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  1. This study evaluated the in vitro antioxidant activity and comparison of anti-inflammatory and cytotoxic activity of Harpagopytum zeyheri with diclofenac.

    Authors: Sibonokuhle F. Ncube, Lyndy J. McGaw, Emmanuel Mfotie Njoya, Hilton G. T. Ndagurwa, Peter J. Mundy and Samson Sibanda

    Citation: BMC Complementary Medicine and Therapies 2021 21:238

    Content type: Research

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  2. Vulvovaginal candidiasis (VVC), the second leading cause of genital infection in women of reproductive age, is caused by yeasts of the genus Candida. Treatment is usually empirical and performed with azoles, whic...

    Authors: Aline Lorenzoni Paniágua, Amabel Fernandes Correia, Lívia Custódio Pereira, Bruna Maciel de Alencar, Fabiana Brandão Alves Silva, Rosane Mansan Almeida and Yanna Karla de Medeiros Nóbrega

    Citation: BMC Complementary Medicine and Therapies 2021 21:237

    Content type: Research article

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  3. Globally, 3 billion people suffer from either migraine or tension-type headache disorder over their lifetime. Approximately 50% of American adults suffering from headache or migraine have used complementary an...

    Authors: Jeremy Y. Ng and Christina Hanna

    Citation: BMC Complementary Medicine and Therapies 2021 21:236

    Content type: Research article

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  4. Siraitia grosvenorii (binomial name Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang), also called Arhat Fruit or Monk’s Fruit, is a dried ripe fruit belonging to the Cucurbitaceae Family. S. grosve...

    Authors: Wei Dong, Jia Zeng, Qin Wang, Xin Jiang and Ting Huang

    Citation: BMC Complementary Medicine and Therapies 2021 21:235

    Content type: Research article

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  5. Uvaria chamae (UC) and Olax subscorpioidea (OS) roots are included in traditional anti-cancer remedies and some studies have identified their chemopreventive/chemotherapeutic potential. This study aimed to identi...

    Authors: Temidayo D. Popoola, Stephanie T. Guetchueng, Kenneth J. Ritchie, Olufunsho Awodele, Nicola M. Dempster, Oluyemi Akinloye, Satyajit D. Sarker and Amos A. Fatokun

    Citation: BMC Complementary Medicine and Therapies 2021 21:234

    Content type: Research article

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  6. The global prevalence of diabetes mellitus is projected to reach approximately 700 million by the year 2045, with roughly 90–95% of all diabetes cases being type 2 in nature. Patients with type 2 diabetes mell...

    Authors: Jeremy Y. Ng, Manav Nayeni and Kevin Gilotra

    Citation: BMC Complementary Medicine and Therapies 2021 21:233

    Content type: Research article

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  7. One of the most prevalent complications of chemotherapy and radiotherapy is oral mucositis (OM) and manifests as erythema and ulceration. Curcumin is one of the components of turmeric and possesses anti-inflam...

    Authors: Seyed Javad Kia, Maryam Basirat, Hamid Saeidi Saedi and Seyed Ali Arab

    Citation: BMC Complementary Medicine and Therapies 2021 21:232

    Content type: Research

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  8. Neorautanenia mitis, Hydnora abyssinica, and Senna surattensis are medicinal plants with a variety of traditional uses. In this study, we sought to isolate the bioactive compounds responsible for some of these ac...

    Authors: Christiana J. Dawurung, Minh T. H. Nguyen, Jutharat Pengon, Kanchana Dokladda, Ratchanu Bunyong, Roonglawan Rattanajak, Sumalee Kamchonwongpaisan, Phuong T. M. Nguyen and Stephen G. Pyne

    Citation: BMC Complementary Medicine and Therapies 2021 21:231

    Content type: Research article

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  9. Little is known about the medical material and practices of tribes in the western border areas of Pakistan. The local population has inhabited this remote and isolated area for centuries, and gained medicinal ...

    Authors: Khalid Ahmad, Mushtaq Ahmad, Franz K. Huber and Caroline S. Weckerle

    Citation: BMC Complementary Medicine and Therapies 2021 21:230

    Content type: Research article

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  10. We previously reported that the tomato glycoalkaloid tomatine inhibited the growth of Trichomonas vaginalis strain G3, Tritrichomonas foetus strain D1, and Tritrichomonas foetus-like strain C1 that cause disease ...

    Authors: Christina C. Tam, Kevin Nguyen, Daniel Nguyen, Sabrina Hamada, Okhun Kwon, Irene Kuang, Steven Gong, Sydney Escobar, Max Liu, Jihwan Kim, Tiffany Hou, Justin Tam, Luisa W. Cheng, Jong H. Kim, Kirkwood M. Land and Mendel Friedman

    Citation: BMC Complementary Medicine and Therapies 2021 21:229

    Content type: Research article

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  11. Traditional Chinese Medicine (TCM) has been a proposed treatment option for ulcerative colitis (UC), however it has been difficult to understand the breadth and depth of evidence as various Chinese medicine th...

    Authors: Yu-Xin Sun, Xiao Wang, Xing Liao, Jing Guo, Wen-Bin Hou, Xin Wang, Jian-Ping Liu and Zhao-Lan Liu

    Citation: BMC Complementary Medicine and Therapies 2021 21:228

    Content type: Research article

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  12. Leucas cephalotes is a common ethnomedicinal plant widely used by traditional healers for the treatment of Malaria and other types of fever. Oleanolic acid and its derivatives have been reported for various types...

    Authors: Sulochana Kaushik, Lalit Dar, Samander Kaushik and Jaya Parkash Yadav

    Citation: BMC Complementary Medicine and Therapies 2021 21:227

    Content type: Research article

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  13. Atopic dermatitis (AD) is a chronic inflammatory skin disease mainly caused by immune stimuli. The current study was conducted to investigate the effects of ROCEN and to compare it with betamethasone (Beta) on...

    Authors: Ramin Goudarzi, Maryam Eskandarynasab, Ahad Muhammadnejad, Ahmad Reza Dehpour and Alireza Partoazar

    Citation: BMC Complementary Medicine and Therapies 2021 21:226

    Content type: Research

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  14. Cisplatin is an outstanding anticancer drug, but its use has been decreased remarkably due to sever nephrotoxicity. R. vesicarius L. is a leafy vegetable that is evident with anti-angeogenic, anti-inflammatory, a...

    Authors: Md. Mahmudul Hasan, Most. Sayla Tasmin, Ahmed M. El-Shehawi, Mona M. Elseehy, Md. Abu Reza and Ariful Haque

    Citation: BMC Complementary Medicine and Therapies 2021 21:225

    Content type: Research

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  15. Oleanolic acid (OA) has multiple pharmaceutical applications including anti-inflammatory activity, but low permeability of the molecule limits its widespread use.

    Authors: Zhiqi Shi, Shugang Pan, Luolin Wang and Sha Li

    Citation: BMC Complementary Medicine and Therapies 2021 21:224

    Content type: Research

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  16. The majority of global population suffer from various functional gastrointestinal disorders. Pugionium cornutum (L.) Gaertn. (PCG) is used to relieve indigestive symptoms in traditional Chinese medicine. However,...

    Authors: Chencan Su, Haoyu Li, Bang Chen, Cong Li, Chunxiao Zhang, Long Xu, Mei Lan and Yehua Shen

    Citation: BMC Complementary Medicine and Therapies 2021 21:223

    Content type: Research

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  17. Increasing attention has been paid to the effect of Epimedium on the nervous system, particularly anti-depression function. In the present study, we applied network pharmacology to introduce a testable hypothesis...

    Authors: Yankai Dong, Bo Tao, Xing Xue, Caixia Feng, Yating Ren, Hengyu Ma, Junli Zhang, Yufang Si, Sisi Zhang, Si Liu, Hui Li, Jiahao Zhou, Ge Li, Zhifei Wang, Juanping Xie and Zhongliang Zhu

    Citation: BMC Complementary Medicine and Therapies 2021 21:222

    Content type: Research article

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  18. Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide. The aim of this study was to evaluate the effects of hydro-alcoholic extract of spinach (HES) on hepatic and serum measureme...

    Authors: Ali Amirinejad, Ali Saneei Totmaj, Farzaneh Mardali, Azita Hekmatdoost, Hadi Emamat, Majid Safa and Farzad Shidfar

    Citation: BMC Complementary Medicine and Therapies 2021 21:221

    Content type: Research

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  19. ECa 233 is a standardized extract of C. asiatica containing the triterpenoid glycosides, madecassoside to asiaticoside in the ratio of (1.5 ± 0.5):1. Anti-inflammatory activities of ECa 233 have been reported; ho...

    Authors: Supannikar Tawinwung, Dhirarin Junsaeng, Supanut Utthiya and Phisit Khemawoot

    Citation: BMC Complementary Medicine and Therapies 2021 21:220

    Content type: Research

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  20. Obtusofolin is the major active ingredient of Catsia tora L., which possesses the activity of improving eyesight and protecting the optic nerve. Investigation on the interaction of obtusofolin with cytochrome ...

    Authors: Na Liu, Ping Chen, Xiaojun Du, Junxia Sun and Shasha Han

    Citation: BMC Complementary Medicine and Therapies 2021 21:218

    Content type: Research

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  21. Traditional Chinese medicine (TCM) has gained widespread application in treating chronic heart failure (CHF) secondary to coronary heart disease (CHD). However, the sound clinical evidence is still lacking. Co...

    Authors: Jiayuan Hu, Ruijin Qiu, Chengyu Li, Min Li, Qianqian Dai, Shiqi Chen, Chen Zhao and Hongcai Shang

    Citation: BMC Complementary Medicine and Therapies 2021 21:217

    Content type: Research article

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  22. In recent years, an increase in the occurrence of illnesses caused by two clinically- important arboviruses has been reported: Zika virus (ZIKV) and Chikungunya virus (CHIKV). There is no licensed antiviral tr...

    Authors: Laura Milena Monsalve-Escudero, Vanessa Loaiza-Cano, Yina Pájaro-González, Andrés Felipe Oliveros-Díaz, Fredyc Diaz-Castillo, Wiston Quiñones, Sara Robledo and Marlen Martinez-Gutierrez

    Citation: BMC Complementary Medicine and Therapies 2021 21:216

    Content type: Research

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  23. The current study was aimed to investigate the anti-allergic activities of the Umbelliferone (UMB) against the acute Histamine and chronic Picryl chloride (PiCl)-induced allergy in mice. UMB is a coumarin deri...

    Authors: Younas, Ashrafullah Khan, Omer Shehzad, Eun Kyoung Seo, Alev Onder and Salman Khan

    Citation: BMC Complementary Medicine and Therapies 2021 21:215

    Content type: Research article

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  24. The results from clinical trials have revealed that the effects of resveratrol supplementation on bone mineral density (BMD) and bone biomarkers are inconsistent. Our objective was to determine the effects of ...

    Authors: Qiangqiang Li, Guangpu Yang, Hongtao Xu, Shaowen Tang and Wayne Yuk-wai Lee

    Citation: BMC Complementary Medicine and Therapies 2021 21:214

    Content type: Research article

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  25. The use of dietary and herbal supplements (DIHES) is widespread among people with multiple sclerosis (PwMS). PwMS are a highly informed patient group, and they use several types of sources to seek information ...

    Authors: Sofie Bergien, Clara M. Petersen, Marie Lynning, Maria Kristiansen and Lasse Skovgaard

    Citation: BMC Complementary Medicine and Therapies 2021 21:213

    Content type: Research article

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  26. Lycium barbarum polysaccharide (LBP), the most abundant functional component of wolfberry, is considered a potent antioxidant and an anti-ageing substance. This review aims to outline the hallmarks of ageing in t...

    Authors: Junguo Ni, Manting Au, Hangkin Kong, Xinluan Wang and Chunyi Wen

    Citation: BMC Complementary Medicine and Therapies 2021 21:212

    Content type: Research article

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  27. The incidence of application of medicinal herbs during pregnancy has increased significantly among women over the past years; however, the safety and efficacy of medicinal herbs during pregnancy are still unclear...

    Authors: Zahra Karimian, Zohreh Sadat, Bahareh Afshar, Maryam Hasani, Marzieh Araban and Mahbubeh Kafaei-Atrian

    Citation: BMC Complementary Medicine and Therapies 2021 21:211

    Content type: Research

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  28. The popular use of traditional medicine in low-income settings has previously been attributed to poverty, lack of education, and insufficient accessibility to conventional health service. However, in many coun...

    Authors: Mengxin Tan, Yuko Otake, Teisi Tamming, Valerie Akuredusenge, Beatha Uwinama and Fabien Hagenimana

    Citation: BMC Complementary Medicine and Therapies 2021 21:210

    Content type: Research article

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  29. The chemical composition and biological activity of Eucalyptus essential oils have been studied extensively (EOs). A few of them were tested for antibacterial effectiveness against otitis strains. The chemical...

    Authors: Elaissi Ameur, Moumni Sarra, Derbali Yosra, Kouja Mariem, Abid Nabil, Frederic Lynen and Khouja Mohamed Larbi

    Citation: BMC Complementary Medicine and Therapies 2021 21:209

    Content type: Research article

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  30. Integrating systems biology is an approach for investigating metabolic diseases in humans. However, few studies use this approach to investigate the mechanism by which Rhizoma coptidis (RC) reduces the effect of ...

    Authors: Yanhua Ji, Kexin Luo, Jiri Mutu Zhang, Peng Ni, Wangping Xiong, Xiaoquan Luo, Guoliang Xu, Hongning Liu and Zhijun Zeng

    Citation: BMC Complementary Medicine and Therapies 2021 21:208

    Content type: Research article

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  31. Bupi Yishen Formula (BYF), a patent traditional Chinese medicine (TCM) formulation, has been used in the clinical treatment of chronic kidney disease (CKD). However, the mechanism of action of BYF has not been...

    Authors: Yenan Mo, Xina Jie, Lixin Wang, Chunlan Ji, Yueyu Gu, Zhaoyu Lu and Xusheng Liu

    Citation: BMC Complementary Medicine and Therapies 2021 21:207

    Content type: Research article

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  32. Alzheimer’s disease (AD) is one of the most common neurodegenerative disorders, but there is still no effective way to stop or slow its progression. Our previous studies demonstrated that extract of Cynomorium so...

    Authors: Dan Cheng, Lei Su, Xu Wang, Xinjie Li, Lingling Li, Mengyuan Hu and Yi Lu

    Citation: BMC Complementary Medicine and Therapies 2021 21:206

    Content type: Research article

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  33. The contemporary evidence-based practice model acknowledges the importance of patient preferences and clinician experience when applying evidence within a clinical setting. Knowledge mobilisation (KM) acknowle...

    Authors: Amie Steel, Matthew Leach, Caragh Brosnan, Vicky Ward and Iva Lloyd

    Citation: BMC Complementary Medicine and Therapies 2021 21:205

    Content type: Research

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  34. Wedelia chinensis has been reported as a folk medicine for the treatment of different diseases including neurodegenerative disease. Although the plant has been studied well for diverse biological activities, the ...

    Authors: Md. Aminul Islam, Shahed Zaman, Kushal Biswas, Md. Yusuf Al-Amin, Md. Kamrul Hasan, A. H. M. K. Alam, Toshihisa Tanaka and Golam Sadik

    Citation: BMC Complementary Medicine and Therapies 2021 21:204

    Content type: Research

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  35. Saffron or stigmas of Crocus sativus L. is one of the most valuable food products with interesting health-promoting properties. C. sativus has been widely used as a coloring and flavoring agent. Stigmas secondary...

    Authors: Olha Mykhailenko, Vilma Petrikaitė, Michal Korinek, Mohamed El-Shazly, Bing-Hung Chen, Chia-Hung Yen, Chung-Fan Hsieh, Ivan Bezruk, Asta Dabrišiūtė, Liudas Ivanauskas, Victoriya Georgiyants and Tsong-Long Hwang

    Citation: BMC Complementary Medicine and Therapies 2021 21:203

    Content type: Research

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  36. Gout is initiated by the precipitation of monosodium urate (MSU) crystals within the joints and soft tissues, and it can eventually cause acute or chronic arthritis. MSU crystals trigger, amplify, and maintain...

    Authors: Hao-fei Fan, Xing-yue Fang, Hao-lin Wu, Yi-qian Xu, Li-chong Gong, Dao-rui Yu, Hao Jia, Xiao-liang Tang and Qi-bing Liu

    Citation: BMC Complementary Medicine and Therapies 2021 21:202

    Content type: Research article

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  37. Over the past few decades, the popularity of complementary and alternative medicine (CAM) has grown considerably and along with it, scrutiny regarding its evidence base. While this is to be expected, and is in...

    Authors: Yasamin Veziari, Saravana Kumar and Matthew Leach

    Citation: BMC Complementary Medicine and Therapies 2021 21:201

    Content type: Research article

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  38. In response to the World Health Organization’s recommendation, policy makers have been adopting evidence-based healthcare approach to promote the development of traditional, complementary and integrative medic...

    Authors: Charlene Hoi Lam Wong, Jeffrey Van Ho Tse, Per Nilsen, Leonard Ho, Irene Xin Yin Wu and Vincent Chi Ho Chung

    Citation: BMC Complementary Medicine and Therapies 2021 21:200

    Content type: Research

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  39. Our current study aimed to evaluate the effect of an Glechoma hederacea extract (Hitrechol®) in normal rats and gallstone diseased mice to explore its underlying mechanisms. Normal rats and C57BL/6 mice with/with...

    Authors: Min Xiao, Mengbi Yang, Xiaoyu Ji, Dan Li, Yuning Xie, Yuanfeng Lyu and Zhong Zuo

    Citation: BMC Complementary Medicine and Therapies 2021 21:199

    Content type: Research

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  40. Degenerative kidney diseases are mostly associated with oxidative stress. Natural products are considered as the antioxidants enrich food that can restrict the progress of oxidative stress induced disorders. T...

    Authors: Samiullah Burki, Zeba Gul Burki, Muhammad Arif Asghar, Imdad Ali and Saba Zafar

    Citation: BMC Complementary Medicine and Therapies 2021 21:198

    Content type: Research

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  41. Dryopteris ramosa has numerous potentials uses in the treatment of different maladies as old traditional medication. The fronds of D. ramose are edible and orally administered for producing antibiotic effect. The...

    Authors: Fiaz Alam, Syed Hurmat Ali Khan and Mohammad Hassham Hassan Bin Asad

    Citation: BMC Complementary Medicine and Therapies 2021 21:197

    Content type: Research

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  42. Metastatic castration-resistant prostate cancer (CRPC) is the leading cause of death among men diagnosed with prostate cancer. Piperlongumine (PL) is a novel potential anticancer agent that has been demonstrat...

    Authors: Ding-fang Zhang, Zhi-chun Yang, Jian-qiang Chen, Xiang-xiang Jin, Yin-da Qiu, Xiao-jing Chen, Hong-yi Shi, Zhi-guo Liu, Min-shan Wang, Guang Liang and Xiao-hui Zheng

    Citation: BMC Complementary Medicine and Therapies 2021 21:195

    Content type: Research article

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  43. Hepatocellular carcinoma (HCC) represents a serious public health problem worldwide and has high morbidity and mortality. Dihydromyricetin (DHM) exhibits anticancer effect on a variety of malignancies, but its...

    Authors: Lianggui Jiang, Wen-Chu Ye, Zuobiao Li, Yongguang Yang, Wei Dai and Mingyi Li

    Citation: BMC Complementary Medicine and Therapies 2021 21:194

    Content type: Research

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  44. Psoriasis is an autoimmune inflammatory skin disease that affects 0.5–3% of the world’s population and current treatment options are posed with limitations. The reduced risk of failure in clinical trials for r...

    Authors: Akachukwu Ibezim, Emmanuel Onah, Ebubechukwu N. Dim and Fidele Ntie-Kang

    Citation: BMC Complementary Medicine and Therapies 2021 21:193

    Content type: Research

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  45. Lippia javanica (lemon bush) is commonly used in the treatment of respiratory ailments, including asthma in southern African countries but there is no scientific evidence to support this claim. This study investi...

    Authors: Mvuyisi O. M. Mfengu, Mathulo Shauli, Godwill A. Engwa, Hannibal T. Musarurwa and Constance R. Sewani-Rusike

    Citation: BMC Complementary Medicine and Therapies 2021 21:192

    Content type: Research

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  46. Metastasis is the leading cause of death among breast cancer patients. MicroRNA-134 has been reported to have a tumor-suppressive role in breast cancer. Ruyiping (RYP), a traditional Chinese formula, has been ...

    Authors: Ziwei Jiang, Lixia Pei, Ying Xie, Qun Ye, Xiaoqiang Liang, Yiyi Ye and Sheng Liu

    Citation: BMC Complementary Medicine and Therapies 2021 21:191

    Content type: Research article

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  47. Obesity is a common medical condition. Among all the classifications of obesity, central obesity is considered to be a significant threat on the health of individuals. Scientific researches have demonstrated t...

    Authors: Linda L. D. Zhong, Xingyao Wu, Tsz Fung Lam, Ying Ping Wong, Peihua Cao, Emily Yen Wong, Shipping Zhang and Zhaoxiang Bian

    Citation: BMC Complementary Medicine and Therapies 2021 21:190

    Content type: Study protocol

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  48. Radioresistance can pose a significant obstacle to the effective treatment of breast cancers. Epithelial–mesenchymal transition (EMT) is a critical step in the acquisition of stem cell traits and radioresistan...

    Authors: Jiraporn Kantapan, Siwaphon Paksee, Aphidet Duangya, Padchanee Sangthong, Sittiruk Roytrakul, Sucheewin Krobthong, Wipob Suttana and Nathupakorn Dechsupa

    Citation: BMC Complementary Medicine and Therapies 2021 21:189

    Content type: Research article

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