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  1. Diabetic retinopathy (DR) has become a worldwide concern because of the rising prevalence rate of diabetes mellitus (DM). Despite much energy has been committed to DR research, it remains a difficulty for diab...

    Authors: Fujiao Nie, Jiazhao Yan, Yanjun Ling, Zhengrong Liu, Chaojun Fu, Xiang Li and Yuhui Qin

    Citation: BMC Complementary Medicine and Therapies 2021 21:118

    Content type: Research article

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  2. The current scientific research direction is development of drugs with a targeted effect on malignant tumors. One of the promising groups is indolocarbazoles and their derivatives, which can initiate various t...

    Authors: Anna Lantsova, Irina Golubeva, Larisa Borisova, Lyudmila Nikolaeva, Lydia Ektova, Maria Dmitrieva and Olga Orlova

    Citation: BMC Complementary Medicine and Therapies 2021 21:117

    Content type: Research article

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  3. A biofilm is an extracellular polymeric substance (EPS) composed of polysaccharides, proteins, nucleic acids, and lipids that impede antibiotics and immune cells, thus providing a shielded environment for bact...

    Authors: Sudip Bhandari, Karan Khadayat, Sami Poudel, Sunil Shrestha, Raju Shrestha, Poonam Devkota, Santosh Khanal and Bishnu P. Marasini

    Citation: BMC Complementary Medicine and Therapies 2021 21:116

    Content type: Research article

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  4. Morus alba L. bark has been widely used in traditional medicine for treating several inflammatory diseases, such as hypertension, diabetes mellitus and coughing; however, the molecular mechanisms underlying its a...

    Authors: Lin Umeyama, Besse Hardianti, Shiori Kasahara, Dya Fita Dibwe, Suresh Awale, Satoru Yokoyama and Yoshihiro Hayakawa

    Citation: BMC Complementary Medicine and Therapies 2021 21:115

    Content type: Research article

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  5. In Sub-Saharan Africa, herbal therapy continues to be utilized for HIV-1 disease management. However, the therapeutic benefits of these substances remain ambiguous. To date, little is known about the effects o...

    Authors: Omalla A. Olwenyi, Bannet Asingura, Prossy Naluyima, Godwin Upoki Anywar, Justine Nalunga, Mariam Nakabuye, Michael Semwogerere, Bernard Bagaya, Fatim Cham, Allan Tindikahwa, Francis Kiweewa, Eliezer Z. Lichter, Anthony T. Podany, Courtney V. Fletcher, Siddappa N. Byrareddy and Hannah Kibuuka

    Citation: BMC Complementary Medicine and Therapies 2021 21:114

    Content type: Research article

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  6. Complementary and Alternative Medicine (CAM) have recently become more popular and accepted worldwide. One principal step to identify the status and organize strategies of CAM is evaluating the manner and the ...

    Authors: Reihaneh Moeini, Seyyed Ali Mozaffarpur, Morteza Mojahedi, Seyed Davoud Nasrolahpour Shirvani, Narjes Gorji, Roshanak Saghebi, Farid Abolhassani Shahreza and Hoda Shirafkan

    Citation: BMC Complementary Medicine and Therapies 2021 21:113

    Content type: Research article

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  7. Elderberry has traditionally been used to prevent and treat respiratory problems. During the COVID-19 pandemic, there has been interest in elderberry supplements to treat or prevent illness, but also concern t...

    Authors: L. Susan Wieland, Vanessa Piechotta, Termeh Feinberg, Emilie Ludeman, Brian Hutton, Salmaan Kanji, Dugald Seely and Chantelle Garritty

    Citation: BMC Complementary Medicine and Therapies 2021 21:112

    Content type: Research article

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  8. Interactive dressings are innovatively designed to interact with the wound surface and alter the wound environment to promote wound healing. In the current study, we integrated the physicochemical properties o...

    Authors: Mohammad Saeid Salami, Gholamreza Bahrami, Elham Arkan, Zhila Izadi, Shahram Miraghaee and Hadi Samadian

    Citation: BMC Complementary Medicine and Therapies 2021 21:111

    Content type: Research article

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  9. The use of herbal and dietary supplement (HDS) in health and disease management has gained global attention. HDS are generally accepted by the public and are associated with positive health behaviours. However...

    Authors: Mohd Shahezwan Abd Wahab, Muhammad Helmi Zaini, Aida Azlina Ali, Shariza Sahudin, Muhammad Zulfadli Mehat, Hafizah Abdul Hamid, Mohd Faiz Mustaffa, Noordin Othman and Sandra Maniam

    Citation: BMC Complementary Medicine and Therapies 2021 21:110

    Content type: Research article

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  10. Acupuncture for post-stroke depression (PSD) has been evolving, but uncertainty remains. To assess the existing evidence from randomized clinical trials (RCTs) of acupuncture for PSD, we sought to draw conclus...

    Authors: Ran Liu, Kun Zhang, Qiu-yu Tong, Guang-wei Cui, Wen Ma and Wei-dong Shen

    Citation: BMC Complementary Medicine and Therapies 2021 21:109

    Content type: Research article

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  11. The use of complementary and alternative medicine (CAM) is increasing worldwide. To the best of knowledge, there is a lack of studies that assess CAM use by Palestinian women during pregnancy. This research ai...

    Authors: Yara Quzmar, Zeina Istiatieh, Hala Nabulsi, Sa’ed H. Zyoud and Samah W. Al-Jabi

    Citation: BMC Complementary Medicine and Therapies 2021 21:108

    Content type: Research article

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  12. Rumex rothschildianus is the sole member of a unique section of the genus Rumex, in the family Polygonaceae. This species is a very rare small dioecious annual, endemic to Palestine that is traditionally used as ...

    Authors: Nidal Jaradat, Mohammed Hawash and Gada Dass

    Citation: BMC Complementary Medicine and Therapies 2021 21:107

    Content type: Research article

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  13. Plants represent an intricate and innovative source for the discovery of novel therapeutic remedies for the management of infectious diseases. The current study aimed at discovering new inhibitors of Leishmania s...

    Authors: Cyrille Armel N. Njanpa, Steven Collins N. Wouamba, Lauve Rachel T. Yamthe, Darline Dize, Brice Mariscal T. Tchatat, Patrick Valère F. Tsouh, Michel Nguiam Pouofo, Jean Bosco Jouda, Bruno Lenta Ndjakou, Norbert Sewald, Simeon Fogue Kouam and Fabrice Fekam Boyom

    Citation: BMC Complementary Medicine and Therapies 2021 21:106

    Content type: Research article

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  14. Mahanintangtong is listed in the Thailand’s National List of Essential Medicines (NLEM). It is used to treat non-specific fevers and illnesses such as pharyngitis and chickenpox. In this study, we investigated...

    Authors: Bhanuz Dechayont, Pathompong Phuaklee, Jitpisute Chunthorng-Orn, Thana Juckmeta, Onmanee Prajuabjinda and Kitrawee Jiraratsatit

    Citation: BMC Complementary Medicine and Therapies 2021 21:105

    Content type: Research article

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  15. Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease in the Western world, and it’s likely to parallel the increasing prevalence of type 2 diabetes, obesity, and o...

    Authors: Tewodros Mengesha, N. Gnana Sekaran and Tsegaye Mehare

    Citation: BMC Complementary Medicine and Therapies 2021 21:104

    Content type: Research article

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  16. Alzheimer’s disease (AD), an age-related neurodegenerative disorder and a serious public health concern, is mainly caused by β-amyloid (Aβ)-induced toxicity. Currently, a limited number of drugs are effective ...

    Authors: Xin Zhang, Chenjing Ma, Long Sun, Zhao He, Ying Feng, Xian Li, Jin Gan and Xiaoming Chen

    Citation: BMC Complementary Medicine and Therapies 2021 21:103

    Content type: Research article

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  17. Total glucosides of paeony (TGP), an active compound extracted from the roots of Paeonia lactiflora Pallas, has been increasingly used as the adjunctive therapy for rheumatoid arthritis (RA) patients. Though TGP ...

    Authors: Bin Liu, Xiang Meng, Yanfang Ma, Huizhen Li, Yuqi Liu, Nannan Shi, Yaolong Chen, Yanping Wang and Cheng Lu

    Citation: BMC Complementary Medicine and Therapies 2021 21:102

    Content type: Research article

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  18. Chinese eye acupuncture, focuses on treating different diseases by applying needle stimulation around the orbit of the eye. Since 1970, it has been used in China for the management of pain-related disorders. T...

    Authors: Yuan Chi, Jürgen Barth, Mei Wang, Nicola Robinson, Zan-Hua Li and Jian-Ping Liu

    Citation: BMC Complementary Medicine and Therapies 2021 21:101

    Content type: Research article

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  19. Acute myocardial injury (AMI), which is induced by renal ischemia-reperfusion (IR), is a significant cause of acute kidney injury (AKI)-related associated death. Obesity increases the severity and frequency of...

    Authors: He Tai, Xiao-lin Jiang, Zhi-ming Lan, Yue Li, Liang Kong, Si-cheng Yao, Nan Song, Mei-jun Lv, Jin Wu, Ping Yang, Xuan-si Xiao, Guan-lin Yang, Jin-song Kuang and Lian-qun Jia

    Citation: BMC Complementary Medicine and Therapies 2021 21:100

    Content type: Research article

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  20. Colorectal cancer (CRC) remains one of the leading causes of cancer-related death worldwide. Gelsemium elegans Benth (GEB) is a traditional Chinese medicine commonly used for treatment for gastrointestinal cancer...

    Authors: Wancai Que, Maohua Chen, Ling Yang, Bingqing Zhang, Zhichang Zhao, Maobai Liu, Yu Cheng and Hongqiang Qiu

    Citation: BMC Complementary Medicine and Therapies 2021 21:99

    Content type: Research article

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  21. Plants with an ethnobotanical history are known to harbor diverse group of endophytic fungi, which constitute major natural sources of bioactive compounds. In the present study, we evaluated the antioxidant ac...

    Authors: Mutiat Ibrahim, Elizabeth Oyebanji, Muinah Fowora, Ayobami Aiyeolemi, Chiamaka Orabuchi, Babajide Akinnawo and Adedotun A. Adekunle

    Citation: BMC Complementary Medicine and Therapies 2021 21:98

    Content type: Research article

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  22. Tinospora cordifolia (Willd).Miers is a perennial climbing medicinal shrub that has been traditionally used for the treatment of chronic inflammatory ailments. Our previous pre- clinical studies on anti-inflammat...

    Authors: Sheena Philip, Greeshma Tom, Padmaja Balakrishnan Nair, Sankar Sundaram and Asha Velikkakathu Vasumathy

    Citation: BMC Complementary Medicine and Therapies 2021 21:97

    Content type: Research article

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  23. The prevalence of complementary and alternative medicine (CAM) use and the modalities used by pediatric oncology patients vary widely across studies. In addition, the changes in the use of CAM over the course ...

    Authors: Emmanuelle Lüthi, Manuel Diezi, Nadia Danon, Julie Dubois, Jérôme Pasquier, Bernard Burnand and Pierre-Yves Rodondi

    Citation: BMC Complementary Medicine and Therapies 2021 21:96

    Content type: Research article

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  24. Herbal medicines are fast gaining popularity. However, their acceptability by modern practitioners is low which is often due to lack of standardization. Several approaches towards standardization of herbals ha...

    Authors: Manasi S. Gholkar, Jia V. Li, Poonam G. Daswani, P. Tetali and Tannaz J. Birdi

    Citation: BMC Complementary Medicine and Therapies 2021 21:95

    Content type: Research article

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  25. In the era of digital and improved conventional medicine, many continue to use traditional and complementary medicine (TCM). The prevalence of its usage is not well reported, especially in patients with end-st...

    Authors: Nor Fadhlina Zakaria, Mohd Tawfeq Mohd Noor and Rafidah Abdullah

    Citation: BMC Complementary Medicine and Therapies 2021 21:94

    Content type: Research article

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  26. In recent decades complementary and alternative medicine (CAM) has been widely used worldwide as well as in Norway, where CAM is offered mainly outside the national health care service, mostly complementary to...

    Authors: Agnete Egilsdatter Kristoffersen, Sara A. Quandt and Trine Stub

    Citation: BMC Complementary Medicine and Therapies 2021 21:93

    Content type: Research article

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  27. Some viruses play a key role in the disturbance of the digestive system. The common viruses which cause infectious diarrhoea (gastroenteritis) include astrovirus, caliciviruses, coronavirus and torovirus which...

    Authors: Katlego E. Motlhatlego, Parvaneh Mehrbod, Fatemeh Fotouhi, Muna Ali Abdalla, Jacobus N. Eloff and Lyndy J. McGaw

    Citation: BMC Complementary Medicine and Therapies 2021 21:92

    Content type: Research article

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  28. Complementary and alternative medicine use among Americans is prevalent. Originating in India, Ayurvedic medicine use in the United States has grown 57% since 2002. CAM accounts for a significant proportion of...

    Authors: Christopher M. Karousatos, Justin K. Lee, David R. Braxton and Tse-Ling Fong

    Citation: BMC Complementary Medicine and Therapies 2021 21:91

    Content type: Case report

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  29. The aim of the present study was to assess the expression and serum level of AMH in first-generation female mice pups following fennel and flaxseed consumption.

    Authors: Fahimeh Pourjafari, Tahereh Haghpanah, Fariba Sharififar, Seyed Noreddin Nematollahi-Mahani, Ali Afgar and Massood Ezzatabadipour

    Citation: BMC Complementary Medicine and Therapies 2021 21:90

    Content type: Research article

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  30. The fronds of Drynaria quercifolia have traditionally been used in rheumatic pain management. The goal of the present study was to validate the potent anti-inflammatory and anti-rheumatoid properties of the metha...

    Authors: Debabrata Modak, Subhashis Paul, Sourav Sarkar, Subarna Thakur and Soumen Bhattacharjee

    Citation: BMC Complementary Medicine and Therapies 2021 21:89

    Content type: Research article

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  31. Tongue squamous cell carcinoma (TSCC) is a common type of oral cancer, with a relatively poor prognosis and low post-treatment survival rate. Various strategies and novel drugs to treat TSCC are emerging and u...

    Authors: Zeyao Zhu, Zhenguang Ying, Meiqi Zeng, Qiang Zhang, Guiqing Liao, Yunliu Liang, Chunman Li, Chengfei Zhang, Xia Wang, Weipeng Jiang, Ping Luan and Ou Sha

    Citation: BMC Complementary Medicine and Therapies 2021 21:88

    Content type: Research article

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  32. Lung cancer is one of the leading causes of death worldwide due to its strong proliferative and metastatic capabilities. The suppression of these aggressive behaviors is of interest in anticancer drug research...

    Authors: Hien Minh Nguyen, Hoai Thi Nguyen, Suthasinee Seephan, Hang Bich Do, Huy Truong Nguyen, Duc Viet Ho and Varisa Pongrakhananon

    Citation: BMC Complementary Medicine and Therapies 2021 21:87

    Content type: Research article

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  33. Phyllanthus tenellus Roxb. has been traditionally used to treat inflammation and liver diseases and its medicinal property may be due to the presence of relatively high levels of hydrosable tannins. Recent report...

    Authors: Swee Keong Yeap, Chean Yeah Yong, Umar Faruq, Hui Kian Ong, Zahiah binti Mohamed Amin, Wan Yong Ho, Shaiful Sharifudin and Indu Bala Jaganath

    Citation: BMC Complementary Medicine and Therapies 2021 21:86

    Content type: Research article

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  34. Many parents choose support such as Complementary and Alternative Medicine (CAM) for themselves and their children who have cancer. The aim of this paper is to describe, how parents who have children with canc...

    Authors: Trine Stub, Sara A. Quandt, Agnete E. Kristoffersen, Miek C. Jong and Thomas A. Arcury

    Citation: BMC Complementary Medicine and Therapies 2021 21:85

    Content type: Research article

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  35. Enterotoxigenic Escherichia coli (ETEC) is classically associated with acute secretory diarrhea, which induces 2 million people death in developing countries over a year, predominantly children in the first years...

    Authors: Xu Song, Yi Yang, Junzhi Li, Mengxue He, Yuanfeng Zou, Renyong Jia, Lixia Li, Juan Hang, Min Cui, Lu Bai and Zhongqiong Yin

    Citation: BMC Complementary Medicine and Therapies 2021 21:84

    Content type: Research article

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  36. Vasculogenic mimicry (VM) is characterized by the formation of tubular structure inside the tumor stroma. It has been shown that a small fraction of cancer cells, namely cancer stem cells (CSCs), could stimula...

    Authors: Sanya Haiaty, Mohammad-Reza Rashidi, Maryam Akbarzadeh, Ahad Bazmany, Mostafa Mostafazadeh, Saba Nikanfar, Zohre Zibaei, Reza Rahbarghazi and Mohammad Nouri

    Citation: BMC Complementary Medicine and Therapies 2021 21:83

    Content type: Research article

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  37. Atopic dermatitis (AD) is a chronic allergic inflammatory skin disease characterized by complex pathogenesis including skin barrier dysfunction, immune-redox disturbances, and pruritus. Prolonged topical treat...

    Authors: Johny Bajgai, Jing Xingyu, Ailyn Fadriquela, Rahima Begum, Dong Heui Kim, Cheol-Su Kim, Soo-Ki Kim and Kyu-Jae Lee

    Citation: BMC Complementary Medicine and Therapies 2021 21:82

    Content type: Research article

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  38. Customers’ expectations and satisfaction are critical to ensure a more effective role of the community pharmacists in promoting the safe use of Complementary and Alternative Medicine (CAM). The aim of this stu...

    Authors: Mohamad Ali Hijazi, Hibeh Shatila, Zeina Omeich, Abdalla El-Lakany, Maha Aboul Ela and Farah Naja

    Citation: BMC Complementary Medicine and Therapies 2021 21:81

    Content type: Research article

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  39. Methylglyoxal (MG) is a highly reactive dicarbonyl precursor for the formation of advanced glycation end products (AGEs) associated with age-related diseases, including diabetes and its complications. Clitoria te...

    Authors: Poramin Chayaratanasin, Sirichai Adisakwattana and Thavaree Thilavech

    Citation: BMC Complementary Medicine and Therapies 2021 21:80

    Content type: Research article

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  40. Sha-Shen-Mai-Dong decoction (SSMD) is a classical prescription widely used in primary Sjogren’s Syndrome (pSS) therapy. This study aims to explore the potential pharmacological mechanism of SSMD on pSS.

    Authors: Yuepeng Jiang, Xiaoxuan Zhao, Jie Yu, Qiao Wang, Chengping Wen and Lin Huang

    Citation: BMC Complementary Medicine and Therapies 2021 21:79

    Content type: Research article

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  41. Oxidative stress and inflammation promote the development of diabetic cardiomyopathy (DCM). Therefore, inhibiting these processes may show beneficial effects in the treatment of patients with DCM. Taohuajing (...

    Authors: Rui Yao, Yu Cao, Changming Wang, Lu Xu, Xuan Zhang, Yuqing Deng, Feng Li and Siwang Wang

    Citation: BMC Complementary Medicine and Therapies 2021 21:78

    Content type: Research article

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  42. Trypanosoma cruzi is the etiological agent of Chagas disease (CD) or American trypanosomiasis, an important public health problem in Latin America. Benznidazole (BZ), a drug available for its treatment, has limit...

    Authors: Marcella Paula Mansano Sarto, Hevillyn Fernanda Lucas da Silva, Nilma de Souza Fernandes, Ana Paula de Abreu, Gerson Zanusso Junior and Max Jean de Ornelas Toledo

    Citation: BMC Complementary Medicine and Therapies 2021 21:77

    Content type: Research article

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  43. Procyanidin B2 (PB2), a unique component of the grape seed and other medicinal plants. PB2 has shown wide anticancer activity in various human cancer cells. However, it remains unclear about the biological eff...

    Authors: Yuqin Li, Xiaolan Lu, Peiying Tian, Kai Wang and Jianping Shi

    Citation: BMC Complementary Medicine and Therapies 2021 21:76

    Content type: Research article

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  44. Anal fissure is a common complication of the anorectal region and one of the most reported causes of anal pain. Acute anal fissure can be cured by surgery or medical treatment. There is an increase in the use ...

    Authors: Mohamad Hadi El Charif, Samer Doughan, Rawya Kredly, Sara Kassas, Rayan Azab and Eman Sbaity

    Citation: BMC Complementary Medicine and Therapies 2021 21:75

    Content type: Study protocol

    Published on:

  45. Medicinal plants have wide medicament application used to prevent and management of many ailments. These plants are used for primary health care in pastoralist communities who are deprived of modern medical ca...

    Authors: Eshetu Gadisa and Elazar Tadesse

    Citation: BMC Complementary Medicine and Therapies 2021 21:74

    Content type: Research article

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  46. Elaeagnus umbellata Thunb. (autumn olive) is a high valued medicinal plant. It belongs to Elaeagnaceae family and is widely distributed in Himalayan regions of Pakistan. In the present study essential oil were ex...

    Authors: Nausheen Nazir, Muhammad Zahoor, Faheem Uddin and Mohammad Nisar

    Citation: BMC Complementary Medicine and Therapies 2021 21:73

    Content type: Research article

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  47. Acute myocardial infarction (AMI) is the most serious and lethal manifestation of coronary heart disease worldwide, presenting extremely high disability and mortality. Our previous studies have shown that Guan...

    Authors: Xiaoxiao Zhang, Changle Shao, Songyi Cheng, Yao Zhu, Bo Liang and Ning Gu

    Citation: BMC Complementary Medicine and Therapies 2021 21:72

    Content type: Research article

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  48. In previous studies, Cassia spectabilis DC leaf has shown a good antiplasmodial activity. Therefore, this study is a follow-up study of the extract of leaf of C. spectabilis DC on its in vitro and in vivo antipla...

    Authors: Wiwied Ekasari, Dewi Resty Basuki, Heny Arwati and Tutik Sri Wahyuni

    Citation: BMC Complementary Medicine and Therapies 2021 21:71

    Content type: Research article

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  49. Large-scale epidemics have changed people’s medical behavior, and patients tend to delay non-urgent medical needs. However, the impact of the pandemic on the use of complementary and alternative medicine remai...

    Authors: Shun-Ku Lin, Chien-Tung Wu, Hui-Jer Chou, Chia-Jen Liu, Fu-Yang Ko, Ching-Hsuan Huang and Jung-Nien Lai

    Citation: BMC Complementary Medicine and Therapies 2021 21:70

    Content type: Research article

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  50. Endoplasmic reticulum stress (ERS) is one of the main mechanisms of spinal cord injury (SCI) pathology and can affect the physiological state of neurons. Icariin (ICA), the main pharmacological component of Ep...

    Authors: Chengjie Wu, Guanglu Yang, Yalan Pan, Lei Wang, Pengcheng Tu, Suyang Zheng, Yang Guo and Yong Ma

    Citation: BMC Complementary Medicine and Therapies 2021 21:69

    Content type: Research article

    Published on:

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