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  1. Physiotherapists (PTs) across the globe are increasingly incorporating filiform needling techniques (e.g., acupuncture, dry needling) into their clinical toolkits; and, the evidence base for these complementar...

    Authors: Nadine Ijaz, Sandy Welsh and Heather Boon

    Citation: BMC Complementary Medicine and Therapies 2021 21:264

    Content type: Research article

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  2. Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related death. Traditional Chinese medicine (TCM) has special advantages in relieving HCC, while Astragalus membranaceus is commonly used in TC...

    Authors: Zhili Liu, Huihan Ma and Zelin Lai

    Citation: BMC Complementary Medicine and Therapies 2021 21:263

    Content type: Research article

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  3. Lack of information exists about the use of traditional and complementary medicine (TCM) use among middle-aged and older adults in India, which led to studying the estimates of past-12-month Ayurveda/Yoga/Natu...

    Authors: Supa Pengpid and Karl Peltzer

    Citation: BMC Complementary Medicine and Therapies 2021 21:262

    Content type: Research

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  4. Osteoarthritis (OA) is the most common form of arthritis, affecting millions of people worldwide and characterised by joint pain and inflammation. It is a complex disease involving inflammatory factors and aff...

    Authors: Sybille Brochard, Julien Pontin, Benoit Bernay, Karim Boumediene, Thierry Conrozier and Catherine Baugé

    Citation: BMC Complementary Medicine and Therapies 2021 21:261

    Content type: Research

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  5. Current therapy of chronic hepatitis C virus (HCV) with direct-acting antivirals (DAAs) has dramatically improved the sustained virologic response (SVR) of affected patients; however, treatment with DAAs remai...

    Authors: Adita Ayu Permanasari, Chie Aoki-Utsubo, Tutik Sri Wahyuni, Lidya Tumewu, Myrna Adianti, Aty Widyawaruyanti, Hak Hotta and Achmad Fuad Hafid

    Citation: BMC Complementary Medicine and Therapies 2021 21:260

    Content type: Research

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  6. According to recent evidence, psychobiotics exert beneficial effects on central nervous system-related diseases, such as mental disorders. Lactobacillus plantarum PS128 (PS128), a novel psychobiotic strain, impro...

    Authors: Hei-Jen Huang, Jie-Ling Chen, Jian-Fu Liao, Yu-Hsin Chen, Min-Wei Chieu, Ya-Yun Ke, Chih-Chieh Hsu, Ying-Chieh Tsai and Hsiu Mei Hsieh-Li

    Citation: BMC Complementary Medicine and Therapies 2021 21:259

    Content type: Research article

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  7. Buchholzia coriacea Engl. is popularly called wonderful cola due to its wide ethnomedicinal use for the treatment of various ailments. We investigated the possible cytotoxic effect of its various fractions on hu...

    Authors: Hope Onohuean, Rahmat Adetutu Adisa and Abdullateef Isiaka Alagbonsi

    Citation: BMC Complementary Medicine and Therapies 2021 21:258

    Content type: Research

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  8. Oxidative stress-induced injury during hypothermic preservation is a universal problem that delays graft function and decrease the success of organ transplantation. Tanshinone IIA (Tan IIA) was reported to exh...

    Authors: Linhao Xu, Yizhou Xu, Zhoujing Zhu, Huiquan Gu, Chaofeng Chen and Jian Chen

    Citation: BMC Complementary Medicine and Therapies 2021 21:257

    Content type: Research

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  9. Microbial resistance, diabetes mellitus, and obesity are global health care problems that have posed a serious threat to both human and environmental ecosystems. The goals of the present investigations are to ...

    Authors: Nidal Jaradat, Mohammad Qadi, Iyad Ali, Fatima Hussein, Linda Issa, Doaa Rashdan, Manal Jamoos, Re’as Najem, Abdulraziq Zarour and Mohammad Arar

    Citation: BMC Complementary Medicine and Therapies 2021 21:256

    Content type: Research

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  10. Adipose tissue is a critical regulator of lipid storage and endocrine function. Impairment of the recruitment of new adipocytes in the adipose tissue is associated with ectopic fat accumulation, diabetes and i...

    Authors: Eunbi Koh, Boram Kim and Kyungoh Choi

    Citation: BMC Complementary Medicine and Therapies 2021 21:255

    Content type: Research article

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  11. Eucalyptol is an active compound of eucalyptus essential oil and was reported to have many medical attributes including cytotoxic effect on breast cancer cells. However, it has low solubility in aqueous soluti...

    Authors: Mira Nadiah Mohd Izham, Yazmin Hussin, Nurul Fattin Che Rahim, Muhammad Nazirul Mubin Aziz, Swee Keong Yeap, Heshu Sulaiman Rahman, Mas Jaffri Masarudin, Nurul Elyani Mohamad, Rasedee Abdullah and Noorjahan Banu Alitheen

    Citation: BMC Complementary Medicine and Therapies 2021 21:254

    Content type: Research article

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  12. Episiotomy is the most commonn surgical procedure in midwifery which as any other wounds can cause infection or delay in healing.

    Authors: Elmira Toomari, Sepideh Hajian, Faraz Mojab, Tayebe Omidkhah and Malihe Nasiri

    Citation: BMC Complementary Medicine and Therapies 2021 21:253

    Content type: Research article

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  13. While evidence-based practice (EBP) is widely accepted across healthcare professions, research investigating its implementation in manual therapy professions such as osteopathy is limited. The primary aim of t...

    Authors: Francesco Cerritelli, Alessio Iacopini, Matteo Galli, Oliver P. Thomson, Tobias Sundberg, Matthew J. Leach and Jon Adams

    Citation: BMC Complementary Medicine and Therapies 2021 21:252

    Content type: Research

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  14. Mild cognitive impairment (MCI) is considered an intermediate phase between normal aging and dementia. As the majority of cases of amnestic MCI (aMCI) progress to Alzheimer’s disease (AD), it is considered the...

    Authors: Hee-Yeon Shin, Ha-Ri Kim, Geon-Ho Jahng, Chul Jin, Seungwon Kwon, Seung-Yeon Cho, Seong-Uk Park, Woo-Sang Jung, Sang-Kwan Moon, Chang-Nam Ko and Jung-Mi Park

    Citation: BMC Complementary Medicine and Therapies 2021 21:251

    Content type: Research article

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  15. Complementary and integrative medical procedures (CIM) play an important role in general practice (GP). Consequently, in some countries (e.g. USA, Australia) specific curricula for the integration of CIM compe...

    Authors: Jan Valentini, Carina Klocke, Corina Güthlin and Stefanie Joos

    Citation: BMC Complementary Medicine and Therapies 2021 21:250

    Content type: Research

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  16. More than 80% of the African population depend on traditional medicine as a primary healthcare. Although the African migrant community is increasing in Australia, there is no research documenting if and how Af...

    Authors: Zewdneh Shewamene, Tinashe Dune and Caroline A. Smith

    Citation: BMC Complementary Medicine and Therapies 2021 21:249

    Content type: Research

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  17. Edible oils have proven health benefits in the prevention and treatment of various disorders since the establishment of human era. This study was aimed to appraise neuropharmacological studies on the commonly ...

    Authors: Mater H. Mahnashi, Bandar A. Alyami, Yahya S. Alqahtani, Ali O. Alqarni, Muhammad Saeed Jan, Muhammad Ayaz, Farhat Ullah, Muhammad Shahid, Umer Rashid and Abdul Sadiq

    Citation: BMC Complementary Medicine and Therapies 2021 21:248

    Content type: Research article

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  18. This study aimed to investigate the prevalence of and the factors associated with the regular use of complementary therapies for Taiwanese patients with systemic lupus erythematosus (SLE).

    Authors: Ming-Chi Lu, Hui-Chin Lo, Hsiu-Hua Chang, Chia-Wen Hsu and Malcolm Koo

    Citation: BMC Complementary Medicine and Therapies 2021 21:247

    Content type: Research article

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  19. Influenza A virus (IAV) infection is a continual threat to the health of animals and humans globally. Consumption of the conventional drugs has shown several side effects and drug resistance. This study was ai...

    Authors: Parvaneh Mehrbod, Hanieh Safari, Zeinab Mollai, Fatemeh Fotouhi, Yasaman Mirfakhraei, Hanieh Entezari, Saied Goodarzi and Zahra Tofighi

    Citation: BMC Complementary Medicine and Therapies 2021 21:246

    Content type: Research article

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  20. Adaptive metabolic response towards a low oxygen environment is essential to maintain rapid tumour proliferation and progression. The vascular network that surrounds the tumour develops an intermittent hypoxic...

    Authors: S. H. Shahruzaman, F. Z. Yusof, S. Maniam, S. Fakurazi and S. Maniam

    Citation: BMC Complementary Medicine and Therapies 2021 21:245

    Content type: Research

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  21. The present study aims to investigate the knowledge, attitude, and performance of Iranian Healthcare Professionals (HP) about Complementary and Alternative Medicine (CAM) modalities.

    Authors: Alireza Jafari, Mohaddeseh Zanganeh, Zahra Kazemi, Elaheh Lael-Monfared and Hadi Tehrani

    Citation: BMC Complementary Medicine and Therapies 2021 21:244

    Content type: Research article

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  22. Quercetin and H19 can promote osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). However, whether quercetin regulates H19 expression to promote osteogenic differentiation of BMSCs is unc...

    Authors: Wei Bian, Shunqiang Xiao, Lei Yang, Jun Chen and Shifang Deng

    Citation: BMC Complementary Medicine and Therapies 2021 21:243

    Content type: Research

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  23. Liquidambaris Fructus (LF) is the infructescence of Liquidambar formosana. In Traditional Chinese Medicine, LF has been used to treat joint pain, a common symptom of arthritis and rheumatism; however, a lack of p...

    Authors: Wen-xuan Li, Ping Qian, Yi-tong Guo, Li Gu, Jessore Jurat, Yang Bai and Dong-fang Zhang

    Citation: BMC Complementary Medicine and Therapies 2021 21:242

    Content type: Research

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  24. Authors: Elaissi Ameur, Moumni Sarra, Derbali Yosra, Khouja Mariem, Abid Nabil, Frederic Lynen and Khouja Mohamed Larbi

    Citation: BMC Complementary Medicine and Therapies 2021 21:241

    Content type: Correction

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    The original article was published in BMC Complementary Medicine and Therapies 2021 21:209

  25. As a prevalent type of cryptogenic fibrotic disease with high mortality, idiopathic pulmonary fibrosis (IPF) still lacks effective therapeutic drugs. The compounds extracted from buds and flowers of Chrysanthemum...

    Authors: Juan Nie, Yanlu Liu, Chaoyue Sun, Jingna Zheng, Baoyi Chen, Jianyi Zhuo, Ziren Su, Xiaoping Lai, Jiannan Chen, Jibiao Zheng and Yucui Li

    Citation: BMC Complementary Medicine and Therapies 2021 21:240

    Content type: Research article

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  26. According to the recent global cancer statistics, breast cancer is the leading cause of deaths among women with 2.3 million new cases globally. Likewise, cervical cancer is also among the leading causes of mor...

    Authors: Mater H. Mahnashi, Yahya S. Alqahtani, Bandar A. Alyami, Ali O. Alqarni, Farhat Ullah, Abdul Wadood, Abdul Sadiq, Azam Shareef and Muhammad Ayaz

    Citation: BMC Complementary Medicine and Therapies 2021 21:239

    Content type: Research

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  27. This study evaluated the in vitro antioxidant activity and comparison of anti-inflammatory and cytotoxic activity of Harpagopytum zeyheri with diclofenac.

    Authors: Sibonokuhle F. Ncube, Lyndy J. McGaw, Emmanuel Mfotie Njoya, Hilton G. T. Ndagurwa, Peter J. Mundy and Samson Sibanda

    Citation: BMC Complementary Medicine and Therapies 2021 21:238

    Content type: Research

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  28. Vulvovaginal candidiasis (VVC), the second leading cause of genital infection in women of reproductive age, is caused by yeasts of the genus Candida. Treatment is usually empirical and performed with azoles, whic...

    Authors: Aline Lorenzoni Paniágua, Amabel Fernandes Correia, Lívia Custódio Pereira, Bruna Maciel de Alencar, Fabiana Brandão Alves Silva, Rosane Mansan Almeida and Yanna Karla de Medeiros Nóbrega

    Citation: BMC Complementary Medicine and Therapies 2021 21:237

    Content type: Research article

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  29. Globally, 3 billion people suffer from either migraine or tension-type headache disorder over their lifetime. Approximately 50% of American adults suffering from headache or migraine have used complementary an...

    Authors: Jeremy Y. Ng and Christina Hanna

    Citation: BMC Complementary Medicine and Therapies 2021 21:236

    Content type: Research article

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  30. Siraitia grosvenorii (binomial name Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang), also called Arhat Fruit or Monk’s Fruit, is a dried ripe fruit belonging to the Cucurbitaceae Family. S. grosve...

    Authors: Wei Dong, Jia Zeng, Qin Wang, Xin Jiang and Ting Huang

    Citation: BMC Complementary Medicine and Therapies 2021 21:235

    Content type: Research article

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  31. Uvaria chamae (UC) and Olax subscorpioidea (OS) roots are included in traditional anti-cancer remedies and some studies have identified their chemopreventive/chemotherapeutic potential. This study aimed to identi...

    Authors: Temidayo D. Popoola, Stephanie T. Guetchueng, Kenneth J. Ritchie, Olufunsho Awodele, Nicola M. Dempster, Oluyemi Akinloye, Satyajit D. Sarker and Amos A. Fatokun

    Citation: BMC Complementary Medicine and Therapies 2021 21:234

    Content type: Research article

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  32. The global prevalence of diabetes mellitus is projected to reach approximately 700 million by the year 2045, with roughly 90–95% of all diabetes cases being type 2 in nature. Patients with type 2 diabetes mell...

    Authors: Jeremy Y. Ng, Manav Nayeni and Kevin Gilotra

    Citation: BMC Complementary Medicine and Therapies 2021 21:233

    Content type: Research article

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  33. One of the most prevalent complications of chemotherapy and radiotherapy is oral mucositis (OM) and manifests as erythema and ulceration. Curcumin is one of the components of turmeric and possesses anti-inflam...

    Authors: Seyed Javad Kia, Maryam Basirat, Hamid Saeidi Saedi and Seyed Ali Arab

    Citation: BMC Complementary Medicine and Therapies 2021 21:232

    Content type: Research

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  34. Neorautanenia mitis, Hydnora abyssinica, and Senna surattensis are medicinal plants with a variety of traditional uses. In this study, we sought to isolate the bioactive compounds responsible for some of these ac...

    Authors: Christiana J. Dawurung, Minh T. H. Nguyen, Jutharat Pengon, Kanchana Dokladda, Ratchanu Bunyong, Roonglawan Rattanajak, Sumalee Kamchonwongpaisan, Phuong T. M. Nguyen and Stephen G. Pyne

    Citation: BMC Complementary Medicine and Therapies 2021 21:231

    Content type: Research article

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  35. Little is known about the medical material and practices of tribes in the western border areas of Pakistan. The local population has inhabited this remote and isolated area for centuries, and gained medicinal ...

    Authors: Khalid Ahmad, Mushtaq Ahmad, Franz K. Huber and Caroline S. Weckerle

    Citation: BMC Complementary Medicine and Therapies 2021 21:230

    Content type: Research article

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  36. We previously reported that the tomato glycoalkaloid tomatine inhibited the growth of Trichomonas vaginalis strain G3, Tritrichomonas foetus strain D1, and Tritrichomonas foetus-like strain C1 that cause disease ...

    Authors: Christina C. Tam, Kevin Nguyen, Daniel Nguyen, Sabrina Hamada, Okhun Kwon, Irene Kuang, Steven Gong, Sydney Escobar, Max Liu, Jihwan Kim, Tiffany Hou, Justin Tam, Luisa W. Cheng, Jong H. Kim, Kirkwood M. Land and Mendel Friedman

    Citation: BMC Complementary Medicine and Therapies 2021 21:229

    Content type: Research article

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  37. Traditional Chinese Medicine (TCM) has been a proposed treatment option for ulcerative colitis (UC), however it has been difficult to understand the breadth and depth of evidence as various Chinese medicine th...

    Authors: Yu-Xin Sun, Xiao Wang, Xing Liao, Jing Guo, Wen-Bin Hou, Xin Wang, Jian-Ping Liu and Zhao-Lan Liu

    Citation: BMC Complementary Medicine and Therapies 2021 21:228

    Content type: Research article

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  38. Leucas cephalotes is a common ethnomedicinal plant widely used by traditional healers for the treatment of Malaria and other types of fever. Oleanolic acid and its derivatives have been reported for various types...

    Authors: Sulochana Kaushik, Lalit Dar, Samander Kaushik and Jaya Parkash Yadav

    Citation: BMC Complementary Medicine and Therapies 2021 21:227

    Content type: Research article

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  39. Atopic dermatitis (AD) is a chronic inflammatory skin disease mainly caused by immune stimuli. The current study was conducted to investigate the effects of ROCEN and to compare it with betamethasone (Beta) on...

    Authors: Ramin Goudarzi, Maryam Eskandarynasab, Ahad Muhammadnejad, Ahmad Reza Dehpour and Alireza Partoazar

    Citation: BMC Complementary Medicine and Therapies 2021 21:226

    Content type: Research

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  40. Cisplatin is an outstanding anticancer drug, but its use has been decreased remarkably due to sever nephrotoxicity. R. vesicarius L. is a leafy vegetable that is evident with anti-angeogenic, anti-inflammatory, a...

    Authors: Md. Mahmudul Hasan, Most. Sayla Tasmin, Ahmed M. El-Shehawi, Mona M. Elseehy, Md. Abu Reza and Ariful Haque

    Citation: BMC Complementary Medicine and Therapies 2021 21:225

    Content type: Research

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  41. Oleanolic acid (OA) has multiple pharmaceutical applications including anti-inflammatory activity, but low permeability of the molecule limits its widespread use.

    Authors: Zhiqi Shi, Shugang Pan, Luolin Wang and Sha Li

    Citation: BMC Complementary Medicine and Therapies 2021 21:224

    Content type: Research

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  42. The majority of global population suffer from various functional gastrointestinal disorders. Pugionium cornutum (L.) Gaertn. (PCG) is used to relieve indigestive symptoms in traditional Chinese medicine. However,...

    Authors: Chencan Su, Haoyu Li, Bang Chen, Cong Li, Chunxiao Zhang, Long Xu, Mei Lan and Yehua Shen

    Citation: BMC Complementary Medicine and Therapies 2021 21:223

    Content type: Research

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  43. Increasing attention has been paid to the effect of Epimedium on the nervous system, particularly anti-depression function. In the present study, we applied network pharmacology to introduce a testable hypothesis...

    Authors: Yankai Dong, Bo Tao, Xing Xue, Caixia Feng, Yating Ren, Hengyu Ma, Junli Zhang, Yufang Si, Sisi Zhang, Si Liu, Hui Li, Jiahao Zhou, Ge Li, Zhifei Wang, Juanping Xie and Zhongliang Zhu

    Citation: BMC Complementary Medicine and Therapies 2021 21:222

    Content type: Research article

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  44. Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide. The aim of this study was to evaluate the effects of hydro-alcoholic extract of spinach (HES) on hepatic and serum measureme...

    Authors: Ali Amirinejad, Ali Saneei Totmaj, Farzaneh Mardali, Azita Hekmatdoost, Hadi Emamat, Majid Safa and Farzad Shidfar

    Citation: BMC Complementary Medicine and Therapies 2021 21:221

    Content type: Research

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  45. ECa 233 is a standardized extract of C. asiatica containing the triterpenoid glycosides, madecassoside to asiaticoside in the ratio of (1.5 ± 0.5):1. Anti-inflammatory activities of ECa 233 have been reported; ho...

    Authors: Supannikar Tawinwung, Dhirarin Junsaeng, Supanut Utthiya and Phisit Khemawoot

    Citation: BMC Complementary Medicine and Therapies 2021 21:220

    Content type: Research

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  46. Obtusofolin is the major active ingredient of Catsia tora L., which possesses the activity of improving eyesight and protecting the optic nerve. Investigation on the interaction of obtusofolin with cytochrome ...

    Authors: Na Liu, Ping Chen, Xiaojun Du, Junxia Sun and Shasha Han

    Citation: BMC Complementary Medicine and Therapies 2021 21:218

    Content type: Research

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  47. Traditional Chinese medicine (TCM) has gained widespread application in treating chronic heart failure (CHF) secondary to coronary heart disease (CHD). However, the sound clinical evidence is still lacking. Co...

    Authors: Jiayuan Hu, Ruijin Qiu, Chengyu Li, Min Li, Qianqian Dai, Shiqi Chen, Chen Zhao and Hongcai Shang

    Citation: BMC Complementary Medicine and Therapies 2021 21:217

    Content type: Research article

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  48. In recent years, an increase in the occurrence of illnesses caused by two clinically- important arboviruses has been reported: Zika virus (ZIKV) and Chikungunya virus (CHIKV). There is no licensed antiviral tr...

    Authors: Laura Milena Monsalve-Escudero, Vanessa Loaiza-Cano, Yina Pájaro-González, Andrés Felipe Oliveros-Díaz, Fredyc Diaz-Castillo, Wiston Quiñones, Sara Robledo and Marlen Martinez-Gutierrez

    Citation: BMC Complementary Medicine and Therapies 2021 21:216

    Content type: Research

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  49. The current study was aimed to investigate the anti-allergic activities of the Umbelliferone (UMB) against the acute Histamine and chronic Picryl chloride (PiCl)-induced allergy in mice. UMB is a coumarin deri...

    Authors: Younas, Ashrafullah Khan, Omer Shehzad, Eun Kyoung Seo, Alev Onder and Salman Khan

    Citation: BMC Complementary Medicine and Therapies 2021 21:215

    Content type: Research article

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