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  1. Fatty acid synthase (FAS) is a promising antifungal target due to its marked structural differences between fungal and mammalian cells. The aim of this study was to evaluate the antifungal activity of flavonoi...

    Authors: Tamires Aparecida Bitencourt, Tatiana Takahasi Komoto, Bruna Gabriele Massaroto, Carlos Eduardo Saraiva Miranda, Rene Oliveira Beleboni, Mozart Marins and Ana Lúcia Fachin
    Citation: BMC Complementary and Alternative Medicine 2013 13:229
    Content type: Research article Published on:

  2. Reactive oxygen species play important roles in renal calcium crystallization. In this study, we examined the effects of catechin, which have been shown to have antioxidant properties on the renal calcium crys...

    Authors: Wei Zhai, Junhua Zheng, Xudong Yao, Bo Peng, Min Liu, Jianhua Huang, Guangchun Wang and Yunfei Xu
    Citation: BMC Complementary and Alternative Medicine 2013 13:228
    Content type: Research article Published on:

  3. In Traditional Chinese Medicine (TCM), tongue diagnosis has been an important diagnostic method for the last 3000 years. Tongue diagnosis is a non-invasive, simple and valuable diagnostic tool. TCM treats the ...

    Authors: Zhu-Mei Sun, Jie Zhao, Peng Qian, Yi-Qin Wang, Wei-Fei Zhang, Chun-Rong Guo, Xiao-Yan Pang, Shun-Chun Wang, Fu-Feng Li and Qi Li
    Citation: BMC Complementary and Alternative Medicine 2013 13:227
    Content type: Research article Published on:

  4. The incidence of lung cancer is expected to increase due to increases in exposure to airborne pollutants and cigarette smoke. Moringa oleifera (MO), a medicinal plant found mainly in Asia and South Africa is used...

    Authors: Charlette Tiloke, Alisa Phulukdaree and Anil A Chuturgoon
    Citation: BMC Complementary and Alternative Medicine 2013 13:226
    Content type: Research article Published on:

  5. While older adults may seek care for low back pain (LBP) from both medical doctors (MDs) and doctors of chiropractic (DCs), co-management between these providers is uncommon. The purposes of this study were to...

    Authors: Kevin J Lyons, Stacie A Salsbury, Maria A Hondras, Mark E Jones, Andrew A Andresen and Christine M Goertz
    Citation: BMC Complementary and Alternative Medicine 2013 13:225
    Content type: Research article Published on:

  6. Complementary medicines (CMs) are widely used by women. Although, women in Australia are frequent users of CM, few studies have examined their utilisation by women attending a family planning service. The aim ...

    Authors: Caroline A Smith, Deborah J Bateson and Edith Weisberg
    Citation: BMC Complementary and Alternative Medicine 2013 13:224
    Content type: Research article Published on:

  7. The use of edible plants is an integral part of dietary behavior in the West region of Cameroon. Dorstenia psilurus (Moraceae) is widely used as spice and as medicinal plant for the treatment of several diseases ...

    Authors: Constant Anatole Pieme, Santosh Kumar Guru, Pantaleon Ambassa, Suresh Kumar, Bathelemy Ngameni, Jeanne Yonkeu Ngogang, Shashi Bhushan and Ajit Kumar Saxena
    Citation: BMC Complementary and Alternative Medicine 2013 13:223
    Content type: Research article Published on:

  8. Melastoma malabathricum (MM) Linn leaves traditionally use in the treatment of diabetic conditions. The aim of the present investigation was to evaluate the antioxidant, antihyperlipidemic and antidiabetic activ...

    Authors: Vikas Kumar, Danish Ahmed, Pushpraj S Gupta, Firoz Anwar and Mohd Mujeeb
    Citation: BMC Complementary and Alternative Medicine 2013 13:222
    Content type: Research article Published on:

  9. Over-proliferation of airway smooth muscle cell (ASMC) is one of the important contributors to airway remodeling in asthma. The aim of this study was to investigate the effect of Shenmai injection (SMI) on the...

    Authors: Limin Zhao, Jizhen Wu, Xiaoyu Zhang, Hongyan Kuang, Yali Guo and Lijun Ma
    Citation: BMC Complementary and Alternative Medicine 2013 13:221
    Content type: Research article Published on:

  10. This study investigates the effect of Xiao-Qing-Long-Tang (XQLT) on neurotrophin in an established mouse model of Dermatophagoides pteronyssinus (Der p)-induced acute allergic asthma and in a LA4 cell line mod...

    Authors: Ren-Shiu Chang, Shulhn-Der Wang, Yu-Chin Wang, Li-Jen Lin, Shung-Te Kao and Jiu-Yao Wang
    Citation: BMC Complementary and Alternative Medicine 2013 13:220
    Content type: Research article Published on:

  11. In this study, we evaluated the anti-inflammatory effect of PM014 on cigarette smoke induced lung disease in the murine animal model of chronic obstructive pulmonary disease (COPD).

    Authors: Kyung-Hwa Jung, Kyoung-Keun Haam, Soojin Park, Youngeun Kim, Seung Ryel Lee, Geunhyeog Lee, Miran Kim, Moochang Hong, Minkyu Shin, Sungki Jung and Hyunsu Bae
    Citation: BMC Complementary and Alternative Medicine 2013 13:219
    Content type: Research article Published on:

  12. Berberis vulgaris is a well known plant with traditional herbal medical history. The aims of this study was to bioscreen and compare the in vitro biological activity (antioxidant, cholinergic, antidaibetic and t...

    Authors: Abeer E Abd El-Wahab, Doaa A Ghareeb, Eman EM Sarhan, Marwa M Abu-Serie and Maha A El Demellawy
    Citation: BMC Complementary and Alternative Medicine 2013 13:218
    Content type: Research article Published on:

  13. Labisia Pumila var. alata (LPva) has shown potential as an alternative to estrogen replacement therapy (ERT) in prevention of estrogen-deficient osteoporosis. In earlier studies using postmenopausal model, LPva ...

    Authors: Siti Noor Fathilah, Norazlina Mohamed, Norliza Muhammad, Isa Naina Mohamed, Ima Nirwana Soelaiman and Ahmad Nazrun Shuid
    Citation: BMC Complementary and Alternative Medicine 2013 13:217
    Content type: Research article Published on:

  14. Crotalaria pallida Ailton is a plant belonging to the Fabaceae family, popularly known as “rattle or rattlesnake” and used in traditional medicine to treat swelling of the joints and as a vermifuge. Previous pha...

    Authors: Paula Karina Boldrin, Flávia Aparecida Resende, Ana Paula Oliveira Höhne, Mariana Santoro de Camargo, Lívia Greghi Espanha, Catarine Haidê Nogueira, Maria do Socorro F Melo, Wagner Vilegas and Eliana Aparecida Varanda
    Citation: BMC Complementary and Alternative Medicine 2013 13:216
    Content type: Research article Published on:

  15. We report results of a pilot study designed to test a novel smoking cessation intervention, Mindfulness Training for Smokers (MTS), in smokers age 18-29 years with regular episodes of binge drinking. Mindfulne...

    Authors: James M Davis, David M Mills, Kristin A Stankevitz, Alison R Manley, Matthew R Majeskie and Stevens S Smith
    Citation: BMC Complementary and Alternative Medicine 2013 13:215
    Content type: Research article Published on:

  16. Ssanghwa-tang (SHT) is a widely used medication for the treatment of fatigue, pain, inflammation, hypothermia, erectile dysfunction, cancer, and osteoporosis in Asia, however, role of SHT on the melanin synthe...

    Authors: Aeyung Kim, Nam-Hui Yim, Minju Im, Young Pil Jung, Chun Liang, Won-Kyung Cho and Jin Yeul Ma
    Citation: BMC Complementary and Alternative Medicine 2013 13:214
    Content type: Research article Published on:

  17. Hyaluronidases have been found as the target enzymes in the development of osteoarthritis (OA) disease. While there is still no curative treatment for this disease, recent studies on the treatment of OA were f...

    Authors: Kamini Citalingam, Seema Zareen, Khozirah Shaari and Syahida Ahmad
    Citation: BMC Complementary and Alternative Medicine 2013 13:213
    Content type: Research article Published on:

  18. Fewer than 6% patients with adenocarcinoma of the pancreas live up to five years after diagnosis. Chemotherapy is currently the standard treatment, however, these tumors often develop drug resistance over time...

    Authors: Liron Berkovich, Gideon Earon, Ilan Ron, Adam Rimmon, Akiva Vexler and Shahar Lev-Ari
    Citation: BMC Complementary and Alternative Medicine 2013 13:212
    Content type: Research article Published on:

  19. Picralima nitida Stapf (Apocynaceae) is a medicinal plant used traditionally in Cameroon to cure various ailments such as gastrointestinal disorders and dysentery. This study reports the in vitro and in vivo ant...

    Authors: Laure Brigitte Mabeku Kouitcheu, Joseph Lebel Tamesse and Jacques Kouam
    Citation: BMC Complementary and Alternative Medicine 2013 13:211
    Content type: Research article Published on:

  20. Human diploid fibroblasts (HDFs) undergo a limited number of cellular divisions in culture and progressively reach a state of irreversible growth arrest, a process termed cellular ageing. Even though beneficia...

    Authors: Suzana Makpol, Thong Wei Yeoh, Farah Adilah Che Ruslam, Khaizurin Tajul Arifin and Yasmin Anum Mohd Yusof
    Citation: BMC Complementary and Alternative Medicine 2013 13:210
    Content type: Research article Published on:

  21. Large-scale pharmaco-epidemiological studies of Chinese herbal medicine (CHM) for treatment of urticaria are few, even though clinical trials showed some CHM are effective. The purpose of this study was to exp...

    Authors: Pei-Shan Chien, Yu-Fang Tseng, Yao-Chin Hsu, Yu-Kai Lai and Shih-Feng Weng
    Citation: BMC Complementary and Alternative Medicine 2013 13:209
    Content type: Research article Published on:

  22. With the emergence of strains resistant to conventional antibiotics, it is important to carry studies using alternative methods to control these microorganisms causing important infections, such as the use of ...

    Authors: Jonatas Rafael de Oliveira, Vinicius Carlos de Castro, Polyana das Graças Figueiredo Vilela, Samira Esteves Afonso Camargo, Cláudio Antonio Talge Carvalho, Antonio Olavo Cardoso Jorge and Luciane Dias de Oliveira
    Citation: BMC Complementary and Alternative Medicine 2013 13:208
    Content type: Research article Published on:

  23. The naphthoquinone pigment, shikonin, is a major component of Lithospermum erythrorhizon and has been shown to have various biological functions, including antimicrobial, anti-inflammatory, and antitumor effects....

    Authors: So Young Gwon, Ji Yun Ahn, Chang Hwa Jung, Bo Kyung Moon and Tae Youl Ha
    Citation: BMC Complementary and Alternative Medicine 2013 13:207
    Content type: Research article Published on:

  24. Qingfei Xiaoyan Wan (QFXY), a traditional Chinese formula, is widely used for relieving cough, asthma, upper respiratory tract infection, bronchitis, pneumonia, and etc. in clinic. Comparing with other anti-as...

    Authors: Zhenying Zhao, Yingbo Miao, Pengwei Pan, Binfeng Cheng, Gang Bai and Hong Wu
    Citation: BMC Complementary and Alternative Medicine 2013 13:206
    Content type: Research article Published on:

  25. Breast cancer survivors who participate in physical activity (PA) are reported to experience improved health-related quality of life (HRQOL). However, the quantitative research exploring the relationship betwe...

    Authors: Heather A Ray and Marja J Verhoef
    Citation: BMC Complementary and Alternative Medicine 2013 13:205
    Content type: Research article Published on:

  26. In order to gain insight into neuroprotective effects of ECa 233, a standardized extract of Centella asiatica, previously demonstrated in animal models of memory impairment induced by transient global ischemia or...

    Authors: Oraphan Wanakhachornkrai, Varisa Pongrakhananon, Preedakorn Chunhacha, Aree Wanasuntronwong, Anusara Vattanajun, Boonyong Tantisira, Pithi Chanvorachote and Mayuree H Tantisira
    Citation: BMC Complementary and Alternative Medicine 2013 13:204
    Content type: Research article Published on:

  27. z-Guggulsterone (z-Gug) and Gugulipid (GL) have been used to treat a variety of ailments. We now report their anti-cancer effect and mechanism against human breast cancer.

    Authors: Guoqin Jiang, Xiao Xiao, Yan Zeng, Kalyanam Nagabhushanam, Muhammed Majeed and Dong Xiao
    Citation: BMC Complementary and Alternative Medicine 2013 13:203
    Content type: Research article Published on:

  28. Chronic unpredictable stress (CUS) can cause behavioral and physiological abnormalities that are important to the prediction of symptoms of depression that may be associated with cerebral glucose metabolic abn...

    Authors: Zheng Lin, Ligen Shi, Jing Lu, Jinhui Li, Hua Hu, Chuantao Zuo, Weijun Tang, Yunrong Lu, Aimin Bao and Lei Xu
    Citation: BMC Complementary and Alternative Medicine 2013 13:202
    Content type: Research article Published on:

  29. Brown propolis is the major type of propolis found in Cuba; its principal component is nemorosone, the major constituent of Clusia rosea floral resins. Nemorosone has received increasing attention due to its stro...

    Authors: Mariana S Camargo, Aline M Prieto, Flavia A Resende, Paula K Boldrin, Cassia RP Cardoso, Mariana F Fernández, José Manuel Molina-Molina, Nicolás Olea, Wagner Vilegas, Osmany Cuesta-Rubio and Eliana A Varanda
    Citation: BMC Complementary and Alternative Medicine 2013 13:201
    Content type: Research article Published on:

  30. Over 50% of adults currently use dietary supplements (DS) but manufacturers do not have to prove the safety or efficacy of a DS before it is marketed. Therefore, consumers may be exposed to inaccurate DS infor...

    Authors: Mary R Rozga, Judith S Stern, Kimber Stanhope, Peter J Havel and Alexandra G Kazaks
    Citation: BMC Complementary and Alternative Medicine 2013 13:200
    Content type: Research article Published on:

  31. Rhabdomyolysis is an uncommon side effect of trabectedin which is used for the second line therapy of metastatic sarcoma after anthracycline and ifosfamide failure. This side effect may be due to pharmacokinet...

    Authors: Sabino Strippoli, Vito Lorusso, Anna Albano and Michele Guida
    Citation: BMC Complementary and Alternative Medicine 2013 13:199
    Content type: Case report Published on:

  32. Germinated brown rice (GBR) is gaining momentum in the area of biomedical research due to its increased use as a nutraceutical for the management of diseases. The effect of GBR on the reproductive organs of oo...

    Authors: Sani I Muhammad, Maznah Ismail, Rozi B Mahmud, Abubakar M Salisu and Zuki A Zakaria
    Citation: BMC Complementary and Alternative Medicine 2013 13:198
    Content type: Research article Published on:

  33. The present study describes the tracheorelaxant and anti-inflammatory effects of Polygonatum verticillatum which may support its medicinal use in hyperactive airway complaints and inflammatory disorders.

    Authors: Haroon Khan, Muhammad Saeed, Malik Hassan Mehmood, Najeeb-ur Rehman, Naveed Muhammad, Ikram-ul Haq, Nadeem Ashraf, Kamal Eldin H El-Tahir and Anwarul-Hassan Gilani
    Citation: BMC Complementary and Alternative Medicine 2013 13:197
    Content type: Research article Published on:

  34. Sapindus saponaria is used traditionally for curing ulcers, external wounds and inflammations. The spermicidal and anti-Trichomonas activity of S. saponaria and its effect on Lactobacillus acidophilus were evalu...

    Authors: Edilson Damke, Joyce K Tsuzuki, Francieli Chassot, Diógenes AG Cortez, Izabel CP Ferreira, Cristiane SS Mesquita, Vânia RS da-Silva, Terezinha IE Svidzinski and Márcia EL Consolaro
    Citation: BMC Complementary and Alternative Medicine 2013 13:196
    Content type: Research article Published on:

  35. Dioscorea villosa (DV) has been used in Brazil as an alternative medicine to attenuate menopause symptoms, as well as for the treatment of joint pain and rheumatoid arthritis. In spite of the popular use of DV f...

    Authors: Claudio Moreira Lima, Adriana Karla Lima, Marcelia G Dória Melo, Mairim Russo Serafini, Dênisson Lima Oliveira, Enrik Barbosa de Almeida, Rosana Souza Siqueira Barreto, Paulo Cesar de Lima Nogueira, Valéria Regina de Souza Moraes, Édica Ramone Andrade Oliveira, Ricardo Luiz Cavalcanti de Albuquerque Jr, Lucindo J Quintans-Júnior and Adriano Antunes \Souza Araújo
    Citation: BMC Complementary and Alternative Medicine 2013 13:195
    Content type: Research article Published on:

  36. Some of ginsenosides, root extracts from Panax ginseng, exert cytotoxicity against cancer cells through disruption of membrane subdomains called lipid rafts. Protopanaxadiol (PPD) exhibits the highest cytotoxic e...

    Authors: Bonggoo Park, Yong-Moon Lee, Jae-Sung Kim, Youl Her, Ju Hee Kang, Seung-Hyun Oh and Hwan-Mook Kim
    Citation: BMC Complementary and Alternative Medicine 2013 13:194
    Content type: Research article Published on:

  37. Arsenic is widely distributed in the environment and has been found to be associated with the various health related problems including skin lesions, cancer, cardiovascular and immunological disorders. The fru...

    Authors: Manish K Singh, Suraj S Yadav, Vineeta Gupta and Sanjay Khattri
    Citation: BMC Complementary and Alternative Medicine 2013 13:193
    Content type: Research article Published on:

  38. The absence of commercialized vaccines and antiviral agents against dengue has made the disease a major health concern around the world. With the current dengue virus transmission rate and incidences, the deve...

    Authors: Sau Har Lee, Yin Quan Tang, Anusyah Rathkrishnan, Seok Mui Wang, Kien Chai Ong, Rishya Manikam, Bobby Joe Payne, Indu Bala Jaganath and Shamala Devi Sekaran
    Citation: BMC Complementary and Alternative Medicine 2013 13:192
    Content type: Research article Published on:

  40. The present study was designed to investigate the antibacterial activities of the methanol extracts of four Cameroonian edible plants, locally used to treat microbial infections, and their synergistic effects ...

    Authors: Jaurès AK Noumedem, Marius Mihasan, Jules R Kuiate, Marius Stefan, Dumitru Cojocaru, Jean P Dzoyem and Victor Kuete
    Citation: BMC Complementary and Alternative Medicine 2013 13:190
    Content type: Research article Published on:

  41. Though Mica, a thin and sheet like mineral, has been used as a mineral medicine for treatment of bleeding, dysentery and inflammation in traditional medicine including Ayurveda, the biological evidences of Mica w...

    Authors: Sung-Yun Cho, Hyo-Jeong Lee, Sun-Mi Cho, Bonglee Kim, Yeon Kwon Jung and Sung-Hoon Kim
    Citation: BMC Complementary and Alternative Medicine 2013 13:189
    Content type: Research article Published on:

  42. Previous studies of Gynura procumbens (G. procumbens) have shown that partially purified fractions of the leaves are capable of lowering the blood pressure of rats by inhibiting angiotensin-converting enzymic act...

    Authors: Hien-Kun Ng, Ting-Fung Poh, Sau-Kuen Lam and See-Ziau Hoe
    Citation: BMC Complementary and Alternative Medicine 2013 13:188
    Content type: Research article Published on:

  43. It has been supposed that green tea polyphenols (GTPs) have neuroprotective effects on brain damage after brain ischemia in animal experiments. Little is known regarding GTPs’ protective effects against the bl...

    Authors: Xiaobai Liu, Zhenhua Wang, Ping Wang, Bo Yu, Yunhui Liu and Yixue Xue
    Citation: BMC Complementary and Alternative Medicine 2013 13:187
    Content type: Research article Published on:

  44. Total glucosides of paeony (TGP) is a biologically active compound extracted from Paeony root. TGP has been used in rheumatoid arthritis therapy for many years. However, the mechanism by which TGP prevents bone l...

    Authors: Chen Chao Wei, Fan Tian You, Li Yu Mei, Sun Jian and Chen Yong Qiang
    Citation: BMC Complementary and Alternative Medicine 2013 13:186
    Content type: Research article Published on:

  45. Hepatocellular carcinoma (HCC) is a common and aggressive cancer, and the treatment options are limited for patients with advanced HCC. Bufalin, the major digoxin-like component of the traditional Chinese medi...

    Authors: Dong-Ze Qiu, Zhou-Ji Zhang, Wei-Zhong Wu and Yun-Ke Yang
    Citation: BMC Complementary and Alternative Medicine 2013 13:185
    Content type: Research article Published on:

  46. Propolis is a resin collected by bees from plant buds and exudates, which is further processed through the activity of bee enzymes. Propolis has been shown to possess many biological and pharmacological proper...

    Authors: Isabel Valença, Filipa Morais-Santos, Vera Miranda-Gonçalves, Ana Margarida Ferreira, Cristina Almeida-Aguiar and Fátima Baltazar
    Citation: BMC Complementary and Alternative Medicine 2013 13:184
    Content type: Research article Published on:

  47. Mitrella kentii (M. kentii) (Bl.) Miq, is a tree-climbing liana that belongs to the family Annonaceae. The plant is rich with isoquinoline alkaloids, terpenylated dihydrochalcones and benzoic acids and has been ...

    Authors: Heyam Mohamed Ali Sidahmed, Ainnul Hamidah Syahadah Azizan, Syam Mohan, Mahmood Ameen Abdulla, Siddig Ibrahim Abdelwahab, Manal Mohamed Elhassan Taha, A Hamid A Hadi, Kamal Aziz Ketuly, Najihah Mohd Hashim, Mun Fai Loke and Jamuna Vadivelu
    Citation: BMC Complementary and Alternative Medicine 2013 13:183
    Content type: Research article Published on:

  48. Leptospirosis, one of the most widespread zoonotic infectious diseases worldwide, is caused by spirochetes bacteria of the genus Leptospira. The present study examined inhibitory activity of purified xanthones an...

    Authors: Weeranuch Seesom, Amornmart Jaratrungtawee, Sunit Suksamrarn, Chantana Mekseepralard, Piniti Ratananukul and Wasana Sukhumsirichart
    Citation: BMC Complementary and Alternative Medicine 2013 13:182
    Content type: Research article Published on:

  49. The growing quantity of Complementary and Alternative Medicine literature requires databases enabled with increasingly powerful search capabilities. To address this need in the area of acupuncture research, a ...

    Authors: Benjamin L Marx, Ryan Milley, Dara G Cantor, Deborah L Ackerman and Richard Hammerschlag
    Citation: BMC Complementary and Alternative Medicine 2013 13:181
    Content type: Database Published on:

  50. Our aim was to evaluate the recovery effects of hydrotherapy after aerobic exercise in cardiovascular, performance and perceived fatigue.

    Authors: Antonio I Cuesta-Vargas, Alvaro Travé-Mesa, Alberto Vera-Cabrera, Dario Cruz-Terrón, Adelaida M Castro-Sánchez, Cesar Fernández-de-las-Peñas and Manuel Arroyo-Morales
    Citation: BMC Complementary and Alternative Medicine 2013 13:180
    Content type: Research article Published on:
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