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A systematic review and meta-analysis on the prevalence of dietary supplement use by military personnel



Although a number of studies have been conducted on the prevalence of dietary supplement (DS) use in military personnel, these investigations have not been previously summarized. This article provides a systematic literature review of this topic.


Literature databases, reference lists, and other sources were searched to find studies that quantitatively examined the prevalence of DS use in uniformed military groups. Prevalence data were summarized by gender and military service. Where there were at least two investigations, meta-analysis was performed using a random model and homogeneity of the prevalence values was assessed.


The prevalence of any DS use for Army, Navy, Air Force, and Marine Corps men was 55%, 60%, 60%, and 61%, respectively; for women corresponding values were 65%, 71%, 76%, and 71%, respectively. Prevalence of multivitamin and/or multimineral (MVM) use for Army, Navy, Air Force, and Marine Corps men was 32%, 46%, 47%, and 41%, respectively; for women corresponding values were 40%, 55%, 63%, and 53%, respectively. Use prevalence of any individual vitamin or mineral supplement for Army, Navy, Air Force, and Marine Corps men was 18%, 27%, 25%, and 24%, respectively; for women corresponding values were 29%, 36%, 40%, and 33%, respectively. Men in elite military groups (Navy Special Operations, Army Rangers, and Army Special Forces) had a use prevalence of 76% for any DS and 37% for MVM, although individual studies were not homogenous. Among Army men, Army women, and elite military men, use prevalence of Vitamin C was 15% for all three groups; for Vitamin E, use prevalence was 8%, 7%, and 9%, respectively; for sport drinks, use prevalence was 22%, 25% and 39%, respectively. Use prevalence of herbal supplements was generally low compared to vitamins, minerals, and sport drinks, ≤5% in most investigations.


Compared to men, military women had a higher use prevalence of any DS and MVM. Army men and women tended to use DSs and MVM less than other service members. Elite military men appeared to use DSs and sport drinks more than other service members.

Peer Review reports


Dietary supplements (DSs) are commercially available products that are consumed as an addition to the usual diet. DSs include ingredients such as vitamins, minerals, herbs (botanicals), amino acids, and a variety of other substances [1]. Marketing claims made for various DSs include the ability to improve overall health status, enhance cognitive or physical performance, increase energy, promote loss of excess weight, attenuate pain, and a variety of other favorable outcomes. The Dietary Supplement Health and Education Act of 1994 [2] established the regulatory framework for DSs in the United States (US). Since this act became law, US sales of DSs have increased from $4 billion in 1994 to $30 billion in 2011 [3, 4], an approximate 8-fold increase over 17 years.

Patterns of DS use may differ among distinctive subpopulations. Like athletes, military personnel often have occupational tasks that require intense and prolonged periods of physical activity. Like athletes, service members may use DSs that have purported ergogenic effects to enhance their occupational performance [59]. Unlike athletes, service members may be working in austere and hostile surroundings under extreme environmental conditions with high risk of injury. As a result, military personnel may use DSs that purportedly enhance health or performance under these conditions. In contrast, the general US population appears to consume DSs primarily for health reasons with only minor concern for performance enhancement [10, 11].

This paper presents a systematic literature review describing the prevalence of DS use in military personnel. No systematic review on this topic has previously been performed. Data collected by our group suggests that the use of DSs by military personnel may exceed that of civilian populations, and that selected subgroups within the military may have even higher DS use than the general military population [8, 12].


Literature searches were conducted in PubMed, Ovid MEDLINE (including OLDMEDLINE), OVID Healthstar, PsycINFO, Cumulative Index to Nursing and Allied Health Literature (CINAHL), the Defense Technical Information Center (DTIC), and publications from the National Institute of Medicine. No limitations were placed on the dates of the searches with the final search completed in January 2014. To assure that descriptors were all inclusive, we examined Medical Subject Headings for “military personnel” and “DSs” in PubMed. Largely as a result of this examination, keywords selected for the search included military personnel, soldier, sailor, airmen, marine, armed forces personnel, coast guard, submariners, Navy, and Air Force personnel combined with nutrition, DS, supplement, vitamin, mineral, amino acid, protein, herb, herbal, sport drink, sport bar, nutriceuticals, neutraceuticals, food supplements, and food supplementation. To find additional studies, the reference lists of the articles obtained were searched as was the literature database of an investigator with extensive experience with DSs. In several cases, authors were contacted to obtain information that was not included in the article.

Articles were selected for the review if they were:

  • Written in English,

  • Provided a quantitative assessment of the prevalence of DS use or prevalence could be calculated from data in the article, and

  • Participants were military personnel.

Studies were exclude if:

  • Participants were other than military personnel,

  • The study that did not allow separation of military personnel from others in the study,

  • Prevalence could not be calculated as a percent of the total sample in the study, or

  • The study that did not include specific DSs.

Data in which DSs were described by terms like “antioxidant”, “pro-performance”, “herbal supplement”, “ergogenics”, “thermogenics”, “bodybuilding”, and the like, were not included in this review because the type of DS was not specific. Exceptions were general categories of vitamins, minerals, sport drinks, sport bars, and energy drinks which were included because so many studies reported these.

Titles were first examined and abstracts were reviewed if the article appeared to involve military personnel and either nutrition or DSs. The full text of the article was retrieved if there was a possibility that DSs were included within the investigation. Quantitative prevalence data were obtained from the text of the article, from tables, or from graphs. If the data was in graphic form, prevalence was estimated from the vertical axis of the graph. Where multiple publications were found on a single study, all individual DS prevalences reported in any of the reports were included in the data extraction. The prevalence of a single type of DS reported in multiple publications from a single study was considered only once in the data extraction and analysis.

The methodological quality of the investigations was assessed using the technique of Loney et al. [13], which was developed specifically for rating prevalence investigations. Studies were graded on an 8-point scale which included assessments for sampling methods, sampling frame, sample size, measurement tools, measurement bias, response rate, statistical presentation, and description of subject sample. The 8 items were rated as either “yes” (1 point) or “no” (no point), based on specific criteria. Thus, the maximum possible score was 8. Three authors independently rated each of the selected articles. Following the independent evaluations, the reviewers met to examine the scores and to reconcile major differences. The average score of the three reviewers served as the methodological quality score. Scores were converted to a percent by dividing the average score for each study by 8 and multiplying by 100%.

The summary statistic derived from each study was the prevalence of specific DS use. This was calculated as the ∑ of individuals using the supplement/∑ of the entire sample × 100%. This expressed use prevalence as a percent of the sample. Data in some studies required recalculation because authors expressed the data as a percent of DS users rather than as a percent of the total sample. Tables were constructed, one containing methodology of each study, and the other containing the prevalences of the DSs reported in the studies. In the methodological table, the “response rate” was calculated as the subjects whose data were used in the investigation divided by the total number of subjects who were asked to participate. The response rates reported by some authors had to be recalculated because the authors reported the number of responses received without considering data that was discarded (e.g., incomplete or improperly completed questionnaires). The prevalence table included columns for the most commonly reported DSs in all articles. These included “any” DS, any vitamins or minerals, multivitamins/multiminerals (MVM), specific vitamins and minerals, creatine, proteins, amino acids, and specific herbal supplements. In cases where a specific supplement was not discussed in a study, the space in the prevalence table was left blank. In studies where at least 4% of the sample used a particular DS not contained in the table columns, that DS was listed in the last column of the prevalence table. Where possible, studies were separated by sex and specific military subgroups (e.g., Army, Navy, Air Force, Marine Corps, Army Rangers, Army Special Forces, Navy Special Operations). In a number of cases the study authors had not separated the data into these categories and so the data was presented as combined. Data were compiled by year to examine if any temporal trends could be discerned.

The Comprehensive Meta-Analysis Statistical Package, Version 2 (Biostat, Englewood NJ). was used to perform meta-analysis on specific groups and specific DSs where there were at least two studies and where subjects were asked about “current” DS use or use ≥1 time/week. A random model was used that involved providing the number of service members using the DS and those not using the DS to produce a summary prevalence estimate (SPE) with a summary 95% confidence interval (S95% CI) that represented the pooled results from the individual investigations. Homogeneity of the prevalence estimates from the studies was assessed using the Q statistic. To examine possible temporal trends, the prevalence of DSs reported in at least 3 studies were plotted by publication year. Curve fitting procedures were applied to these plots including linear, logarithmic, and second order polynomial fits.


The search produced 2,930 potential publications. Figure 1 shows the number of publications included and excluded at each stage of the literature search. Thirty-three unique investigations in 38 publications met the review criteria. Seven reports were in government technical reports [1420], two were only in abstract form [21, 22], 9 were in an Institute of Medicine report on the use of DSs in military personnel [2331], and 20 reports were in peer-reviewed journal articles [59, 12, 3245]. Three individual studies had two reports each [15, 19, 25, 30, 32, 38] and one produced three relevant publications [8, 41, 42].

Figure 1
figure 1

Records included and excluded at each stage of literature review.

Two studies that involved DS use in military groups were excluded. One study of repatriated Vietnam prisoners-of- war was not included because of the unusual circumstances and because the vitamin intake was not voluntary in some cases [46]. Also excluded was one study that asked physicians about DSs reported by patients, as opposed to participants self-reporting their DS use [47].

Table 1 shows the subjects and methods used to obtain data from the 33 unique investigations. Most studies involved US service members, but two studies were conducted among deployed British soldiers [7, 40] and one in Macedonian Special Operations Soldiers [45]. Among the US service members, several studies examined elite military service members including Army Rangers [5, 22, 27, 30, 38], Army Special Forces [12, 28], and Navy Sea, Air, Land (SEAL) personnel [36]. Other studies involved general samples of Army soldiers [6, 8, 14, 16, 23, 26], Air Force personnel [17, 31], Navy [37] and Marine Corps personnel [9, 18, 37], Marine and Air Force trainees [20, 36, 39], senior military officers [29], military officers in training [15, 35], men initiating training to become Ranger and Special Forces soldiers [33], and multiple service groups [19, 24, 25, 34, 43, 44].

Table 1 Methods in investigations of DS use by military personnel

In most unique studies (n = 31), the data were collected by having service members self-report their DS use on questionnaires. Most of the questionnaires were specifically designed to obtain information on DSs and focused on this topic [69, 12, 17, 2124, 2631, 33, 34, 36],[3842, 45]. Other studies obtained DS information from questionnaires that had items on DS use but were designed for more general purposes, often to collect a range of nutritional measures [5, 14, 16, 1820, 25, 37, 43, 44]. Two unique investigations obtained DS information from 7-day food records complimented with interviews by dietitians [15, 32, 35].

The reporting timeframe differed among studies. In many investigations, service members reported DS use ≥1 time/week, or these data could be calculated from the information provided in the articles [6, 8, 16, 19, 2529, 33, 41, 42]. Other studies examined current use but did not clearly define the frequency of use [7, 12, 14, 23, 24, 30, 31, 34],[38, 40]. In other studies, service members reported use in the last 7 days [15, 32, 35], last month [9], last 3 months [24, 45], last 6 months [22], last 12 months [18, 37, 43], or last two years [17]. Two studies examined the lifetime prevalence of DS use in Marine and Air Force basic trainees [36, 39]. Two studies reported daily use [5, 44] and in one study the reporting timeframe was not stated [21].

The response rate was not provided in 15 unique studies [5, 9, 12, 15, 16, 2023, 2729, 31],[35, 45]. In the 18 other unique investigations, the response rates ranged from 35% [37] to 99% [33] with only 10 unique investigations having response rates ≥66% [7, 8, 14, 18, 26, 33, 34, 36],[43, 44].

Rating from the methodological quality reviews ranged from 25% to 91% of available points, with an average ± standard deviation rating of 52 ± 20%. Only 8 studies (24%) had a rating of 70% or better. Several studies were only reported in an Institute of Medicine publication on DS use in the military [48] and received relatively lower scores because of the lack of detail provided [23, 24, 2629, 31]. The study by Bray et al. [19] was particularly well conducted in that the investigators attempted to collect a random sample of the entire military and clearly outlined their sampling methods, sampling frame, questionnaire, and results.

Table 2 shows available data on the prevalence of DS use by service members. Twenty-six unique investigations provided the prevalence of “any” DS use [59, 12, 15, 1822, 24, 2629, 31, 33],[35, 36, 3840, 43, 45] and 17 reported on multivitamin use [69, 12, 16, 19, 2124, 2629, 33, 45]. Only 10 unique investigations reported on specific vitamins and mineral supplements [6, 12, 2224, 26, 28, 29, 33, 45] and 7 reported on specific herbal supplements [6, 17, 23, 29, 33, 39, 45]. Nineteen unique investigations reported on supplementation with creatine [57, 12, 18, 2124, 2628, 33, 34, 36],[3840, 45] and 20 reported on amino acid and/or protein supplements [59, 12, 16, 2124, 2628, 33, 34, 3840],[45]. Finally, supplementation with sport drinks were reported in 11 investigations [5, 8, 12, 21, 23, 2629, 39, 45], sport bars in 10 studies [8, 12, 16, 2123, 2628, 33], and energy drinks in 3 investigations [8, 9, 44]. None of the studies identified the use prevalence of specific brands of MVM, vitamins, minerals, amino acids, proteins, botanicals, sport drinks or sport bars.

Table 2 Prevalence of dietary supplement use by military personnel

Table 3 shows summary data on US military DS use where questionnaires had asked about “current use” or use ≥1 time per week. Only 13 studies were included in these meta-analyses (Figure 1) because the other studies used different reporting timeframes or reported on a DS that was not included in any other study. Additional data from Bray et al. [19] was included in the table because this investigation was the only one to ask about use of any DS, multivitamins, or any vitamin or mineral supplement ≥1 time/week among Navy, Air Force, and Marine personnel. Meta-analyses indicated that the prevalence of any DS use was relatively consistent among Army studies. Among men in the four military services, use of supplements of any kind ranged from 53% to 61% of the surveyed groups; among women, use of supplements of any kind ranged from 66% to 76%. Female Army officers in training tended to have a much lower use of DSs. Reported supplement use among elite Army and Navy groups was less homogenous ranging from 56% to 90% of the surveyed groups, but was, in the main, higher than general military samples.

Table 3 Summary data on prevalence of dietary supplement use by military personnel by gender and service

Table 3 shows prevalence data on MVM use by military personnel. Army studies demonstrated a lack of homogeneity for both men and women. Among men in the four military services, MVM use ranged from 24% to 47% with Army men less likely to consume multivitamins than men in the other services. Among women, MVM use ranged from 28% to 63% in the four services, again with Army women less likely to consume multivitamins than women in other services. Reported MVM use among elite military groups appeared to be similar to that of Army men but the prevalence values lacked homogeneity and ranged from 26% to 64%.

Table 3 shows that studies on the use prevalence of any vitamin or mineral supplement by Army men and women lacked homogeneity. Nonetheless, data suggested women used vitamin and mineral supplements more often than men, regardless of service. Among all four services, prevalence of use of any vitamin or mineral supplement among men ranged from 7% to 27% while for women this range was 23% to 40%.

Table 3 shows other DSs that had multiple studies and fit the table criteria (current use or use ≥ 1 times/week). These included Vitamin C, Vitamin E, calcium, iron, proteins, protein or amino acids, creatine, sport drinks, and sport bars. Multiple studies (i.e., ≥2) were limited to Army men, Army women, and some elite military groups. The prevalence of Vitamin C supplementation was 15% for Army men, Army women, and Special Forces soldiers, although the latter estimate lacked homogeneity. The prevalence of Vitamin E supplementation was similar among Army men and the Special Forces soldiers and slightly higher than that of Army women. Calcium supplementation was slightly more prevalent among Army women compared to Army men, although the two available male studies were not homogeneous. Creatine use appeared more prevalent among samples of elite Army men compared to general male Army samples, although prevalence values differed considerably. When the Navy SEAL study [21] was eliminated from the analysis of creatine prevalence, studies on Rangers and Special Forces soldiers had a SPE = 19% and S95% CI = 16-21 (p = 0.88 for homogeneity). Use prevalence of sport drinks was similar among the general samples of Army men and women. Meta-analysis suggested that elite military group use of sport drinks was higher than in general Army samples but studies of elite groups lacked homogeneity, with individual study prevalences ranging from 19% to 71%. The prevalence of sport bar usage was low among samples of Army men and even lower among Army women. Sport bar usage appeared much higher in some samples of elite military groups but there was a lack of homogeneity with prevalences ranging from 6% to 52%.

The curve fitting procedures did not indicate any significant temporal trends among studies. This can be appreciated by examining the data presented by year in Table 3.


This review demonstrates that the prevalence of DS use was high among members of the military services. Available data indicated that the self-reported prevalence of DS current use or use ≥1 time/week was slightly lower among Army men (55%) than among men in the other 3 military services (~60%). Female service members reported a higher prevalence of DS use than male service members but again, Army women reported a slightly lower use of DSs of any kind (66%) compared to women in the other 3 services (71 to 76%). The pattern of MVM use was similar to that of the overall use prevalence. That is, Army men and women report MVM use prevalences lower than the other services but women in all services report use prevalences higher than their male counterparts in the same service. Prevalence estimates varied in groups of elite service members (Army Rangers, Army Special Forces, and Navy SEALs) but generally, the use prevalence of supplements of any kind was higher (56% to 90%) than that of other service members. Interestingly, male and female Army officers in training tended to have a lower prevalence of DS use, possibly related to the fact that they were eating in military dining facilities and had busy training schedules.

MVM appeared to be the most commonly used DS among the general population of military personnel with 24% to 47% of male and 28% to 63% of female service members using these supplements. This is in consonance with data on athletes [49, 50] and the general US population [5156] where MVM are also the most commonly consumed DS. Table 4 shows summary data from the National Health Interview Surveys (NHIS) [54, 55, 57] and the National Health and Nutrition Surveys (NHANES) [5861], both of which are nationally representative samples of the general US population. It was difficult to directly compare military MVM prevalence data to that of these national surveys because the military and civilian studies differed in terms of the reporting timeframe, methods used to collect the data, and the years when the data were collected. Despite these issues, it was possible to make some general observations. The NHANES and NHIS surveys indicated that women were more likely to use DSs than men, in agreement with the military data. Both NHANES and NHIS surveys observed a temporal trend indicating that DS use increased over time, although the most recent NHANES data suggested a leveling off [60, 61]. No such temporal trends could be discerned in the military data, possibly because of the shorter time over which the studies were conducted and lack of questionnaire standardization across studies. Use of MVM appeared to be higher in the military compared to these civilian samples.

Table 4 Summary data on DS Use in United States national surveys

Among military personnel, the most common rationale for taking MVMs was to promote general health with 76% of individuals reporting this reason in one study [8]. Most MVM supplements contain at least 10 vitamins and/or minerals with a great range of dosages [62]. Systematic and narrative reviews on the effects of MVM supplements on health have indicated that there is little convincing evidence that these DSs influence the incidence of cataracts, cardiovascular disease, diabetes [6365], or cancers of the prostate, lungs, or breast [64, 6668]. On the other hand some studies suggest MVM supplements may improve cognitive functioning [69, 70], reduce infection risk in older individuals [71], reduce colon cancer risk [72] and, when used for primary prevention, reduce the risk of all-cause mortality [73], although results are not consistent [65]. The determination of the safety of vitamins and minerals differs from that of other substances like toxins or other chemicals because a certain level of vitamins and minerals are needed for good health but above or below that level, an adverse effect may occur. Thus, there is a “U-shaped” relationship between the dosage and the likelihood of adverse effects and dose–response curve will differ for different DSs [74].

Use prevalence of individual vitamins and minerals were less often reported in military studies but a few studies of Army personnel had examined Vitamin C, Vitamin E, calcium, and iron [6, 12, 26]. Generally, the use prevalence of Vitamin C was similar among Army men, women, and Special Forces Soldiers (15%). Vitamin E use prevalence was about the same among Army men, Army women, and elite groups (7-12%). Women appeared more likely to supplement with calcium (14%) compared to Army men (9%). Table 4 provides data on Vitamin C, Vitamin E, and calcium supplementation from the NHIS. Again, comparisons with the military data are limited for reasons cited above. Nonetheless, the NHIS and NHANES general trends were similar to the military data in that men and women were about equally likely to supplement with Vitamins C and E and women were more likely to use calcium.

Vitamin C and E are antioxidant vitamins and they have been studied in disease states like cancer, cardiovascular disease, and macular degeneration where oxidative stress mechanisms produce cellular damage [75, 76]. In systematic reviews, Vitamin C and E supplementation either alone or in combination with other substances did not reduce the incidence of cardiovascular disease [64, 75, 77] or prostate cancer [66]. Supplemental Vitamin C may have modestly reduced the risk of breast cancer but Vitamin E did not [78]. Vitamin C and E from any source (diet or supplements) appeared to reduce the incidence of endometrial cancer [79]. Calcium supplementation with Vitamin D reduced stress fracture risk in basic training [80].

The prevalence of herbal supplement use by military personnel was small, usually 5% or less of the groups surveyed [6, 17, 23, 29, 33, 39, 45], although ginseng use was 14% in one Army study [6]. The nationally representative NHIS data from 2007 indicated that 17%, 12%, 12%, and 11% of the surveyed group had used Echinacea, garlic supplements, ginseng, and ginkgo biloba, respectively, in the last 30 days [81]. In athletic groups, 2% to 10% reported current use of ginseng and 4 to 7% reported current use of Echinacea [50, 82, 83].

Sport drinks are a general category of beverages that contain water, carbohydrates, minerals, and electrolytes, and may contain small amounts of vitamins. They are designed to be used during and after sport and exercise activities for rehydration, replacement of electrolytes lost during sweating, and energy (i.e., supply carbohydrates during activity or replenish muscle glycogen post-activity) [84, 85]. Sport drinks appeared to be a very common nutritional supplement used by elite military groups, although the use prevalence range was wide (19% to 71%) in the various investigations. Sport drink use prevalence was also high among the general male and female military population (~23%) but this did not exceed the use prevalence for MVMs in these groups. The relatively high use of sport drinks among elite military groups is in consonance with studies of elite athletes showing that the use of sport drinks exceeds that of multivitamins [8688]. Data from the NHIS indicated that 22% reported the use of sport or energy drinks ≥1 time/week but that survey did not provide data on the two beverages separately [89]. Data from NHANES indicated an almost tripling in the use of sport and energy drinks (combined) among adolescents and young adults (12 to 34 years of age) over the 1999 to 2008 period [90].

Creatine was a DS with relatively high use prevalence among elite service members (20%) and among Army men (14%), although the two studies on Army men had widely varying prevalence values [6, 26]. The 2007 NHIS survey reported a 3% use prevalence in the general US population [81]. Studies on athletes have found that creatine use prevalence is highly variable and dependent on the sport. Athletes in strength and power sports (e.g., weightlifting, football, track and field) used creatine to a greater extent than those involved in endurance activities [9194]. Research has generally shown that creatine supplementation can improve strength and performance in short-term, high intensity physical activities [9598]. In combination with resistance training, creatine increased maximal muscle strength to a greater extent than resistance training alone [99].

In elite military groups, the use prevalence for protein supplements was about 20% but varied widely, between 12% and 47% [8, 12, 21, 27]. The only study to report on the protein supplementation in the general male army population found a use prevalence of 13% [26], while another study reporting on combined proteins and amino acids found a use prevalence of 20% [8]. One national survey (Health and Diet Survey conducted by the US Food and Drug Administration) reported that about 1% of the total sample had used amino acid supplements in the last year [56]. The Recommended Daily Allowance for protein is 0.8 gmkg body weight −1day−1[100]. However, summaries of studies indicated that the daily average intake of protein among strength-trained athletes was 2.1 gmkg−1day−1[101] while that among endurance athletes was 1.8 ± 0.4 gmkg−1day−1 for men and 1.2 ± 0.03 gmkg−1day−1 for women [102]. A recent consensus statement on the efficacy of protein supplementation in military personnel recommended 1.5 to 2.0 gmkg−1day−1 for service members involved in substantially increased metabolic demand and 1.2 to 1.5 gmkg−1day−1 for older service members [103]. A meta-analysis of 22 studies suggested that protein supplementation (>1.2 gmkg−1day−1) with resistance training resulted in modestly greater gains in fat-free mass (0.7 kg, 95% CI = 0.5-0.9 kg) and strength when compared to training without protein supplementation [104].

Three studies reported on energy drink consumption among soldiers [42] and among soldiers and marines deployed in Afghanistan [9, 44]. Prevalence of energy drink usage was 25% among female soldiers [42] and 41% to 45% among male soldiers and marines [9, 42, 44]. There are about 500 brands of energy drinks available worldwide and about 200 are available in the US [105, 106]. Literature reviews examining commonly available energy drinks found that virtually all contained caffeine, taurine, and B-Vitamins, while other common ingredients contained in most included guarana, ginseng, sugars, and carnitine. Other ingredients found in some energy drinks include ginkgo biloba, milk thistle, branched-chain amino acids, choline, chromium, green tea, hornet saliva, inositol, yerba mate, triglycerides, proline, pyruvate, royal jelly, schizandra, aloe vera, bee pollen, borage oil, and stabilized oxygen. Reviews have generally concluded that except for some relatively weak evidence for glucose and guarana, there was little evidence for a positive effect on cognitive or physical performance for any of those ingredients other than caffeine [106108]. Caffeine has been shown to increase performance during long-term exercise, shorter-term high intensity exercise (60–180 sec), and high intensity intermittent exercise, but effects on muscle strength are equivocal. Caffeine may produce ergogenic effects through a variety of mechanisms that include increasing fat oxidation (thus sparing glucose and muscle glycogen during long-term exercise), central nervous system stimulation, a direct action on muscles, and/or a competitive inhibition with adenosine. The adenosine mechanism involves caffeine occupying adenosine sites in the central nervous system which increase catecholamine release and lipolysis. Tolerance to caffeine has often been reported and may be associated with the up-regulation of adenosine receptors [109112].

Of interest were the studies on Marine Corps and Air Force trainees that asked about lifetime prevalence of DS use [36, 39]. About 82% of the participants in these two studies were men. The lifetime prevalence of any DS use was 41% [36] and 50% [39]. These prevalences were lower than those reported by Bray et al. [19] for longer-serving Marine and AF personnel (~60%). These data suggest that a number of service members have used DSs before entering the Air Force or Marine Corps but that prevalence becomes higher once individuals spend time in these services. Military service may increase DS use because of the demands of the occupations and the belief that DSs will improve health and increase performance on occupational tasks.

In the nine investigations that examined the prevalence of DS use in elite military units [5, 8, 12, 21, 22, 27, 28, 38],[45], all but two [22, 38] reported a higher use of DSs (any use) among these elite service members compared to non-elite male military samples. This is similar to results found for elite athletes where athletes participating at higher levels of competition (Olympic, national, or international level) were more likely to use DSs than those competing as recreational athletes [49]. Elite athletes and elite service members may be similar in that they seek to gain additional physical advantages from the use of DSs.

Five studies provided information on the reasons that service members used DSs [6, 8, 9, 19, 33]. In four of the five, “general health” was listed as the reason with the highest frequency with performance enhancement listed as second most common (first in Cassler et al. study [9] of deployed marines). Thus, service members reported using DSs for the same reason as civilians, [10, 11] but a second very common reason was performance enhancement which is seldom mentioned in civilian investigations. In this sense, service members are like athletes who also report performance enhancement as a high frequency reason for DS use [113115]. Like athletes, service members’ occupational tasks require a high level of physical performance; they are unlike most athletes in that their activity may be performed in hostile locations and under adverse and austere environmental conditions.

Future studies on the prevalence of DS use should consider five major issues. First, the definition of DSs should be clearly stated on the questionnaire instructions. The legal definition provided by The Dietary Supplement Health and Education Act of 1994 [2] can serve as a standard. Second, studies should be specific about the types of DSs used by study participants. Reporting in general categories like “antioxidant”, “energy”, “herbal”, “bodybuilding”, and the like does not provide the specificity needed for comparisons across studies and the identification of specific DS use. Third, the reporting timeframe should be specific and include several periods. The most useful reporting timeframes appear to be daily, 2–6 times/week, 1 time/week and 1 time/month. Fourth, the response rate of survey should be specified and, if possible, characteristics of respondents and non-respondents should be described so that possible bias can be assessed. Finally, studies are needed that use the same experimental methods to compare DS use across all the military services over time.

There were limitations to this review. Studies differed on the reporting timeframe, questionnaire construction, and supplement definitions which made it difficult to directly compare results across all studies. In the meta-analysis, an attempt was made to control for the reporting timeframe by only examining studies asking service members about current supplement use or use ≥1 day/week. We only examined specific DSs and did not include DSs that were included in broad categories (e.g., antioxidant, ergogenics, bodybuilding). Thus, we may have underestimated DSs in some categories, although most unique studies (n = 24, 72%) did report use of “any” DS. Some questionnaires involved “checklists” of specific DSs that may have elicited better subject recall than open-ended questions asking subjects to list the DSs that they used. In most studies, the actual questionnaire structure and/or questionnaire items were not specified and the only apparent fact was that the questionnaire did or did not focus on DSs. It is possible that some service members may have been involved in one or more surveys but the number of these individuals would likely have been very small. Some values had to be estimated from graphic presentations which could have resulted in small errors. The analyses of temporal trends depended on the publication year which was likely not the year that the data were collected. Other problems common to self-reporting included the accuracy of subject recall and the possible reluctance of some individuals to report specific DSs that they used.


In conclusion, this review provided a comprehensive overview of military DS use by gender and type of military service. It demonstrated that Army personnel tended to use DSs and MVM less than other service members but that regardless of service, the use of any DS and MVMs are higher among women than men. Military personnel’s use of herbal supplements is small, <5% in most investigations. Elite military men appeared to use DSs and sport drinks more than other service members.

Authors’ information

The views, opinions, and/or findings contained in this report are those of the authors and should not be construed as official Department of the Army position, policy, or decision, unless so designated by other official documentation. Approved for public release; distribution is unlimited.



United States


Dietary supplement




Summary prevalence estimate

S95% CI:

Summary 95% confidence Interval


Sea, air, land (Navy Special Operations Personnel)


Defense technical information center


National Health and Nutrition Survey


National Health Interview Survey

95% CI:

95% confidence interval.


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We would like to thank Claudia Coleman and Dr Wayne Askew who assisted us in obtaining references. This research was supported in part by an appointment to the Knowledge Preservation Program at the US Army Research Institute of Environmental Medicine (USARIEM) and the Army Institute of Public Health (AIPH) administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USARIEM. Funding was also provided by the Department of Defense Center for Dietary Supplement Research and the Medical Research and Development Command.

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Correspondence to Joseph J Knapik.

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The authors have no competing interests.

Authors’ contributions

JJK obtained references, compiled the data, performed the methodology quality review, performed the statistical analysis, interpreted the data, and drafted the manuscript. RS obtained references, compiled the data, performed the methodology quality review, assisted with the statistical analysis and data interpretation, and helped draft the manuscript. SSH performed the methodology quality review, assisted in data interpretation, and helped draft the manuscript. KA, EF, and HRL assisted with data interpretation and helped draft the manuscript. All authors read, commented on, and approved the final manuscript.

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Knapik, J.J., Steelman, R.A., Hoedebecke, S.S. et al. A systematic review and meta-analysis on the prevalence of dietary supplement use by military personnel. BMC Complement Altern Med 14, 143 (2014).

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  • Vitamins
  • Minerals
  • Multivitamins
  • Vitamin C
  • Vitamin E
  • Calcium
  • Iron
  • Protein
  • Creatine
  • Sport drink