Bateman ED, Hurd SS, Barnes PJ, Bousquet J, Drazen JM, FitzGerald M, Gibson P, Ohta K, O'Byrne P, Pedersen SE, Pizzichini E, Sullivan SD, Wenzel SE, Zar HJ: Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J. 2008, 31 (1): 143-178. 10.1183/09031936.00138707.
Article
CAS
PubMed
Google Scholar
Holgate ST, Davies DE: Rethinking the pathogenesis of asthma. Immunity. 2009, 31 (3): 362-367. 10.1016/j.immuni.2009.08.013.
Article
CAS
PubMed
Google Scholar
Gern JE, Lemanske RF, Busse WW: Early life origins of asthma. J Clin Invest. 1999, 104 (7): 837-843. 10.1172/JCI8272.
Article
CAS
PubMed
PubMed Central
Google Scholar
Claudio L, Tulton L, Doucette J, Landrigan PJ: Socioeconomic factors and asthma hospitalization rates in New York City. J Asthma. 1999, 36 (4): 327-343. 10.3109/02770909909068225.
Article
Google Scholar
Bousquet J, Jeffery PK, Busse WW, Johnson M, Vignola AM: Asthma From bronchoconstriction to airways inflammation and remodeling. Am J Respir Crit Care Med. 2000, 161 (5): 1720-1745. 10.1164/ajrccm.161.5.9903102.
Article
CAS
PubMed
Google Scholar
Kroegel C: Global Initiative for Asthma (GINA) guidelines: 15 years of application. Expert Rev Clin Immunol. 2009, 5 (3): 239-249. 10.1586/eci.09.1.
Article
PubMed
Google Scholar
Dorinsky : The salmeterol multicenter asthma research trial: A comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterol (vol 129, pg 15, 2006). Chest. 2006, 129 (5): 1393-
Google Scholar
Gibson PG, Powell H, Ducharme FM: Differential effects of maintenance long-acting beta-agonist and inhaled corticosteroid on asthma control and asthma exacerbations. J Allergy Clin Immun. 2007, 119 (2): 344-350. 10.1016/j.jaci.2006.10.043.
Article
CAS
PubMed
Google Scholar
Lemanske RF, Sorkness CA, Mauger EA, Lazarus SC, Boushey HA, Fahy JV, Drazen JM, Chinchilli VM, Craig T, Fish JE, Ford JG, Israel E, Kraft M, Martin RJ, Nachman SA, Peters SP, Spahn JD, Szefler SJ: Inhaled corticosteroid reduction and elimination in patients with persistent asthma receiving salmeterol - A randomized controlled trial. Jama-J Am Med Assoc. 2001, 285 (20): 2594-2603. 10.1001/jama.285.20.2594.
Article
CAS
Google Scholar
Wechsler ME, Pauwels R, Drazen JM: Leukotriene modifiers and Churg-Strauss syndrome - Adverse effect or response to corticosteroid withdrawal?. Drug Saf. 1999, 21 (4): 241-251. 10.2165/00002018-199921040-00001.
Article
CAS
PubMed
Google Scholar
Barnes PJ: Theophylline - New perspectives for an old drug. Am J Resp Crit Care. 2003, 167 (6): 813-818. 10.1164/rccm.200210-1142PP.
Article
Google Scholar
Hou Y, Li R, Shi Q, Cheng B, Wang L, Bai R: Investigation of the Anti-asthmatic Mechanism of QingFeiXiaoYanWan. Acta Scientiarum Naturalium Universitatis Nankaiensis. 2009, 5: 103-107.
Google Scholar
Cheng B, Hou Y, Wang L, Dong L, Peng J, Bai G: Dual-bioactivity-based liquid chromatography-coupled quadrupole time-of-flight mass spectrometry for NF-kappaB inhibitors and beta2AR agonists identification in Chinese Medicinal Preparation Qingfei Xiaoyan Wan. Anal Bioanal Chem. 2012, 404 (8): 2445-2452. 10.1007/s00216-012-6332-9.
Article
CAS
PubMed
Google Scholar
Vogel G, Vogel WH, Vogel HG: Drug Discovery and Evaluation: Pharmacological Assays. 1997, Berlin: Springer
Book
Google Scholar
Fan X, Shi M, Wang Y, Liang Q, Luo G: Transcriptional profiling analysis of HMP-treated rats with experimentally induced myocardial infarction. J Ethnopharmacol. 2011, 137 (1): 199-204. 10.1016/j.jep.2011.05.010.
Article
CAS
PubMed
Google Scholar
Mutter GL, Zahrieh D, Liu CM, Neuberg D, Finkelstein D, Baker HE, Warrington JA: Comparison of frozen and RNALater solid tissue storage methods for use in RNA expression microarrays. BMC Genomics. 2004, 5: 88-94. 10.1186/1471-2164-5-88.
Article
PubMed
PubMed Central
Google Scholar
Pedotti P, Hoen PA T, Vreugdenhil E, Schenk GJ, Vossen RH, Ariyurek Y, De Hollander M, Kuiper R, Van Ommen G, Den Dunnen JT, Boer JM, De Menezes RX: Can subtle changes in gene expression be consistently detected with different microarray platforms?. BMC Genomics. 2008, 9: 124-136. 10.1186/1471-2164-9-124.
Article
PubMed
PubMed Central
Google Scholar
Basic BLAST.http://blast.ncbi.nlm.nih.gov/Blast.cgi,
Molecule Annotation System.http://bioinfo.capitalbio.com/mas3/,
Fan X, Li X, Lv S, Wang Y, Zhao Y, Luo G: Comparative proteomics research on rat MSCs differentiation induced by Shuanglong Formula. J Ethnopharmacol. 2010, 131 (3): 575-580. 10.1016/j.jep.2010.07.036.
Article
CAS
PubMed
Google Scholar
Human Protein Reference Database.http://www.hprd.org/,
Genetic Association Database.http://geneticassociationdb.nih.gov/,
Cline MS, Smoot M, Cerami E, Kuchinsky A, Landys N, Workman C, Christmas R, Avila-Campilo I, Creech M, Gross B, Hanspers K, Isserlin R, Kelley R, Killcoyne S, Lotia S, Maere S, Morris J, Ono K, Pavlovic V, Pico AR, Vailaya A, Wang PL, Adler A, Conklin BR, Hood L, Kuiper M, Sander C, Schmulevich I, Schwikowski B, Warner GJ: Integration of biological networks and gene expression data using Cytoscape. Nat Protoc. 2007, 2 (10): 2366-2382. 10.1038/nprot.2007.324.
Article
CAS
PubMed
PubMed Central
Google Scholar
NCBI EST database.http://www.ncbi.nlm.nih.gov/nucest/,
KEGG PATHWAY Database.http://www.genome.jp/kegg/pathway.html,
GenMapp: Gene Map Annotation and Pathway Profiler.http://www.genmapp.org/default.html,
BioCarta.http://www.biocarta.com/genes/index.asp,
Bates JH, Rincon M, Irvin CG: Animal models of asthma. Am J Physiol Lung Cell Mol Physiol. 2009, 297 (3): L401-L410. 10.1152/ajplung.00027.2009.
Article
CAS
PubMed
PubMed Central
Google Scholar
Canning BJ: Modeling asthma and COPD in animals: a pointless exercise?. Curr Opin Pharmacol. 2003, 3 (3): 244-250. 10.1016/S1471-4892(03)00045-6.
Article
CAS
PubMed
Google Scholar
Szelenyi I: Animal models of bronchial asthma. Inflamm Res. 2000, 49 (12): 639-654. 10.1007/s000110050642.
Article
CAS
PubMed
Google Scholar
Holgate ST: Pathogenesis of asthma. Clin Exp Allergy. 2008, 38 (6): 872-897. 10.1111/j.1365-2222.2008.02971.x.
Article
CAS
PubMed
Google Scholar
Kitanaka J, Kitanaka N, Takemura M, Wang XB, Hembree CM, Goodman NL, Uhl GR: Isolation and Sequencing of a putative promoter region of the murine G protein beta 1 subunit (GNB1) gene. Dna Sequence. 2002, 13 (1): 39-45.
Article
CAS
PubMed
Google Scholar
Moya-Quiles MR, Ballesta-Martinez MJ, Lopez-Gonzalez V, Glover G, Guillen-Navarro E: A compound heterozygous mutation in the EDAR gene in a Spanish family with autosomal recessive hypohidrotic ectodermal dysplasia. Arch Dermatol Res. 2010, 302 (4): 307-310. 10.1007/s00403-009-1013-z.
Article
CAS
PubMed
Google Scholar
Shaul YD, Seger R: The MEK/ERK cascade: From signaling specificity to diverse functions. Bba-Mol Cell Res. 2007, 1773 (8): 1213-1226. 10.1016/j.bbamcr.2006.10.005.
CAS
Google Scholar
McCubrey JA, Milella M, Tafuri A, Martelli AM, Lunghi P, Bonati A, Cervello M, Lee JT, Steelman LS: Targeting the Raf/MEK/ERK pathway with small-molecule inhibitors. Curr Opin Investig Drugs. 2008, 9 (6): 614-630.
CAS
PubMed
Google Scholar
Verhaeghe C, Remouchamps C, Hennuy B, Vanderplasschen A, Chariot A, Tabruyn SP, Oury C, Bours V: Role of IKK and ERK pathways in intrinsic inflammation of cystic fibrosis airways. Biochem Pharmacol. 2007, 73 (12): 1982-1994. 10.1016/j.bcp.2007.03.019.
Article
CAS
PubMed
Google Scholar
Perkins ND: Post-translational modifications regulating the activity and function of the nuclear factor kappa B pathway. Oncogene. 2006, 25 (51): 6717-6730. 10.1038/sj.onc.1209937.
Article
CAS
PubMed
Google Scholar
Weiss T, Shalit I, Blau H, Werber S, Halperin D, Levitov A, Fabian I: Anti-inflammatory effects of moxifloxacin on activated human monocytic cells: Inhibition of NF-KB and mitogen-activated protein kinase activation and of synthesis of proinflammatory ctokines. Antimicrob Agents Ch. 2004, 48 (6): 1974-1982. 10.1128/AAC.48.6.1974-1982.2004.
Article
CAS
Google Scholar
Lee FS, Peters RT, Dang LC, Maniatis T: MEKK1 activates both I kappa B kinase alpha and I kappa B kinase beta. P Natl Acad Sci Usa. 1998, 95 (16): 9319-9324. 10.1073/pnas.95.16.9319.
Article
CAS
Google Scholar
Fontana J, Fulton D, Chen Y, Fairchild TA, McCabe TJ, Fujita N, Tsuruo T, Sessa WC: Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and NO release. Circ Res. 2002, 90 (8): 866-873. 10.1161/01.RES.0000016837.26733.BE.
Article
CAS
PubMed
Google Scholar
Ozes ON, Mayo LD, Gustin JA, Pfeffer SR, Pfeffer LM, Donner DB: NF-kappa B activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature. 1999, 401 (6748): 82-85. 10.1038/43466.
Article
CAS
PubMed
Google Scholar
Sato S, Fujita N, Tsuruo T: Modulation of Akt kinase activity by binding to Hsp90. P Natl Acad Sci Usa. 2000, 97 (20): 10832-10837. 10.1073/pnas.170276797.
Article
CAS
Google Scholar
Gettins P, Olson ST: Exosite Determinants of Serpin Specificity. J Biol Chem. 2009, 284 (31): 20441-20445. 10.1074/jbc.R800064200.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ekeowa UI, Marciniak SJ, Lomas DA: alpha(1)-antitrypsin deficiency and inflammation. Expert Rev Clin Immunol. 2011, 7 (2): 243-252. 10.1586/eci.10.95.
Article
CAS
PubMed
Google Scholar
Janciauskiene SM, Bals R, Koczulla R, Vogelmeier C, Kohnlein T, Welte T: The discovery of alpha 1-antitrypsin and its rote in health and disease. Resp Med. 2011, 105 (8): 1129-1139. 10.1016/j.rmed.2011.02.002.
Article
Google Scholar
Shigetomi H, Onogi A, Kajiwara H, Yoshida S, Furukawa N, Haruta S, Tanase Y, Kanayama S, Noguchi T, Yamada Y, Oi H, Kobayashi H: Anti-inflammatory actions of serine protease inhibitors containing the Kunitz domain. Inflamm Res. 2010, 59 (9): 679-687. 10.1007/s00011-010-0205-5.
Article
CAS
PubMed
Google Scholar
Zhang B, Hu Y, Ma JX: Anti-inflammatory and antioxidant effects of SERPINA3K in the retina. Invest Ophthalmol Vis Sci. 2009, 50 (8): 3943-3952. 10.1167/iovs.08-2954.
Article
PubMed
Google Scholar
Meyer N, Akdis CA: Vascular Endothelial Growth Factor as a Key Inducer of Angiogenesis in the Asthmatic Airways. Curr Allergy Asthma Rep. 2013, 13 (1): 1-9. 10.1007/s11882-012-0317-9.
Article
CAS
PubMed
Google Scholar
Budd DC, Holmes AM: Targeting TGF beta superfamily ligand accessory proteins as novel therapeutics for chronic lung disorders. Pharmacol Therapeut. 2012, 135 (3): 279-291. 10.1016/j.pharmthera.2012.06.001.
Article
CAS
Google Scholar
Engelse MA, Neele JA, Bronckers A, Pannekoek H, De Vries C: Vascular calcification: expression patterns of the osteoblast-specific gene core binding factor alpha-1 and the protective factor matrix gla protein in human atherogenesis. Cardiovasc Res. 2001, 52 (2): 281-289. 10.1016/S0008-6363(01)00375-3.
Article
CAS
PubMed
Google Scholar
Bostrom K, Zebboudj AF, Yao YC, Lin TS, Torres A: Matrix GLA protein stimulates VEGF expression through increased transforming growth factor-beta 1 activity in endothelial cells. J Biol Chem. 2004, 279 (51): 52904-52913. 10.1074/jbc.M406868200.
Article
PubMed
Google Scholar
Boulet LP, Turcotte H, Laviolette M, Naud F, Bernier MC, Martel S, Chakir J: Airway hyperresponsiveness, inflammation, and subepithelial collagen deposition in recently diagnosed versus long-standing mild asthma - Influence of inhaled corticosteroids. Am J Resp Crit Care. 2000, 162 (4): 1308-1313. 10.1164/ajrccm.162.4.9910051.
Article
CAS
Google Scholar
Vignola AM, Mirabella F, Costanzo G, Di Giorgi R, Gjomarkaj M, Bellia V, Bonsignore G: Airway remodeling in asthma. Chest. 2003, 123S (3): 417S-422S.
Article
Google Scholar
Burgess JK: The role of the extracellular matrix and specific growth factors in the regulation of inflammation and remodelling in asthma. Pharmacol Therapeut. 2009, 122 (1): 19-29. 10.1016/j.pharmthera.2008.12.002.
Article
CAS
Google Scholar