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  1. Abused women, who suffer from chronic psychological stress, have been shown to have shorter telomeres than never abused women. Telomere shortening is associated with increased risk of cell death, and it is bel...

    Authors: Agnes Tiwari, Cecilia Lai Wan Chan, Rainbow Tin Hung Ho, George Sai Wah Tsao, Wen Deng, Athena Wai Lin Hong, Daniel Yee Tak Fong, Helina Yin King Yuk Fung, Emily Pei Shin Pang, Denise Shuk Ting Cheung and Joyce Lai Chong Ma
    Citation: BMC Complementary and Alternative Medicine 2014 14:300
    Content type: Study protocol Published on:

  2. Annona muricata leaves have been reported to have antiproliferative effects against various cancer cell lines. However, the detailed mechanism has yet to be defined. The current study was designed to evaluate th...

    Authors: Soheil Zorofchian Moghadamtousi, Habsah Abdul Kadir, Mohammadjavad Paydar, Elham Rouhollahi and Hamed Karimian
    Citation: BMC Complementary and Alternative Medicine 2014 14:299
    Content type: Research article Published on:

  3. Obesity is an important risk factor for cardiovascular and metabolic diseases and could affect mortality rates. Body mass index (BMI) and waist circumference (WC) have been used to classify obesity, and waist-...

    Authors: Younghwa Baek, Kihyun Park, Siwoo Lee and Eunsu Jang
    Citation: BMC Complementary and Alternative Medicine 2014 14:298
    Content type: Research article Published on:

  4. Anthemis palestina (Asteraceae) extends across the Mediterranean region, southwest Asia and eastern Africa. Although traditionally used for several applications, in vitro investigation of biological functions as...

    Authors: Sanaa K Bardaweel, Khaled A Tawaha and Mohammad M Hudaib
    Citation: BMC Complementary and Alternative Medicine 2014 14:297
    Content type: Research article Published on:

  5. Plantago ovata husk therapy could be used in patients with Parkinson disease to reduce the symptoms of gastrointestinal disorders, but it is important to know whether this compound modifies levodopa pharmacoki...

    Authors: M Nelida Fernandez-Martinez, Luis Hernandez-Echevarria, Matilde Sierra-Vega, M Jose Diez-Liebana, Angela Calle-Pardo, Demetrio Carriedo-Ule, Ana M Sahagún-Prieto, Anna Anguera-Vila and Juan Jose Garcia-Vieitez
    Citation: BMC Complementary and Alternative Medicine 2014 14:296
    Content type: Research article Published on:

  6. Selective Alzheimer Disease Indicator-1 (or Seladin-1) is a multifunctional protein first discovered by downregulation of its expression in Alzheimer’s disease. Interestingly, the expression of this protein is...

    Authors: Heng Kai Yen, Afifah-Radiah Fauzi, Laily Bin Din, Valerie J McKelvey-Martin, Chan Kok Meng, Salmaan Hussain Inayat-Hussain and Nor Fadilah Rajab
    Citation: BMC Complementary and Alternative Medicine 2014 14:295
    Content type: Research article Published on:

  7. Eriosema laurentii De Wild. (Leguminosae) is a plant used in Cameroon against infertility and gynecological or menopausal complaints. In our previous report, a methanol extract of its aerial parts was shown to e...

    Authors: Sylvin Benjamin Ateba, Dieudonné Njamen, Svjetlana Medjakovic, Martin Zehl, Hanspeter Kaehlig, Alois Jungbauer and Liselotte Krenn
    Citation: BMC Complementary and Alternative Medicine 2014 14:294
    Content type: Research article Published on:

  8. Oral mucositis is one of the common complications of cancer chemotherapy and about 40% of the patients who take chemotherapy protocols, experience this irritating problem. The purpose of this study was to draw...

    Authors: Mohammad Ali Raeessi, Neda Raeessi, Yunes Panahi, Homa Gharaie, Seyyed Masoud Davoudi, Alireza Saadat, Ali Akbar Karimi Zarchi, Fereshteh Raeessi, Seyyed Mostafa Ahmadi and Hamidreza Jalalian
    Citation: BMC Complementary and Alternative Medicine 2014 14:293
    Content type: Research article Published on:

  9. Low back pain (LBP) is a major health issue due to its high prevalence rate and socioeconomic cost. While spinal manipulation (SM) is recommended for LBP treatment by recently published clinical guidelines, th...

    Authors: Ting Xia, David G Wilder, Maruti R Gudavalli, James W DeVocht, Robert D Vining, Katherine A Pohlman, Gregory N Kawchuk, Cynthia R Long and Christine M Goertz
    Citation: BMC Complementary and Alternative Medicine 2014 14:292
    Content type: Study protocol Published on:

  10. We hypothesized that C. borivilianum root, known to improve male reproductive performance, prevents impairment in characteristics, morphology and elevation of oxidative stress in sperm of diabetics. We therefore ...

    Authors: Nelli Giribabu, Kilari Eswar Kumar, Somesula Swapna Rekha, Sekaran Muniandy and Naguib Salleh
    Citation: BMC Complementary and Alternative Medicine 2014 14:291
    Content type: Research article Published on:

  11. Stroke is one of the most common causes of cognitive impairment. Up to 75% of stroke survivors may be considered to have cognitive impairment, which severely limit individual autonomy for successful reintegrat...

    Authors: Shanli Yang, Haicheng Ye, Jia Huang, Jing Tao, Cai Jiang, Zhicheng Lin, Guohua Zheng and Lidian Chen
    Citation: BMC Complementary and Alternative Medicine 2014 14:290
    Content type: Study protocol Published on:

  12. It is generally reported that garlic (Allium sativum) harms pathogenic but not beneficial bacteria. Although numerous studies supporting the alleged garlic effects on pathogens are available, there are limited st...

    Authors: Jemma Booyens and Mapitsi Silvester Thantsha
    Citation: BMC Complementary and Alternative Medicine 2014 14:289
    Content type: Research article Published on:

  13. Flavonoids, which have been identified in a variety of plants, have been demonstrated to elicit beneficial effects on memory. Some studies have reported that flavonoids derived from Erythrina plants can provide s...

    Authors: Daniela Rodrigues de Oliveira, Cláudia R Zamberlam, Renan Barreta Gaiardo, Gizelda Maia Rêgo, Janete M Cerutti, Alberto J Cavalheiro and Suzete M Cerutti
    Citation: BMC Complementary and Alternative Medicine 2014 14:288
    Content type: Research article Published on:

  14. Advanced glycation endproducts (AGE) and advanced oxidation protein products (AOPP) play a pivotal role in the development of diabetes associated diseases. The herbal medicines Padma 28 and Padma Circosan have...

    Authors: Ewa Grzebyk and Agnieszka Piwowar
    Citation: BMC Complementary and Alternative Medicine 2014 14:287
    Content type: Research article Published on:

  15. Free radicals are involved in neuronal cell death in human neurodegenerative diseases. Since ancient times, honeybee venom has been used in a complementary medicine to treat various diseases and neurologic dis...

    Authors: Sang Mi Han, Jung Min Kim, Kwan Kyu Park, Young Chae Chang and Sok Cheon Pak
    Citation: BMC Complementary and Alternative Medicine 2014 14:286
    Content type: Research article Published on:

  16. Activation of extracellular signal-regulated kinase1/2 (ERK1/2) in dorsal horn of the spinal cord by peripheral inflammation is contributed to inflammatory pain hypersensitivity. Although electroacupuncture (E...

    Authors: Jian-Qiao Fang, Jun-Fan Fang, Yi Liang and Jun-Ying Du
    Citation: BMC Complementary and Alternative Medicine 2014 14:285
    Content type: Research article Published on:

  18. In Europe, extracts of Equisetum arvense (common horsetail) have a long tradition in the treatment of inflammatory disorders. To understand the molecular basis for its use, we investigated the immunomodulatory ca...

    Authors: Carsten Gründemann, Karin Lengen, Barbara Sauer, Manuel Garcia-Käufer, Martin Zehl and Roman Huber
    Citation: BMC Complementary and Alternative Medicine 2014 14:283
    Content type: Research article Published on:

  19. Cisplatin (CP) is known as a potent anti-cancer drug. The most therapeutic adverse effect of CP is induced hepatotoxicity. In the present study, the protective effect of thymoquinone (TQ) on CP-induced hepatot...

    Authors: Abdulrahman L Al-Malki and Ahmed Amir Radwan Sayed
    Citation: BMC Complementary and Alternative Medicine 2014 14:282
    Content type: Research article Published on:

  20. In recent years, there has been considerable interest in using botanical agents to prevent skin damage resulting from solar UV-irradiation. Buddleja cordata is a plant that is known as “tepozan”. Some people in M...

    Authors: José Guillermo Avila Acevedo, Adriana Montserrat Espinosa González, Diana Matamoros De Maria y Campos, José del Carmen Benitez Flores, Tzasna Hernández Delgado, Saul Flores Maya, Jorge Campos Contreras, José Luis Muñoz López and Ana María García Bores
    Citation: BMC Complementary and Alternative Medicine 2014 14:281
    Content type: Research article Published on:

  21. The 3β, 6β, 16β-trihydroxylup-20(29)-ene (TTHL) is a pentacyclic triterpene obtained from the medicinal plant Combretum leprosum Mart. In folk medicine, this plant is popularly known as mofumbo, cipoaba or mufumb...

    Authors: Cassiana Macagnan Viau, Dinara Jaqueline Moura, Valdir Alves Facundo and Jenifer Saffi
    Citation: BMC Complementary and Alternative Medicine 2014 14:280
    Content type: Research article Published on:

  22. Zuo-Jin-Wan (ZJW), a traditional Chinese medicine formula, has been identified to be effective against drug resistance in cancer. In the present study, we investigated the effect of ZJW on acquired oxaliplatin...

    Authors: Hua Sui, Shu-Fang Pan, Yu Feng, Bao-Hui Jin, Xuan Liu, Li-Hong Zhou, Feng-Gang Hou, Wen-Hai Wang, Xiao-Ling Fu, Zhi-Fen Han, Jian-Lin Ren, Xiao-Lan Shi, Hui-Rong Zhu and Qi Li
    Citation: BMC Complementary and Alternative Medicine 2014 14:279
    Content type: Research article Published on:

  23. There is urgent need to discover new antimicrobial compounds with diverse chemical structures and mechanisms of action due to increasing new and re-emerging infectious diseases. Additionally, appearance of und...

    Authors: Tariro A Chitemerere and Stanley Mukanganyama
    Citation: BMC Complementary and Alternative Medicine 2014 14:278
    Content type: Research article Published on:

  24. Flavonoid-rich aqueous fraction of methanolic extract of Hibiscus sabdariffa calyx was evaluated for its anti-hepatotoxic activities in streptozotocin-induced diabetic Wistar rats.

    Authors: David O Adeyemi, Victor O Ukwenya, Efere M Obuotor and Stephen O Adewole
    Citation: BMC Complementary and Alternative Medicine 2014 14:277
    Content type: Research article Published on:

  25. Positive patient expectations are often believed to be associated with greater benefits from complementary and alternative medicine (CAM) treatments. However, clinical studies of CAM treatments for chronic pai...

    Authors: Clarissa Hsu, Karen J Sherman, Emery R Eaves, Judith A Turner, Daniel C Cherkin, DeAnn Cromp, Lisa Schafer and Cheryl Ritenbaugh
    Citation: BMC Complementary and Alternative Medicine 2014 14:276
    Content type: Research article Published on:

  26. The essential oil of Pinus koraiensis (EOPK) is biologically active compound obtained from the leaves of P. koraiensis. The goal of this study was to investigate the anti-cancer mechanism of EOPK in HCT116 colore...

    Authors: Sun-Mi Cho, Eun-Ok Lee, Sung-Hoon Kim and Hyo-Jeong Lee
    Citation: BMC Complementary and Alternative Medicine 2014 14:275
    Content type: Research article Published on:

  27. Flueggea leucopyrus Willd is a shrub grown in many parts of the dry zones in Sri Lanka. The leaves of F. leucopyrus has been used for treating cancer in the traditional system of medicine in Sri Lanka. Hence, th...

    Authors: Preethi Soysa, Irushi Shamalika De Silva and Jayantha Wijayabandara
    Citation: BMC Complementary and Alternative Medicine 2014 14:274
    Content type: Research article Published on:

  28. Many Chinese patent medicines (CPMs) have been authorized by the Chinese State of Food and Drug Administration for the treatment of the common cold. A number of clinical trials have been conducted and publishe...

    Authors: Wei Chen, Bo Liu, Li-qiong Wang, Jun Ren and Jian-ping Liu
    Citation: BMC Complementary and Alternative Medicine 2014 14:273
    Content type: Research article Published on:

  29. Type 2 diabetes is a serious problem for developed countries. Prevention of prediabetes progression to type 2 diabetes with the use of natural products appears to a cost-effective solution. Previously we showe...

    Authors: Jong-Gwan Kim, Sung-Hoon Jo, Kyoung-Soo Ha, Sung-Chul Kim, Young-Cheul Kim, Emmanouil Apostolidis and Young-In Kwon
    Citation: BMC Complementary and Alternative Medicine 2014 14:272
    Content type: Research article Published on:

  30. Sutherlandia frutescens (L.) R.Br. (SF) is a South African plant that is widely used to treat stress, infections, cancer, and chronic diseases, many of which involve oxidative stress. The aim of the study was to...

    Authors: Shakila Tobwala, Weili Fan, Connor J Hines, William R Folk and Nuran Ercal
    Citation: BMC Complementary and Alternative Medicine 2014 14:271
    Content type: Research article Published on:

  32. Some Ficus species have been used in traditional African medicine in the treatment of diabetes. The antidiabetic potential of certain species has been confirmed in vivo but the mechanism of activity remains uncer...

    Authors: Oyinlola O Olaokun, Lyndy J McGaw, Maurice D Awouafack, Jacobus N Eloff and Vinny Naidoo
    Citation: BMC Complementary and Alternative Medicine 2014 14:269
    Content type: Research article Published on:

  33. Bushen-Qiangdu-Zhilv Decoction (BQZ) is one of famous traditional Chinese medical formula for treating ankylosing spondylitis (AS). However, the mechanisms underlying effects of BQZ remains unknown. Pro-inflam...

    Authors: Run-Yue Huang, Jie-Hua Lin, Xiao-Hong He, Xiong Li, Chuan-Li Lu, Ying-Yan Zhou, Jun Cai and Yi-Ting He
    Citation: BMC Complementary and Alternative Medicine 2014 14:268
    Content type: Research article Published on:

  34. Valerian is commonly used for the treatment of insomnia and anxiety. Valerian extracts allosterically modulate GABA-A receptors and induced an anxiolytic activity. This activity is closely related to valerenic...

    Authors: Axel Becker, Falko Felgentreff, Helmut Schröder, Beat Meier and Axel Brattström
    Citation: BMC Complementary and Alternative Medicine 2014 14:267
    Content type: Research article Published on:

  35. Artemisia annua L. has been used for many centuries in Chinese traditional medicine. Artemisinin, the active principle was first isolated and identified in the 1970s becoming the global back bone to the fight ag...

    Authors: Fabricio de Faveri Favero, Rogério Grando, Fabiana R Nonato, Ilza MO Sousa, Núbia CA Queiroz, Giovanna B Longato, Rafael RT Zafred, João E Carvalho, Humberto M Spindola and Mary A Foglio
    Citation: BMC Complementary and Alternative Medicine 2014 14:266
    Content type: Research article Published on:

  36. Korean red ginseng (KRG) is a processed ginseng from raw ginseng to enhance safety, preservation and efficacy, known having beneficial effects on women’s health due to its estrogen like function. While estroge...

    Authors: Mihi Yang, Ho-Sun Lee, Min-Woo Hwang and Mirim Jin
    Citation: BMC Complementary and Alternative Medicine 2014 14:265
    Content type: Research article Published on:

  37. Eupatorium cannabinum L. has long been utilized in traditional medicine, however no information is available regarding cellular effects of full extracts. Here we assessed the effects of E. cannabinum ethanolic e...

    Authors: Edna Ribeiro-Varandas, Filipe Ressurreição, Wanda Viegas and Margarida Delgado
    Citation: BMC Complementary and Alternative Medicine 2014 14:264
    Content type: Research article Published on:

  38. Post-fermented tea has been used for the prevention of metabolic syndrome in Western China. Present study reports the biochemical mechanism of lipid-lowering effects of Jing-wei fu tea (JWFT), a variety of pos...

    Authors: Jie Zhou, Liang Zhang, Jingsong Zhang and Xiaochun Wan
    Citation: BMC Complementary and Alternative Medicine 2014 14:263
    Content type: Research article Published on:

  39. Use of food supplements-containing phytoestrogens among postmenopausal women is rapidly increasing. Although phytoestrogens are often perceived as safe, evidence for overall positive risk-benefit profile is st...

    Authors: Anna Girardi, Carlo Piccinni, Emanuel Raschi, Ariola Koci, Benedetta Vitamia, Elisabetta Poluzzi and Fabrizio De Ponti
    Citation: BMC Complementary and Alternative Medicine 2014 14:262
    Content type: Research article Published on:

  40. The prevalence of obesity is increasing in industrialized countries. Obesity increases the risk of coronary artery disease, stroke, cancer, hypertension, and type-2 diabetes. Unfortunately, conventional obesit...

    Authors: Nan Yang, Danna Chung, Changda Liu, Banghao Liang and Xiu-Min Li
    Citation: BMC Complementary and Alternative Medicine 2014 14:261
    Content type: Research article Published on:

  41. Acupuncture is safe and may be effective for severe chronic constipation. The World Gastroenterology Organisation recommends prucalopride for patients for whom previous laxative use failed to provide satisfact...

    Authors: Baoyan Liu, Yang Wang, Jiani Wu, Qian Mo, Weiming Wang, Liyun He, Shiyan Yan and Zhishun Liu
    Citation: BMC Complementary and Alternative Medicine 2014 14:260
    Content type: Study protocol Published on:

  43. The continuous spread of multidrug-resistant (MDR) bacteria, partially due to efflux pumps drastically reduced the efficacy of the antibiotic armory, increasing the frequency of therapeutic failure. The search...

    Authors: Francesco K Touani, Armel J Seukep, Doriane E Djeussi, Aimé G Fankam, Jaurès A K Noumedem and Victor Kuete
    Citation: BMC Complementary and Alternative Medicine 2014 14:258
    Content type: Research article Published on:

  44. Recently, enormous research has been focused on natural bioactive compounds possessing potential antioxidant and anticancer properties using cell lines and animal models. Acacia nilotica (L.) is widely distribute...

    Authors: Shalini Mohan, Kalaivani Thiagarajan, Rajasekaran Chandrasekaran and Joseph Arul
    Citation: BMC Complementary and Alternative Medicine 2014 14:257
    Content type: Research article Published on:

  45. Rikkunshito is a traditional Japanese herbal medicine that is used to treat appetite loss associated with cancer and other disorders. The formulation contains various constituents that influence cell signaling...

    Authors: Yuko Nagamura, Kiyoshi Terawaki, Yasuhito Uezono and Toshihiko Tsukada
    Citation: BMC Complementary and Alternative Medicine 2014 14:256
    Content type: Research article Published on:

  46. Our previous studies have demonstrated the treatment benefits of dense cranial electroacupuncture stimulation (DCEAS), a novel brain stimulation therapy in patients with major depression, postpartum depression...

    Authors: Sui-Cheung Man, Ben H B Hung, Roger M K Ng, Xiao-Chun Yu, Hobby Cheung, Mandy P M Fung, Leonard S W Li, Kwok-Pui Leung, Kei-Pui Leung, Kevin W Y Tsang, Eric Ziea, Vivian T Wong and Zhang-Jin Zhang
    Citation: BMC Complementary and Alternative Medicine 2014 14:255
    Content type: Research article Published on:

  47. Recent studies have demonstrated that side population (SP) cells isolated from various cancer cell lines and primary tumors possess stem cell-like properties. Sesamin, a food-derived agent, possesses anti-canc...

    Authors: Xiang Kong, Ming-zhe Ma, Yan Zhang, Ming-zhe Weng, Wei Gong, Li-qun Guo, Jun-xiu Zhang, Guo-dong Wang, Qing Su, Zhi-wei Quan and Jie-ren Yang
    Citation: BMC Complementary and Alternative Medicine 2014 14:254
    Content type: Research article Published on:

  48. Artemisia capillaris (AC) has been recognized as one of the promising candidates for hepatoprotective, hypoglycemic, hypolipidemic, antiobesitic and anti-inflammatory therapeutic effectiveness. This study evalua...

    Authors: Eungyeong Jang, Min-Hee Shin, Ki-Suk Kim, Yoomi Kim, Yun-Cheol Na, Hong-Jung Woo, Youngchul Kim, Jang-Hoon Lee and Hyeung-Jin Jang
    Citation: BMC Complementary and Alternative Medicine 2014 14:253
    Content type: Research article Published on:

  49. Development of tumour resistance to chemotherapeutic drugs and concerns over their toxic effects has led to the increased use of medicinal herbs or natural products by cancer patients. Strobilanthes crispus is a ...

    Authors: Nik Soriani Yaacob, Nik Nursyazni Nik Mohamed Kamal and Mohd Nor Norazmi
    Citation: BMC Complementary and Alternative Medicine 2014 14:252
    Content type: Research article Published on:

  50. Drug transporters play important roles in the absorption, distribution, and elimination of drugs and thereby, modulate drug efficacy and toxicity. With a growing use of poly pharmacy, concurrent administration...

    Authors: Im-Sook Song, Tae Yeon Kong, Hyeon-Uk Jeong, Eun Nam Kim, Soon-Sang Kwon, Hee Eun Kang, Sang-Zin Choi, Miwon Son and Hye Suk Lee
    Citation: BMC Complementary and Alternative Medicine 2014 14:251
    Content type: Research article Published on:
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