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  1. Herbal medicines are widely used in the world especially in developing countries. Pregnant women use herbal products to treat pregnancy related illnesses due to prior experience of herbal medicine use and easy...

    Authors: Yaschilal Muche Belayneh, Tewodros Yoseph and Solomon Ahmed
    Citation: BMC Complementary Medicine and Therapies 2022 22:146
  2. Use of natural products has been proposed as an efficient method in modulation of immune system and treatment of cancers. The aim of this study was to investigate the potential of cryptotanshinone (CPT), narin...

    Authors: Shokoofe Noori, Mitra Nourbakhsh, Hossein Imani, Niloofar Deravi, Niloufar Salehi and Zohreh Abdolvahabi
    Citation: BMC Complementary Medicine and Therapies 2022 22:145
  3. Chronic exposure to ultraviolet B (UVB) causes a series of adverse skin reactions, such as erythema, sunburn, photoaging, and cancer, by altering signaling pathways related to inflammation, oxidative stress, a...

    Authors: Bei Chen, Honghong Chen, Haidong Qu, Kun Qiao, Min Xu, Jingna Wu, Yongchang Su, Yan Shi, Zhiyu Liu and Qin Wang
    Citation: BMC Complementary Medicine and Therapies 2022 22:144
  4. Cinnamon (Cinnamomum zeylanicum) and Clove (Syzygium aromaticum) essential oils are two medicinally important plant-derived substances with a wide range of biological properties. Besides, nanoemulsion-based gels ...

    Authors: Fariba Esmaeili, Masoumeh Zahmatkeshan, Yaser Yousefpoor, Hiva Alipanah, Ehsan Safari and Mahmoud Osanloo
    Citation: BMC Complementary Medicine and Therapies 2022 22:143
  5. The potential of essential oils (EOs) and of their principal constituents for eradication of biofilm and at the same time the research of new potential acetylcholinesterase inhibitors is gaining increasing int...

    Authors: Lucia Caputo, Francesca Capozzolo, Giuseppe Amato, Vincenzo De Feo, Florinda Fratianni, Giovanni Vivenzio and Filomena Nazzaro
    Citation: BMC Complementary Medicine and Therapies 2022 22:142
  6. Diabetic retinopathy (DR), one of the most common and severe microvascular complication of diabetes mellitus (DM), is mainly caused by diabetic metabolic disorder. So far, there is no effective treatment for D...

    Authors: Yao Chen, Jiaojiao Sun, Zhiyun Zhang, Xiaotong Liu, Qiaozhi Wang and Yang Yu
    Citation: BMC Complementary Medicine and Therapies 2022 22:141
  7. Mosquito-borne diseases such as malaria and encephalitis are still the cause of several hundred thousand deaths annually. The excessive use of chemical insecticides for transmission control has led to environm...

    Authors: Alireza Sanei-Dehkordi, Mohammad Djaefar Moemenbellah-Fard, Mostafa Saffari, Elham Zarenezhad and Mahmoud Osanloo
    Citation: BMC Complementary Medicine and Therapies 2022 22:140
  8. Crinum latifolium L. (Amaryllidaceae) has been used in Southeast Asian traditional medicine to alleviate the symptoms of benign prostatic hyperplasia (BPH). The pathological mechanism of BPH is associated with th...

    Authors: Wisuwat Thongphichai, Tamonwan Uttarawichien, Pithi Chanvorachote, Supaporn Pitiporn, Todsaphol Charoen-ame, Pakakrong Kwankhao, Pasarapa Towiwat and Suchada Sukrong
    Citation: BMC Complementary Medicine and Therapies 2022 22:139
  9. Alleviating suffering and improving quality of life are universally shared goals. In this context, we implemented a pilot study to assess the feasibility and acceptability of a mindfulness intervention in the ...

    Authors: Virginie Prevost, Sophie Lefevre-Arbogast, Alexandra Leconte, Claire Delorme, Sandrine Benoit, Titi Tran and Bénédicte Clarisse
    Citation: BMC Complementary Medicine and Therapies 2022 22:138
  10. Cancer-related incidence and mortality rates are rapidly increasing worldwide. However, no studies have examined the effect of cancer as a single factor on the use of traditional, complementary, and alternativ...

    Authors: Dongsu Kim, Soo-Hyun Sung, Seungwon Shin and Minjung Park
    Citation: BMC Complementary Medicine and Therapies 2022 22:137
  11. Authors: Hei-Jen Huang, Jie-Ling Chen, Jian-Fu Liao, Yu-Hsin Chen, Min-Wei Chieu, Ya-Yun Ke, Chih-Chieh Hsu, Ying-Chieh Tsai and Hsiu Mei Hsieh-Li
    Citation: BMC Complementary Medicine and Therapies 2022 22:136

    The original article was published in BMC Complementary Medicine and Therapies 2021 21:259

  12. Trachyspermum ammi, commonly known as Ajwain, is a member of the Apiaceae family. It is a therapeutic herbal spice with diverse pharmacological properties, used in traditional medicine for various ailments. Howev...

    Authors: Saud O. Alshammari, Taibah Aldakhil, Qamar A. Alshammari, David Salehi and Aftab Ahmed
    Citation: BMC Complementary Medicine and Therapies 2022 22:135
  13. The genus Eryngium is a member of the Apiaceae family that has shown different pharmacological effects mainly including anti-inflammatory, analgesic, anti-cancer, hepatoprotective, and anti-oxidant. Previous r...

    Authors: Haleh Forouhandeh, Zahra Rezaei Param, Ommoleila Molavi, Parina Asgharian and Vahideh Tarhriz
    Citation: BMC Complementary Medicine and Therapies 2022 22:134
  14. The blood-testis barrier (BTB) is a physical barrier of the testis to prevent various exogenous substrates from entering apical compartments and provides immune privilege for spermatogenesis, which is essentia...

    Authors: Junjun Li, Yaodong You, Peihai Zhang, Xiaopeng Huang, Liang Dong, Fang Yang, Xujun Yu and Degui Chang
    Citation: BMC Complementary Medicine and Therapies 2022 22:133
  15. Cordyceps species have been used as tonics to enhance energy, stamina, and libido in traditional Asian medicine for more than 1600 years, indicating their potential for improving reproductive hormone disorders an...

    Authors: Dongyeop Jang, Eunjoo Lee, Sullim Lee, Yongsam Kwon, Ki Sung Kang, Chang-Eop Kim and Daeyoung Kim
    Citation: BMC Complementary Medicine and Therapies 2022 22:132
  16. Cognitive health is of great interest to society, with neuroinflammation and systemic inflammation age-related risk factors that are linked to declines in cognitive performance. Several botanical ingredients h...

    Authors: Gemma Margetts, Sotirios Kleidonas, Nawel S. Zaibi, Mohamed S. Zaibi and Kieron D. Edwards
    Citation: BMC Complementary Medicine and Therapies 2022 22:131
  17. Medicinal plants have been successfully used as an alternative source of drugs for the treatment of microbial diseases. Finding a novel treatment for malaria is still challenging, and various extracts from dif...

    Authors: Ahmed M. Abdou, Abdel-latif S. Seddek, Noha Abdelmageed, Mohamed O. Badry and Yoshifumi Nishikawa
    Citation: BMC Complementary Medicine and Therapies 2022 22:130
  18. Jianpi Qinghua Fomula (JPQHF), a clinically proven prescription,has been applied to cure insulin resistance(IR) and type 2 diabetes (T2DM) for more than 20 years. Here, we will unravel the underlying molecular...

    Authors: Yahua Liu, Xu Han, Mengjie Cai, Shenyi Jin, Zihui Yan, Hao Lu and Qingguang Chen
    Citation: BMC Complementary Medicine and Therapies 2022 22:129
  19. Complementary and alternative medicine (CAM) is defined as a group of diverse medical and healthcare practices outside of conventional medicine modalities. The use of CAM is steadily increasing despite gaps in...

    Authors: Brittany R. Odegard, Mollie R. Ferguson, Farah Naja, Jennifer Ayoub and Jinan Banna
    Citation: BMC Complementary Medicine and Therapies 2022 22:128
  20. The International Cohort on Lifestyle Determinants of Health (INCLD Health) is an ongoing, prospective cohort study assessing the health behaviours and lifestyles of higher education students, including their ...

    Authors: Adam Sadowski, Ryan S. Wexler, Douglas Hanes, Lita Buttolph, Tediana Torrens, Jillian Moehle, Hadil Sarrar, Joanna Harnett, David T. Zava and Ryan Bradley
    Citation: BMC Complementary Medicine and Therapies 2022 22:127
  21. Home remedies are anchored in patients’ everyday life, but their use in Western cultures remains scarcely explored. Our objectives were to investigate primary care patients’ perspectives and use of non-pharmac...

    Authors: Neria E. Winkler, Paul Sebo, Dagmar M. Haller and Hubert Maisonneuve
    Citation: BMC Complementary Medicine and Therapies 2022 22:126
  22. The current drug treatments for benign prostatic hyperplasia (BPH) have negative side effects. Therefore, it is important to find effective alternative therapies with significantly fewer side effects. Our prev...

    Authors: Guifang Huang, Xiao He, Zesheng Xue, Yiming Long, Jiakuan Liu, Jinming Cai, Pengfei Tang, Bangmin Han, Bing Shen, Ruimin Huang and Jun Yan
    Citation: BMC Complementary Medicine and Therapies 2022 22:125
  23. Bacteria-mediated cancer immunotherapy (BCI) robustly stimulates the immune system and represses angiogenesis, but tumor recurrence and metastasis commonly occur after BCI. The natural product Ilex kudingcha C. J...

    Authors: Haixia Xu, Linghua Piao, Xiande Liu and Sheng-nan Jiang
    Citation: BMC Complementary Medicine and Therapies 2022 22:123
  24. Toxoplasmosis is caused by an intracellular zoonotic protozoan, Toxoplasma gondii, which could be lethal in immunocompromised patients. This study aimed to synthesize Neem oil-loaded solid lipid nanoparticles (Ne...

    Authors: Sara Nemati, Hanieh Mohammad Rahimi, Zahra Hesari, Meysam Sharifdini, Nooshin Jalilzadeh Aghdam, Hamed Mirjalali and Mohammad Reza Zali
    Citation: BMC Complementary Medicine and Therapies 2022 22:122
  25. Rheum tanguticum (R. tanguticum) is an edible and medicinal plant that exhibits high antioxidant activity. The purpose of the present study was to investigate the bioactive components of its seeds and the potent...

    Authors: Lingling Wang, Feng Xiong, Shuo Zhao, Yang Yang and Guoying Zhou
    Citation: BMC Complementary Medicine and Therapies 2022 22:121
  26. Scutellaria barbata D.Don (SBD) is derived from the dried whole plant of Labiate which has been widely used to treat patients with multiple cancer. It was previously reported that the ethanol extract of SBD is...

    Authors: Dongya Sheng, Bei Zhao, Wenjing Zhu, Tiantian Wang and Yu Peng
    Citation: BMC Complementary Medicine and Therapies 2022 22:120
  27. Interstitial cystitis (IC) has a chronic chemical irritation and inflammation of non-bacterial origin in the bladder wall leading to various severe symptoms. There is evidence that chronic inflammation is signifi...

    Authors: Adrienn Horváth, Edina Pandur, Katalin Sipos, Giuseppe Micalizzi, Luigi Mondello, Andrea Böszörményi, Péter Birinyi and Györgyi Horváth
    Citation: BMC Complementary Medicine and Therapies 2022 22:119
  28. Although the vast majority of cancer patients use natural health products (NHPs), 59% of oncology healthcare providers (HCP) report not receiving any education on NHPs. KNOWintegrativeoncology.org (KNOW) is a ...

    Authors: Jen Green, Heather Wright, Dugald Seely, Mark Legacy, Maureen Anderson, Hallie Armstrong, Casey Martell, Sarah Soles and Lynda G. Balneaves
    Citation: BMC Complementary Medicine and Therapies 2022 22:118
  29. Lipotropic molecules are effective therapeutic targets to counteract non-alcoholic fatty liver disease (NAFLD). Lipotropic compounds are capable of removing fat from the liver and/or manage the reduction of th...

    Authors: Leila Sandra Nnanga, Bruno Dupon Akamba Ambamba, Fils Armand Ella, Damaris Enyegue Mandob and Judith Laure Ngondi
    Citation: BMC Complementary Medicine and Therapies 2022 22:117
  30. Diosmin has been reported to treat diabetes, but its role in diabetic nephropathy (DN) remains unclear. This research investigated the mechanism by which diosmin alleviated high glucose (HG)-induced HK-2 cell ...

    Authors: Jiuhong Deng, Chao Zheng, Zhou Hua, Haideng Ci, Guiying Wang and Lijing Chen
    Citation: BMC Complementary Medicine and Therapies 2022 22:116
  31. Trans-cinnamaldehyde (TCA) is one of the main pharmaceutical ingredients of Cinnamomum cassia Presl, which has been shown to have therapeutic effects on a variety of cardiovascular diseases. This study was carrie...

    Authors: Dongdong Qian, Jing Tian, Sining Wang, Xiaoli Shan, Pei Zhao, Huihua Chen, Ming Xu, Wei Guo, Chen Zhang and Rong Lu
    Citation: BMC Complementary Medicine and Therapies 2022 22:115
  32. Viral infections have a history of abrupt and severe eruptions through the years in the form of pandemics. And yet, definitive therapies or preventive measures are not present. Herbal medicines have been a sou...

    Authors: Madiha Haider, Vivek Anand, M. Ghalib Enayathullah, Yash Parekh, Sushma Ram, Surekha Kumari, Anmol, Gayatri Panda, Manjari Shukla, Dhwani Dholakia, Arjun Ray, Sudipta Bhattacharyya, Upendra Sharma, Kiran Kumar Bokara, Bhavana Prasher and Mitali Mukerji
    Citation: BMC Complementary Medicine and Therapies 2022 22:114
  33. Traditional Chinese medicine (TCM) and Western medicine are available and have a long history in Hong Kong. Little is known on the intention to use TCM in Hong Kong. In this study, the intention to use TCM was...

    Authors: Tommy K. C. Ng, Man Fung Lo, Ben Y. F. Fong and Hilary H. L. Yee
    Citation: BMC Complementary Medicine and Therapies 2022 22:113
  34. The compound Danshen Dripping Pill (CDDP), which is a mixture of extracts from Radix Salviae and Panax notoginseng, is a patented traditional Chinese medicine that is widely used in multiple countries for relievi...

    Authors: Yang-Xi Hu, Hong-Min You, Chang-Zhen Ren, Bo-Wen Hu, Lu-Jun Zhang, Yan-Da Zhang, Zhi-Qing He, Ru Ding, Zhi-Fu Guo and Chun Liang
    Citation: BMC Complementary Medicine and Therapies 2022 22:112
  35. Oral malignancies have a significant effect on the quality of life among the affected patients. Curcumin is an antioxidant with a low bioavailability in the target tissue. Niosomes are carriers of increasing t...

    Authors: Behzad Fazli, Soussan Irani, Hassan Bardania, Mahdieh-Sadat Moosavi and Bita Rohani
    Citation: BMC Complementary Medicine and Therapies 2022 22:109
  36. Alzheimer’s disease (AD) pathogenesis is associated with amyloid-β (Aβ)-induced neuroinflammation. In AD, the activation of microglia caused by Aβ accumulation is followed by the synthesis and release of pro-i...

    Authors: Nutchareeporn Nillert, Chantana Boonyarat, Jariya Umka Welbat, Komsun Bunreungthong, Ploenthip Puthongking and Wanassanun Pannangrong
    Citation: BMC Complementary Medicine and Therapies 2022 22:108
  37. Advances in systems science creates an opportunity to bring a complexity perspective to health care practices and research. While medical knowledge has greatly progressed using a reductionist and mechanistic p...

    Authors: Kim D. Graham, Amie Steel and Jon Wardle
    Citation: BMC Complementary Medicine and Therapies 2022 22:107
  38. Pediatric integrative medicine, combining conventional and complementary medical approaches for children and adolescents, is an integral part of the health care system in Switzerland. However, there is still a...

    Authors: Benedikt M. Huber and Pierre-Yves Rodondi
    Citation: BMC Complementary Medicine and Therapies 2022 22:106
  39. Coronavirus disease 2019 (COVID-19) is a novel infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Despite the paucity of evidence, various complementary, alternative...

    Authors: Jeremy Y. Ng, Wael Abdelkader and Cynthia Lokker
    Citation: BMC Complementary Medicine and Therapies 2022 22:105
  40. Identifying what therapies constitute complementary, alternative, and/or integrative medicine (CAIM) is complex for a multitude of reasons. An operational definition is dynamic, and changes based on both histo...

    Authors: Jeremy Y. Ng, Tushar Dhawan, Ekaterina Dogadova, Zhala Taghi-Zada, Alexandra Vacca, L. Susan Wieland and David Moher
    Citation: BMC Complementary Medicine and Therapies 2022 22:104
  41. Chinese herbal medicine (CHM) is characterized by “multi- compounds, multi-targets and multi-pathway”, which has advanced benefits for preventing and treating complex diseases, but there still exists unsolved ...

    Authors: Dao-jin Xue, Zheng Zhen, Ke-xin Wang, Jia-lin Zhao, Yao Gao, Yu-peng Chen, You-bi Shen, Zi-zhuang Peng, Dao-gang Guan and Tao Huang
    Citation: BMC Complementary Medicine and Therapies 2022 22:103
  42. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Shalini Mohan, Kalaivani Thiagarajan, Balaji Sundaramoorthy, Vivek Gurung, Manas Barpande, Shilpi Agrawal and Rajasekaran Chandrasekaran
    Citation: BMC Complementary Medicine and Therapies 2022 22:102

    The original article was published in BMC Complementary Medicine and Therapies 2016 16:229

  43. Disordered endothelial cell activation plays an important role in the pathophysiology of atherosclerosis, cancer, sepsis, viral infections, and inflammatory responses. There is interest in developing novel the...

    Authors: Yaritza Inostroza-Nieves, Shirley Valentin-Berrios, Christopher Vega, Gregory N. Prado, Claribel Luciano-Montalvo, José R. Romero and Alicia Rivera
    Citation: BMC Complementary Medicine and Therapies 2022 22:101
  44. Chronic myeloid leukemia (CML) is a myeloproliferative tumor originating from hematopoietic stem cells, and resistance to tyrosine kinase inhibitors (TKI) has become a major cause of treatment failure. Alterna...

    Authors: Xiang Qin, Xi Chen, Ling Guo, Jing Liu, You Yang, Yan Zeng, Cheng Li, Wenjun Liu and Wenzhe Ma
    Citation: BMC Complementary Medicine and Therapies 2022 22:100
  45. Hepatitis C virus infection is the main cause of liver ailments across the globe. Several HCV genotypes have been identified in different parts of the world. Effective drugs for combating HCV infections are av...

    Authors: Mahim Khan, Waqar Rauf, Fazal-e- Habib, Moazur Rahman, Shoaib Iqbal, Aamir Shehzad and Mazhar Iqbal
    Citation: BMC Complementary Medicine and Therapies 2022 22:98
  46. Dealing with the symptom burden of cancer diagnosis and treatment has led parents to seek different self-management strategies including Alternative and Complementary Medicine (CAM). The aim of this study was ...

    Authors: Dana C. Mora, Grete Overvåg, Miek C. Jong, Agnete E. Kristoffersen, Debbie C. Stavleu, Jianping Liu and Trine Stub
    Citation: BMC Complementary Medicine and Therapies 2022 22:97
  47. Various pathogenic bacterial infections caused by acupuncture have raised widespread concern, but paravertebral abscesses and bloodstream infections of Burkholderia pseudomallei (B.pseudomallei) after acupuncture...

    Authors: Lingyan Xiao, Tong Zhou, Jun Chen, Yanqing Hu and Yishan Zheng
    Citation: BMC Complementary Medicine and Therapies 2022 22:95