Articles

Athrixia phylicoides tea infusion (bushman tea) improves adipokine balance, glucose homeostasis and lipid parameters in a diet-induced metabolic syndrome rat model

Central obesity and insulin resistance are associated with metabolic syndrome (MetS) which is aggravated by diet and sedentary lifestyle. Athrixia phylicoides (AP) is reported by rural communities to have medicin...

Authors: Madigoahle A. M. Mokwena, Godwill Azeh Engwa, Benedicta N. Nkeh-Chungag and Constance R. Sewani-Rusike

Ficus deltoidea ameliorates biochemical, hormonal, and histomorphometric changes in letrozole-induced polycystic ovarian syndrome rats

Insulin resistance and hormonal imbalances are key features in the pathophysiology of polycystic ovarian syndrome (PCOS). We have previously shown that Ficus deltoidea var. deltoidea Jack (Moraceae) can improve i...

Authors: Muhammad Aliff Haslan, Nurdiana Samsulrizal, Nooraain Hashim, Noor Syaffinaz Noor Mohamad Zin, Farshad H. Shirazi and Yong Meng Goh

Antitrypanosomal activity of hydromethanol extract of leaves of Cymbopogon citratus and seeds of Lepidium sativum: in-vivo mice model

Trypanosomiasis is one of the neglected tropical diseases of both humans and animals which decreases their productivity and causes death in the worst scenario. Unavailability of vaccines, the low therapeutic i...

Authors: Ayechew Yetayeh Emiru, Eyasu Makonnen, Fikru Regassa, Fekadu Regassa and Takele Beyene Tufa

Arctiin suppresses H9N2 avian influenza virus-mediated inflammation via activation of Nrf2/HO-1 signaling

H9N2 avian influenza viruses (AIVs) infect avian and mammalian hosts and provide internal genes for new emerging highly pathogenic avian viruses that cause severe pneumonia with high mortality, for which few m...

Authors: Beixian Zhou, Linxin Wang, Yueyun Liang, Jing Li and Xiping Pan

Potentilla reptans L. postconditioning protects reperfusion injury via the RISK/SAFE pathways in an isolated rat heart

Our previous study indicated that Potentilla reptans root has a preconditioning effect by its antioxidant and anti-apoptotic effects in an isolated rat heart ischemia/reperfusion (IR) model. In the present study,...

Authors: Ayesheh Enayati, Aref Salehi, Mostafa Alilou, Hermann Stuppner, Mirali Polshekan, Maryam Rajaei, Mona Pourabouk, Ali Jabbari, Zohreh Mazaheri, Narguess Yassa, Hamid Reza Moheimani and Vahid Khori

Anti-inflammatory effect of lavender (Lavandula angustifolia Mill.) essential oil prepared during different plant phenophases on THP-1 macrophages

Pseudomonas aeruginosa is the most common Gram-negative bacterium associated with nosocomial respiratory infections. Lavender essential oil is mainly used in aromatherapy, but it has several pharmacological and ...

Authors: Edina Pandur, Alex Balatinácz, Giuseppe Micalizzi, Luigi Mondello, Adrienn Horváth, Katalin Sipos and Györgyi Horváth

Activity of antifungal drugs and Brazilian red and green propolis extracted with different methodologies against oral isolates of Candida spp.

Oral candidiasis is an opportunistic disease caused by fungi of the Candida genus. The occurrence of Candida spp. resistance to the commercial antifungal drugs points to the search for alternative treatments. Pro...

Authors: Ana Rita Sokolonski, Maísa Santos Fonseca, Bruna Aparecida Souza Machado, Kathleen Ramos Deegan, Roberto Paulo Correia Araújo, Marcelo Andrés Umsza-Guez, Roberto Meyer and Ricardo W. Portela

Complementary medicine in Germany: a multi-centre cross-sectional survey on the usage by and the needs of patients hospitalized in university medical centers

The results of recent surveys indicate that more than 50% of the German population has experience with complementary and alternative medicine (CAM) or uses CAM regularly. This study investigated the CAM usage ...

Authors: Ann-Kathrin Lederer, Alexandra Baginski, Lena Raab, Stefanie Joos, Jan Valentini, Carina Klocke, Yvonne Samstag, Katrin Hübner, Ivana Andreeva, Thomas Simmet, Tatiana Syrovets, Susanne Hafner, Anna Freisinger, Maximilian Andreas Storz and Roman Huber

Sinoacutine inhibits inflammatory responses to attenuates acute lung injury by regulating NF-κB and JNK signaling pathways

Stephania yunnanensis H. S. Lo is widely used as an antipyretic, analgesic and anti-inflammatory herbal medicine in SouthWest China. In this study, we investigated the anti-inflammatory activity and mechanism of...

Authors: Yuancui Zhao, Lili Cui, Xing Xin Yang, Xingqian Sun, Yunkuan Liu, Zixian Yang, Liyuan Zhu, Chaorui Peng, Danye Li, Junfei Cai and Yunshu Ma

Effect of cranberry supplementation on liver enzymes and cardiometabolic risk factors in patients with NAFLD: a randomized clinical trial

We aimed to evaluate the effect of cranberry supplementation on serum liver enzymes, hepatic steatosis, and cardiometabolic risk factors in patients with non-alcoholic fatty liver (NAFLD).

Authors: Kourosh Masnadi Shirazi, Elham Shirinpour, Arman Masnadi Shirazi and Zeinab Nikniaz

Ethanolic extract of Mucuna pruriens leaves ameliorates carbon tetrachloride and rifampicin-induced hepatotoxicity and nephrotoxicity in wistar albino rat

Mucuna pruriens (L.) has been used for the treatment of several ailments in folkloric medicine. The present study therefore investigates the hepatoprotective and nephroprotective potentials of its leaves extract...

Authors: Temidayo Ogunmoyole, Ayomide Micheal Ola-Awe and Omotola Grace Fatile

Protective effect of Palmijihwanghwan in a mouse model of cigarette smoke and lipopolysaccharide-induced chronic obstructive pulmonary disease

Palmijihwanghwan (PJH) is a traditional medicine and eight constituents derived from PJH possess anti-inflammatory activities. However, the scientific evidence for its potential as a therapeutic agent for inflam...

Authors: Eun Bok Baek, Jin-hyung Rho, Eunhye Jung, Chang-Seob Seo, Jin-Hee Kim and Hyo-Jung Kwun

The ethanol extract of Garcinia subelliptica Merr. induces autophagy

Garcinia subelliptica Merr. is a multipurpose coastal tree, the potential medicinal effects of which have been studied, including cancer suppression. Here, we present evidence that the ethanol extract of G. subel...

Authors: Kyun Ha Kim, Ji Yeon Lee, Wan Yi Li, Sangwoo Lee, Han-Sol Jeong, Jun-Yong Choi and Myungsoo Joo

The use of Caralluma fimbriata as an appetite suppressant and weight loss supplement: a systematic review and meta-analysis of clinical trials

Obesity prevalence has increased during the past few decades, causing a pandemic with an influx in other co-morbidities. Many factors influence weight gain in an obesogenic environment therefore strategies for...

Authors: Ranil Jayawardena, Tormalli V. Francis, Sachith Abhayaratna and Priyanga Ranasinghe

Chinese patent herbal medicine Huaiqihuang for Henoch-Schonlein purpura nephritis in children: a systematic review of randomized controlled trials

Henoch-Schönlein purpura nephritis (HSPN) is listed as the most common secondary glomerular diseases among children. Approximately 15 to 20% of children eventually could develop into chronic renal failure. Chi...

Authors: Xue Xue, Xue-han Liu, Chun-li Lu, Xin-yan Jin, Qiang Liu, Xiao-qin Wang and Jian-ping Liu

Novel mesoporous silica nanocarriers containing gold; a rapid diagnostic tool for tuberculosis

Tuberculosis (TB) is major health concern and reason of deaths from decades to current date. Even though with a lot of advancements, diagnostic techniques, and discovery of standard antibiotics TB remains cruc...

Authors: Chang Sun, Xiaoying Zhang, Jialu Wang, Yahao Chen and Cunren Meng

Antiproliferative, antibacterial, and antioxidant activities of Bauhinia strychnifolia Craib aqueous extracts in gut and liver perspective

Bauhinia strychnifolia Craib is an herb in Thai traditional medicine. Its decoction is traditionally used as an anticancer, antidiarrheal, and hangover remedy for centuries. Several studies described bioactiviti...

Authors: Suranat Phonghanpot and Faongchat Jarintanan

Arecae pericarpium extract induces porcine lower-esophageal-sphincter contraction via muscarinic receptors

Gastroesophageal reflux disease (GERD) is associated with lower esophageal sphincter (LES) incompetence. In some patients, GERD is refractory to acid reduction therapy which is the main treatment for GERD. So ...

Authors: Shu-Leei Tey, Chi-Ying Li, Li-Wei Lin, Li-Ching Chang, Yea-Ling Chen, Fang-Rong Chang, San-Nan Yang and Ching-Chung Tsai

Polyphenol-rich extract of Ocimum gratissimum leaves prevented toxic effects of cyclophosphamide on the kidney function of Wistar rats

Cyclophosphamide (CP) is one of the potent and low cost chemotherapy used in clinical setting against a variety of tumors. However, its association with nephrotoxicity limits its therapeutic use. Ocimum gratissim...

Authors: Quadri K. Alabi, Rufus O. Akomolafe, Joseph G. Omole, Ayodeji Aturamu, Mokolade S. Ige, Oyindasola O. Kayode and Deborah Kajewole-Alabi

Ethyl acetate extract of Elephantopus mollis Kunth induces apoptosis in human gastric cancer cells

Gastric cancer is one of the most leading causes of cancer death worldwide. Therefore, treatment studies have been being conducted, one of which is screening of novel agents from medicinal herbs. Elephantopus mol...

Authors: Tran Dang Thanh Tam, Truong Thi Bich Ngoc, Nguyen Thi Hoai Nga, Nguyen Thi My Trinh, Tran Linh Thuoc and Dang Thi Phuong Thao

Chemical profiles of the active fraction from Prinsepia utilis Royle leaves and its anti-benign prostatic hyperplasia evaluation in animal models

The Prinsepia utilis Royle leaves (P. utilis) is a folk herb used for benign prostatic hyperplasia (BPH) control by ethnic minorities for centuries in China with rich in resources. Our previous studies have confi...

Authors: Ying Peng, Chongsheng Peng, Yang Wu, Chongzhi Sun and Xiaobo Li

Combined antihypertensive effect of unripe Rubus coreanus Miq. and Dendropanax morbiferus H. Lév. Extracts in 1 kidney-1 clip hypertensive rats and spontaneously hypertensive rats

We previously showed that enzymatically hydrolyzed Dendropanax morbiferus H. Lév. leaf (Hy-DP) and unripe Rubus coreanus Miq. (5-uRCK) extracts exhibit potent vasodilator effects on isolated aortic rings from rat...

Authors: Soyi Park, Ki Hoon Lee, Hakjoon Choi, Goeun Jang, Wan Seok Kang, Eun Kim, Jin Seok Kim, Chang-su Na and Sunoh Kim

Crude extract and isolated bioactive compounds from Notholirion thomsonianum (Royale) Stapf as multitargets antidiabetic agents: in-vitro and molecular docking approaches

Diabetes mellitus is a common disease effecting the lifestyles of majority world population. In this research work, we have embarked the potential role of crude extracts and isolated compounds of Notholirion thom...

Authors: Mater H. Mahnashi, Yahya S. Alqahtani, Ali O. Alqarni, Bandar A. Alyami, Muhammad Saeed Jan, Muhammad Ayaz, Farhat Ullah, Umer Rashid and Abdul Sadiq

Immunomodulatory and anti-inflammatory effects of Phellinus linteus mycelium

The present study extensively aimed to evaluate the underlying mechanism of the immunomodulatory and anti-inflammatory effects of Phellinus linteus mycelium (PLM).

Authors: Mi-Rae Shin, Ji Hye Lee, Jin A Lee, Min Ju Kim, Hae-Jin Park, Byeong Wook Park, Seung Bo Seo and Seong-Soo Roh

Herbal medicines use and associated factors among pregnant women in Debre Tabor town, north West Ethiopia: a mixed method approach

Use of herbal medicines during pregnancy has been increase in many developing and developed countries. In spite of the studies done on herbal medicine, no study has addressed use of herbal medicine among pregn...

Authors: Getu Tesfaw Addis, Birhanu Demeke Workneh and Mesfin Haile Kahissay

Active constituent of Polygala tenuifolia attenuates cognitive deficits by rescuing hippocampal neurogenesis in APP/PS1 transgenic mice

Alzheimer’s disease (AD) is the most common dementia worldwide, and there is still no satisfactory drug or therapeutic strategy. Polygala tenuifolia is a traditional Chinese medicine with multiple neuroprotective...

Authors: Xiao-feng Wang, Hong-he Xiao, Yu-tong Wu, Liang Kong, Ji-cong Chen, Jing-xian Yang and Xiao-le Hu

Correction to: Thymoquinone inhibited vasculogenic capacity and promoted mesenchymal-epithelial transition of human breast cancer stem cells

Authors: Sanya Haiaty, Mohammad-Reza Rashidi, Maryam Akbarzadeh, Ahad Bazmani, Mostafa Mostafazadeh, Saba Nikanfar, Zohre Zibaei, Reza Rahbarghazi and Mohammad Nouri

Antibacterial and anti-Trichomonas Vaginalis effects of Rosa Damascena mill petal oil (a persian medicine product), aqueous and hydroalcoholic extracts

Oils in traditional medicine are important products and used routinely for therapeutic purposes. Rose oil (Rosa damascene Mill), a product of Persian medicine, is advised for the treatment of Infectious diseases ...

Authors: Fatemeh Saghafi, Farzaneh Mirzaie, Elham Gorji, Razieh Nabimeybodi, Mehdi Fattahi, Hamed Mahmoodian and Rahele Zareshahi

A mixed-methods survey of physiotherapists who practice acupuncture and dry needling in Ontario, Canada: practice characteristics, motivations, and professional outcomes

Physiotherapists (PTs) across the globe are increasingly incorporating filiform needling techniques (e.g., acupuncture, dry needling) into their clinical toolkits; and, the evidence base for these complementar...

Authors: Nadine Ijaz, Sandy Welsh and Heather Boon

Revealing the potential mechanism of Astragalus membranaceus improving prognosis of hepatocellular carcinoma by combining transcriptomics and network pharmacology

Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related death. Traditional Chinese medicine (TCM) has special advantages in relieving HCC, while Astragalus membranaceus is commonly used in TC...

Authors: Zhili Liu, Huihan Ma and Zelin Lai

Utilization of complementary and traditional medicine practitioners among middle-aged and older adults in India: results of a national survey in 2017–2018

Lack of information exists about the use of traditional and complementary medicine (TCM) use among middle-aged and older adults in India, which led to studying the estimates of past-12-month Ayurveda/Yoga/Natu...

Authors: Supa Pengpid and Karl Peltzer

The benefit of combining curcumin, bromelain and harpagophytum to reduce inflammation in osteoarthritic synovial cells

Osteoarthritis (OA) is the most common form of arthritis, affecting millions of people worldwide and characterised by joint pain and inflammation. It is a complex disease involving inflammatory factors and aff...

Authors: Sybille Brochard, Julien Pontin, Benoit Bernay, Karim Boumediene, Thierry Conrozier and Catherine Baugé

An in vitro study of an Artocarpus heterophyllus substance as a hepatitis C antiviral and its combination with current anti-HCV drugs

Current therapy of chronic hepatitis C virus (HCV) with direct-acting antivirals (DAAs) has dramatically improved the sustained virologic response (SVR) of affected patients; however, treatment with DAAs remai...

Authors: Adita Ayu Permanasari, Chie Aoki-Utsubo, Tutik Sri Wahyuni, Lidya Tumewu, Myrna Adianti, Aty Widyawaruyanti, Hak Hotta and Achmad Fuad Hafid

Lactobacillus plantarum PS128 prevents cognitive dysfunction in Alzheimer’s disease mice by modulating propionic acid levels, glycogen synthase kinase 3 beta activity, and gliosis

According to recent evidence, psychobiotics exert beneficial effects on central nervous system-related diseases, such as mental disorders. Lactobacillus plantarum PS128 (PS128), a novel psychobiotic strain, impro...

Authors: Hei-Jen Huang, Jie-Ling Chen, Jian-Fu Liao, Yu-Hsin Chen, Min-Wei Chieu, Ya-Yun Ke, Chih-Chieh Hsu, Ying-Chieh Tsai and Hsiu Mei Hsieh-Li

Anti-apoptotic effect of Buchholzia coriacea Engl. stem back extracts on AsPC-1 and mechanisms of action

Buchholzia coriacea Engl. is popularly called wonderful cola due to its wide ethnomedicinal use for the treatment of various ailments. We investigated the possible cytotoxic effect of its various fractions on hu...

Authors: Hope Onohuean, Rahmat Adetutu Adisa and Abdullateef Isiaka Alagbonsi

Tanshinone IIA attenuates renal injury during hypothermic preservation via the MEK/ERK1/2/GSK-3β pathway

Oxidative stress-induced injury during hypothermic preservation is a universal problem that delays graft function and decrease the success of organ transplantation. Tanshinone IIA (Tan IIA) was reported to exh...

Authors: Linhao Xu, Yizhou Xu, Zhoujing Zhu, Huiquan Gu, Chaofeng Chen and Jian Chen

Phytochemical screening, antiobesity, antidiabetic and antimicrobial assessments of Orobanche aegyptiaca from Palestine

Microbial resistance, diabetes mellitus, and obesity are global health care problems that have posed a serious threat to both human and environmental ecosystems. The goals of the present investigations are to ...

Authors: Nidal Jaradat, Mohammad Qadi, Iyad Ali, Fatima Hussein, Linda Issa, Doaa Rashdan, Manal Jamoos, Re’as Najem, Abdulraziq Zarour and Mohammad Arar

Torreya nucifera seed oil improves 3T3-L1 adipocyte differentiation

Adipose tissue is a critical regulator of lipid storage and endocrine function. Impairment of the recruitment of new adipocytes in the adipose tissue is associated with ectopic fat accumulation, diabetes and i...

Authors: Eunbi Koh, Boram Kim and Kyungoh Choi

Physicochemical characterization, cytotoxic effect and toxicity evaluation of nanostructured lipid carrier loaded with eucalyptol

Eucalyptol is an active compound of eucalyptus essential oil and was reported to have many medical attributes including cytotoxic effect on breast cancer cells. However, it has low solubility in aqueous soluti...

Authors: Mira Nadiah Mohd Izham, Yazmin Hussin, Nurul Fattin Che Rahim, Muhammad Nazirul Mubin Aziz, Swee Keong Yeap, Heshu Sulaiman Rahman, Mas Jaffri Masarudin, Nurul Elyani Mohamad, Rasedee Abdullah and Noorjahan Banu Alitheen

Evaluation the effect of Silybum marianum ointment on episiotomy wound healing and pain intensity in primiparous women: a randomized triple blind clinical trial

Episiotomy is the most commonn surgical procedure in midwifery which as any other wounds can cause infection or delay in healing.

Authors: Elmira Toomari, Sepideh Hajian, Faraz Mojab, Tayebe Omidkhah and Malihe Nasiri

Evidence-based practice among Italian osteopaths: a national cross-sectional survey

While evidence-based practice (EBP) is widely accepted across healthcare professions, research investigating its implementation in manual therapy professions such as osteopathy is limited. The primary aim of t...

Authors: Francesco Cerritelli, Alessio Iacopini, Matteo Galli, Oliver P. Thomson, Tobias Sundberg, Matthew J. Leach and Jon Adams

Efficacy and safety of Kami-guibi-tang for mild cognitive impairment: a pilot, randomized, double-blind, placebo-controlled trial

Mild cognitive impairment (MCI) is considered an intermediate phase between normal aging and dementia. As the majority of cases of amnestic MCI (aMCI) progress to Alzheimer’s disease (AD), it is considered the...

Authors: Hee-Yeon Shin, Ha-Ri Kim, Geon-Ho Jahng, Chul Jin, Seungwon Kwon, Seung-Yeon Cho, Seong-Uk Park, Woo-Sang Jung, Sang-Kwan Moon, Chang-Nam Ko and Jung-Mi Park

Integration of complementary and integrative medicine competencies in general practice postgraduate education – development of a novel competency catalogue in Germany

Complementary and integrative medical procedures (CIM) play an important role in general practice (GP). Consequently, in some countries (e.g. USA, Australia) specific curricula for the integration of CIM compe...

Authors: Jan Valentini, Carina Klocke, Corina Güthlin and Stefanie Joos

Acculturation and use of traditional medicine among African migrant women in Sydney: a mixed method study

More than 80% of the African population depend on traditional medicine as a primary healthcare. Although the African migrant community is increasing in Australia, there is no research documenting if and how Af...

Authors: Zewdneh Shewamene, Tinashe Dune and Caroline A. Smith

Neuroprotective potentials of selected natural edible oils using enzyme inhibitory, kinetic and simulation approaches

Edible oils have proven health benefits in the prevention and treatment of various disorders since the establishment of human era. This study was aimed to appraise neuropharmacological studies on the commonly ...

Authors: Mater H. Mahnashi, Bandar A. Alyami, Yahya S. Alqahtani, Ali O. Alqarni, Muhammad Saeed Jan, Muhammad Ayaz, Farhat Ullah, Muhammad Shahid, Umer Rashid and Abdul Sadiq

Factors associated with the use of complementary therapies in Taiwanese patients with systemic lupus erythematosus: a cross-sectional study

This study aimed to investigate the prevalence of and the factors associated with the regular use of complementary therapies for Taiwanese patients with systemic lupus erythematosus (SLE).

Authors: Ming-Chi Lu, Hui-Chin Lo, Hsiu-Hua Chang, Chia-Wen Hsu and Malcolm Koo

Potential antiviral effects of some native Iranian medicinal plants extracts and fractions against influenza A virus

Influenza A virus (IAV) infection is a continual threat to the health of animals and humans globally. Consumption of the conventional drugs has shown several side effects and drug resistance. This study was ai...

Authors: Parvaneh Mehrbod, Hanieh Safari, Zeinab Mollai, Fatemeh Fotouhi, Yasaman Mirfakhraei, Hanieh Entezari, Saied Goodarzi and Zahra Tofighi

The cytotoxic effect of Baeckea frustescens extracts in eliminating hypoxic breast cancer cells

Adaptive metabolic response towards a low oxygen environment is essential to maintain rapid tumour proliferation and progression. The vascular network that surrounds the tumour develops an intermittent hypoxic...

Authors: S. H. Shahruzaman, F. Z. Yusof, S. Maniam, S. Fakurazi and S. Maniam

Iranian healthcare professionals’ knowledge, attitudes, and use of complementary and alternative medicine: a cross sectional study

The present study aims to investigate the knowledge, attitude, and performance of Iranian Healthcare Professionals (HP) about Complementary and Alternative Medicine (CAM) modalities.

Authors: Alireza Jafari, Mohaddeseh Zanganeh, Zahra Kazemi, Elaheh Lael-Monfared and Hadi Tehrani

Quercetin promotes bone marrow mesenchymal stem cell proliferation and osteogenic differentiation through the H19/miR-625-5p axis to activate the Wnt/β-catenin pathway

Quercetin and H19 can promote osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). However, whether quercetin regulates H19 expression to promote osteogenic differentiation of BMSCs is unc...

Authors: Wei Bian, Shunqiang Xiao, Lei Yang, Jun Chen and Shifang Deng