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Genus Curcuma: chemical and ethnopharmacological role in aging process

BMC Complementary Medicine and Therapies volume 24, Article number: 31 (2024) Cite this article

Abstract

Aging or senescence is part of human life development with many effects on the physical, mental, and physiological aspects which may lead to age-related deterioration in many organs. Genus Curcuma family Zingieraceae represents one of the well-studied and medically important genera with more than eighty species. The genus is reported to contain different classes of biologically active compounds that are mainly presented in diphenylheptanoids, diphenylpentanoids, diphenylalkanoids, phenylpropene derivatives, alkaloids, flavonoids, chromones, terpenoids, phenolic acids and volatile constituents. Rhizomes and roots of such species are rich with main phytoconstituents viz. curcumin, demethoxycurcumin and bis-demethoxycurcumin. A wide variety of biological activities were demonstrated for different extracts and essential oils of genus Curcuma members including antioxidant, anti-inflammatory, cytotoxic and neuroprotective. Thus, making them as an excellent safe source for nutraceutical products and as a continuous promising area of research on lead compounds that may help in the slowing down of the aging process especially the neurologic and mental deterioration that are usually experienced upon aging. In this review different species of the genus Curcuma were summarized with their phytochemical and biological activities highlighting their role as antiaging agents. The data were collected from different search engines viz. Pubmed®, Google Scholar®, Scopus® and Web of Science® limiting the search to the period between 2003 up till now.

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Introduction

Medicinal plants were utilized for decades as medicine and curative agents for human beings. Aging is the sequential or progressive change in an organism with continuous process of natural change usually begins in early adulthood which leads to an increased risk of debility, disease, and death. Senescence consists of a lot of manifestations related to the aging process. Aging is an inevitable process that includes a progressive and irreversible decrease in physiological abilities which leads to many diseases such as cardiovascular diseases, musculoskeletal disorders and arthritis, neurodegenerative diseases, and cancer. Different mechanisms had postulated the role of aging in cancer development including oxidative stress, DNA damage and mutation, cell aging, decreased immunity, one or all of them may lead to cancer development by aging [1, 2].

Several theories were exploited in order to understand the aging sequences and consequences. Aging can be attributed to one of such theories or a punch of them (Fig. 1) [3].

Fig. 1
figure 1

Diagram showing different theories of the aging process

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1-The cellular theory (Fig. 1) includes intrinsic timing mechanisms and signals, accidental events, programmed genetic signals, damage in DNA or protein structure, waste accumulation or general molecular wear and tear. 2-The physiologic theory (Fig. 1) includes oxidative stress, immunologic, neuro endocrinologic, metabolic, and insulin signaling, and caloric restriction [3].

3-The oxidative stress theory (Fig. 1) is the most common explanation over the last decade evaluating the role of the antioxidant vitamins such as B12, folic acid, A, C, D and E and their effect in slowing oxidative stress [4,5,6]. This theory was emphasized through reversal of the oxidative stress pathway, which may lead to extended life span [7].

4-The gene mutation theory (Fig. 1) explains that deletions, mutations, translocations, and polyploidy are aged-related chromosomal abnormalities that may end in either gene slowing or expression of specific genes that activate certain types of cancers [7].

5-The autoimmune theory (Fig. 1) involved the idea that the human body started to produce autoantibodies to its own tissues and/or deficit primarily in T-cell function led to the development of infections, chronic disease, and cancer, especially autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus [8].

6-The calorie restriction theory (Fig. 1) and mutations in insulin-signaling pathways might result in alterations in body size and composition, enhanced resistance to oxidative stress. 7- Telomere theory (Fig. 1) stated that the telomerase enzyme added telomere repeats to the ends of chromosomes. Critical shortening of the telomeric DNA owing to loss of the enzyme telomerase was the signal for the initiation of cellular senescence [9]. Despite the many theories trying to explain the aging process a lot of mechanisms are still not understood and the aging process usually differ for the same person and from one person to another [10].

A lot of research and review articles has been published with the terms “aging” or “antiaging” in order to either explain the aging process or try to find a solution to the process flow or outcomes. Moreover, many natural compounds and extracts carried a potential antiaging activity through affecting the oxidative stress, inflammation, neurologic function, cardiovascular system, etc. The antiaging activity of such natural agents can be proved through many mechanisms, in vitro and in vivo models [11, 12].

Plants that act as antiaging carry a lot of valuable active ingredients that may help reverse the aging process. Polyphenolic compounds represent an important class of phytoconstituents and they possess potent biological activities like antioxidant, anti-inflammatory and anticancer properties which play a role in delaying, preventing or treating aging-related diseases such as cancers, nephrosclerosis, arthritis, neurodegenerative and cardiovascular diseases [13]. The main antiaging polyphenolics include quercetin, luteolin, catechins, curcumin, resveratrol and lignans. Moreover, other classes of phytoconstituents were reported as antiaging agents such as saponins from Panax ginseng, Gynostemma pentaphyllum and Glycyrrhiza glabra, and in few marine organisms such as starfish and sea cucumbers in addition to alkaloids, polysaccharides and essential oils [14].

Macro- and micronutrients such as vitamins, minerals (as micronutrients), essential and branched amino acids, polyunsaturated fatty acids (PUFA), probiotics together with the above mentioned phytoconstituents are well-known sources of antiaging natural sources. They provide this via reversal of oxidative stress in the body as well as their effects on the atherosclerosis caused by chronic inflammation thus preventing or delaying age-related diseases such as diabetes, cancer, neurodegeneration, and cardiovascular illnesses [15]. Genus Curcuma is rich in many documented antioxidants and anti-inflammatory active constituents with reported antiaging activities such as curcumin which has a key role played in aging reversal through its antioxidant, immunomodulatory and anti-inflammatory properties [10, 16]. Moreover, the promising neuroprotective activity of curcumin was reported against many neurodegenerative diseases viz. Alzheimer’s, Parkinson’s and multiple sclerosis [17]. Thus, genus Curcuma was chosen here in this review article in order to shed light on its main active phytoconstituents with particular use as antiaging natural source. This review article for the first time addresses the relation between the biological activity of the genus Curcuma in relation to aging with emphasis on the main active ingredients responsible for this activity.

Ethnopharmacology

Genus Curcuma is one of the most popular and important genera of the family Zingiberaceae, which is comprised of 93 species. Genus Curcuma L. is composed of perennial and rhizomatous species. It is naturally found in the tropical and subtropical regions and is mainly distributed in India, Thailand, China, Malaysia, Indonesia and Northern Australia. Genus Curcuma members carry unique inflorescence with compound spike and prominent bracts each subtending a cincinnus of two-ten flowers, which are attached to each other forming pouches at the base. Several Curcuma species are famous and familiar with their medicinal uses including; C. longa, C. zedoaria, C. amada, C. aromatic, C. angustifolia, C. neilgherrensis, C. kudagensis, C. thalakaveriensis, C. pseudomontana and C. coriacea, C. aeruginosa, C. angustifolia, C. amada, C. aromatic, C. australasica, C. caesia, C. mangga and C. sumatrana [18, 19].

Curcuma contains many phytoconstituents namely, phenolics, alkaloids, diaryl pentanoids and essential oils. Curcuma has been widely used in folk medicine, especially in the Islamic era, for the treatment of many skin and liver conditions also for hemorrhoids, asthma, inflammation and leprosy. Curcumin is a natural polyphenolic compound isolated from genus Curcuma with different biological and pharmacological properties including antioxidant, immunostimulant, anti-inflammatory, anti-microbial, cardiovascular, renal and liver-protective, anti-cancer, anti-rheumatic, and anti-aging [10].

A lot of species belonging to the genus Curcuma were reported to carry interesting folk medicinal uses and some of them can be summarized as follows. Curcuma longa (Turmeric), is commonly used in folk medicine for many ailments viz. cancer, diabetes, arthritis, diarrhoea, inflammation, psoriasis, hepatobiliary diseases, sore throats, rheumatism, antiseptic, gastric and peptic ulcers which are usually related to many valuable phytoconstituents mainly curcumin [20]. Turmeric has been widely used in South and Southeast Asia for thousands of years. It has been valued as a spice in ‘curry’ especially in marriage and religious ceremonies for Indian people. Nowadays, turmeric is much valued for healthy beverages such as turmeric latte, aka and haldi doodh [21,22,23,24]. Curcuma caesia also known as black turmeric carried a lot of uses in folk medicine for many conditions such as asthma, fever, cancer, wounds, allergies, toothache, leprosy, bronchitis, epilepsy, hemorrhoids, leukoderma and rheumatoid arthritis. C. caesia has been found to be medicinally active as anti-bacterial in acne, analgesic, worm repellent, anti-asthmatic, anti-inflammatory, anti-bacterial, anti-fungal, anti-diabetic, anti-proliferative, anticancer, anti-ulcer, hepatoprotective, nephroprotective, neuroprotective and cytotoxic agent [25]. Curcuma aeruginosa Roxb. rhizome has been reported in traditional medicine as a disinfectant, expectorant, and tonic. Moreover, it has been used for wound healing, diarrhea, dysmenorrhea, fever, coughs, and asthma. Researchers have reported the medicinal use of this rhizome as anticancer, antioxidant, antimicrobial, anti-dengue, immunostimulant, anthelmintic, anti-inflammatory, anti-androgenic, analgesic, uterine relaxant and antipyretic [26].

Curcuma zedoaroides rhizomes were traditionally used by Thai people as antiseptic and wound healing aid against snake bites by king Cobra. The inhibitory effect of C. zedoaroides extract and its fractions on inflammation were detected by reduction of nitric oxide release using RAW264.7 cells. The improvement capabilities on wound healing were determined on fibroblast L929 cells proliferation and migration assays (IC50 = 14.0–14.6μg/ml) [27]. Curcuma zedoaria Rosc is a perennial herb found in tropical countries, such as India, Japan and Thailand. Different organs of this species are utilized in Ayurveda and other folk medicines for the treatment of different ailments such as diarrhoea, cancer, flatulence and dyspepsia [28]. Curcuma angustifolia Roxb. (Indian Arrowroot) is widely distributed in India and some parts of Nepal, Thailand, Bangladesh and Pakistan. It is traditionally used as medicine for treating various diseases and also used as food. Few data are available about its application in pharmacology and therapeutics. Secondary metabolites found in Indian Arrowroot include essential oils, alkaloids, flavonoids, terpenoids, phytosterols, terpenes, phenols, and others. Pharmacological activities such as antioxidant, anti-inflammatory, anti-proliferative, anti-ulcerogenic, hepatoprotective, and anti-cancerous activities have been shown [29].

Recent advances in the field of antiaging natural products

Anti-aging research projects are usually targeting certain age-related disorders such as Parkinson's Disease (PD), Alzheimer's Disease (AD), cardiovascular diseases, cancer, and chronic obstructive pulmonary diseases. The causes of such disorders and illnesses are numerous and many molecular mechanisms are involved such as telomere shortening, NF-κB pathway, adiponectin receptor pathway, insulin, and IGF signaling pathway, AMPK, mTOR and mitochondrial dysfunction [30].

Recently, three signaling pathways that can help delay aging were discovered including the lower activity of insulin/IGF-1 (insulin-like growth factor) signaling, mTOR (mammalian target of rapamycin) nutrient sensing signaling networks and “NAD World” (NAD, nicotinamide adenine dinucleotide) or NAMPT/NAD/SIRT1, an ubiquitous network involved in the metabolic homeostasis of aging consisting of two parts: NAD +—dependent protein deacetylases SIRT1 (sirtuin) and NAMPT (nicotinamide phosphor-ribosyl-transferase), a driver that mediated NAD biosynthesis. mTOR integrates at least two functionally different complexes in mammals, in particular mTORC1 (mTOR complex 1) and mTORC2 (mTOR complex 2) [31].

Different marine sources acted as a new and effective means of antiaging natural products isolation. Crustaceans and seaweeds can provide potent antioxidants such as carotenoids and phenolic compounds. The carotenoid, astaxanthin, isolated from crustaceans or other marine organisms had potential antioxidant and anti-wrinkle activity against skin aging via enhancing skin elasticity and reducing wrinkle formation due to immune-modulating, anti-inflammatory and DNA repair effects. Astaxanthin can also prevent neurodegenerative disorders. Laminarin extracted from brown algae attenuates UV-induced skin damage. In addition to that, marine microorganisms such as microalgae, bacteria and myxomycetes can be sources of antibacterial, antiviral, antitumoral and antioxidant phytoconstituents. The green microalgae named Dunaliella salina can delay skin aging owing to its anti-inflammatory and antiglycation effects while its carbohydrate content can benefit skin health [15].

Role of genus Curcuma members in aging

Phytoconstituents

Diphenylheptanoids (Diarylheptanoids) (Fig. 2)

Fig. 2
figure 2

Summary of the main identified phytoconstituents from different species of genus Curcuma

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Diphenylheptanoids (diarylheptanoids) represents one of the main identified chemical classes from genus Curcuma. This class is best represented by curcumin (curcumin I) which was reported to be isolated from the rhizomes of C. aromatica (hydromethanol extract of the rhizome through reversed phase HPLC, ethyl acetate extract of the rhizome), C. longa (methanol extract), C. manga (methanol extract, hexane and ethyl acetate fractions), C. xanchorrhiza (essential oil extracted by supercritical CO2) and C. zedoaria (ethyl acetate fraction) [24, 32,33,34,35,36,37,38,39]. Many different derivatives belonging to the diarylheptanoid class were isolated from different Curcuma species and can be detailed herein. Most of the diarylheptanoids were reported from C. longa rhizome viz. demethoxycurcumin (curcumin II) [24, 33, 35, 37, 40, 41], bisdemethoxycurcumin (curcumin III) [42] [24, 37, 38, 41], methylcurcumin, sodium curcuminate [35], octahydrocurcumin (C. longa, leaves) [43], tetrahydroxycurcumin [44], cyclocurcumin, calebin-A, 1-(4-hydroxy-3-methoxyphenyl)-7-(3, 4-dihydroxyphenyl)-1,6-heptadiene-3, 5-dione and 1-(4-hydroxyphenyl)-7-(3, 4-dihydroxyphenyl)-1,6-heptadiene-3, 5-dione [24, 38, 45], 5-hydroxyl-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-4,6-heptadiene-3-one, 5-hydroxyl-1,7-bis(4-hydroxy-3-methoxyphenyl)-4,6-heptadiene-3-one, 1,7-bis-(4-hydroxyphenyl)-1-heptene-3,5-dione, 3-hydroxy-1,7-bis-(4-hydroxyphenyl)-6-heptene-1,5-dione and 5-hydroxyl-7-(4-hydroxy-3-methoxyphenyl)-1-(4-hydroxyphenyl)-4,6-heptadiene-3-one [46]. In addition to that, 5-hydroxy-7-(4-hydroxyphenyl)-lphenyl-(1E)-l-heptene and 7-(3,4-dihydroxyphenyl ~ 5-hydroxy-l-phenyl-(1E)-1-heptene were isolated from C. xanchorrhiza (rhizome) [38] while (3S)-1,7-bis-(4-hydroxyphenyl)-(6E)-6-hepten-3-ol, (3R)-1,7-bis(4-hydroxyphenyl)-(6E)-6-hepten-3-ol, (3S)-1-(3,4-dihydroxyphenyl)-7-(4-hydroxyphenyl)-(6E)-6hepten-3-ol, (3R)-1-(3,4-dihydroxyphenyl)-7-(4-hydroxyphenyl)-(6E)-6hepten-3-ol, (3S)-3-acetoxy-1-(3,4-dihydroxyphenyl)-7-(4hydroxyphenyl)-(6E)-6-heptene and (3R)-3-acetoxy-1-(3,4-dihydroxyphenyl)-7-(4hydroxyphenyl)-(6E)-6-heptene were identified from the rhizome of C. kwangsiensis [47]. Moreover, curcumaromin A, curcumaromin B and curcumaromin C were reported from C. aromatica rhizome [35] but demethoxycurcumin was defined the rhizomes of C. aromatica rhizome, C. amada and C. manga [24, 33, 35, 37, 40, 41]. From C. aeruginosa rhizome, tetrahydro-bisdemethoxycurcumin was identified [48]. Octahydrocurcumin was also isolated from C. mangga (leaves) [43] while bis-demethoxy curcumin from C. amada and C. manga rhizomes [24, 37, 38, 41].

Diphenylpentanoids (Fig. 2)

Most of the diphenylpentanoids isolated from genus Curcuma were from C. longa. Three diphenylpentanoids were isolated and identified from the rhizome methanol extract of C. longa namely; (1E,4E)-1,5-bis-(4-dihydroxy)-1, 4-pentadien-3-one, (1E,4E)-1,5-bis-(4-dihydroxy-3-methoxyphenyl)-1,4-pentadien-3-one and (1E,4E)-1-(4-hydroxy-3-methoxyphenyl)-5-(4-hydroxyphenyl)-1,4-pentadien-3-one [49,50,51,52,53,54]. In addition to that, 1,5-bis-(4-hydroxyphenyl)-penta-(1E,4E)-1,4-dien-3-one was reported from the root ethyl acetate extract of the same species [55].

Diphenylalkanoids (Fig. 2)

The extract of C. amada rhizome yielded three diphenylalkanoids which were named following the species name as amadanoic acid A (aryl-C9-aryl skeleton), amadanoic acid B (aryl-C9-aryl skeleton) and amadandiol (aryl-C15-aryl skeleton) [56].

Monomeric and dimeric phenylpropene derivatives (Fig. 2)

Monomeric phenylpropene derivatives can be best represented by calebin A, 400-(4000- hydroxyphenyl-3000-methoxy)-200-oxo-300-butenyl-3-(40-hydroxyphenyl)-propenoate and 400-(4000-hydroxyphenyl)-200- oxo-300-butenyl-3-(40 -hydroxyphenyl-30 -methoxy)-propenoate which were derived from C. oligantha rhizome [56]. While 1-p-coumaroyl-cinnamic acid, 1-feruloyloxy-2-methoxycinnamic acid and 1-feruloyloxy-cinnamic acid isolated from C. chuanyujin rhizome were belonging to the dimeric polypropene derivatives [57].

Alkaloids (Fig. 2)

The Curcuma alkaloids were mainly isolated from the root extracts of different species where aurantiamide and curcuminol I were defined from C. wenyujin (root) [58, 59] and 2-(20 -methyl-10 -propenyl)-4,6-dimethyl-7-hydroxyquinoline was reported from C. longa [60].

Flavonoid glycosides (Fig. 2)

Different classes of flavonoids and their derivatives were isolated from genus Curcuma. Quercetin, naringenin and malvidin 3-rutinoside were reported from C. comosa (aerial parts), C. longa (rhizome), C. zedoaria (rhizome), C. alismatifolia (flower) extracts [61]. The aerial parts extract of C. longa showed the presence of quercetin 3-(2-galloyl-rhamnosyl-robinobioside), quercetin 3-rutinoside, quercetin 3-rhamnosyl-(1 → 2)-rhamnoside and quercetin-3-O-rhamnoside [62].

Chromone derivatives (Fig. 2)

Chromones from genus Curcuma were mainly represented by 2-decyl-5-hydroxy-4H-chromen-4-one, 7-butoxy4-methyl-3-pentyl-2H-chromen-2-one, 3-butyl7-hydroxy-4-methyl-6-pentyl-2H-chromen-2-one, 3-isobutyl-4-methyl-7-pentyloxy-2H-chromate2-one, 1-(4-isopropyl-2,2-dimethyl-7-propoxy-2H-(chromate-6-il)-etanon from C. aeruginosa rhizome [63]. Moreover, another chromone named ermanin was reported from C. zedoaria [39].

Terpenes (Fig. 2)

Sesquiterpenes

A type of monocyclic sesquiterpene named turmerone (II) was reported from the essential oil C. longa rhizome [64,65,66,67]. Moreover, from C. phaeocaulis rhizome methanol extract a number of eudesmane sesquiterpenes were isolated namely; phaeusmanes A–H [68]. Curcumenone (cyclopropane-sesquiterpene) together with curcumanolide A and curcumanolide B were reported from C. zedoaria dried rhizome [69]. Two sesquiterpenoids, cadinane-type, namely; curcujinone A and curcujinone B were isolated from the ethanol extract of the root tubers of C. wenyujin [65].

Sesterpenes

Curcusesterterpene A, curcusesterterpene B and curcusesterterpene C from C. aromatica rhizome [56].

Diterpenes

Labadane diterpene such as 5S,9S,10S,15R-(-)-curcuminol D and 5S,9S,10S,15R-(-)-curcuminol H was reported from C. kwangsiensis [56] while the rhizome extract of C. wenyujin contained mainly isopimarane-type diterpenes named curcumrinol A and curcumrinol B [56].

Triterpenes

Three triterpenes were isolated from the rhizome of C. longa namely; hop-17(21)-en-3b-ol, hop-17(21)- en-3b-yl acetate and hopenone I [56]. Different triterpenoids were identified from the rhizome of C. zanthorrhiza through UPLC/MS. The identified compounds were zedoarolide B, zedoalactone B, curcumenolactone C, bisacurone, zedoarol, camphor, 13-hydroxygermacrone, iso-velleral, coronarin E, curcumenolactone A, gamma-bicyclohomo farnesal, curcumalactone, agaruspirol, spathulenol, zedoaraldehyde, gweicurculactone, arturmerone, curzerenone, curzerenone, curcumene and xanthorrhizol [70].

Curcuma mangga Val. rhizome n-hexane extract showed the presence of zedoarondiol, curcumenol, curcumenone and 13-hydroxygermacrone [71]. Similarly, difurocumenone, aerugidiol, zedoalactone A, zedoalactone B, zedoarondiol, curzerenone, furanodienone, furanogermenone, zedoarol, curcumenol, isocurcumenol, aeruginolactone, aeruginone, furanodiene, germacrone, zederone, dehydrocurdione, dehydrocurdione, aeruginon, curcumenon, pyrocurzerenone, dehydrochromolaenin, curzeone, linderazulene, 8,12-epoxy-1(10),4(15),7,11-germacratetraen-6-one, 1(10),4(5)-diepoxygermacrone, isoaromadendrene epoxide were reported from C. aeruginosa rhizome [26].

Temu mangga (Curcuma manga) rhizomes from Indonesia was extracted with n-hexane which was then subjected to LC/MS. Triterpenoids were the major identified compounds such as zedoarondiol, curcumenol, curcumenone and 13-hydroxygermacrone [72]. The ethyl acetate extract of C. kwangsiensis was rich in (12Z,14R)-7β-hydroxylabda-8(17),12-diene-14,15,16-triol, (12Z,14S)- 7β-hydroxlabda-8(17),12-diene-14,15,16-triol and (4S)-hydroxy-(8)-methoxy-(5S)-(H)-guaia1(10),7(11)-dien-12,8-olide [64]. Different triterpenoids viz. curcumenol, 7α,11α-epoxy-5β-hydroxy-9-guaiaen-8-one, curdione, (1S, 4S, 5S,10S)-germacrone, zederone, curcumanolide A, curcumanolide B, gajutsulactone B and wenyujinin C were isolated from the petroleum ether extract of the root tubers of C. wenyujin [65].

Phenolic acids (Fig. 2)

Gallic acid, protocatechuic acid, gentisic acid, vanillic acid, syringic acid, p-coumaric acid, caffeic acid, ferulic acid were defined from C. amada [73] while vanillin and (E)-4-(4-hydroxy-3-methoxyphenyl)but-3-en-2-one were isolated from C. longa [74].

Volatile constituents

A lot of the well-known volatile components were reported from various species of genus Curcuma. The identified volatile constituents belonged to both the oxygenated and non-oxygenated hydrocarbons viz. α-pinene, α-fenchene, camphene, camphene hydrate, β-pinene, 3-carene, 2-thujene, sabinene, 6-isopropylidenebicyclo[3.1.0]hexane, bi-cyclo [3.1.0] hexane-3-one, 1,8-cineol (eucalyptol), norbornyl acetate, trans-chrysanthenyl acetate, borneol, isoborneol, 4,7,7-trimethyl-bicyclo [2.2.1] heptan-1-ol, endo-1,5,6,7-tetramethylbicyclo[3.2.0]hept-6-en-3-ol, 2-oxabicyclo (3.2.1) octane 1.4-dimethyl-8-methylene, terpene-4-ol, isopulegol, p-mentha-1,4 (8)-diene, 2-menthen-1-ol, L-carveol, menth-1-en-9-ol, α-terpineol, β-terpineol, camphor (1R,4R), acetophenone, p-cymen-8-ol, thymol, 2-methoxy-4 vinylphenol, (E,E,E)-3,7,11,15-tetramethylhexadeca-1,3,6,10,14-pentaene, 2,6,11,15-tetramethylhexadeca-2,6,8,10,14-pentaene, Z-α-farnesene, Z-β-farnesene, myrcene, (E)-β-ocimene, (Z)-β-ocimene (cisocimene), cis-dihydroocimene, transdihydroocimene, hexadecane, heptadecane, octadecane, 2-methylheptan-3-ol, nonan-2-ol, n-nonacosan-1-ol, undecanol, L-octen-3-ol and linalool which were identified from the essential oil or n-hexane extract of C. aeruginosa (rhizome), C. aromatic (leaves), C. manga (rhizome), C. caesia (leaves), C. longa (leaves, rhizome), C. amada (leaves, rhizome), C. angustifolia (rhizome), C. zedoaria.(rhizome), C. inodora (leaves, rhizome), C. purpurascens (leaves, rhizome) and C. xanthorrhiza (rhizome) using GC/MS analyses [18].

Total phenolic and total flavonoid contents

Curcuma aeruginosa is a rhizomatous medicinal plant with beneficial pharmacological activities. The aim of this work was to analyze the agro-morphological, extract yield, and phenolic content often C. aeruginosa accessions which were collected from different locations in Indonesia. Cultivation was carried out in the open field in West Java of Indonesia using a completely randomized design. Qualitative and quantitative parameters were used to investigate agro-morphological traits. Total phenolic and total flavonoids contents were determined in ethanol extracts of samples. The plants were phenotypically diverse, in which there were significant variations among the ten C. aeruginosa accessions in number of leaves, plant height, number of shoots, fresh weight of rhizome, and dry weight of rhizome characters. Variability in the totalphenolic and total flavonoid contents ranged from 29.08–46.92mg GAE/g, and 21.31–33.81mgQE/g, respectively. Six accessions had high phenolic content and extract yield [75].

The antibiofilm and antioxidant activities associated with turmeric were the main focus of thestudy. Antibacterial activity was explored against bacteria isolated from dental plaques and dental unit water lines exhibiting resistance against antibiotics and biocides respectively. This study provides a comparison of the natural plant extract against synthetic mouthwash, chemicals andcommonly prescribed antibiotics. Methanol extract was more effective as compared to otherextracts. Minimum inhibitory concentrations (MIC) ranged from 2.5-10mg/ml. Time based killing kinetic assay showed a significant reduction of bacterial load with increasing concentration of turmeric. Micro titer plate assay indicated significant inhibition of biofilm formation in cellstreated with turmeric extract. Phytochemical screening of plant extracts showed the presence of vital secondary metabolites. Flavonoid content and total phenolic content varied among extracts, phenolic content for methanol extract was 61.669mg GAE/gm dry extract and flavonoid content was 3.119mg quercitin/gm dry extract. The values of ferric reducing power were in the range of 5.55–15.55mmol of FeSO4 equivalent/liter of the extract. Antioxidant activities and total phenolic content of the turmeric extracts had significant positive correlation. On the basis of these resultsturmeric may confidently be recommended as natural antibiofilm and antioxidant agent [76].

Genus Curcuma and endophytes

Genus Curcuma carries a large variety of plant-associated fungi either as rhizosphere-associated microbial species or as endophytes. Both rhizospheric and endophytic species are directly or indirectly involved in growth promotion and disease management in plants and also play an important role in the modulation of morphological growth, secondary metabolite production, curcumin content, antioxidant properties, etc. [77]. The endophytes are usually defined as “non-pathogenic microorganisms that colonize the internal parts of the plant, helping in enhancing the plant growth mechanism and protection by helping the host plants to produce phytohormones like indole acetic acid, gibberellins and cytokinin which promotes the growth of the plant’. They act as a reaction elicitor that help to induce the production of certain plant secondary metabolites. The produced 2ry metabolites may protect the plant from pests and insects also it carries antimicrobial properties against plant pathogens, thus protecting the host during abiotic and biotic stress conditions. Part of these produced 2ry metabolites are of valuable medicinal role [78].

Ceratobasidium ramicola IBRLCM127 was detected as an endophytic fungus from the rhizomes of C. mangga. This fungal endophyte presented promising antimicrobial activity upon screening using agar plug assay where it inhibited eleven bacteria. Gram-positive bacteria were most susceptible to such endophytes (inhibition zones of ≥ 21 mm). Gram-negative bacteria, (Proteus mirabilis, Yersinia enterocolitica, Escherichia coli IBRL 0157, Salmonella typhimurium, Klebsiella pneumoniae ATCC 13883 and Acinetobacter antratus) were the most susceptible (inhibition zones ≥ 21 mm) while Pseudomonas aeruginosa ATCC 27844 was the least susceptible (inhibition zone 11 to ≤ 20 mm). MIC and MBC for Gram-positive bacteria were both in the range of 125.00 to 500.00 µg/mL, while for Gram-negative bacteria the range of 125.00 to 250.00 and 250.00 to 500.00 µg/mL were recorded, respectively [79].

The search for endophytes to produce L-asparaginase is gaining much attention recently. Talaromyces pinophilus, an endophytic fungus isolated from the rhizomes of C. amada was tested for its ability to produce the L-asparaginase enzyme. The enzyme production was performed via Submerged Fermentation (SmF) followed by Solid-state Fermentation (SSF). Optimal concentrations of various metal salts were incorporated in the optimized liquid medium, by one-factor-at-a-time experiments. To further enhance L-asparaginase production, SSF was carried out using Polyurethane Foam (PUF) as inert support impregnated with the optimized liquid medium. This study highlighted the benefits of carrying out SSF with PUF, using the same liquid medium optimized for SmF—a novel approach to enhance the enzyme yield (in our case an increase of about 27% was observed) [80]. Similarly, another study evaluated the potential purification and isolation of l-asparaginase from the same endophytic fungus mentioned above. Maximum enzyme activity could be achieved at pH 8.0 and with temperature 28 °C. The enzyme Exhibits 95% and 98% of its total activity at physiological pH and temperature, respectively. The enzyme activity is largely unhindered in the presence of metal ions such as Ca2+, Cu2+, Fe2+, Mg2+, Mn2+, Zn2+. Increase in the enzyme activity in the presence of thiol groups and reduction in the same upon addition of thiol blockers indicates the involvement of cysteine in the enzyme’s catalytic activity. The enzyme is a heterodimer of 62 kDa and 39 kDa. The enzyme has a Km of 6.4 mM, its turnover number towards L-asparagine is 286.3 s−1. The enzyme has 16% glutaminase activity; its Km towards glutamine is 13.3 mM and turnover number is 54.6 s−1 [81].

Ceratobasidium ramicola IBRLCM127 is one of the endophytic fungi isolated from C. mangga rhizome. This endophyte had potential anti-candidal activity. The fungal ethyl acetate extract showed significant inhibitory zones against C. albicans (MIC = 2.5 mg/ml [82]. C. longa showed the presence of forty-four endophytic. The isolated endophytes were fermented in Potato Dextrose Broth (PDB) media, filtered, extracted with ethyl acetate and then were analyzed by TLC and screened for their antioxidant activity. Six of the isolated endophytes presented antioxidant activities more than 65% namely; K.Cl.Sb.R9 (93.58%), K.Cl.Sb.A11 (81.49%), KCl.Sb.B1 (78.81%), KCl.Sb.R11 (71.67%) and K.Cl.Sb.A12 (67.76%) from Sukabumi and K.Cl.Cb.U1 (69.27%) from Cibinong [83].

Five phytoconstituents were characterized from the endophytic fungus EZG0807 associated with the root of C. wenyujin. The isolated compounds were namely; curcumin, cinnamic acid, 1,4-dihydroxyanthraquinone, gibberellic acid, and kaempferol [84]. An endophytic fungus, Chaetomium globosum, was isolated from C. wenyujin. This endophytic fungus was found rich in chaetoglobosin X, erogosterol, ergosterol 5α,8-peroside and 2-methyl-3-hydroxy indole. Chaetoglobosin X exhibited a broader antifungal spectrum and showed the strongest cytotoxic activity against H22 and MFC cancer cell lines [85]. The ability of C. longa associated endophytic fungi to convert the main metabolite curcumin was investigated. Diaporthe sp. (an endophytic filamentous fungus) converted curcumin into four colorless derivatives such as (3R,5R)-tetrahydrocurcumin, neohexahydrocurcumin, (3S,5S)-octahydrocurcumin and meso-octahydrocurcumin [86].

Biological activities of genus Curcuma

Different biological processes had been linked to aging including oxidative stress, inflammation, neurological disorders, hyperlipidemia and cancer. Curcuma species extracts were reported to combat such changes as detailed below in Table 1.

Table 1 Antiaging biological activities of genus Curcuma
Full size table

Curcuma or turmeric is famous by its potent phytochemicals namely curcumin, demethoxycurcumin, bis-demethoxycurcumin, zingiberene, curcumenol, curcumol, eugenol, tetrahydrocurcumin, triethylcurcumin, turmerin, turmerones, and turmeronols. Although curcumin is the most abundant and well-known active ingredient of curcuma, many research articles had addressed the idea of the presence of other active components synergizing with curcumin. Three main curcumin analogs (diferuloylmethane, demethoxycurcumin and bis-demothycurcumin) were causing such synergism. In some cases, bisdemethoxycurcumin was found more potent compared to curcumin and in other cases a mixture of the two compounds lead to higher activity. On the other hand, tetrahydrocurcumin (a metabolite of curcumin) has been shown to be active in some systems and not in others. Despite extensive research on Curcuma and its active metabolites, a lot of questions are still to be answered including the optimum dosage for effective biological activities, bioavailability and serum levels of curcumin as the main active metabolite is low also the concentration of curcumin in tissues and in cell culture [87].

Toxicity studies on genus Curcma

A study was conducted to evaluate the possible toxic effects of two hundred compounds from turmeric in regard of bacterial mutagenicity, rodent carcinogenicity and human hepatotoxicity. One hundred and eighty four compounds were found toxic while one hundred and thirty six were mutagenic, one hundred fifty three compounds were carcinogenic and sixty four were hepatotoxic [107]. According to both the FAO/WHO reports on food additives, the daily intake of curcumin should not exceed 0–1mg/kg body weight for no adverse effects. Chronic toxicity studies on curcumin concluded that it can be administered safely at oral doses of up to 8 g per day. Moreover, in vivo studies in rats found that the oral administration of 1 g/kg of curcumin resulted in that it was excreted unmodified with faeces (about 75%) with minor appearance in urine. It is worthy noted also that, curcumin showed extremely low serum levels. The average peak serum concentrations after taking 4mg, 6mg and 8mg/day of curcumin were 0.51 ± 0.11µM, 0.63 ± 0.06µM and 1.77 ± 1.87µM, respectively [108].

Bioavailability and metabolic pathways involved in Curcuma consumption

Clinical trials on curcumin human consumption had concluded that the compound is safe up to 12 g/day however it suffers from poor bioavailability. This low bioavailability can be attributed to its poor absorption, rapid metabolism, and rapid systemic elimination. Many research articles were carried out in order to improve curcumin bioavailability through many approaches including: the use of adjuvant like piperine that interferes with glucuronidation, incorporating the compound in liposomes, curcumin nanoparticles, developing curcumin-phospholipid complex and structural modification of curcumin into more bioavailable leads. Curcumin and its derivatives has een proven as potent antioxidant, anti-inflammatory and anticancer agents thus improving their bioavailability as a future research target may lead to the development of promising drug leads and nutraceutical formulations that are potent against many age-related diseases and disorders [109,110,111].

Discussion

Natural products show diverse chemical classes accounting for more than 200,000 of functional metabolites belonging to different classes such as flavonoids, phenolic acids, phenylpropanoids, terpenoids and alkaloids [112].

Aromatic and medicinal plants serve as abundant sources of natural products, many of which possess significant benefits for human health. These benefits include as the prevention and/or treatment of various cancers, as well as inflammatory, cardiovascular and neurodegenerative diseases. Apart from species and/or organ specific accumulation patterns, natural products occur in response to various abiotic and biotic stresses. They serve diverse biological functions, acting as attractants, repellants and other olfactory signaling molecules involved in olfactory communication. Additionally, they play an essential role in growth and development [113].

Genus Curcuma has long been tied to the idea of age reversal through its vital ingredient curcumin which belongs to a wider umbrella named the curcuminoides which comprises the diphenylpentanoids, diphenyheptanoids, diarylheptanoids, etc. Curcumin showed its significant and powerful antiaging activity through many mechanisms viz. reducing the levels of the oxidative radicals and enzymes (malonaldehyde, lipid peroxidase) in the brain tissue, reducing cell aging and increasing cell viability, repairing damaged cardiovascular endothelium, reducing artery stiffness and enhancing its elasticity and also by having a protective role against radiation damage [114,115,116].

Other research articles and review articles discussed either genus Curcuma phytoconstituents or studied the possible biological activities of curcumin as the main phytoconstituent of Curcuma as follows. One review article discussed the ethnobotanical properties, phytochemical constituents and biological activities of two Curcuma species namely; C. longa and C. zedoaria [18]. Another review article listed the main phytoconstituents and biological activities of genus Curcuma [56]. Moreover, Curcumin effect on the brain age-related disorders was the focus of one article where the neuroprotective, antioxidant and anti-inflammatory activity effects of curcumin were detailed. Curcumin showed neurologic protection via its effect on oxidative stress proteins and its anti-inflammatory activity against inflammation of the microgalia [36]. It is worthy noted here that this current review article is considered the first linking the different biological effects of the whole members of genus Curcuma to its possible antiaging effects through the last twenty years.

Although Curcumin and other curcuminoides represent the corner stone for the antiaging role of genus Curcuma, the presence of other phytoconstituents was found to be essential for such activity. Triterpenoids occurring together with curcuminodes in the Curcuma extract were found to play a synergestic role via enhancing the curcuminoides absorption due to the lipophilic nature of the terpenoids. Curcuma triterpenoids may also act as anti-inflammatory agents helping in the down regulation of nuclear factor KB thus reducing the oxidative stress level and modulating the aging process [117].

Curcumin despite being the main active agent of Curcuma with reported evidence on its efficacy and safety, it has not yet been approved as a therapeutic agent due to its low bioavailability, instability at physiological pH, insolubility in water, slow uptake by cells and rapid metabolism inside the cells [108, 118].

Alzheimer, Parkinson’s and dementia together with physical health deterioration are normal players in the process of aging leading to many limitations on people quality of life. The presence of strong antioxidant, cytotoxic and anti-inflammatory agents such as those reported from genus Curcuma may help in the prophylactic and treatment measures related to aging [119].

Conclusions and future perspectives

In conclusion, the genus Curcuma, with almost eighty species, carry a lot of interesting phytoconstituents belonging to many chemical classes. The rhizomes followed by the roots represent the most studied part of genus Curcuma being rich in the main phytoconstituents. The vast array of biological activities played by the members of genus Curcuma has positioned them as an important part of the research targets, especially those against aging and senile-related diseases. Alzheimer, Parkinson’s and dementia together with many neurologic defects that accompany aging are usually the result of oxidative stress and prolonged inflammation thus the presence of strong antioxidants and anti-inflammatory effects played by Curcuma extracts may help in slowing down or reversing such deteriorations. More research is needed concerning the other parts of the genus Curcuma such as the leaves, seeds, and stems. The biological activities are in most cases due to the high curcumin content although few research articles addressed the synergistic role that may be played by the other ingredients of the Curcuma extracts. Moreover, molecular mechanisms confirming the reported biological activities may be a noteworthy future research interest.

Availability of data and materials

Not applicable.

References

  1. Butnariu M: Plant genome engineering for improved flavonoids production. Plants as Bioreactors for Industrial Molecules 2023:215–240.

  2. Chaachouay N, Benkhnigue O, Fadli M, El Ibaoui H, El Ayadi R, Zidane L. Ethnobotanical and ethnopharmacological study of medicinal and aromatic plants used in the treatment of respiratory system disorders in the Moroccan Rif. Ethnobot Res Appl. 2019;18:1–16.

    Google Scholar 

  3. Cefalu CA. Theories and mechanisms of aging. Clin Geriat Med. 2011;27(4):491–506.

    Article  Google Scholar 

  4. Chakraborti S. Handbook of oxidative stress in cancer: therapeutic aspects. Singapore: Springer Nature; 2022. p. 4121. https://doi.org/10.1007/978-981-16-5422-0.

  5. Ashraf H, Moussa A, Seleem A, Eldahshan OA, Singab A-N. UPLC-ESI/MS/MS profiling and anti-inflammatory activity of Gleditsia caspica. Arch Pharm Sci Ain Shams Uni. 2020;4(1):124–34.

    Google Scholar 

  6. Ashraf H, Moussa AY, Eldahshan OA, Singab ANB. Genus Gleditsia: a phytochemical and biological review (2015–2020). J Biol Act Prod Nat. 2022;12(1):1–23.

    CAS  Google Scholar 

  7. Trevisan K, Cristina-Pereira R, Silva-Amaral D, Aversi-Ferreira TA. Theories of aging and the prevalence of Alzheimer’s disease. BioMed Res Int. 2019;2019:1–9. https://doi.org/10.1155/2019/9171424.

    Article  CAS  Google Scholar 

  8. Rejeski WJ, Fanning J. Models and theories of health behavior and clinical interventions in aging: a contemporary, integrative approach. Clin Interv Aging. 2019;14:1007.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Barja G. Towards a unified mechanistic theory of aging. Exp Gerontol. 2019;124:110627.

    Article  PubMed  Google Scholar 

  10. Benameur T, Soleti R, Panaro MA, La Torre ME, Monda V, Messina G, Porro C. Curcumin as prospective anti-aging natural compound: focus on brain. Molecules. 2021;26(16):4794.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Shen LR, Parnell LD, Ordovas JM, Lai CQ. Curcumin and aging. BioFactors. 2013;39(1):133–40.

    Article  CAS  PubMed  Google Scholar 

  12. Ding A-J, Zheng S-Q, Huang X-B, Xing T-K, Wu G-S, Sun H-Y, Qi S-H, Luo H-R. Current perspective in the discovery of anti-aging agents from natural products. Nat Prod Bioprospect. 2017;7:335–404.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Qiao J, Wang C, Chen Y, Yu S, Liu Y, Yu S, Jiang L, Jin C, Wang X, Zhang P. Herbal/natural compounds resist hallmarks of brain aging: from molecular mechanisms to therapeutic strategies. Antioxidants. 2023;12(4):920.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Gao L, Liu X, Luo X, Lou X, Li P, Li X, et al. Antiaging effects of dietary supplements and natural products. Front Pharmacol. 2023;14:1192714. https://doi.org/10.3389/fphar.2023.1192714.

  15. Bjørklund G, Shanaida M, Lysiuk R, Butnariu M, Peana M, Sarac I, Strus O, Smetanina K, Chirumbolo S. Natural compounds and products from an anti-aging perspective. Molecules. 2022;27(20):7084.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Akbari B, Baghaei-Yazdi N, Bahmaie M, Mahdavi Abhari F. The role of plant-derived natural antioxidants in reduction of oxidative stress. BioFactors. 2022;48(3):611–33.

    Article  CAS  PubMed  Google Scholar 

  17. Benameur T, Giacomucci G, Panaro MA, Ruggiero M, Trotta T, Monda V, Pizzolorusso I, Lofrumento DD, Porro C, Messina G. New promising therapeutic avenues of curcumin in brain diseases. Molecules. 2021;27(1):236.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Ayati Z, Ramezani M, Amiri MS, Moghadam AT, Rahimi H, Abdollahzade A, et al. Ethnobotany, phytochemistry and traditional uses of Curcuma spp. and pharmacological profile of two important species (C. longa and C. zedoaria): a review. Curr Pharma Des. 2019;25(8):871–935.

  19. Zhang J. Plantlist: looking up the status of plant scientific names based on the plant list database. R package version 0.5. 3. 2019. Accessed Nov 2023.

  20. Iweala EJ, Uche ME, Dike ED, Etumnu LR, Dokunmu TM, Oluwapelumi AE, et al. Curcuma longa (turmeric): ethnomedicinal uses, phytochemistry, pharmacological activities and toxicity profiles-A review. Pharmacol Res-Mod Chin Med. 2023:100222. https://doi.org/10.1016/j.prmcm.2023.100222.

  21. Paleker G. Rhizome networks: Turmeric’s global journey from haldi doodh to turmeric latte. Agenda. 2023:1–8. https://doi.org/10.1080/10130950.2023.2177554.

  22. Meghwal M, Devu S, Singh H, Goswami TK. Piperine and curcumin. In: A Centum of Valuable Plant Bioactives. 1st ed. Elsevier; 2021. p. 589–612. eBook ISBN: 9780128229248.

  23. Mathai NJ, Sony D, Mane PP, Shetty CB, Latheef L, Kamath K, et al. Antiarthritic effects of turmeric and curcumin: a revisit. Polyphenols: Prevention and Treatment of Human Disease. 2018:247–52. https://doi.org/10.1016/B978-0-12-813008-7.00020-5.

  24. Ashraf K. A comprehensive review on Curcuma longa Linn.: phytochemical, pharmacological, and molecular study. Int J Green Pharm (IJGP). 2017;11(04):671–85. https://doi.org/10.22377/ijgp.v11i04.134.

  25. Haida Z, Nakasha JJ, Sinniah UR, Hakiman M. Ethnomedicinal uses, phytochemistry, pharmacological properties and toxicology of Curcuma caesia Roxb.: a review. Adv Trad Med. 2022:1–17. https://doi.org/10.1007/s13596-022-00658-y.

  26. Sari AP, Supratman U. Phytochemistry and biological activities of Curcuma aeruginosa (Roxb.). Ind J Chem. 2022;22(2):576–98.

    CAS  Google Scholar 

  27. Tungcharoen P, Sudsai T, Leejae S, Wattanapiromsakul C, Tansakul P, Tewtrakul S. Wound healing activity of Curcuma zedoaroides. Songklanakarin J Sci Technol. 2016;38(6):101–7. https://doi.org/10.1016/j.ijbiomac.2018.05.066.

  28. Lobo R, Prabhu KS, Shirwaikar A, Shirwaikar A. Curcuma zedoaria Rosc. (white turmeric): a review of its chemical, pharmacological and ethnomedicinal properties. J Pharm Pharmacol. 2009;61(1):13–21.

  29. Kityania S, Talukdar AD, Nath R, Nath D, Choudhury MD, Nizamee AMH, et al. Ethnomedicinal, phytochemical and nutra-pharmaceutical potentials of Indian arrowroot (Curcuma angustifolia Roxb). Comb Chem High Throughput Screen. 2022:880–91. https://doi.org/10.2174/1386207325666220524142858.

  30. Muzammil A, Waqas M, Umar A, Sufyan M, Rehman A, Haider A, Akram H, Khan SA, Afzal M, Wajid M. Anti-aging natural compounds and their role in the regulation of metabolic pathways leading to longevity. Mini Rev Med Chem. 2021;21(18):2630–56.

    Article  CAS  PubMed  Google Scholar 

  31. Cătană C-S, Atanasov AG, Berindan-Neagoe I. Natural products with anti-aging potential: affected targets and molecular mechanisms. Biotechnol Adv. 2018;36(6):1649–56.

    Article  PubMed  Google Scholar 

  32. Bamba Y, Yun YS, Kunugi A, Inoue H. Compounds isolated from Curcuma aromatica Salisb. inhibit human P450 enzymes. J Nat Med. 2011;65:583–7.

    Article  CAS  PubMed  Google Scholar 

  33. Pant N, Misra H, Jain D. Phytochemical investigation of ethyl acetate extract from Curcuma aromatica Salisb rhizomes. Arab J Chem. 2013;6(3):279–83.

    Article  CAS  Google Scholar 

  34. Ahmad S, Ali M, Ansari S, Ahmed F. Chemical constituents from the rhizomes of Curcuma aromatica Salisb. Der Pharma Chem. 2011;3(2):505–11.

    CAS  Google Scholar 

  35. Araújo CC, Leon LL. Biological activities of Curcuma longa L. Mem Inst Oswaldo Cruz Rio de Janerio. 2001;96:723–8.

  36. Abdel-Lateef E, Mahmoud F, Hammam O, El-Ahwany E, El-Wakil E, Kandil S, et al. Bioactive chemical constituents of Curcuma longa L. rhizomes extract inhibit the growth of human hepatoma cell line (HepG2). Acta Pharma. 2016;66(3):387–3980.

  37. Malek SNA, Lee GS, Hong SL, Yaacob H, Wahab NA, Faizal Weber J-F, et al. Phytochemical and cytotoxic investigations of Curcuma mangga rhizomes. Molecules. 2011;16(6):4539–48.

  38. Suksamrarn A, Eiamong S, Piyachaturawat P, Charoenpiboonsin J. Phenolic diarylheptanoids from Curcuma xanthorrhiza. Phytochemistry. 1994;36(6):1505–8.

    Article  CAS  Google Scholar 

  39. Chen J-J, Tsai T-H, Liao H-R, Chen L-C, Kuo Y-H, Sung P-J, et al. New sesquiterpenoids and anti-platelet aggregation constituents from the rhizomes of Curcuma zedoaria. Molecules. 2016;21(10):1385.

  40. Jang MK, Lee HJ, Kim JS, Ryu J-H. A curcuminoid and two sesquiterpenoids from Curcuma zedoaria as inhibitors of nitric oxide synthesis in activated macrophages. Arch Pharm Res. 2004;27:1220–5.

    Article  CAS  PubMed  Google Scholar 

  41. Gupta A, Gupta M, Kumar S. Simultaneous determination of curcuminoids in Curcuma samples using high performance thin layer chromatography. J Liq Chromatogr Relat Technol. 1999;22(10):1561–9.

    Article  CAS  Google Scholar 

  42. Ramirez-Ahumada Mdel C, Timmermann BN, Gang DR. Biosynthesis of curcuminoids and gingerols in turmeric (Curcuma longa) and ginger (Zingiber officinale): identification of curcuminoid synthase and hydroxycinnamoyl-CoA thioesterases. Phytochemistry. 2006;67(18):2017–29. https://doi.org/10.1016/j.phytochem.2006.06.028.

  43. Liu Y, Nair MG. Curcuma longa and Curcuma mangga leaves exhibit functional food property. Food Chem. 2012;135(2):634–40.

    Article  CAS  PubMed  Google Scholar 

  44. Park B-S, Kim J-G, Kim M-R, Lee S-E, Takeoka GR, Oh K-B, et al. Curcuma longa L. constituents inhibit sortase A and Staphylococcus aureus cell adhesion to fibronectin. J Agric Food Chem. 2005;53(23):9005–9.

  45. Li W, Wang S, Feng J, Xiao Y, Xue X, Zhang H, et al. Structure elucidation and NMR assignments for curcuminoids from the rhizomes of Curcuma longa. Magn Reson Chem. 2009;47(10):902–8.

  46. Kita T, Imai S, Sawada H, Seto H. Isolation of dihydrocurcuminoids from cell clumps and their distribution in various parts of turmeric (Curcuma longa). Biosci Biotechnol Biochem. 2009;73(5):1113–7.

    Article  CAS  PubMed  Google Scholar 

  47. Li J, Zhao F, Li MZ, Chen LX, Qiu F. Diarylheptanoids from the rhizomes of Curcuma kwangsiensis. J Nat Prod. 2010;73(10):1667–71.

    Article  CAS  PubMed  Google Scholar 

  48. Septaningsih DA, Darusman LK, Afendi FM, Heryanto R. Liquid chromatography mass spectrometry (LC-MS) fingerprint combined with chemometrics for identification of metabolites content and biological activities of Curcuma aeruginosa. Ind J Chem. 2018;18(1):43–52.

    CAS  Google Scholar 

  49. Masuda T, Jitoe A, Isobe J, Nakatani N, Yonemori S. Anti-oxidative and anti-inflammatory curcumin-related phenolics from rhizomes of Curcuma domestica. Phytochemistry. 1993;32(6):1557–60.

    Article  CAS  Google Scholar 

  50. Park S-Y, Kim DS. Discovery of natural products from Curcuma longa that protect cells from beta-amyloid insult: a drug discovery effort against Alzheimer’s disease. J Nat Prod. 2002;65(9):1227–31.

    Article  CAS  PubMed  Google Scholar 

  51. Wang X, Jiang Y, Wang Y-W, Huang M-T, Ho C-T, Huang Q. Enhancing anti-inflammation activity of curcumin through O/W nanoemulsions. Food Chem. 2008;108(2):419–24.

    Article  CAS  PubMed  Google Scholar 

  52. Li R, Xiang C, Ye M, Li H-F, Zhang X, Guo D-A. Qualitative and quantitative analysis of curcuminoids in herbal medicines derived from Curcuma species. Food Chem. 2011;126(4):1890–5.

    Article  CAS  PubMed  Google Scholar 

  53. Xiao J, Nian S, Huang Q. Assembly of kafirin/carboxymethyl chitosan nanoparticles to enhance the cellular uptake of curcumin. Food Hydrocoll. 2015;51:166–75.

    Article  CAS  Google Scholar 

  54. Dao TT, Nguyen PH, Won HK, Kim EH, Park J, Won BY, et al. Curcuminoids from Curcuma longa and their inhibitory activities on influenza A neuraminidases. Food Chem. 2012;134(1):21–8.

  55. Wang L-Y, Zhang M, Zhang C-F, Wang Z-T. Diaryl derivatives from the root tuber of Curcuma longa. Biochem Sys Ecol. 2008;5(36):476–80.

    Article  Google Scholar 

  56. Sun W, Wang S, Zhao W, Wu C, Guo S, Gao H, et al. Chemical constituents and biological research on plants in the genus Curcuma. Crit Rev Food Sci Nutr. 2017;57(7):1451–523.

  57. Xia Q, Zhao KJ, Huang ZG, Zhang P, Dong TT, Li SP, Tsim KW. Molecular genetic and chemical assessment of Rhizoma Curcumae in China. J Agric Food Chem. 2005;53(15):6019–26.

    Article  CAS  PubMed  Google Scholar 

  58. Huang X, Qin F, Zhang H-M, Xiao H-B, Wang L-X, Zhang X-Y, Ren P. Cardioprotection by Guanxin II in rats with acute myocardial infarction is related to its three compounds. J Ethnopharmacol. 2009;121(2):268–73.

    Article  CAS  PubMed  Google Scholar 

  59. Ma Z-J, Meng Z-K, Zhang P. Chemical constituents from the radix of Curcuma wenyujin. Fitoterapia. 2009;80(6):374–6.

    Article  CAS  PubMed  Google Scholar 

  60. Wang R, Li Y-B, Li Y-H, Xu Y. Wu H-l, Li X-J: Curcumin protects against glutamate excitotoxicity in rat cerebral cortical neurons by increasing brain-derived neurotrophic factor level and activating TrkB. Brain Res. 2008;1210:84–91.

    Article  CAS  PubMed  Google Scholar 

  61. Chokchaisiri R, Innok P, Suksamrarn A. Flavonoid glycosides from the aerial parts of Curcuma comosa. Phytochem Lett. 2012;5(2):361–6.

    Article  CAS  Google Scholar 

  62. Kim DW, Lee SM, Woo HS, Park J-Y, Ko BS, Heo JD, et al. Chemical constituents and anti-inflammatory activity of the aerial parts of Curcuma longa. J Funct Food. 2016;26:485–93.

  63. Sugita P, Octaviana N, Wukirsari T, Rahayu D. Chemical constituent and antioxidant activity of methanol extract from Indonesian Curcuma aeruginosa Roxb. rhizome. Drug Invent Today. 2018;10(1):293–7.

    Google Scholar 

  64. Yuan H-L, Zhao Y-L, Ding C-F, Zhu P-F, Jin Q, Liu Y-P, et al. Anti-inflammatory and antinociceptive effects of Curcuma kwangsiensis and its bioactive terpenoids in vivo and in vitro. J Ethnopharmacol. 2020;259:112935.

  65. Zhou C-X, Zhang L-S, Chen F-F, Wu H-S, Mo J-X, Gan L-S. Terpenoids from Curcuma wenyujin increased glucose consumption on HepG2 cells. Fitoterapia. 2017;121:141–5.

    Article  CAS  PubMed  Google Scholar 

  66. Zohmachhuana A, Lalnunmawia F, Mathipi V, Lalrinzuali K, Kumar NS. Curcuma aeruginosa Roxb. exhibits cytotoxicity in A-549 and HeLa cells by inducing apoptosis through caspase-dependent pathways. Biomed Pharmacother. 2022;150:113039. https://doi.org/10.1016/j.biopha.2022.113039.

  67. Gandhi R, Vig O, Mukherji S. Terpenoids—VI: a novel unambiguous synthesis of DL-ar-turmerone. Tetrahedron. 1959;7(3–4):236–40.

  68. Liu Y, Ma J, Wang Y, Donkor PO, Li Q, Gao S, et al. Eudesmane-type sesquiterpenes from Curcuma phaeocaulis and their inhibitory activities on nitric oxide production in RAW 264.7 cells. Eu J Org Chem. 2014;2014(25):5540–8.

  69. Shiobara Y, Asakawa Y, Kodama M, Yasuda K, Takemoto T. Curcumenone, curcumanolide A and curcumanolide B, three sesquiterpenoids from Curcuma zedoaria. Phytochemistry. 1985;24(11):2629–33.

    Article  CAS  Google Scholar 

  70. Klau ME, Rohaeti E, Rafi M, Artika IM, Ambarsari L, Nurcholis W. Metabolite profiling of Curcuma xanthorriza varieties grown in different regions using UHPLC-Q-Orbitrap-HRMS and chemometrics analysis. Biointerface Res Appl Chem. 2023;13:1–13.

    Google Scholar 

  71. Ganur AN, Kurniawanti K, Sugita P, Ambarsari L, Syahbirin G, Ilmiawati A, et al. Identified compounds from ethyl acetate phase of temu mangga (Curcuma mangga Val.) using LC-MS/MS and their potential as anticancer against MCF-7 cells. Trop J Nat Prod Res. 2022;6(12):1941–6. https://doi.org/10.26538/tjnpr/v6i12.7.

  72. Ganur AN, Rahayu DU, Dianhar H, Irwanto I, Sugita P. Terpenoid from Indonesian temu mangga (Curcuma mangga, Val) rhizomes and review of its anticancer towards MCF-7 breast cells. In: AIP Conference Proceedings. AIP Publishing; 2021. https://doi.org/10.1063/5.0051538.

  73. Siddaraju MN, Dharmesh SM. Inhibition of gastric H+, K+-ATPase and Helicobacter pylori growth by phenolic antioxidants of Zingiber officinale. Mol Nutr Food Res. 2007;51(3):324–32.

    Article  CAS  PubMed  Google Scholar 

  74. Chen J-J, Tsai C-S, Hwang T-L, Shieh P-C, Chen J-F, Sung P-J. Sesquiterpenes from the rhizome of Curcuma longa with inhibitory activity on superoxide generation and elastase release by neutrophils. Food Chem. 2010;119(3):974–80.

    Article  CAS  Google Scholar 

  75. Khumaida N, Syukur M, Bintang M, Nurcholis W. Phenolic and flavonoid content in ethanol extract and agro-morphological diversity of Curcuma aeruginosa accessions growing in West Java. Indonesia Biodivers J Biol Divers. 2019;20(3):656–63.

    Article  Google Scholar 

  76. Hayat S, Sabri AN. Screening for antibiofilm and antioxidant potential of turmeric (Curcuma longa) extracts. Pak J Pharma Sci. 2016;29(4):1163–70.

    CAS  Google Scholar 

  77. Kumar A, Singh AK, Kaushik MS, Mishra SK, Raj P, Singh PK, et al. Interaction of turmeric (Curcuma longa L.) with beneficial microbes: a review. 3 Biotech. 2017;7(6):357. https://doi.org/10.1007/s13205-017-0971-7.

  78. Thankam SR, Manuel SG. Identification and characterization of endophytic bacteria isolated from Curcuma longa. Proceedings of the National Academy of Sciences, India Section B: Biological Sciences. 2023. p. 93. https://doi.org/10.1007/s40011-023-01466-3.

  79. Muazzam K, Darah I. The evaluation of antibacterial activity of fungal endophyte Ceratobasidium ramicola IBRLCM127 colonizing in rhizomes of medicinal plant, Curcuma mangga Valeton & Zijp. In: IOP Conference Series: Earth and Environmental Science: 2020. IOP Publishing; 2020. p. 012083. https://doi.org/10.1088/1755-1315/596/1/012083.

  80. Krishnapura PR, Belur PD. L-Asparaginase production using solid-state fermentation by an endophytic Talaromyces pinophilus isolated from rhizomes of Curcuma amada. J Pure Appl Microbiol. 2020;14(1):307–18. https://doi.org/10.22207/JPAM.14.1.32.

  81. Krishnapura PR, Belur PD. Partial purification and characterization of L-asparaginase from an endophytic Talaromyces pinophilus isolated from the rhizomes of Curcuma amada. J Mol Catal B: Enzymatic. 2016;124:83–91.

    Article  CAS  Google Scholar 

  82. Rahman KAMA, Ibrahim D. Ceratobasidium ramicola IBRLCM127, an endophytic fungus isolated from Curcuma mangga Valeton & Zijp with strong anti-candidal activity. J Appl Pharma Sci. 2019;9(11):086–92.

    Article  Google Scholar 

  83. Rachman F, Septiana E, Lekatompessy S, Widowati T, Sukiman HI, Simanjuntak P. Screening for endophytic fungi from turmeric plant (Curcuma longa L.) of Sukabumi and Cibinong with potency as antioxidant compounds producer. Pak J Biol Sci: PJBS. 2015;18(1):42–5.

    PubMed  Google Scholar 

  84. Yan J, Qi N, Wang S, Gadhave K, Yang S. Characterization of secondary metabolites of an endophytic fungus from Curcuma wenyujin. Curr Microbiol. 2014;69:740–4.

    Article  CAS  PubMed  Google Scholar 

  85. Wang Y, Xu L, Ren W, Zhao D, Zhu Y, Wu X. Bioactive metabolites from Chaetomium globosum L18, an endophytic fungus in the medicinal plant Curcuma wenyujin. Phytomedicine. 2012;19(3–4):364–8.

    Article  CAS  PubMed  Google Scholar 

  86. Maehara S, Ikeda M, Haraguchi H, Kitamura C, Nagoe T, Ohashi K, et al. Microbial conversion of curcumin into colorless hydroderivatives by the endophytic fungus Diaporthe sp. associated with Curcuma longa. Chem Pharma Bull. 2011;59(8):1042–4. https://doi.org/10.1248/cpb.59.1042.

  87. Balaji S, Chempakam B. Toxicity prediction of compounds from turmeric (Curcuma longa L). Food Chem Toxicol. 2010;48(10):2951–9.

    Article  CAS  PubMed  Google Scholar 

  88. Kartini S, Juariah S, Mardhiyani D, Bakar MFA, Bakar FIA, Endrini S. Phytochemical properties, antioxidant activity and α-amilase inhibitory of Curcuma caesia. J Adv Res Appl Sci Eng Technol. 2023;30(1):255–63.

    Google Scholar 

  89. Borah A, Paw M, Gogoi R, Loying R, Sarma N, Munda S, et al. Chemical composition, antioxidant, anti-inflammatory, anti-microbial and in-vitro cytotoxic efficacy of essential oil of Curcuma caesia Roxb. leaves: An endangered medicinal plant of North East India. Ind Crop Prod. 2019;129:448–54.

  90. Wuttikul K, Sainakham M. In vitro bioactivities and preparation of nanoemulsion from coconut oil loaded Curcuma aromatica extracts for cosmeceutical delivery systems. Saudi J Biol Sci. 2022;29(12):103435.

  91. Kusumadewi AP, Martien R, Pramono S, Setyawan AA, Windarsih A, Rohman A. Application of FTIR spectroscopy and chemometrics for correlation of antioxidant activities, phenolics and flavonoid contents of Indonesian Curcuma xanthorrhiza. Int J Food Prop. 2022;25(1):2364–72.

    Article  CAS  Google Scholar 

  92. Setyowati E, Ikawati Z, Hertiani T, Pramantara I. Antioxidant activity and lipase enzyme inhibition of Gynura procumbens (Lour.) Merr. and Curcuma xanthorrhiza Roxb. and their correlation with chemometric methods. Health Environment Res On. 2020;2845–54. https://doi.org/10.31838/ijpr/2020.SP2.294.

  93. Mekonnen A, Desta W. Comparative study of the antioxidant and antibacterial activities of Rumex abyssinicus with commercially available Zingiber officinale and Curcuma longa in Bahir Dar city. Ethiopia Chem Biol Technol Agric. 2021;8:1–11.

    Google Scholar 

  94. Akter J, Hossain MA, Takara K, Islam MZ, Hou D-X. Antioxidant activity of different species and varieties of turmeric (Curcuma spp): Isolation of active compounds. Comp Biochem Physiol C: Toxicol Pharmacol. 2019;215:9–17.

    CAS  PubMed  Google Scholar 

  95. Fernandes F, Barroso MF, De Simone A, Emriková E, Dias-Teixeira M, Pereira JP, Chlebek J, Fernandes VC, Rodrigues F, Andrisano V. Multi-target neuroprotective effects of herbal medicines for Alzheimer’s disease. J Ethnopharmacol. 2022;290:115107.

  96. Sudha N, Vanisree AJ. Neuroprotective role of Curcuma amada in F1 progeny of Juvenile Danio rerio (Zebrafish) from nickel chloride induced maternal stress in gestationally challenged adult fishes. Res J Pharm Technol. 2021;14(8):4215–20.

    Google Scholar 

  97. Pintatum A, Maneerat W, Logie E, Tuenter E, Sakavitsi ME, Pieters L, et al. In vitro anti-inflammatory, anti-oxidant, and cytotoxic activities of four Curcuma species and the isolation of compounds from Curcuma aromatica rhizome. Biomolecules. 2020;10(5):799.

  98. Abimbola O, Ahmad M, Temitayo O. Anti-inflammatory actions and Salmonella typhimurium-bacteraemia clearance by methanol extract of Curcuma longa Linn. (turmeric). Mal J Microbiol. 2019;15(1):24–33.

    CAS  Google Scholar 

  99. Doan CC, Le TL, Ho NQC, La THL, Nguyen VC, Nguyen TPT, et al. Bioactive chemical constituents, in vitro anti-proliferative activity and in vivo toxicity of the extract of Curcuma singularis Gagnep rhizomes. J Ethnopharmacol. 2022;284:114803.

  100. Alamri AH, Debnath S, Alqahtani T, Alqahtani A, Alshehri SA, Ghosh A. Enhancing plant-derived smart nano inhibitor in targeting mammalian target of rapamycin (mTOR) in breast cancer using Curcuma longa-derived compound curcumin. Environment Sci Pollut Res Int. 2023. https://doi.org/10.1007/s11356-023-25375-0. Advance online publication.

  101. Salehi B, Rodrigues CF, Peron G, Dall’Acqua S, Sharifi-Rad J, Azmi L, Shukla I, Singh Baghel U, Prakash Mishra A, Elissawy AM. Curcumin nanoformulations for antimicrobial and wound healing purposes. Phytother Res. 2021;35(5):2487–99.

  102. Nugraha AP, Yudianto DO, Anwar AA, Purnamasari AE, Mappananrang RA, Faradilla N, Luthfi M. Noor TNEBT, Nugraha AP, Nugraha AP: Potential of curcumin-quercetin loaded nanostructured lipid carriers as oral squamous cell carcinoma adjuvant therapy by downregulating AKT/PI3K signaling pathway. Res J Pharm Technol. 2022;15(11):5353–8.

    Article  Google Scholar 

  103. Parida R, Nayak S. Anti-proliferative activity of in vitro Zingiberaceae essential oil against human cervical cancer (HeLa) cell line. Res J Pharm Technol. 2022;15(1):325–8.

    Article  Google Scholar 

  104. Nag A. Evaluation of cytotoxicity and antioxidant properties of some Zingiberaceae plants. Int J Green Pharm (IJGP). 2018;12(04):870–5. https://doi.org/10.22377/ijgp.v12i04.2268.

    Article  Google Scholar 

  105. Sumathi S. Apoptosis-induced in vitro anticancer activity of methanolic extract of leaves and rhizomes of Curcuma amada Roxb. against breast cancer cells. Int J Green Pharm (IJGP). 2016;10(2):98–103. https://doi.org/10.22377/ijgp.v10i2.648.

  106. Uchendu IK, Agu CE. Anti-nephrotoxic and antihyperlipidaemic potentials of aqueous extracts of turmeric (Curcuma longa) in hypercholesterolaemic albino rat. Pharmacologyonline. 2018;3:1–11.

    CAS  Google Scholar 

  107. Soleimani V, Sahebkar A, Hosseinzadeh H. Turmeric (Curcuma longa) and its major constituent (curcumin) as nontoxic and safe substances. Phytother Res. 2018;32(6):985–95.

    Article  CAS  PubMed  Google Scholar 

  108. Siviero A, Gallo E, Maggini V, Gori L, Mugelli A, Firenzuoli F, Vannacci A. Curcumin, a golden spice with a low bioavailability. J Herb Med. 2015;5(2):57–70.

    Article  Google Scholar 

  109. Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB. Bioavailability of curcumin: Problems and promises. Mol Pharma. 2007;4(6):807–18.

    Article  CAS  Google Scholar 

  110. Lu PS, Inbaraj BS, Chen BH. Determination of oral bioavailability of curcuminoid dispersions and nanoemulsions prepared from Curcuma longa Linnaeus. J Sci Food Agric. 2018;98(1):51–63.

    Article  CAS  PubMed  Google Scholar 

  111. Yang K-Y, Lin L-C, Tseng T-Y, Wang S-C, Tsai T-H. Oral bioavailability of curcumin in rat and the herbal analysis from Curcuma longa by LC–MS/MS. J Chromatogr B. 2007;853(1–2):183–9.

    Article  CAS  Google Scholar 

  112. Butnariu M, Quispe C, Sharifi-Rad J, Pons-Fuster E, Lopez-Jornet P, Zam W, Das T, Dey A, Kumar M, Pentea M. Naturally-occurring bioactives in oral cancer: Preclinical and clinical studies, bottlenecks and future directions. Front Biosci-Scholar. 2022;14(3):24.

    Article  CAS  Google Scholar 

  113. Tietel Z, Butnariu M. Biosynthesis, purification, characterization and uses of natural compounds in plants. Front Plant Sci. 14:1162676. https://doi.org/10.3389/fpls.2023.1162676.

  114. Bahrami A, Montecucco F, Carbone F, Sahebkar A. Effects of curcumin on aging: molecular mechanisms and experimental evidence. BioMed Res Int. 2021;2021:1–13. https://doi.org/10.1155/2021/8972074.

    Article  CAS  Google Scholar 

  115. Bielak-Zmijewska A, Grabowska W, Ciolko A, Bojko A, Mosieniak G, Bijoch Ł, Sikora E. The role of curcumin in the modulation of ageing. Int J Mol Sci. 2019;20(5):1239.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  116. Butnariu M, Quispe C, Koirala N, Khadka S, Salgado-Castillo CM, Akram M, et al. Bioactive effects of curcumin in human immunodeficiency virus infection along with the most effective isolation techniques and type of nanoformulations. Int J Nanomed. 2022:3619–32. https://doi.org/10.2147/IJN.S364501.

  117. Afzal A, Oriqat G, Akram Khan M, Jose J, Afzal M. Chemistry and biochemistry of terpenoids from Curcuma and related species. J Biol Act Prod Nat. 2013;3(1):1–55.

    CAS  Google Scholar 

  118. Jamwal R. Bioavailable curcumin formulations: A review of pharmacokinetic studies in healthy volunteers. J Integr Med. 2018;16(6):367–74.

    Article  PubMed  Google Scholar 

  119. Risacher SL, Saykin AJ. Neuroimaging in aging and neurologic diseases. Handb Clin Neurol. 2019;167:191–227.

    Article  PubMed  PubMed Central  Google Scholar 

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  1. Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo, 11566, Egypt

    Esraa A. Elhawary, Ashaimaa Y. Moussa & Abdel Nasser B. Singab

  2. Center for Drug Discovery Research and Development, Ain Shams University, Cairo, 11566, Egypt

    Abdel Nasser B. Singab

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The idea of the article and supervision by Prof. Abdel Nasser B. Singab. Collection of the data and writing the manuscript by Dr. Ashaimaa Y. Mousa and Dr. Esraa A. Elhawary. All contributed equally.

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Elhawary, E.A., Moussa, A.Y. & Singab, A.N.B. Genus Curcuma: chemical and ethnopharmacological role in aging process. BMC Complement Med Ther 24, 31 (2024). https://doi.org/10.1186/s12906-023-04317-w

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