Articles

Evaluation of cholinesterase inhibitory and antioxidant activity of Wedelia chinensis and isolation of apigenin as an active compound

Wedelia chinensis has been reported as a folk medicine for the treatment of different diseases including neurodegenerative disease. Although the plant has been studied well for diverse biological activities, the ...

Authors: Md. Aminul Islam, Shahed Zaman, Kushal Biswas, Md. Yusuf Al-Amin, Md. Kamrul Hasan, A. H. M. K. Alam, Toshihisa Tanaka and Golam Sadik

Bio-guided bioactive profiling and HPLC-DAD fingerprinting of Ukrainian saffron (Crocus sativus stigmas): moving from correlation toward causation

Saffron or stigmas of Crocus sativus L. is one of the most valuable food products with interesting health-promoting properties. C. sativus has been widely used as a coloring and flavoring agent. Stigmas secondary...

Authors: Olha Mykhailenko, Vilma Petrikaitė, Michal Korinek, Mohamed El-Shazly, Bing-Hung Chen, Chia-Hung Yen, Chung-Fan Hsieh, Ivan Bezruk, Asta Dabrišiūtė, Liudas Ivanauskas, Victoriya Georgiyants and Tsong-Long Hwang

Effects of Stephania hainanensis alkaloids on MSU-induced acute gouty arthritis in mice

Gout is initiated by the precipitation of monosodium urate (MSU) crystals within the joints and soft tissues, and it can eventually cause acute or chronic arthritis. MSU crystals trigger, amplify, and maintain...

Authors: Hao-fei Fan, Xing-yue Fang, Hao-lin Wu, Yi-qian Xu, Li-chong Gong, Dao-rui Yu, Hao Jia, Xiao-liang Tang and Qi-bing Liu

Addressing barriers to the conduct and application of research in complementary and alternative medicine: a scoping review

Over the past few decades, the popularity of complementary and alternative medicine (CAM) has grown considerably and along with it, scrutiny regarding its evidence base. While this is to be expected, and is in...

Authors: Yasamin Veziari, Saravana Kumar and Matthew Leach

Barriers and facilitators to promoting evidence uptake in Chinese medicine: a qualitative study in Hong Kong

In response to the World Health Organization’s recommendation, policy makers have been adopting evidence-based healthcare approach to promote the development of traditional, complementary and integrative medic...

Authors: Charlene Hoi Lam Wong, Jeffrey Van Ho Tse, Per Nilsen, Leonard Ho, Irene Xin Yin Wu and Vincent Chi Ho Chung

Protective effect of Glechoma hederacea extract against gallstone formation in rodent models

Our current study aimed to evaluate the effect of an Glechoma hederacea extract (Hitrechol®) in normal rats and gallstone diseased mice to explore its underlying mechanisms. Normal rats and C57BL/6 mice with/with...

Authors: Min Xiao, Mengbi Yang, Xiaoyu Ji, Dan Li, Yuning Xie, Yuanfeng Lyu and Zhong Zuo

Phytochemical, acute toxicity and renal protective appraisal of Ajuga parviflora hydromethanolic leaf extract against CCl₄ induced renal injury in rats

Degenerative kidney diseases are mostly associated with oxidative stress. Natural products are considered as the antioxidants enrich food that can restrict the progress of oxidative stress induced disorders. T...

Authors: Samiullah Burki, Zeba Gul Burki, Muhammad Arif Asghar, Imdad Ali and Saba Zafar

Phytochemical, antimicrobial, antioxidant and enzyme inhibitory potential of medicinal plant Dryopteris ramosa (Hope) C. Chr.

Dryopteris ramosa has numerous potentials uses in the treatment of different maladies as old traditional medication. The fronds of D. ramose are edible and orally administered for producing antibiotic effect. The...

Authors: Fiaz Alam, Syed Hurmat Ali Khan and Mohammad Hassham Hassan Bin Asad

Osteopathic empirical research: a bibliometric analysis from 1966 to 2018

Despite the increasing use of osteopathy, a manipulative complementary and alternative medicine therapy, in the general population, its efficacy continues to be debated. In this era of evidence-based practice,...

Authors: Chantal Morin and Isabelle Gaboury

Piperlongumine inhibits migration and proliferation of castration-resistant prostate cancer cells via triggering persistent DNA damage

Metastatic castration-resistant prostate cancer (CRPC) is the leading cause of death among men diagnosed with prostate cancer. Piperlongumine (PL) is a novel potential anticancer agent that has been demonstrat...

Authors: Ding-fang Zhang, Zhi-chun Yang, Jian-qiang Chen, Xiang-xiang Jin, Yin-da Qiu, Xiao-jing Chen, Hong-yi Shi, Zhi-guo Liu, Min-shan Wang, Guang Liang and Xiao-hui Zheng

Anticancer effects of dihydromyricetin on the proliferation, migration, apoptosis and in vivo tumorigenicity of human hepatocellular carcinoma Hep3B cells

Hepatocellular carcinoma (HCC) represents a serious public health problem worldwide and has high morbidity and mortality. Dihydromyricetin (DHM) exhibits anticancer effect on a variety of malignancies, but its...

Authors: Lianggui Jiang, Wen-Chu Ye, Zuobiao Li, Yongguang Yang, Wei Dai and Mingyi Li

A computational multi-targeting approach for drug repositioning for psoriasis treatment

Psoriasis is an autoimmune inflammatory skin disease that affects 0.5–3% of the world’s population and current treatment options are posed with limitations. The reduced risk of failure in clinical trials for r...

Authors: Akachukwu Ibezim, Emmanuel Onah, Ebubechukwu N. Dim and Fidele Ntie-Kang

Lippia javanica (Zumbani) herbal tea infusion attenuates allergic airway inflammation via inhibition of Th2 cell activation and suppression of oxidative stress

Lippia javanica (lemon bush) is commonly used in the treatment of respiratory ailments, including asthma in southern African countries but there is no scientific evidence to support this claim. This study investi...

Authors: Mvuyisi O. M. Mfengu, Mathulo Shauli, Godwill A. Engwa, Hannibal T. Musarurwa and Constance R. Sewani-Rusike

Ruyiping formula inhibits metastasis via the microRNA-134-SLUG axis in breast cancer

Metastasis is the leading cause of death among breast cancer patients. MicroRNA-134 has been reported to have a tumor-suppressive role in breast cancer. Ruyiping (RYP), a traditional Chinese formula, has been ...

Authors: Ziwei Jiang, Lixia Pei, Ying Xie, Qun Ye, Xiaoqiang Liang, Yiyi Ye and Sheng Liu

Electro-acupuncture for central obesity: randomized, patient-assessor blinded, sham-controlled clinical trial protocol

Obesity is a common medical condition. Among all the classifications of obesity, central obesity is considered to be a significant threat on the health of individuals. Scientific researches have demonstrated t...

Authors: Linda L. D. Zhong, Xingyao Wu, Tsz Fung Lam, Ying Ping Wong, Peihua Cao, Emily Yen Wong, Shipping Zhang and Zhaoxiang Bian

A radiosensitizer, gallotannin-rich extract from Bouea macrophylla seeds, inhibits radiation-induced epithelial-mesenchymal transition in breast cancer cells

Radioresistance can pose a significant obstacle to the effective treatment of breast cancers. Epithelial–mesenchymal transition (EMT) is a critical step in the acquisition of stem cell traits and radioresistan...

Authors: Jiraporn Kantapan, Siwaphon Paksee, Aphidet Duangya, Padchanee Sangthong, Sittiruk Roytrakul, Sucheewin Krobthong, Wipob Suttana and Nathupakorn Dechsupa

Breast cancer cell line toxicity of a flavonoid isolated from Baccharis densiflora

Flavonoids are compounds of interest in the search for new anti-cancer therapies. We have previously isolated the methoxyflavones 5,4′-dihydroxy-6,7,8,3′-tetramethoxyflavone (8-methoxycirsilineol), 5,4′-dihydr...

Authors: Wendy Soria Sotillo, Santiago Tarqui, Xiaoli Huang, Giovanna Almanza and Stina Oredsson

Immunomodulatory, trypanocide, and antioxidant properties of essential oil fractions of Lippia alba (Verbenaceae)

Parasite persistence, exacerbated and sustained immune response, and continuous oxidative stress have been described to contribute to the development of the cardiac manifestations in Chronic Chagas Disease. Ne...

Authors: Wendy Lorena Quintero, Erika Marcela Moreno, Sandra Milena Leal Pinto, Sandra Milena Sanabria, Elena Stashenko and Liliana Torcoroma García

Chitosan nanoparticles containing limonene and limonene-rich essential oils: potential phytotherapy agents for the treatment of melanoma and breast cancers

Melanoma and breast cancers are two common cancers worldwide. Due to the side effects of chemotherapy drugs and the occurring resistance against them, the development of green drugs has been received more atte...

Authors: Hiva Alipanah, Mojtaba Farjam, Elham Zarenezhad, Ghazaal Roozitalab and Mahmoud Osanloo

Insight into the characteristics of research published in traditional, complementary, alternative, and integrative medicine journals: a bibliometric analysis

Traditional, complementary, alternative and integrative medicine (TCAIM) can be described as diverse medical and healthcare interventions, practices, products, or disciplines that are not considered as part of...

Authors: Jeremy Y. Ng

Evaluation of antinociceptive activity of Ilex dipyrena Wall. in mice

In order to find a new natural resource for pain-relief, the analgesic effects of Ilex dipyrena crude extract, fractions, and subfractions were evaluated in in-vivo mouse models with possible mechanism of action.

Authors: Amjad Ali, Abdul Nasir, Syed Wadood Ali Shah, Atif Ali Khan Khalil, Mi-jeong Ahn, Syed Muhammad Mukarram Shah, Fazli Subhan, Muhammad Faheem, Wasim Sajjad, Mohammad Shoaib, Saeed Ahmad, Nausheen Nazir and Mohammad Nisar

Metagenomic and phytochemical analyses of kefir water and its subchronic toxicity study in BALB/c mice

In recent years, researchers are interested in the discovery of active compounds from traditional remedies and natural sources, as they reveal higher therapeutic efficacies and improved toxicological profiles....

Authors: Muganti Rajah Kumar, Swee Keong Yeap, Nurul Elyani Mohamad, Janna Ong Abdullah, Mas Jaffri Masarudin, Melati Khalid, Adam Thean Chor Leow and Noorjahan Banu Alitheen

Facilitators and barriers to the clinical administration of herbal medicine in Ghana: a qualitative study

Herbal medicine administration in conventional health care services is gaining popularity lately. Much has not been documented on the perceived enhancers and challenges to herbal medicine administration at the...

Authors: Comfort Asare, Lydia Aziato and Daniel Boamah

A systems pharmacology approach based on oncogenic signalling pathways to determine the mechanisms of action of natural products in breast cancer from transcriptome data

Narrow spectrum of action through limited molecular targets and unforeseen drug-related toxicities have been the main reasons for drug failures at the phase I clinical trials in complex diseases. Most plant-de...

Authors: Regan Odongo, Asuman Demiroglu-Zergeroglu and Tunahan Çakır

Identification of 3,3′-O-dimethylellagic acid and apigenin as the main antiplasmodial constituents of Endodesmia calophylloides Benth and Hymenostegia afzelii (Oliver.) Harms

Endodesmia calophylloides and Hymenostegia afzelii belong to the Guttiferae and Caesalpiniaceae plant families with known uses in African ethno-medicine to treat malaria and several other diseases. This study aim...

Authors: Rodrigue Keumoe, Jean Garba Koffi, Darline Dize, Patrick Valère Tsouh Fokou, Joseph Tchamgoue, Lawrence Ayong, Bruno Lenta Ndjakou, Norbert Sewald, Bathelemy Ngameni and Fabrice Fekam Boyom

The effect of apple cider vinegar on lipid profiles and glycemic parameters: a systematic review and meta-analysis of randomized clinical trials

Elevated lipid profiles and impaired glucose homeostasis are risk factors for several cardiovascular diseases (CVDs), which, subsequently, represent a leading cause of early mortality, worldwide. The aim of th...

Authors: Amir Hadi, Makan Pourmasoumi, Ameneh Najafgholizadeh, Cain C. T. Clark and Ahmad Esmaillzadeh

Toxicity and bacterial anti-motility activities of the hydroethanolic extract of Acacia senegal (L.) Willd (Fabaceae) leaves

Acacia senegal is a plant traditionally used for its various properties, including the treatment of infectious diseases. Recently, our team has demonstrated the ability of the hydroethanolic extract of the leaves...

Authors: René Dofini Magnini, Mathieu Nitiéma, Geoffroy G. Ouédraogo, Sylvain Ilboudo, Alimata Bancé, Hassanata Millogo-Koné, Carole Di Giorgio, Jean-Marie Pagès, Adama Hilou and Anne Davin-Regli

Characterization of the antibacterial activity from ethanolic extracts of the botanical, Larrea tridentata

β-lactam antibiotics are a class of broad-spectrum antibiotics consisting of all antibiotic agents that contain a β-lactam ring in their molecular structures. β-lactam antibiotics are only known to be isolated...

Authors: Tiffany Turner, Guillermo Ruiz, Johanne Gerstel and Jeffrey Langland

Bioactive fractions and compound of Ardisia crispa roots exhibit anti-arthritic properties mediated via angiogenesis inhibition in vitro

Ardisia crispa (Thunb.) A.DC (Primulaceae), is a medicinal herb traditionally used by Asian people as remedies to cure inflammatory related diseases, including rheumatism. The plant roots possess various pharmaco...

Authors: Joan Anak Blin, Roslida Abdul Hamid and Huzwah Khaza’ai

Lipidomics study of the therapeutic mechanism of Plantaginis Semen in potassium oxonate-induced hyperuricemia rat

Plantaginis Semen has been widely used as folk medicine and health care food against hyperuricemia (HUA) and gout, but its pharmacological mechanism remains unclear. This study investigated the therapeutic mec...

Authors: Fei Yang, Wenjun Shi, Liting Wang, Nankun Qin, Chengxiang Wang, Yuying Guo, Guang Xu, Jie Fang, Xue Yu and Qun Ma

A cross-sectional study of traditional Chinese medicine practitioner’s knowledge, treatment strategies and integration of practice of chronic pelvic pain in women

Chronic pelvic pain (CPP) in women is persistent, intermittent cyclical and non-cyclical lower abdominal pain, lasting for more than 6 months. Traditional Chinese Medicine (TCM) is a popular treatment option f...

Authors: Susan Arentz, Caroline Smith, Rebecca Redmond, Jason Abbott and Mike Armour

Ameliorated biomechanical properties of carotid arteries by puerarin in spontaneously hypertensive rats

An emerging body of evidence indicates that puerarin (PUE) plays an important role in the treatment of angina pectoris, myocardial ischemia-reperfusion injury, hypertension and other cardiovascular diseases, b...

Authors: Xiaoxia Fang, Sheng Dong, Yun Wu, Yun He, Min Lu, Dandan Shi, Na Feng, Songhe Yin, Yan Jiang, Anhua Zhang, Yan Ding, Qiufang Zhang, Junming Tang, Wenjun Zhang and Xiju He

Ethanol extract of mulberry leaves partially restores the composition of intestinal microbiota and strengthens liver glycogen fragility in type 2 diabetic rats

Mulberry leaf as a traditional Chinese medicine is able to treat obesity, diabetes, and dyslipidemia. It is well known that diabetes leads to intestinal microbiota dysbiosis. It is also recently discovered tha...

Authors: Zhan-Zhong Liu, Qing-Hua Liu, Zhao Liu, Jia-Wei Tang, Eng-Guan Chua, Fen Li, Xue-Song Xiong, Meng-Meng Wang, Peng-Bo Wen, Xin-Yi Shi, Xiang-Yu Xi, Xiao Zhang and Liang Wang

The use of complementary and alternative medicine by adults with allergies: a Czech national representative survey

The prevalence rates of the use of Complementary and Alternative Medicine (CAM) in allergy patients range from 42% in the United States up to 50% in Europe. In the Czech Republic, no such data exists. Our aim ...

Authors: Jitka Pokladnikova, A-La Park, Jan Draessler, Anna Lukacisinova and Irena Krcmova

Multiple facial candidal abscesses after self-administered acupuncture in a patient with undiagnosed diabetes mellitus: a case report

Facial abscess caused by Candida albicans infection is a rare condition even in immunocompromised patients, and only a few cases have been reported. To our knowledge, this is the first case of multiple facial can...

Authors: Jae Yun Sung, Ju Mi Kim, Jong Uk Lee, Yeon Hee Lee and Sung Bok Lee

Polysaccharides from Ganoderma Sinense - rice bran fermentation products and their anti-tumor activities on non-small-cell lung cancer

Non-small-cell lung cancer (NSCLC) accounts more than 80% of the lung cancer cases. Polysaccharides in rice bran and its fermentation products have been proven to suppress many cancers. However, the report on ...

Authors: Wei Han, Hongjuan Chen, Lin Zhou, Haijie Zou, Xiaohong Luo, Bo Sun and Xuhui Zhuang

Effect of the standard herbal preparation, STW5, treatment on dysbiosis induced by dextran sodium sulfate in experimental colitis

The standardized herbal preparation, STW 5, is effective clinically in functional gastrointestinal disorders and experimentally in ulcerative colitis (UC). The present study explores whether the beneficial eff...

Authors: Sarah S. Mohamed, Nourtan F. Abdeltawab, Walaa Wadie, Lamiaa A. Ahmed, Ramy M. Ammar, Sabine Rabini, Heba Abdel-Aziz and Mohamed T. Khayyal

The trends of complementary alternative medicine use among cancer patients

The use of complementary and alternative medicine (CAM) is common among cancer patients and it may reflect the individual and societal beliefs on cancer therapy. Our study aimed to evaluate the trends of CAM u...

Authors: Abdul Rahman Jazieh, Khadega A. Abuelgasim, Husam I. Ardah, Mohammad Alkaiyat and Omar B. Da’ar

The effect of the Verbascum Thapsus on episiotomy wound healing in nulliparous women: a randomized controlled trial

The pain and discomfort caused by episiotomy affect the quality of life of the mothers, so rapid and complete repair of the episiotomy is very important. Due to the effective ingredients of Verbascum Thapsus, it ...

Authors: Sahar Taleb and Maryam Saeedi

Phytochemical analysis and versatile in vitro evaluation of antimicrobial, cytotoxic and enzyme inhibition potential of different extracts of traditionally used Aquilegia pubiflora Wall. Ex Royle

Himalayan Columbine (Aquilegia pubiflora Wall. Ex Royle) is a medicinal plant and have been used as traditional treatments for various human diseases including skin burns, jaundice, hepatitis, wound healing, card...

Authors: Hasnain Jan, Hazrat Usman, Muzamil Shah, Gouhar Zaman, Sadaf Mushtaq, Samantha Drouet, Christophe Hano and Bilal Haider Abbasi

Antibacterial, antifungal and antioxidant activities of whole plant chemical constituents of Rumex abyssinicus

Antibiotic resistance has contributed to the burden of infectious diseases both in the hospital and community setting, and represents a great threat to public health. Previous studies have revealed the role of...

Authors: Irene Chinda Kengne, Léonel Donald Tsamo Feugap, Abdel Jélil Njouendou, Claudia Darille Jouogo Ngnokam, Mahamat Djamalladine Djamalladine, David Ngnokam, Laurence Voutquenne-Nazabadioko and Jean-De-Dieu Tamokou

Matrine suppresses cell growth of diffuse large B-cell lymphoma via inhibiting CaMKIIγ/c-Myc/CDK6 signaling pathway

C-Myc aberrations confer a more aggressive clinic behavior in diffuse large B-cell lymphoma (DLBCL). Matrine is an alkaloid extracted from Sophora flavescens Ait. It possesses anti-cancer property through inhibit...

Authors: Jianyou Gu, Xiao Wang, Ling Zhang, Jingjing Xiang, Jingya Li, Zheng Chen, Yu Zhang, Junfa Chen and Jianping Shen

Effect of herbal extracts on peripheral nerve regeneration after microsurgery of the sciatic nerve in rats

Recent experimental studies using herbal extracts have shown the possibility of peripheral nerve regeneration. This study aimed to investigate the effects of herbal extracts on peripheral nerve regeneration in...

Authors: Young Jun Kim, Kyu Jin Kim, Jae Hoon Lee, Seong-Uk Park and Seung-Yeon Cho

Cryptolepine inhibits hepatocellular carcinoma growth through inhibiting interleukin-6/STAT3 signalling

Diverse signalling pathways are involved in carcinogenesis and one of such pathways implicated in many cancers is the interleukin 6/signal transducer and activator of transcription 3 (IL-6/STAT3) signalling pa...

Authors: Seth A. Domfeh, Patrick W. Narkwa, Osbourne Quaye, Kwadwo A. Kusi, Gordon A. Awandare, Charles Ansah, Alimatu Salam and Mohamed Mutocheluh

Targeting the hallmarks of cancer: the effects of silibinin on proliferation, cell death, angiogenesis, and migration in colorectal cancer

Silibinin, as a chemopreventive agent, has shown anti-cancer efficacy against different types of cancers. In the present study, we investigated the anti-cancer activities of silibinin on CT26 mouse colon cell ...

Authors: Saba Sameri, Chiman Mohammadi, Mehrnaz Mehrabani and Rezvan Najafi

Biological evaluation of Safrole oil and Safrole oil Nanoemulgel as antioxidant, antidiabetic, antibacterial, antifungal and anticancer

Safrole is a natural compound extracted from various plants, and has shown various biological activities. The current study aimed to investigate the antioxidant, antidiabetic, antimicrobial, and anticancer act...

Authors: Ahmad M. Eid and Mohammed Hawash

Antlerogenic stem cells extract accelerate chronic wound healing: a preliminary study

Chronic wounds constitute a significant medical and social problem. Chronic wound treatment may be supported by various techniques, such as negative pressure therapy, phototherapy or stem cells therapy, yet mo...

Authors: Janusz Kmiecik, Michał Jerzy Kulus, Jarosław Popiel, Agnieszka Cekiera and Marek Cegielski

Retraction Note: Herbal formula GAPT prevents beta amyloid deposition induced Ca²⁺/Calmodulin-dependent protein kinase II and Ca²⁺/Calmodulin-dependent protein phosphatase 2B imbalance in APPV717I mice

Authors: Jing Shi, Xuekai Zhang, Long Yin, Mingqing Wei, Jingnian Ni, Ting Li, Pengwen Wang, Jinzhou Tian and Yongyan Wang

Pyrvinium pamoate can overcome artemisinin’s resistance in anaplastic thyroid cancer

Anaplastic thyroid carcinoma is a highly lethal subtype of thyroid cancer without effective therapies. Drug resistance in anaplastic thyroid carcinoma poses a significant problem. Although artemisinin exerts a...

Authors: Yitian Li

Exploring the bone sparing effects of postbiotics in the post-menopausal rat model

Post-menopausal osteoporosis is a concern of health organizations, and current treatments do not seem enough. Postbiotics as bioactive compounds produced by probiotics may be an attractive alternative for bone...

Authors: Nima Montazeri-Najafabady, Younes Ghasemi, Mohammad Hossein Dabbaghmanesh, Yousef Ashoori, Pedram Talezadeh, Farhad Koohpeyma, Seyedeh Narjes Abootalebi and Ahmad Gholami