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  1. Atopic dermatitis (AD) is a chronic allergic inflammatory skin disease characterized by complex pathogenesis including skin barrier dysfunction, immune-redox disturbances, and pruritus. Prolonged topical treat...

    Authors: Johny Bajgai, Jing Xingyu, Ailyn Fadriquela, Rahima Begum, Dong Heui Kim, Cheol-Su Kim, Soo-Ki Kim and Kyu-Jae Lee

    Citation: BMC Complementary Medicine and Therapies 2021 21:82

    Content type: Research article

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  2. Methylglyoxal (MG) is a highly reactive dicarbonyl precursor for the formation of advanced glycation end products (AGEs) associated with age-related diseases, including diabetes and its complications. Clitoria te...

    Authors: Poramin Chayaratanasin, Sirichai Adisakwattana and Thavaree Thilavech

    Citation: BMC Complementary Medicine and Therapies 2021 21:80

    Content type: Research article

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  3. Sha-Shen-Mai-Dong decoction (SSMD) is a classical prescription widely used in primary Sjogren’s Syndrome (pSS) therapy. This study aims to explore the potential pharmacological mechanism of SSMD on pSS.

    Authors: Yuepeng Jiang, Xiaoxuan Zhao, Jie Yu, Qiao Wang, Chengping Wen and Lin Huang

    Citation: BMC Complementary Medicine and Therapies 2021 21:79

    Content type: Research article

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  4. Oxidative stress and inflammation promote the development of diabetic cardiomyopathy (DCM). Therefore, inhibiting these processes may show beneficial effects in the treatment of patients with DCM. Taohuajing (...

    Authors: Rui Yao, Yu Cao, Changming Wang, Lu Xu, Xuan Zhang, Yuqing Deng, Feng Li and Siwang Wang

    Citation: BMC Complementary Medicine and Therapies 2021 21:78

    Content type: Research article

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  5. Trypanosoma cruzi is the etiological agent of Chagas disease (CD) or American trypanosomiasis, an important public health problem in Latin America. Benznidazole (BZ), a drug available for its treatment, has limit...

    Authors: Marcella Paula Mansano Sarto, Hevillyn Fernanda Lucas da Silva, Nilma de Souza Fernandes, Ana Paula de Abreu, Gerson Zanusso Junior and Max Jean de Ornelas Toledo

    Citation: BMC Complementary Medicine and Therapies 2021 21:77

    Content type: Research article

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  6. Procyanidin B2 (PB2), a unique component of the grape seed and other medicinal plants. PB2 has shown wide anticancer activity in various human cancer cells. However, it remains unclear about the biological eff...

    Authors: Yuqin Li, Xiaolan Lu, Peiying Tian, Kai Wang and Jianping Shi

    Citation: BMC Complementary Medicine and Therapies 2021 21:76

    Content type: Research article

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  7. Anal fissure is a common complication of the anorectal region and one of the most reported causes of anal pain. Acute anal fissure can be cured by surgery or medical treatment. There is an increase in the use ...

    Authors: Mohamad Hadi El Charif, Samer Doughan, Rawya Kredly, Sara Kassas, Rayan Azab and Eman Sbaity

    Citation: BMC Complementary Medicine and Therapies 2021 21:75

    Content type: Study protocol

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  8. Medicinal plants have wide medicament application used to prevent and management of many ailments. These plants are used for primary health care in pastoralist communities who are deprived of modern medical ca...

    Authors: Eshetu Gadisa and Elazar Tadesse

    Citation: BMC Complementary Medicine and Therapies 2021 21:74

    Content type: Research article

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  9. Elaeagnus umbellata Thunb. (autumn olive) is a high valued medicinal plant. It belongs to Elaeagnaceae family and is widely distributed in Himalayan regions of Pakistan. In the present study essential oil were ex...

    Authors: Nausheen Nazir, Muhammad Zahoor, Faheem Uddin and Mohammad Nisar

    Citation: BMC Complementary Medicine and Therapies 2021 21:73

    Content type: Research article

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  10. Acute myocardial infarction (AMI) is the most serious and lethal manifestation of coronary heart disease worldwide, presenting extremely high disability and mortality. Our previous studies have shown that Guan...

    Authors: Xiaoxiao Zhang, Changle Shao, Songyi Cheng, Yao Zhu, Bo Liang and Ning Gu

    Citation: BMC Complementary Medicine and Therapies 2021 21:72

    Content type: Research article

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  11. In previous studies, Cassia spectabilis DC leaf has shown a good antiplasmodial activity. Therefore, this study is a follow-up study of the extract of leaf of C. spectabilis DC on its in vitro and in vivo antipla...

    Authors: Wiwied Ekasari, Dewi Resty Basuki, Heny Arwati and Tutik Sri Wahyuni

    Citation: BMC Complementary Medicine and Therapies 2021 21:71

    Content type: Research article

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  12. Large-scale epidemics have changed people’s medical behavior, and patients tend to delay non-urgent medical needs. However, the impact of the pandemic on the use of complementary and alternative medicine remai...

    Authors: Shun-Ku Lin, Chien-Tung Wu, Hui-Jer Chou, Chia-Jen Liu, Fu-Yang Ko, Ching-Hsuan Huang and Jung-Nien Lai

    Citation: BMC Complementary Medicine and Therapies 2021 21:70

    Content type: Research article

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  13. Endoplasmic reticulum stress (ERS) is one of the main mechanisms of spinal cord injury (SCI) pathology and can affect the physiological state of neurons. Icariin (ICA), the main pharmacological component of Ep...

    Authors: Chengjie Wu, Guanglu Yang, Yalan Pan, Lei Wang, Pengcheng Tu, Suyang Zheng, Yang Guo and Yong Ma

    Citation: BMC Complementary Medicine and Therapies 2021 21:69

    Content type: Research article

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  14. Despite the growing conventional healthcare coverage in Eritrea, traditional medicine (TM) remains an essential source of healthcare service to the population. This study, therefore, aims at exploring the atti...

    Authors: Sirak Tesfamariam, Filmon Tesfai, Lemlem Hussien, Yonatan Ateshim, Dawit Yemane, Mulugeta Russom, Hagos Ahmed, Iyassu Bahta, Solyana Ngusbrhan Kidane, Josephine Namboze and Ossy Muganga Julius Kasilo

    Citation: BMC Complementary Medicine and Therapies 2021 21:68

    Content type: Research article

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  15. This descriptive study provides the first examination of global naturopathic education, regulation and practice frameworks that have potential to constrain or assist professional formation and integration in g...

    Authors: J. M. Dunn, A. E. Steel, J. Adams, I. Lloyd, N. De Groot, T. Hausser and J. Wardle

    Citation: BMC Complementary Medicine and Therapies 2021 21:67

    Content type: Research article

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  16. High glucose (HG)-induced reactive oxygen species (ROS) overproduction impairs angiogenesis that is one pivotal factor of wound healing process. Angiogenesis impairment induces delayed wound healing, whereby i...

    Authors: Chatchai Nensat, Worawat Songjang, Rutaiwan Tohtong, Tuangporn Suthiphongchai, Suchada Phimsen, Panthip Rattanasinganchan, Pornphimon Metheenukul, Sarawut Kumphune and Arunya Jiraviriyakul

    Citation: BMC Complementary Medicine and Therapies 2021 21:66

    Content type: Research article

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  17. The new paradigm of intercultural policies focuses on rethinking the common public culture. In Ecuador, the “Buen Vivir” plan seeks to incorporate the ancestral medical knowledge, experience and beliefs of tradit...

    Authors: Estefanía Bautista-Valarezo, Víctor Duque, Veronique Verhoeven, Jorge Mejia Chicaiza, Kristin Hendrickx, Ruth Maldonado-Rengel and Nele R.M. Michels

    Citation: BMC Complementary Medicine and Therapies 2021 21:65

    Content type: Research article

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  18. The disparity of harvesting locations can influence the chemical composition of a plant species, which could affect its quality and bioactivity. Terminalia albida is widely used in traditional Guinean medicine wh...

    Authors: Aissata Camara, Mohamed Haddad, Mohamed Sahar Traore, Florence Chapeland-Leclerc, Gwenaël Ruprich-Robert, Isabelle Fourasté, Mamadou Aliou Balde, Jade Royo, Melissa Parny, Philippe Batigne, Marie Salon, Agnès Coste, Aliou Mamadou Balde and Agnès Aubouy

    Citation: BMC Complementary Medicine and Therapies 2021 21:64

    Content type: Research article

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  19. The prevalence of CAM use is increasing. This integrative review investigated New Zealand healthcare professionals’ practice of, attitudes toward, and knowledge about complementary and alternative medicine (CAM).

    Authors: Lizhou Liu, Yong Tang, G. David Baxter, Haiyan Yin and Steve Tumilty

    Citation: BMC Complementary Medicine and Therapies 2021 21:63

    Content type: Research article

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  20. Euphorbia helioscopia, conventionally known as sun spurge, has been used as a traditional medicine to treat different diseases owing to its reported antitumor, antiviral and antioxidant activities.

    Authors: Imtiaz Mustafa, Muhammad Naeem Faisal, Ghulam Hussain, Humaira Muzaffar, Muhammad Imran, Muhammad Umar Ijaz, Muhammad Umar Sohail, Arslan Iftikhar, Arslan Shaukat and Haseeb Anwar

    Citation: BMC Complementary Medicine and Therapies 2021 21:62

    Content type: Research article

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  21. Atractylodes lancea (Thunb) DC. (AL) and bioactive compounds β-eudesmol and atractylodin have been demonstrated in the in vitro and in vivo studies for their potential clinical use in cholangiocarcinoma. The stud...

    Authors: Inthuon Kulma, Luxsana Panrit, Tullayakorn Plengsuriyakarn, Wanna Chaijaroenkul, Siriprapa Warathumpitak and Kesara Na-Bangchang

    Citation: BMC Complementary Medicine and Therapies 2021 21:61

    Content type: Research article

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  22. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Misbahuddin Rafeeq, Hussam Aly Sayed Murad, Hossam Mohammed Abdallah and Ali M. El-Halawany

    Citation: BMC Complementary Medicine and Therapies 2021 21:60

    Content type: Correction

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    The original article was published in BMC Complementary Medicine and Therapies 2021 21:28

  23. Deer Sinew serves as a medicinal food, and has been used for treating skeletal diseases, especially bone diseases in a long history. Thus, it could become an alternative option for the prevention and therapeut...

    Authors: Zhenwei Zhou, Daqing Zhao, Pengcheng Zhang, Mei Zhang, Xiangyang Leng and Baojin Yao

    Citation: BMC Complementary Medicine and Therapies 2021 21:59

    Content type: Research article

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  24. This study aimed to evaluate the effect of nanoemulsion containing peppermint and rosemary essential oils in rats with osteoarthritis (OA).

    Authors: Mojgan Mohammadifar, Mohammad Hossein Aarabi, Fatemeh Aghighi, Maryam Kazemi, Zarichehr Vakili, Mohammad Reza Memarzadeh and Sayyed Alireza Talaei

    Citation: BMC Complementary Medicine and Therapies 2021 21:57

    Content type: Research article

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  25. Childbearing women have been using various herbs to assist with pregnancy, labour and birth for centuries. One of the most common is raspberry leaf. The evidence base for the use of raspberry leaf is however u...

    Authors: Rebekah Bowman, Jan Taylor, Sally Muggleton and Deborah Davis

    Citation: BMC Complementary Medicine and Therapies 2021 21:56

    Content type: Research article

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  26. Polycystic ovary syndrome (PCOS) is one of the most prevalent endocrinopathies in women during the reproductive age. Herbal medicines are used increasingly alone or in supplement with chemical medicines for th...

    Authors: E. Bandariyan, A. Mogheiseh and A. Ahmadi

    Citation: BMC Complementary Medicine and Therapies 2021 21:55

    Content type: Research article

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  27. Sleep disorders encompass a wide range of conditions which affect the quality and quantity of sleep, with insomnia being a specific type of sleep disorder of focus in this review. Complementary and alternative...

    Authors: Jeremy Y. Ng and Nandana D. Parakh

    Citation: BMC Complementary Medicine and Therapies 2021 21:54

    Content type: Research article

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  28. Distraction osteogenesis (DO) is an effective treatment in craniomaxillofacial surgery. However, the issue of sufficient blood supply at the regeneration tissue has limited its wide application. Panax notoginseng...

    Authors: Peiqi Zhu, Weidong Jiang, Shixi He, Tao Zhang, Fengchun Liao, Di Liu, Xiaoning An, Xuanping Huang and Nuo Zhou

    Citation: BMC Complementary Medicine and Therapies 2021 21:53

    Content type: Research article

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  29. Ursolic acid (UA) is an anti-cancer herbal compound. In the present study, we observed the effects of UA on anchorage-dependent and -independent growth of human colorectal cancer (CRC) RKO cells.

    Authors: Jia-Lu Zheng, Shuang-Shuang Wang, Ke-Ping Shen, Lei Chen, Xiao Peng, Jin-Fang Chen, Hong-Mei An and Bing Hu

    Citation: BMC Complementary Medicine and Therapies 2021 21:52

    Content type: Research article

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  30. Chlorella vulgaris is a microalga potentially used for pharmaceutical, animal feed, food supplement, aquaculture and cosmetics. The current study aims to study the antioxidant and prooxidant effect of Chlorella v...

    Authors: Eman A. El-fayoumy, Sanaa M. M. Shanab, Hanan S. Gaballa, Mohamed A. Tantawy and Emad A. Shalaby

    Citation: BMC Complementary Medicine and Therapies 2021 21:51

    Content type: Research article

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  31. The aim of this study was to assess the knowledge, attitude, and practice of complementary and alternative medicine (CAM) and its impact on antiepileptic drug (AED) adherence among patients with epilepsy.

    Authors: Muhammad Junaid Farrukh, Mohd Makmor-Bakry, Ernieda Hatah and Tan Hui Jan

    Citation: BMC Complementary Medicine and Therapies 2021 21:50

    Content type: Research article

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  32. Otostegia integrifolia Benth. (Lamiaceae) leaves are used to treat hypertension in Ethiopian folk medicine. However, the claim has so far not been investigated scientifically. Thus, the objective of this study wa...

    Authors: Abel Degu, Abiy Abebe and Ephrem Engidawork

    Citation: BMC Complementary Medicine and Therapies 2021 21:49

    Content type: Research article

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  33. Pelargonium sidoides DC (Geraniaceae) root extract, EPs®7630 or “Kaloba®”, is a widely used herbal remedy for respiratory infections, with some evidence of effectiveness for acute bronchitis. However, it is not y...

    Authors: Merlin Willcox, Catherine Simpson, Sam Wilding, Beth Stuart, Dia Soilemezi, Amy Whitehead, Alannah Morgan, Emma Wrixon, Shihua Zhu, Guiqing Yao, Fran Webley, Ruiyang Yan, Jennifer Bostock, Margaret Bell, Gareth Griffiths, Geraldine Leydon…

    Citation: BMC Complementary Medicine and Therapies 2021 21:48

    Content type: Research article

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  34. The frequent incidence of fungal infection and widespread of antibiotic resistance are emergent concerns in public health. Hence, there is a need to harness the potential of natural bioactive compounds from pl...

    Authors: Clement Olusola Ogidi, Ayokunbi Elizabeth Ojo, Oluwatayo Benjamin Ajayi-Moses, Oluwatoyin Modupe Aladejana, Oluwakemi Abike Thonda and Bamidele Juliet Akinyele

    Citation: BMC Complementary Medicine and Therapies 2021 21:47

    Content type: Research article

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  35. Physicians who include complementary medicine in their practice are thought to have an understanding of health and disease different from that of colleagues practicing conventional medicine. The aim of this st...

    Authors: N. Mittring-Junghans, C. Holmberg, C. M. Witt and M. Teut

    Citation: BMC Complementary Medicine and Therapies 2021 21:46

    Content type: Research article

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  36. Solanum nigrum L. decoction has been used as a folklore medicine in China to prevent the postoperative recurrence of bladder cancer (BC). However, there are no previous pharmacological studies on the protective m...

    Authors: Yang Dong, Lin Hao, Kun Fang, Xiao-xiao Han, Hui Yu, Jian-jun Zhang, Long-jun Cai, Tao Fan, Wen-da Zhang, Kun Pang, Wei-ming Ma, Xi-tao Wang and Cong-hui Han

    Citation: BMC Complementary Medicine and Therapies 2021 21:45

    Content type: Research article

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  37. Nonalcoholic steatohepatitis (NASH), a liver disease caused by a nonalcoholic fatty liver, is increasing in incidence worldwide. Owing to the complexity of its pathogenic mechanisms, there are no therapeutic a...

    Authors: Yang-Ju Son, Da Seul Jung, Ji Min Shin, Myungsuk Kim, Gyhye Yoo and Chu Won Nho

    Citation: BMC Complementary Medicine and Therapies 2021 21:44

    Content type: Research article

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  38. Periodontitis is a chronic infection initiated by oral bacterial and their virulence factors, yet the severity of periodontitis is largely determined by the dysregulated host immuno-inflammatory response. Baic...

    Authors: Manman Ren, Ya Zhao, Zhiqi He, Jian Lin, Chuchu Xu, Fen Liu, Rongdang Hu, Hui Deng and Yi Wang

    Citation: BMC Complementary Medicine and Therapies 2021 21:43

    Content type: Research article

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  39. The sentence of “Danshen (Salvia Miltiorrhizae Radix et Rhizoma) and Siwu decoction are similar in function” was first recorded in an ancient Chinese medical book “Fu Ren Ming Li Lun”. This theory has far-reac...

    Authors: Yang Li, Li Qiao, Cong Chen, Zhenguo Wang and Xianjun Fu

    Citation: BMC Complementary Medicine and Therapies 2021 21:42

    Content type: Research article

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  40. The latest coronavirus SARS-CoV-2, discovered in China and rapidly spread Worldwide. COVID-19 affected millions of people and killed hundreds of thousands worldwide. There are many ongoing studies investigatin...

    Authors: Aslı Deniz Aydın, Faruk Altınel, Hüseyin Erdoğmuş and Çağdaş Devrim Son

    Citation: BMC Complementary Medicine and Therapies 2021 21:41

    Content type: Research article

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  41. There is preliminary evidence to suggest curcumin can alleviate digestive symptoms in adults with self-reported digestive complaints and irritable bowel syndrome. However, in all these trials, curcumin was use...

    Authors: Adrian L. Lopresti, Stephen J. Smith, Alethea Rea and Shavon Michel

    Citation: BMC Complementary Medicine and Therapies 2021 21:40

    Content type: Research article

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  42. Curcumin, a natural polyphenolic substance, has been known for more than two millennia as having strong anti-inflammatory activity towards multiple ailments, including arthritis. The main drawback of curcumin ...

    Authors: Ieva Rinkunaite, Egidijus Simoliunas, Milda Alksne, Dominyka Dapkute and Virginija Bukelskiene

    Citation: BMC Complementary Medicine and Therapies 2021 21:39

    Content type: Research article

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  43. Tripterygium hypoglaucum Hutch (THH) both has prominent efficacy and unwarranted toxicity in the treatment of autoimmune diseases. Nevertheless, its pharmacological and toxicological profiles still remain to be e...

    Authors: Dan Zhang, Yizhu Dong, Jintao Lv, Bing Zhang, Xiaomeng Zhang and Zhijian Lin

    Citation: BMC Complementary Medicine and Therapies 2021 21:38

    Content type: Research article

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  44. Considering the advantages of using medicinal herbs as supplementary treatments to sensitize conventional anti-cancer drugs, studying functional mechanisms and regulatory effects of Echinacea purpurea (as a non-c...

    Authors: Fatemeh Hosami, Azadeh Manayi, Vahid Salimi, Farshad Khodakhah, Mitra Nourbakhsh, Britt Nakstad and Masoumeh Tavakoli-Yaraki

    Citation: BMC Complementary Medicine and Therapies 2021 21:37

    Content type: Research article

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  45. During the fresh cycles of in vitro fertilization and embryo transfer, a disturbance in the reproductive endocrine environment following controlled ovarian hyperstimulation (COH) is closely related to compromi...

    Authors: Yufan Song, Fanru Zhou, Xiujuan Tan, Xia Liu, Jiahui Ding, Chu Zhang, Fan Li, Wenxin Zhu, Wenwen Ma, Runan Hu and Mingmin Zhang

    Citation: BMC Complementary Medicine and Therapies 2021 21:36

    Content type: Research article

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  46. Water-soluble, but not lipid-soluble, extract of Dicranopteris linearis leaves has been proven to possess hepatoprotective activity. The present study aimed to validate the hepatoprotective and antioxidant activi...

    Authors: Zainul Amiruddin Zakaria, Adibah Sahmat, Azfar Hizami Azmi, Amal Syahirah Nur Zainol, Maizatul Hasyima Omar, Tavamani Balan, Lilis Sulistyorini, R. Azizah and Muhammad Nazrul Hakim Abdullah

    Citation: BMC Complementary Medicine and Therapies 2021 21:35

    Content type: Research article

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  47. Panax notoginseng is one of the most valuable traditional Chinese medicines. Polysaccharides in P. notoginseng has been shown to significantly reduce the incidence of human diseases. However the application of fe...

    Authors: Shiquan You, Xiuqin Shi, Dan Yu, Dan Zhao, Quan An, Dongdong Wang, Jiachan Zhang, Meng Li and Changtao Wang

    Citation: BMC Complementary Medicine and Therapies 2021 21:34

    Content type: Research article

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  48. Microcirculatory disturbance is closely associated with multiple diseases such as ischemic and septic stroke. Luteolin (3,4,5,7-tetrahydroxyflavone) is a vascular protective flavonoid present in several dietar...

    Authors: Jie Su, Han-Ting Xu, Jing-Jing Yu, Mei-Qiu Yan, Ting Wang, Ya-Jun Wu, Bo Li, Wen-Jie Lu, Chuan Wang, Shan-Shan Lei, Si-Min Chen, Su-Hong Chen and Gui-Yuan Lv

    Citation: BMC Complementary Medicine and Therapies 2021 21:33

    Content type: Research article

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  49. Inflammation is the main key role in developing chronic diseases including cancer, cardiovascular diseases, diabetes, arthritis, and neurodegenerative diseases which possess a huge challenge for treatment. Wit...

    Authors: Yazan Ranneh, Abdah Md Akim, Hasiah Ab. Hamid, Huzwah Khazaai, Abdulmannan Fadel, Zainul Amiruddin Zakaria, Mohammed Albujja and Mohd Fadzelly Abu Bakar

    Citation: BMC Complementary Medicine and Therapies 2021 21:30

    Content type: Review

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