known about its role as a protector agains...

    Authors: Margareth Duran-Izquierdo, María Taboada-Alquerque, Lucellys Sierra-Marquez, Neda Alvarez-Ortega, Elena Stashenko and Jesus Olivero-Verbel
    Citation: BMC Complementary Medicine and Therapies 2022 22:184
  8. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12906-020-2834-8.

    Authors: Li-Min Zhang, Rong-Rong Zhen, Chao Gu, Tian-Li Zhang, Yue Li, Miao Jin, Bing Hu and Hong-Mei An
    Citation: BMC Complementary Medicine and Therapies 2022 22:183
  9. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Ignacio Peralta, Carla Marrassini, Malen Saint Martin, Laura Cogoi, Maria Rosario Alonso, Alejandro Gugliucci and Claudia Anesini
    Citation: BMC Complementary Medicine and Therapies 2022 22:182

    The original article was published in BMC Complementary Medicine and Therapies 2022 22:84

  10. Anthocyanin-containing plant extracts and carotenoids, such as astaxanthin, have been well-known for their antiviral and anti-inflammatory activity, respectively. We hypothesised that a mixture of Ribes nigrum L.

    Authors: Rinu Sivarajan, Heike Oberwinkler, Valeria Roll, Eva-Maria König, Maria Steinke and Jochen Bodem
    Citation: BMC Complementary Medicine and Therapies 2022 22:181
  11. Atherosclerosis (AS) is the primary cause of cardiovascular disease and the incidence is extremely common; however, there are currently few drugs that can effectively treat AS. Although oridonin has been widel...

    Authors: Zhipeng Chen, Heqian Liu, Xiaoqi Zhao, Subinur Mamateli, Cheng Liu, Lei Wang, Jing Yu, Yutong Liu, Jing Cai and Tong Qiao
    Citation: BMC Complementary Medicine and Therapies 2022 22:180
  12. Cisplatin (CisPT) is a chemotherapeutic that outcome in adverse effects including neurotoxicity. We examined the efficacy of hydaspica ethyl acetate extract (AHE) against CisPT-prompted neurotoxicity.

    Authors: Tayyaba Afsar, Suhail Razak and Ali Almajwal
    Citation: BMC Complementary Medicine and Therapies 2022 22:179
  13. Tetrapleura tetraptera is a medicinal spice traditionally used to treat cancer, diabetes, and several other ailments. This study analyzed the cytotoxicity of the dichloromethane methanol extract of T. tetraptera ...

    Authors: Idrios N. Bonsou, Armelle T. Mbaveng, Gaëlle S. Nguenang, Godloves F. Chi, Victor Kuete and Thomas Efferth
    Citation: BMC Complementary Medicine and Therapies 2022 22:178
  14. As a traditional herbal medicine, Dracaena angustifolia Roxb has been used as an anti-inflammatory agent by the Li people in Hainan, China. In preliminary phytochemical studies conducted in our lab, its fractions...

    Authors: Jiling Yi, Ting Zhao, Yuanlin Zhang, Yanxing Tan, Xiao Han, Yulin Tang and Guangying Chen
    Citation: BMC Complementary Medicine and Therapies 2022 22:177
  15. Luteolin, a flavonoid compound with anti-inflammatory activity, has been reported to alleviate cerebral ischemia/reperfusion (I/R) injury. However, its potential mechanism remains unclear.

    Authors: Lu Li, Guanghua Pan, Rong Fan, Dalei Li, Lei Guo, Lili Ma, Hui Liang and Jiaoxue Qiu
    Citation: BMC Complementary Medicine and Therapies 2022 22:176
  16. Traditional Korean Medicine (TKM) is highly integrated with the modern health care system of South Korea and is actively used in the public health field. Since 2014, the Ministry of Health and Welfare of South...

    Authors: Eunhye Hyun, Jiseon Ryu, Kibong Kim, Sangjae Lee, Seungtae Kim and Byungmook Lim
    Citation: BMC Complementary Medicine and Therapies 2022 22:175
  17. Polysaccharides from wampee have been reported to process various biological activities, while the relationship between structure and bioactivities has been barely addressed. Pectin, an abundant water-soluble ...

    Authors: Weiyu Fu, Xuehua Liao, Qian Zhang, Yuzhen Zhu, Si Mei, Qian Li, Xin Zhou, Xiaojun Li, Hui Luo, Hua Ye and Kefeng Wu
    Citation: BMC Complementary Medicine and Therapies 2022 22:174
  18. Conventional cancer treatments, such as chemotherapy, radiation therapy, and surgery, often affect the patients’ quality of life due to their serious side effects, indicating the urgent need to develop less to...

    Authors: Mahla Amirzadeh, Sara Soltanian and Neda Mohamadi
    Citation: BMC Complementary Medicine and Therapies 2022 22:173
  19. Globally, ischemic stroke is a major health threat to humans that causes lifelong disability and death. Mentha arvensis (MA) has been used in traditional medicine to alleviate oxidative stress and inflammation-re...

    Authors: Md Sadikul Islam, Ha-Young Shin, Yeo-Jin Yoo, Eui-Yong Lee, Ryunhee Kim, Young-Jin Jang, Md Rashedunnabi Akanda, Hyun-Jin Tae, In-Shik Kim, Dongchoon Ahn and Byung-Yong Park
    Citation: BMC Complementary Medicine and Therapies 2022 22:172
  20. Psychologists, and their clients, are engaging with complementary medicine (CM). Increasing evidence for CM approaches, such as improved nutrition and St John’s wort, has led to their inclusion in the Royal Au...

    Authors: Carrie Thomson-Casey, Jon Adams and Erica McIntyre
    Citation: BMC Complementary Medicine and Therapies 2022 22:171
  21. Busulfan is an antineoplastic medication that is broadly utilized for cancer treatment. It affects the testicular function and leads to sterility. The present study aimed to evaluate the effects of ellagic aci...

    Authors: Amirabbas Rostami, Sina Vakili, Farhad Koohpeyma, Bahia Namavar Jahromi, Ziba Afshari Aghajari, Fatemeh Mahmoudikohani, Forough Saki, Marzieh Mahmoodi, Khojaste Rahimi Jaberi, Ahmad Movahedpour, Majid Jafari Khorchani and Saam Noroozi
    Citation: BMC Complementary Medicine and Therapies 2022 22:170
  22. Pithecellobium dulce (Roxb.), an evergreen medium-sized, spiny tree which have vast nutritional values and widely used in ayurvedic medicines and home remedies. The plant has also been a rich source of biological...

    Authors: Masuma Akter, Mst. Shahnaj Parvin, Md. Mahadi Hasan, Md. Aziz Abdur Rahman and Md. Ekramul Islam
    Citation: BMC Complementary Medicine and Therapies 2022 22:169
  23. Current therapies for alcohol-induced liver injury are of limited efficacy and associated with significant side effects. With the proposed pathophysiology of alcohol-induced liver injury to be related to deran...

    Authors: Maneerat Chayanupatkul, Kanjana Somanawat, Natthaya Chuaypen, Naruemon Klaikeaw, Natcha Wanpiyarat, Prasong Siriviriyakul, Somying Tumwasorn and Duangporn Werawatganon
    Citation: BMC Complementary Medicine and Therapies 2022 22:168
  24. Vascular damage, autoimmune abnormalities, and fibrosis are the three pathological features of systemic sclerosis (SSc).However, pulmonary vascular damage is the main factor affecting the progression and progn...

    Authors: Kai Li, Qian Wang, Qin Lv, Kelei Guo, Li Han, Peipei Duan, Yongzheng Deng and Hua Bian
    Citation: BMC Complementary Medicine and Therapies 2022 22:167
  25. Ginsenoside Rg-1 (Rg-1), a triterpenoid saponin abundantly present in Panax ginseng, is a type of naturally occurring steroid with known anti-diabetic and anti-inflammatory effects. In this study, we sought to co...

    Authors: A Young Han, Su Min Ha, You Kyoung Shin and Geun Hee Seol
    Citation: BMC Complementary Medicine and Therapies 2022 22:166
  26. Vitamin D (Vit D) supplementation and Aerobic Training (AT) exert several beneficial effects such as antioxidant and anti-inflammatory actions. The literature on the effects of AT and Vit D supplementation on ...

    Authors: Rastegar Hoseini, Hiwa Ahmed Rahim and Jalal Khdhr Ahmed
    Citation: BMC Complementary Medicine and Therapies 2022 22:165
  27. Influenza A virus infection due to drug resistance and side effects of the conventional antiviral drugs yet remains a serious public health threat for humans and animals. Forsythiaside A is an effective ingred...

    Authors: Xiao Zheng, Ziqi Chen, Shanshan Shi, Huijun Yan, Junmei Zhou, Lifang Jiang, Hongli Wang, Guanghui Hou and Zhenyou Jiang
    Citation: BMC Complementary Medicine and Therapies 2022 22:164
  28. Previous studies in our laboratory in ex vivo assays have demonstrated H. hemerocallidea extract as potential antidiabetic agent through increased insulin release from pancreatic beta cells. Thus, for this study ...

    Authors: N. M. Mkolo, O. O. Olaokun, P. H. King, I. Janse van Rensburg, J. N. Eloff and V. Naidoo
    Citation: BMC Complementary Medicine and Therapies 2022 22:163
  29. In Korea, conventional medicine (CM) and traditional Korean medicine (KM) are run as a dual healthcare system; however, the backgrounds and characteristics of the users of both medical services have not yet be...

    Authors: Yui Sasaki, Jeong-Su Park, Sunju Park, Chunhoo Cheon, Yong-Cheol Shin, Seong-Gyu Ko and Bo-Hyoung Jang
    Citation: BMC Complementary Medicine and Therapies 2022 22:162
  30. In 2019, investigators from China, South Korea and the United States of America initiated a coordinated multinational trial. The trial included three parallel randomized studies with a planned pooled analysis ...

    Authors: Sylvia Baedorf Kassis, Weidong Lu, Sarah A. White, Im Hee Shin, Sung Hwan Park, Young Ju Jeong, Chang Yao, Jennifer Ligibel and Barbara E. Bierer
    Citation: BMC Complementary Medicine and Therapies 2022 22:161
  31. The present study aimed to determine the protective effects of hypaconitine (HA) and glycyrrhetinic acid (GA) against chronic heart failure (CHF) in the rats and to explore the underlying molecular mechanisms.

    Authors: Liqin Wang, Haiming Deng, Tengyu Wang, Yun Qiao, Jianbing Zhu and Mingfeng Xiong
    Citation: BMC Complementary Medicine and Therapies 2022 22:160
  32. Croton macrostachyus is an important plant in traditional African medicine, widely utilized to treat a variety of diseases. In Kenya, HIV-infected patients use leaf and root decoctions of the plant as a cure for...

    Authors: Ermias Mergia Terefe, Faith A. Okalebo, Solomon Derese, Moses K. Langat, Eduard Mas-Claret, Nada H. Aljarba, Saad Alkahtani, Gaber El-Saber Batiha, Arabinda Ghosh, Eman A. El-Masry and Joseph Muriuki
    Citation: BMC Complementary Medicine and Therapies 2022 22:159
  33. The 7β-(3-ethyl-cis-crotonoyloxy)-1α-(2-methylbutyryloxy)-3,14-dehydro-Z-notonipetranone (ECN), a sesquiterpenoid isolated from the Tussilago farfara Linneaus (Asteraceae), was evaluated against acute Carrageenan...

    Authors: Amna Khan, Li Zhang, Chang Hu Li, Ashraf Ullah Khan, Bushra Shal, Adnan Khan, Sajjad Ahmad, Fakhar ud Din, Zia ur rehman, Feng Wang and Salman Khan
    Citation: BMC Complementary Medicine and Therapies 2022 22:158
  34. Hypertension and its associated dysfunction of the blood-brain barrier (BBB) are considered to contribute to cerebral small vessel disease (cSVD). Angiotensin II (Ang II), as an important vasoactive peptide of...

    Authors: Yu Yan Xie, Yun Wei Lu and Gu Ran Yu
    Citation: BMC Complementary Medicine and Therapies 2022 22:157
  35. Despite the number of deaths and the significant economic and social costs associated with Chagas, Leishmaniasis and Malaria diseases worldwide, available drugs are limited and have serious side effects and hi...

    Authors: Camila M. Clemente, Sara M. Robledo and Soledad Ravetti
    Citation: BMC Complementary Medicine and Therapies 2022 22:156
  36. Individual acupuncture (AP) is a safe and effective treatment for cancer-related pain and other symptoms in cancer survivors. However, access to individual AP is limited, and costs can be prohibitive. Group AP...

    Authors: Devesh Oberoi, Erica N. Reed, Katherine-Ann Piedalue, Jessa Landmann and Linda E. Carlson
    Citation: BMC Complementary Medicine and Therapies 2022 22:155
  37. The study was planned to investigate the phytochemicals, antidiabetic and antioxidant studies of A. consanguineum.

    Authors: Mater H. Mahnashi, Yahya S. Alqahtani, Ali O. Alqarni, Bandar A. Alyami, Omaish S. Alqahtani, Muhammad Saeed Jan, Fida Hussain, Zia Ul Islam, Farhat Ullah, Muhammad Ayaz, Muhammad Abbas, Umer Rashid and Abdul Sadiq
    Citation: BMC Complementary Medicine and Therapies 2022 22:154
  38. Gout is a common disease with high incidence due to unhealthy diet and living habits. Simiao Powder, as a classic formula consisted of four common herbs, has been widely used in clinical practice since ancient...

    Authors: Huachong Xu, Jialin Wu, Shiqi Wang, Lu Xu, Pei Liu, Yucong Shi, Sizhi Wu, Li Deng and Xiaoyin Chen
    Citation: BMC Complementary Medicine and Therapies 2022 22:152
  39. Asthma and idiopathic pulmonary fibrosis (IPF) are common chronic diseases of the respiratory system in clinical practice. However, the relationship and molecular links remain unclear, and the current treatmen...

    Authors: Yuanyuan Zhong, Lingli Hu, Wenjing Chen, Bin Wang, Jing Sun and Jingcheng Dong
    Citation: BMC Complementary Medicine and Therapies 2022 22:151
  40. Endometrial carcinoma is one of the two cancers with rising mortality and morbidity in recent years. In the light of many controversies about its treatment, it is urgent to construct a new prognostic model and...

    Authors: Zhiheng Lin, Xiaohui Sui, Wenjian Jiao, Ying Wang and Junde Zhao
    Citation: BMC Complementary Medicine and Therapies 2022 22:150
  41. Antimicrobial peptides (AMPs) are important effectors of the innate defense system. Cathelicidins, (CRAMP in mouse/rat, LL-37 in human) is one of the two major classes of AMPs in humans. The upregulation of LL...

    Authors: Nagat Siednamohammeddeen, Rehab Badi, Tahane Mohammeddeen, Khalid Enan and AmalSaeed
    Citation: BMC Complementary Medicine and Therapies 2022 22:149
  42. Massage is a widely acceptable and popular form of complementary medicine (CM) among Australian women. While there is some research that reports on massage use in younger women, there is minimal research explo...

    Authors: Suzy Ladanyi, Jon Adams and David Sibbritt
    Citation: BMC Complementary Medicine and Therapies 2022 22:148
  43. Gao-Zi-Yao has long been a unique way for treating various diseases. The present study is to explore the effect of Gao-Zi-Yao on learning and memory function in old spontaneous hypertensive rats (SHR) and its ...

    Authors: Meng-Xiao Han, Wen-Yi Jiang, Yan Jiang, Lin-Hui Wang, Rong Xue, Guo-Xing Zhang and Jing-Wei Chen
    Citation: BMC Complementary Medicine and Therapies 2022 22:147
  44. Herbal medicines are widely used in the world especially in developing countries. Pregnant women use herbal products to treat pregnancy related illnesses due to prior experience of herbal medicine use and easy...

    Authors: Yaschilal Muche Belayneh, Tewodros Yoseph and Solomon Ahmed
    Citation: BMC Complementary Medicine and Therapies 2022 22:146
  45. Use of natural products has been proposed as an efficient method in modulation of immune system and treatment of cancers. The aim of this study was to investigate the potential of cryptotanshinone (CPT), narin...

    Authors: Shokoofe Noori, Mitra Nourbakhsh, Hossein Imani, Niloofar Deravi, Niloufar Salehi and Zohreh Abdolvahabi
    Citation: BMC Complementary Medicine and Therapies 2022 22:145
  46. Chronic exposure to ultraviolet B (UVB) causes a series of adverse skin reactions, such as erythema, sunburn, photoaging, and cancer, by altering signaling pathways related to inflammation, oxidative stress, a...

    Authors: Bei Chen, Honghong Chen, Haidong Qu, Kun Qiao, Min Xu, Jingna Wu, Yongchang Su, Yan Shi, Zhiyu Liu and Qin Wang
    Citation: BMC Complementary Medicine and Therapies 2022 22:144
  47. Cinnamon (Cinnamomum zeylanicum) and Clove (Syzygium aromaticum) essential oils are two medicinally important plant-derived substances with a wide range of biological properties. Besides, nanoemulsion-based gels ...

    Authors: Fariba Esmaeili, Masoumeh Zahmatkeshan, Yaser Yousefpoor, Hiva Alipanah, Ehsan Safari and Mahmoud Osanloo
    Citation: BMC Complementary Medicine and Therapies 2022 22:143
  48. The potential of essential oils (EOs) and of their principal constituents for eradication of biofilm and at the same time the research of new potential acetylcholinesterase inhibitors is gaining increasing int...

    Authors: Lucia Caputo, Francesca Capozzolo, Giuseppe Amato, Vincenzo De Feo, Florinda Fratianni, Giovanni Vivenzio and Filomena Nazzaro
    Citation: BMC Complementary Medicine and Therapies 2022 22:142