Articles
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Citation: BMC Complementary Medicine and Therapies 2023 23:159
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Decoding the key compounds and mechanism of Shashen Maidong decoction in the treatment of lung cancer
Lung cancer is a malignant tumour with the fastest increase in morbidity and mortality around the world. The clinical treatments available have significant side effects, thus it is desirable to identify alter...
Citation: BMC Complementary Medicine and Therapies 2023 23:158 -
Analysis of the potential biological mechanisms of diosmin against renal fibrosis based on network pharmacology and molecular docking approach
Interstitial fibrosis is involved in the progression of various chronic kidney diseases and renal failure. Diosmin is a naturally occurring flavonoid glycoside that has antioxidant, anti-inflammatory, and anti...
Citation: BMC Complementary Medicine and Therapies 2023 23:157 -
Kaixin Jieyu Granule attenuates neuroinflammation-induced depressive-like behavior through TLR4/PI3K/AKT/FOXO1 pathway: a study of network pharmacology and experimental validation
Kaixin Jieyu Granule (KJG), an improved formula of Kai-xin-san and Si-ni-san, is a highly effective formula with demonstrated efficacy in preventing depression in previous studies. However, the underlying mole...
Citation: BMC Complementary Medicine and Therapies 2023 23:156 -
Multiform-based Baduanjin exercise prevention and treatment for idiopathic pulmonary fibrosis: study protocol for a randomized controlled trial
In this study, we will combine the traditional Baduanjin with Yijin Jing and Wuqinxi to create an optimized Baduanjin exercise program with three different forms (vertical, sitting, and horizontal) to adapt to...
Citation: BMC Complementary Medicine and Therapies 2023 23:155 -
Amburana cearensis seed extract stimulates astrocyte glutamate homeostatic mechanisms in hippocampal brain slices and protects oligodendrocytes against ischemia
Stroke is a leading cause of death and disability worldwide. A major factor in brain damage following ischemia is excitotoxicity caused by elevated levels of the neurotransmitter glutamate. In the brain, gluta...
Citation: BMC Complementary Medicine and Therapies 2023 23:154 -
Bactericidal and anti-inflammatory effects of Moquilea tomentosa Benth. flavonoid-rich leaf extract
Natural products are an important source of bioproducts with pharmacological properties. Here we investigate the components of leaves from M. tomentosa Benth. (Fritsch) (Chrysobalanaceae) and its effects on bacte...
Citation: BMC Complementary Medicine and Therapies 2023 23:153 -
Deciphering the pharmacological mechanisms of Fraxini Cortex for ulcerative colitis treatment based on network pharmacology and in vivo studies
Ulcerative colitis (UC) is a common type of inflammatory bowel disease. Due to the elusive pathogenesis, safe and effective treatment strategies are still lacking. Fraxini Cortex (FC) has been widely used as a me...
Citation: BMC Complementary Medicine and Therapies 2023 23:152 -
Paliurus spina-christi Mill fruit extracts improve glucose uptake and activate the insulin signaling pathways in HepG2 insulin-resistant cells
Paliurus spina-christi Mill. (PSC) fruit is frequently used in the treatment of diabetes mellitus in Mediterranean regions. Here, we investigated the effects of various PSC fruit extracts (PSC-FEs) on glucose con...
Citation: BMC Complementary Medicine and Therapies 2023 23:151 -
Protective effects of the Terminalia bellirica tannin-induced Nrf2/HO-1 signaling pathway in rats with high-altitude pulmonary hypertension
Oxidative stress and endothelial cell dysfunction induced by high-altitude hypoxia have important roles in the pathological process of high-altitude pulmonary hypertension (HAPH). Tannins present in Terminalia be...
Citation: BMC Complementary Medicine and Therapies 2023 23:150 -
The effect of probiotic supplementation on episiotomy wound healing among primiparous women: a triple-blind randomized clinical trial
Probiotics increase the defense power of immune system and accelerate the wound healing process by anti-inflammatory mechanisms at the wound site. The present study aimed at evaluating the effect of Lactobacil...
Citation: BMC Complementary Medicine and Therapies 2023 23:149 -
Retraction Note: Protocatechuic aldehyde from Salvia miltiorrhiza exhibits an anti-inflammatory effect through inhibiting MAPK signalling pathway
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12906-020-03090-4.
Citation: BMC Complementary Medicine and Therapies 2023 23:148 -
Study on the absolute configuration and biological activity of rotenoids from the leaves and twigs of Millettia pyrrhocarpa Mattapha, Forest & Hawkins, sp. Nov
M. pyrrhocarpa is a new plant in the Fabaceae: Faboideae family that is found in Thailand. A literature search revealed that the Milletia genus is rich in bioactive compounds possessing a wide range of biological...
Citation: BMC Complementary Medicine and Therapies 2023 23:147 -
In vitro antioxidant and free-radical scavenging activities of polar leaf extracts of Vernonia amygdalina
Plants are able to deliver a huge number of differing bioactive compounds which may supplement the requirements of the human body by acting as natural antioxidants. Antioxidants are mindful for the defense com...
Citation: BMC Complementary Medicine and Therapies 2023 23:146 -
The ethanolic extract of Salvia lachnostachys Benth is not maternotoxic, does not alter reproductive performance, but has teratogenic potential
Salvia lachnostachys Benth is native to Brazil and has anti-inflammatory, anti-arthritic, cytotoxic, antitumor, and antihyperalgesic activities. The population, including pregnant women, consume this plant to tre...
Citation: BMC Complementary Medicine and Therapies 2023 23:145 -
Preclinical evaluation of antimalarial activity of CPF-1 formulation as an alternative choice for the treatment of malaria
Kheaw Hom remedy is a traditional Thai medicine used to treat fever. Some plants used in the Kheaw Hom remedy show promising in vitro antimalarial activity. This study prepared novel formulations of plants fro...
Citation: BMC Complementary Medicine and Therapies 2023 23:144 -
Investigation of the activity of baicalein towards Zika virus
Zika virus (ZIKV) is a mosquito transmitted virus spread primarily by Aedes species mosquitoes that can cause disease in humans, particularly when infection occurs in pregnancy where the virus can have a signific...
Citation: BMC Complementary Medicine and Therapies 2023 23:143 -
Traditional bone setting service users and associated factors among people with trauma in Mecha district, Ethiopia
World Health Organization stated that traditional medicine is an important part of health care and countries need to consider integrating it into their primary health care system. Traditional bone setting has ...
Citation: BMC Complementary Medicine and Therapies 2023 23:142 -
Diallyl disulfide alleviates hypercholesterolemia induced by a western diet by suppressing endoplasmic reticulum stress in apolipoprotein E-deficient mice
The endoplasmic reticulum (ER) plays a pivotal role in maintaining cellular metabolic homeostasis. ER stress refers to the accumulation of misfolded proteins, which can trigger an unfolded protein response for...
Citation: BMC Complementary Medicine and Therapies 2023 23:141 -
The effects of melissa officinalis on depression and anxiety in type 2 diabetes patients with depression: a randomized double-blinded placebo-controlled clinical trial
Depression is more common in diabetic patients, with a 1.5-fold increased risk of death.Melissa officinalis (M. officinalis) have anti-diabetic and anti-depression activities. The study aimed to determine the eff...
Citation: BMC Complementary Medicine and Therapies 2023 23:140 -
Cytotoxic activity of essential oil from Leaves of Myrcia splendens against A549 Lung Cancer cells
Plants of the Myrcia genus have been widely used in folk medicine to treat various diseases, including cancer. Myrcia splendens species has a diverse chemical constitution, but the biological activities of its es...
Citation: BMC Complementary Medicine and Therapies 2023 23:139 -
Development of a novel, entirely herbal-based mouthwash effective against common oral bacteria and SARS-CoV-2
Parallel to the growth of the oral healthcare market, there is a constantly increasing demand for natural products as well. Many customers prefer products that contain fewer toxic agents, therefore providing a...
Citation: BMC Complementary Medicine and Therapies 2023 23:138 -
The use of traditional medicine practitioner services for childhood illnesses among childbearing women: a multilevel analysis of demographic and health surveys in 32 sub-Saharan African countries
Insights into the use of traditional medicine practitioners (TMP)-for common childhood diseases such as diarrhea and respiratory infections are important to understand the role of Traditional Medicine (TM) in ...
Citation: BMC Complementary Medicine and Therapies 2023 23:137 -
Effect of γ-tocopherol supplementation on premenstrual symptoms and natriuresis: a randomized, double-blind, placebo-controlled study
This randomized, double-blind, placebo-controlled study aimed to investigate the effects of γ-tocopherol (Toc) supplementation on premenstrual symptoms and natriuresis.
Citation: BMC Complementary Medicine and Therapies 2023 23:136 -
Phytochemical constituents, antioxidant and antibacterial activities of Plectocephalus varians (A. Rich.) C. Jeffrey ex Cufod root extracts
Plants have been used to treat diverse types of diseases in different cultural groups around the globe. In this regard, the root of Plectocephalus varians (P. varians) is claimed to have a beneficiary effect in t...
Citation: BMC Complementary Medicine and Therapies 2023 23:135 -
The efficacy and safety of Sanqi Qushi Granule in patients with idiopathic membranous nephropathy ——protocol of a multicenter, randomized control trial (SQ-AUTUMN)
Adult nephropathy is mainly caused by idiopathic membranous nephropathy (IMN). In cases of proteinuria, Modified Ponticelli Regimens (MPR) are often successful. However, it can cause adverse side effects. Oral...
Citation: BMC Complementary Medicine and Therapies 2023 23:134 -
Correction: Protocatechuic aldehyde acts synergistically with dacarbazine to augment DNA double-strand breaks and promote apoptosis in cutaneous melanoma cells
An amendment to this paper has been published and can be accessed via the original article.
Citation: BMC Complementary Medicine and Therapies 2023 23:133 -
Mellitin peptide quantification in seasonally collected crude bee venom and its anticancer effects on myelogenous K562 human leukaemia cell line
Apitherapy is an emerging field in cancer research, particularly in developing communities. The potency of Melittin (MEL), a major constituent in bee venom is accounted for the cytotoxic capacity against cance...
Citation: BMC Complementary Medicine and Therapies 2023 23:132 -
Sodium selenite preserves rBM-MSCs’ stemness, differentiation potential, and immunophenotype and protects them against oxidative stress via activation of the Nrf2 signaling pathway
The physiological level of reactive oxygen species (ROS) is necessary for many cellular functions. However, during the in-vitro manipulations, cells face a high level of ROS, leading to reduced cell quality. Prev...
Citation: BMC Complementary Medicine and Therapies 2023 23:131 -
Untargeted lipidomic analysis and network pharmacology for parthenolide treated papillary thyroid carcinoma cells
With fast rising incidence, papillary thyroid carcinoma (PTC) is the most common head and neck cancer. Parthenolide, isolated from traditional Chinese medicine, inhibits various cancer cells, including PTC cel...
Citation: BMC Complementary Medicine and Therapies 2023 23:130 -
Panax quinquefolius saponin inhibits vascular smooth muscle cell calcification via activation of nuclear factor-erythroid 2-related factor 2
Panax quinquefolius saponin (PQS) is the main active component of Panax quinquefolius. Emerging evidence suggests that PQS exerts beneficial effects against cardiovascular diseases. However, the role and mechanis...
Citation: BMC Complementary Medicine and Therapies 2023 23:129 -
Mechanisms of action of Fu Fang Gang Liu liquid in treating condyloma acuminatum by network pharmacology and experimental validation
Condyloma acuminatum (CA) is a sexually transmitted disease characterized by the anomalous proliferation of keratinocytes caused by human papillomavirus (HPV) infection. Fu Fang Gang Liu liquid (FFGL) is an ef...
Citation: BMC Complementary Medicine and Therapies 2023 23:128 -
Retraction Note: Suppression of NF-κB signaling by ECN in an arthritic model of inflammation
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12906-022-03629-7.
Citation: BMC Complementary Medicine and Therapies 2023 23:127 -
Effectiveness and safety analysis of Danggui Shaoyao Powder for the treatment of non-alcoholic fatty liver disease: study protocol for a randomized, double-blind, placebo-controlled clinical trial
The incidence of non-alcoholic fatty liver disease (NAFLD) has been on the rise in recent years, and there are no effective drugs to treat NAFLD; therefore, effective prevention and treatment of NAFLD have bec...
Citation: BMC Complementary Medicine and Therapies 2023 23:126 -
Correction: Baicalin promotes apoptosis and inhibits proliferation and migration of hypoxia-induced pulmonary artery smooth muscle cells by up-regulating A2a receptor via the SDF-1/CXCR4 signaling pathway
Citation: BMC Complementary Medicine and Therapies 2023 23:125 -
Protoscolicidal effects of curcumin nanoemulsion against protoscoleces of Echinococcus granulosus
The aim of the present study was to assess in vitro protoscolicidal effects of curcumin nanoemulsion (CUR-NE) against protoscoleces of cystic echinococcosis (CE)/hydatid cysts.
Citation: BMC Complementary Medicine and Therapies 2023 23:124 -
Nigella sativa powder for helicobacter pylori infected patients: a randomized, double-blinded, placebo-controlled clinical trial
This double-blind, placebo-controlled, clinical trial was conducted to define the effects of Nigella sativa (N. Sativa) powder plus conventional medical treatment of Helicobacter pylori (H. pylori) on serum ghrel...
Citation: BMC Complementary Medicine and Therapies 2023 23:123 -
Potential mechanisms of osthole against bladder cancer cells based on network pharmacology, molecular docking, and experimental validation
Osthole was traditionally used in treatment for various diseases. However, few studies had demonstrated that osthole could suppress bladder cancer cells and its mechanism was unclear. Therefore, we performed a...
Citation: BMC Complementary Medicine and Therapies 2023 23:122 -
Resveratrol induces proliferation and differentiation of mouse pre-osteoblast MC3T3-E1 by promoting autophagy
In mouse, it was discovered that resveratrol (Res) enhanced osteoporosis (OP) by boosting osteogenesis. Besides, Res can also have an impact on MC3T3-E1 cells, which are crucial for the control of osteogenesis...
Citation: BMC Complementary Medicine and Therapies 2023 23:121 -
Traditional medicine users in a treated chronic disease population: a cross-sectional study in Indonesia
Traditional medicine (TM) is commonly used as a treatment in Indonesia. This raises the need for an analysis of its potential development and irrational use. Therefore, we analyze the proportion of TM users am...
Citation: BMC Complementary Medicine and Therapies 2023 23:120 -
Anti-proliferative activity of Artemisia marschalliana on cancerous cell lines
The genus Artemisia of the Asteraceae family has different species that are used in the treatment of a wide range of diseases, including cancers due to the presence of valuable compounds and important medicinal p...
Citation: BMC Complementary Medicine and Therapies 2023 23:119 -
Prevotella histicola suppresses ferroptosis to mitigate ethanol-induced gastric mucosal lesions in mice
Ethanol-induced gastric mucosal lesions (EGML) is one of the most common digestive disorders for which current therapies have limited outcomes in clinical practice. Prevotella histicola (P. histicola) has shown p...
Citation: BMC Complementary Medicine and Therapies 2023 23:118 -
The neuroprotective effects of the combined extract of mulberry fruit and mulberry leaf against hydrogen peroxide-induced cytotoxicity in SH-SY5Y Cells
The prevalence of dementia is increasing, and most of the causes are related to neuronal cell death. Unfortunately, no effective strategy is available for protecting against this condition. Based on the use of...
Citation: BMC Complementary Medicine and Therapies 2023 23:117 -
Xiaoyaosan ameliorates depressive-like behavior and susceptibility to glucose intolerance in rat: involvement of LepR-STAT3/PI3K pathway in hypothalamic arcuate nucleus
Accumulating evidence has demonstrated that arcuate nucleus (ARC) of the hypothalamus is likely responsible for the close association between chronic stress, depression, and diabetes. Xiaoyaosan (XYS), a Chine...
Citation: BMC Complementary Medicine and Therapies 2023 23:116 -
In vitro anti-yeast activity, kinetics and mechanism of action of essential oils from two cameroonian medicinal plants
Treatment of Candida infections have become increasingly difficult due to antifungal drug resistance, which has drawn attention toward the search for innovative and effective drugs. This study aimed to assess ...
Citation: BMC Complementary Medicine and Therapies 2023 23:115 -
Bangpungtongsung-san for patients with major depressive disorder: study protocol for a randomized controlled phase II clinical trial
Bangpungtongsung-san (BTS) is a representative herbal medicine that has been widely used for patients with obesity in east Asian countries. Various preclinical studies have demonstrated the anti-depressive eff...
Citation: BMC Complementary Medicine and Therapies 2023 23:114 -
Correction: Anti-inflammatory effect of naringin and sericin combination on human peripheral blood mononuclear cells (hPBMCs) from patient with psoriasis
Citation: BMC Complementary Medicine and Therapies 2023 23:113 -
Polysaccharides extracted from mulberry fruits (Morus nigra L.): antioxidant effect of ameliorating H2O2-induced liver injury in HepG2 cells
Mori Fructus is an economical and readily available traditional Chinese medicine and food. Polysaccharides in Mori Fructus have clear antioxidant activity and have been found to alleviate oxidative stress (OS)-in...
Citation: BMC Complementary Medicine and Therapies 2023 23:112 -
Protocatechuic aldehyde acts synergistically with dacarbazine to augment DNA double-strand breaks and promote apoptosis in cutaneous melanoma cells
Despite rapid developments in immunotherapy and targeted therapy, dacarbazine (DTIC)-based chemotherapy still has been placed at the first-line for advanced melanoma patients who are after failure of immunothe...
Citation: BMC Complementary Medicine and Therapies 2023 23:111 -
Adjuvant music therapy for patients with hypertension: a meta-analysis and systematic review
High blood pressure, anxiety, depression and sleep disorder is very common in patients with hypertension. We aimed to perform a meta-analysis to evaluate the effects of adjuvant music therapy for patients with...
Citation: BMC Complementary Medicine and Therapies 2023 23:110