Articles

Network analysis indicating the pharmacological mechanism of Yunpi-Qufeng-Chushi-prescription in prophylactic treatment of rheumatoid arthritis

Rheumatoid arthritis (RA), is an autoimmune inflammatory disease with increasing global morbidity and high disability. Early treatment is an effective intervention to slow down joint deformation. However, as f...

Authors: Lin Li, Donghai Zhou, Qiuping Liu, Dianming Li, Qiao Wang, Xiaowei Shi, Chengping Wen and Lin Huang

Echinacea purpurea (L.) Moench treatment of monocytes promotes tonic interferon signaling, increased innate immunity gene expression and DNA repeat hypermethylated silencing of endogenous retroviral sequences

Herbal remedies of Echinacea purpurea tinctures are widely used today to reduce common cold respiratory tract infections.

Authors: Ken Declerck, Claudina Perez Novo, Lisa Grielens, Guy Van Camp, Andreas Suter and Wim Vanden Berghe

Correction to: Hepatoprotective effect of silymarin on fructose induced nonalcoholic fatty liver disease in male albino wistar rats

Authors: Tewodros Mengesha, Natesan Gnanasekaran and Tsegaye Mehare

Retraction Note: Antimalarial efficacy of Pongamia pinnata (L) Pierre against Plasmodium falciparum (3D7 strain) and Plasmodium berghei (ANKA)

Authors: P. V. V. Satish and K. Sunita

In vitro study on the effect of cornin on the activity of cytochrome P450 enzymes

Cornin is a commonly used herb in cardiology for its cardioprotective effect. The effect of herbs on the activity of cytochrome P450 enzymes (CYP450s) can induce adverse drug-drug interaction even treatment fa...

Authors: Qun Zhang, Zengqiang Qu, Yanqing Zhou, Jin Zhou, Junwei Yang, Shengjian Li, Qiuping Xu and Xuedong Zhou

A plant-based medicinal food inhibits the growth of human gastric carcinoma by reversing epithelial–mesenchymal transition via the canonical Wnt/β-catenin signaling pathway

Natural products, especially those with high contents of phytochemicals, are promising alternative medicines owing to their antitumor properties and few side effects. In this study, the effects of a plant-base...

Authors: Xuxi Chen, Wuyang Yue, Lin Tian, Na Li, Yiyi Chen, Lishi Zhang and Jinyao Chen

Vincetoxicum arnottianum modulates motility features and metastatic marker expression in pediatric rhabdomyosarcoma by stabilizing the actin cytoskeleton

Prevention of metastatic invasion is one of the main challenges in the treatment of alveolar rhabdomyosarcoma. Still the therapeutic options are limited. Therefore, an anti-tumor screening was initiated focusi...

Authors: Anna Adamus, Iftikhar Ali, Vasileios Vasileiadis, Luai Al-Hileh, Jan Lisec, Marcus Frank, Guido Seitz and Nadja Engel

A mechanistic study on the inhibition of bacterial growth and inflammation by Nerium oleander extract with comprehensive in vivo safety profile

Nerium oleander (L.) is well known traditionally used medicinal plant with several pharmacological activities. However, the anti-bacterial, anti-inflammatory activity and in vivo toxicity potential of floral part...

Authors: Yousra Shafiq, Syed Baqir Shyum Naqvi, Ghazala H. Rizwani, Muhammad Arif Asghar, Rabia Bushra, Sana Ghayas, Ahad Abdul Rehman and Muhammad Asif Asghar

Effects of vitamin K2 supplementation on atherogenic status of individuals with type 2 diabetes: a randomized controlled trial

This study was aimed to examine the effects of vitamin K2 supplementation on atherogenic status, assessed by insulin resistance (IR)-related indexes, in patients with type 2 diabetes mellitus (T2DM).

Authors: Fatemeh Rahimi Sakak, Nazanin Moslehi, Hengameh Abdi and Parvin Mirmiran

Effects of Green cardamom (Elettaria cardamomum Maton) and its combination with cyclophosphamide on Ehrlich solid tumors

Cardamom (Elettaria cardamomum) is a spice and exhibits potent antioxidant and biological activities through distinct molecular mechanisms. However, the anticancer effect of cardamom was not explored yet in Ehrli...

Authors: Rafa S. Almeer, Meshael Alnasser, Nada Aljarba and Gadah I. AlBasher

Effect of acupuncture treatment in patients with mild to moderate atopic dermatitis: a randomized, participant- and assessor-blind sham-controlled trial

Atopic dermatitis (AD) is a chronic recurrent inflammatory skin disease that affects 1–3% of adults worldwide. Currently, it is not possible to completely cure AD; therefore, alternative treatments need to be ...

Authors: Jung Gun Park, Hyangsook Lee, Mijeong Yeom, Younbyoung Chae, Hi-Joon Park and Kyuseok Kim

Correction to: Chemopreventive effect of Betulinic acid via mTOR -Caspases/Bcl2/Bax apoptotic signaling in pancreatic cancer

An amendment to this paper has been published and can be accessed via the original article.

Authors: Yangyang Guo, Hengyue Zhu, Min Weng, Cheng Wang and Linxiao Sun

Neuroprotective effects of pomegranate (Punica granatum L.) juice and seed extract in paraquat-induced mouse model of Parkinson’s disease

Paraquat, (PQ), an herbicide that can induce Parkinsonian-like symptoms in rodents and humans. The consumption of phytochemical-rich plants can reduce the risk of chronic illnesses such as inflammation and neu...

Authors: Samah M. Fathy, Heba A. El-Dash and Noha I. Said

Pharmacokinetics of five phthalides in volatile oil of Ligusticum sinense Oliv.cv. Chaxiong, and comparison study on physicochemistry and pharmacokinetics after being formulated into solid dispersion and inclusion compound

The dried rhizome of Ligusticum sinense Oliv.cv. Chaxiong has been used to treat cardiovascular and cerebrovascular diseases, atherosclerosis, anemia and stroke. A high purity extract from chaxiong (VOC, brownish...

Authors: Peng-yi Hu, Ying-huai Zhong, Jian-fang Feng, Dong-xun Li, Ping Deng, Wen-liu Zhang, Zhi-qiang Lei, Xue-mei Liu and Guo-song Zhang

Alisol A 24-acetate stimulates lipolysis in 3 T3-L1 adipocytes

Alisol A 24-acetate (AA-24-a), one of the main active triterpenes isolated from the well-known medicinal plant Alisma orientale (Sam.) Juz., exhibits multiple biological activities including hypolipidemic activit...

Authors: Hai-xia Lou, Wen-cheng Fu, Jia-xiang Chen, Tian-tian Li, Ying-ying Jiang, Chun-hui Liu and Wen Zhang

The beneficial effects of the composite probiotics from camel milk on glucose and lipid metabolism, liver and renal function and gut microbiota in db/db mice

Probiotics may have beneficial effects on patients with type 2 diabetes mellitus (T2DM). We separated 4 lactobacillus and 1 saccharomycetes from traditional fermented cheese whey (TFCW) and prepared composite ...

Authors: Tabusi Manaer, Lan Yu, Xin-Hua Nabi, Dinareer Dilidaxi, Lu Liu and Jialehasibieke Sailike

Salvia miltiorrhiza hydroalcoholic extract inhibits postoperative peritoneal adhesions in rats

One of the most prevalent postoperative complications is believed to be intra-abdominal peritoneal adhesions, which is followed by several complications. Several adhesion prevention products have been examined...

Authors: Abbas Raisi, Omid Dezfoulian, Farshid Davoodi, Shayan Taheri and Soroush Afshar Ghahremani

Oral magnesium supplementation for insomnia in older adults: a Systematic Review & Meta-Analysis

Magnesium supplementation is often purported to improve sleep; however, as both an over-the-counter sleep aid and a complementary and alternative medicine, there is limited evidence to support this assertion. ...

Authors: Jasmine Mah and Tyler Pitre

Antimicrobial activity of the volatile substances from essential oils

Essential oils are volatile and lipophilic liquid extracts made from plants as secondary metabolites that can be obtained by distillation. To date, several studies have investigated the direct antimicrobial activ...

Authors: Mareshah Abers, Sydney Schroeder, Linna Goelz, Adrienne Sulser, Tiffany St. Rose, Keely Puchalski and Jeffrey Langland

The effect of a mindfulness-based stress intervention on neurobiological and symptom measures in adolescents with early life stress: a randomized feasibility study

Early life stress (ELS) has been linked to poor mental and physical health outcomes in adolescence and adulthood. Mindfulness reduces symptoms of depression and anxiety and improves cognitive and social outcom...

Authors: Zsofia P. Cohen, Kelly T. Cosgrove, Elisabeth Akeman, Sara Coffey, Kent Teague, Jennifer Hays-Grudo, Martin P. Paulus, Robin L. Aupperle and Namik Kirlic

Portulaca oleracea seeds’ extract alleviates acrylamide-induced testicular dysfunction by promoting oxidative status and steroidogenic pathway in rats

Acrylamide (ACR) is a widespread industrial and food contaminant that garnered considerable attention for its carcinogenic, neurotoxic, and reproductive toxic effects. The antioxidant effects of Portulaca olerace...

Authors: Ola M. Farag, Reham M. Abd-Elsalam, Shymaa A. El Badawy, Hanan A. Ogaly, Muhammad A. Alsherbiny and Kawkab A. Ahmed

In vitro antibacterial activity of Loxostylis alata extracts and isolated compounds against Salmonella species

Owing to antibiotic resistance, alternative antimicrobials from medicinal plants are receiving attention as leads for anti-infective agents. This study aimed to investigate selected tree species and their cons...

Authors: Dorcas A. Gado, Muna Ali Abdalla, Aroke S. Ahmed, Balungile Madikizela, Sanah M. Nkadimeng, Marthie M. Ehlers and Lyndy J. McGaw

Investigation of the idiosyncratic hepatotoxicity of Polygonum multiflorum Thunb. through metabolomics using GC-MS

The idiosyncratic hepatotoxicity of Polygonum multiflorum (PM) has attracted considerable interest, but the idiosyncratically hepatotoxic components and endogenous metabolite changes resulting from idiosyncratic ...

Authors: Yan Lin, Rong Xiao, Bo-hou Xia, Zhi-min Zhang, Chun Li, Ping Wu, Duan-fang Liao and Li-mei Lin

Antidiarrheal, antimicrobial and antioxidant potentials of methanol extract of Colocasia gigantea Hook. f. leaves: evidenced from in vivo and in vitro studies along with computer-aided approaches

Colocasia gigantea, locally named as kochu is well-known due to its various healing power. This research is to investigate the antidiarrheal, antimicrobial and antioxidant possibilities of the methanol soluble ex...

Authors: Safaet Alam, Mohammad A. Rashid, Md. Moklesur Rahman Sarker, Nazim Uddin Emon, Mohammad Arman, Isa Naina Mohamed and Mohammad Rashedul Haque

Effect of Shuangdan Mingmu capsule, a Chinese herbal formula, on oxidative stress-induced apoptosis of pericytes through PARP/GAPDH pathway

Diabetic retinopathy (DR) has become a worldwide concern because of the rising prevalence rate of diabetes mellitus (DM). Despite much energy has been committed to DR research, it remains a difficulty for diab...

Authors: Fujiao Nie, Jiazhao Yan, Yanjun Ling, Zhengrong Liu, Chaojun Fu, Xiang Li and Yuhui Qin

A new indolocarbazole derivative in melanoma and carcinoma lung in vivo treatment

The current scientific research direction is development of drugs with a targeted effect on malignant tumors. One of the promising groups is indolocarbazoles and their derivatives, which can initiate various t...

Authors: Anna Lantsova, Irina Golubeva, Larisa Borisova, Lyudmila Nikolaeva, Lydia Ektova, Maria Dmitrieva and Olga Orlova

Phytochemical analysis of medicinal plants of Nepal and their antibacterial and antibiofilm activities against uropathogenic Escherichia coli

A biofilm is an extracellular polymeric substance (EPS) composed of polysaccharides, proteins, nucleic acids, and lipids that impede antibiotics and immune cells, thus providing a shielded environment for bact...

Authors: Sudip Bhandari, Karan Khadayat, Sami Poudel, Sunil Shrestha, Raju Shrestha, Poonam Devkota, Santosh Khanal and Bishnu P. Marasini

Anti-inflammatory effects of Morus alba Linne bark on the activation of toll-like receptors and imiquimod-induced ear edema in mice

Morus alba L. bark has been widely used in traditional medicine for treating several inflammatory diseases, such as hypertension, diabetes mellitus and coughing; however, the molecular mechanisms underlying its a...

Authors: Lin Umeyama, Besse Hardianti, Shiori Kasahara, Dya Fita Dibwe, Suresh Awale, Satoru Yokoyama and Yoshihiro Hayakawa

In-vitro Immunomodulatory activity of Azadirachta indica A.Juss. Ethanol: water mixture against HIV associated chronic CD4⁺ T-cell activation/ exhaustion

In Sub-Saharan Africa, herbal therapy continues to be utilized for HIV-1 disease management. However, the therapeutic benefits of these substances remain ambiguous. To date, little is known about the effects o...

Authors: Omalla A. Olwenyi, Bannet Asingura, Prossy Naluyima, Godwin Upoki Anywar, Justine Nalunga, Mariam Nakabuye, Michael Semwogerere, Bernard Bagaya, Fatim Cham, Allan Tindikahwa, Francis Kiweewa, Eliezer Z. Lichter, Anthony T. Podany, Courtney V. Fletcher, Siddappa N. Byrareddy and Hannah Kibuuka

The prevalence of complementary and alternative medicine use in the general population of Babol, North of Iran, 2018

Complementary and Alternative Medicine (CAM) have recently become more popular and accepted worldwide. One principal step to identify the status and organize strategies of CAM is evaluating the manner and the ...

Authors: Reihaneh Moeini, Seyyed Ali Mozaffarpur, Morteza Mojahedi, Seyed Davoud Nasrolahpour Shirvani, Narjes Gorji, Roshanak Saghebi, Farid Abolhassani Shahreza and Hoda Shirafkan

Elderberry for prevention and treatment of viral respiratory illnesses: a systematic review

Elderberry has traditionally been used to prevent and treat respiratory problems. During the COVID-19 pandemic, there has been interest in elderberry supplements to treat or prevent illness, but also concern t...

Authors: L. Susan Wieland, Vanessa Piechotta, Termeh Feinberg, Emilie Ludeman, Brian Hutton, Salmaan Kanji, Dugald Seely and Chantelle Garritty

Co-electrospun nanofibrous mats loaded with bitter gourd (Momordica charantia) extract as the wound dressing materials: in vitro and in vivo study

Interactive dressings are innovatively designed to interact with the wound surface and alter the wound environment to promote wound healing. In the current study, we integrated the physicochemical properties o...

Authors: Mohammad Saeid Salami, Gholamreza Bahrami, Elham Arkan, Zhila Izadi, Shahram Miraghaee and Hadi Samadian

The use of herbal and dietary supplement among community-dwelling elderly in a suburban town of Malaysia

The use of herbal and dietary supplement (HDS) in health and disease management has gained global attention. HDS are generally accepted by the public and are associated with positive health behaviours. However...

Authors: Mohd Shahezwan Abd Wahab, Muhammad Helmi Zaini, Aida Azlina Ali, Shariza Sahudin, Muhammad Zulfadli Mehat, Hafizah Abdul Hamid, Mohd Faiz Mustaffa, Noordin Othman and Sandra Maniam

Acupuncture for post-stroke depression: a systematic review and meta-analysis

Acupuncture for post-stroke depression (PSD) has been evolving, but uncertainty remains. To assess the existing evidence from randomized clinical trials (RCTs) of acupuncture for PSD, we sought to draw conclus...

Authors: Ran Liu, Kun Zhang, Qiu-yu Tong, Guang-wei Cui, Wen Ma and Wei-dong Shen

The use of complementary and alternative medicine during pregnancy: a cross-sectional study from Palestine

The use of complementary and alternative medicine (CAM) is increasing worldwide. To the best of knowledge, there is a lack of studies that assess CAM use by Palestinian women during pregnancy. This research ai...

Authors: Yara Quzmar, Zeina Istiatieh, Hala Nabulsi, Sa’ed H. Zyoud and Samah W. Al-Jabi

Phytochemical analysis, in-vitro anti-proliferative, anti-oxidant, anti-diabetic, and anti-obesity activities of Rumex rothschildianus Aarons. extracts

Rumex rothschildianus is the sole member of a unique section of the genus Rumex, in the family Polygonaceae. This species is a very rare small dioecious annual, endemic to Palestine that is traditionally used as ...

Authors: Nidal Jaradat, Mohammed Hawash and Gada Dass

Bio-guided isolation of anti-leishmanial natural products from Diospyros gracilescens L. (Ebenaceae)

Plants represent an intricate and innovative source for the discovery of novel therapeutic remedies for the management of infectious diseases. The current study aimed at discovering new inhibitors of Leishmania s...

Authors: Cyrille Armel N. Njanpa, Steven Collins N. Wouamba, Lauve Rachel T. Yamthe, Darline Dize, Brice Mariscal T. Tchatat, Patrick Valère F. Tsouh, Michel Nguiam Pouofo, Jean Bosco Jouda, Bruno Lenta Ndjakou, Norbert Sewald, Simeon Fogue Kouam and Fabrice Fekam Boyom

Antibacterial, anti-inflammatory and antioxidant activities of Mahanintangtong and its constituent herbs, a formula used in Thai traditional medicine for treating pharyngitis

Mahanintangtong is listed in the Thailand’s National List of Essential Medicines (NLEM). It is used to treat non-specific fevers and illnesses such as pharyngitis and chickenpox. In this study, we investigated...

Authors: Bhanuz Dechayont, Pathompong Phuaklee, Jitpisute Chunthorng-Orn, Thana Juckmeta, Onmanee Prajuabjinda and Kitrawee Jiraratsatit

Hepatoprotective effect of silymarin on fructose induced nonalcoholic fatty liver disease in male albino wistar rats

Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease in the Western world, and it’s likely to parallel the increasing prevalence of type 2 diabetes, obesity, and o...

Authors: Tewodros Mengesha, Natesan Gnanasekaran and Tsegaye Mehare

Effect of policosanol from insect wax on amyloid β-peptide-induced toxicity in a transgenic Caenorhabditis elegans model of Alzheimer’s disease

Alzheimer’s disease (AD), an age-related neurodegenerative disorder and a serious public health concern, is mainly caused by β-amyloid (Aβ)-induced toxicity. Currently, a limited number of drugs are effective ...

Authors: Xin Zhang, Chenjing Ma, Long Sun, Zhao He, Ying Feng, Xian Li, Jin Gan and Xiaoming Chen

Clinical safety of total glucosides of paeony adjuvant therapy for rheumatoid arthritis treatment: a systematic review and meta-analysis

Total glucosides of paeony (TGP), an active compound extracted from the roots of Paeonia lactiflora Pallas, has been increasingly used as the adjunctive therapy for rheumatoid arthritis (RA) patients. Though TGP ...

Authors: Bin Liu, Xiang Meng, Yanfang Ma, Huizhen Li, Yuqi Liu, Nannan Shi, Yaolong Chen, Yanping Wang and Cheng Lu

Eye acupuncture for pain conditions: a scoping review of clinical studies

Chinese eye acupuncture, focuses on treating different diseases by applying needle stimulation around the orbit of the eye. Since 1970, it has been used in China for the management of pain-related disorders. T...

Authors: Yuan Chi, Jürgen Barth, Mei Wang, Nicola Robinson, Zan-Hua Li and Jian-Ping Liu

Tanshinone IIA combined with CsA inhibit myocardial cell apoptosis induced by renal ischemia-reperfusion injury in obese rats

Acute myocardial injury (AMI), which is induced by renal ischemia-reperfusion (IR), is a significant cause of acute kidney injury (AKI)-related associated death. Obesity increases the severity and frequency of...

Authors: He Tai, Xiao-lin Jiang, Zhi-ming Lan, Yue Li, Liang Kong, Si-cheng Yao, Nan Song, Mei-jun Lv, Jin Wu, Ping Yang, Xuan-si Xiao, Guan-lin Yang, Jin-song Kuang and Lian-qun Jia

A network pharmacology-based investigation on the bioactive ingredients and molecular mechanisms of Gelsemium elegans Benth against colorectal cancer

Colorectal cancer (CRC) remains one of the leading causes of cancer-related death worldwide. Gelsemium elegans Benth (GEB) is a traditional Chinese medicine commonly used for treatment for gastrointestinal cancer...

Authors: Wancai Que, Maohua Chen, Ling Yang, Bingqing Zhang, Zhichang Zhao, Maobai Liu, Yu Cheng and Hongqiang Qiu

Extracts of endophytic fungi from leaves of selected Nigerian ethnomedicinal plants exhibited antioxidant activity

Plants with an ethnobotanical history are known to harbor diverse group of endophytic fungi, which constitute major natural sources of bioactive compounds. In the present study, we evaluated the antioxidant ac...

Authors: Mutiat Ibrahim, Elizabeth Oyebanji, Muinah Fowora, Ayobami Aiyeolemi, Chiamaka Orabuchi, Babajide Akinnawo and Adedotun A. Adekunle

Tinospora cordifolia chloroform extract inhibits LPS-induced inflammation via NF-κB inactivation in THP-1cells and improves survival in sepsis

Tinospora cordifolia (Willd).Miers is a perennial climbing medicinal shrub that has been traditionally used for the treatment of chronic inflammatory ailments. Our previous pre- clinical studies on anti-inflammat...

Authors: Sheena Philip, Greeshma Tom, Padmaja Balakrishnan Nair, Sankar Sundaram and Asha Velikkakathu Vasumathy

Complementary and alternative medicine use by pediatric oncology patients before, during, and after treatment

The prevalence of complementary and alternative medicine (CAM) use and the modalities used by pediatric oncology patients vary widely across studies. In addition, the changes in the use of CAM over the course ...

Authors: Emmanuelle Lüthi, Manuel Diezi, Nadia Danon, Julie Dubois, Jérôme Pasquier, Bernard Burnand and Pierre-Yves Rodondi

¹H nuclear magnetic resonance-based metabolite profiling of guava leaf extract: an attempt to develop a prototype for standardization of plant extracts

Herbal medicines are fast gaining popularity. However, their acceptability by modern practitioners is low which is often due to lack of standardization. Several approaches towards standardization of herbals ha...

Authors: Manasi S. Gholkar, Jia V. Li, Poonam G. Daswani, P. Tetali and Tannaz J. Birdi

Use of complementary and alternative medicine in Norway: a cross-sectional survey with a modified Norwegian version of the international questionnaire to measure use of complementary and alternative medicine (I-CAM-QN)

In recent decades complementary and alternative medicine (CAM) has been widely used worldwide as well as in Norway, where CAM is offered mainly outside the national health care service, mostly complementary to...

Authors: Agnete Egilsdatter Kristoffersen, Sara A. Quandt and Trine Stub

Anti-influenza A virus activity of two Newtonia species and the isolated compound myricetin-3-o-rhamnoside

Some viruses play a key role in the disturbance of the digestive system. The common viruses which cause infectious diarrhoea (gastroenteritis) include astrovirus, caliciviruses, coronavirus and torovirus which...

Authors: Katlego E. Motlhatlego, Parvaneh Mehrbod, Fatemeh Fotouhi, Muna Ali Abdalla, Jacobus N. Eloff and Lyndy J. McGaw