- Research article
- Open Access
Use of alternative medicine, ginger and licorice among Danish pregnant women – a prospective cohort study
BMC Complementary and Alternative Medicine volume 19, Article number: 5 (2019)
The use of alternative medicines and dietary supplements is constantly changing, as are dietary habits. One example of this phenomenon is the current popularity of ginger products as an everyday health boost. Ginger and licorice has also been shown to ameliorate nausea a common complaint in early pregnancy. Alternative medicines are often regarded as safe. However, they might affect fetal development, such as through alterations of hormone metabolism and cytochrome P450 function. Health care professionals may be unaware of the supplementation habits of pregnant women, which may allow adverse exposures to go unnoticed, especially if the rates of use in pregnancy are not known. We therefore investigated the use of alternative medicines and licorice among pregnant Danish women.
A total of 225 pregnant women were included in a prospective cohort when attending the national prenatal screening program at gestational weeks 10–16. Participants were asked to complete a questionnaire regarding their socio-economic status and lifestyle habits, including their intake of alternative medicine and licorice.
We found that 22.7% of women reported taking alternative medicines, with 14.7% reporting daily consumption. Ginger supplements were consumed by 11.1%, mainly as health boost and 87.1% reported consumption of licorice. Regular or daily licorice consumption was reported by 38.2 and 7.1%, respectively. Notably, the use of licorice was reflected by an increase in blood pressure of the pregnant women.
The use of licorice and alternative medicines appears to be common in pregnant Danish women, supporting the need for further investigations into the safety of alternative medicine use during pregnancy and the importance of up-to-date personalized counseling regarding popular health trends and lifestyle habits.
In modern society, everyday lifestyles are constantly changing. With the plethora of internet-based platforms, new health trends can spread rapidly among pregnant women. Such habits may escape the attention of health care professionals, allowing adverse exposures in early pregnancy to go undetected. International data supports the hypothesis that pregnant women perceive herbal and conventional medications as quite harmless . Moreover, a recent study reported that recommendations to take contra-indicated herbal medicines during pregnancy may come directly from health care professionals .
A multinational study from 2016 suggested that up to 60% of all pregnant women use herbal-based alternative medicines . However, cultural differences in the use of alternative medicine are well-established, even within the Scandinavian and Nordic countries. In Iceland, the prevalence has been reported to be as high as 35%, in contrast to Norway and Sweden where the prevalence has been reported to be 17 and 4%, respectively . However, the prevalence of such use among pregnant women in Denmark has not previously been published.
Importantly, the safety of many herbal remedies has never been investigated in human pregnancies, as no strict rules for safety testing apply to alternative medicine  despite their teratogenic potential . Several adverse effects caused by alternative medicine in pregnancy have been described, including miscarriage, preterm delivery, and malformations. Interestingly, recent data suggest that between 2.5–13% of pregnant women use alternative medicines together with prescribed medications . However, there are limited published data investigating the adverse effects of alternative medicine due to their direct chemical toxicity, herbal-drug or herbal-herbal interactions.
Studies have shown that the majority (76%) of women who self-administer herbal medicine during pregnancy do not disclose their use to their doctor or midwife , making such use a potential safety concern.
Common exposure during pregnancy includes the use of ginger, which for decades has been the most widely used herbal remedy in the management of pregnancy-related nausea and vomiting. In addition, ginger is thought to strengthen the immune system and generally boost human health, leading to an increased popularity in recent years. At present, ginger is often added to consumables routinely sold in Danish supermarkets, such as teas and shots. The use of ginger as a health booster could lead to increased and continuous consumption throughout pregnancy, yet no guidelines currently exist in relation to the permissible amount of ginger exposure, even though ginger as a dietary supplement is not recommended by the Danish Veterinary and Food Administration. Several studies have found occasional use of ginger as an anti-emetic to be safe . However, recent reports have shown that pharmacologically active substances in ginger may increase the risk of bleeding by decreasing platelet aggregation , and ginger-based compounds have been suspected to increase the risk of stillbirth . If unaware of these potential risk pregnant women might continue their ginger habits throughout pregnancy – in particular if also obtaining a reduction of nausea that might give them the impression that ginger is well-tolerated by the body. Originally, licorice was used against upper respiratory problems and stomach inflammation while today it is primarily eaten for pleasure. However, a double-blind randomized study found a positive effect of licorice in prevention of acid reflux and vomiting . Nausea and vomiting are common complains during pregnancy underlining that eating habits may also reflect a subconscious “self-medication” strategy in particular in Scandinavia were licorice based candies are well-known and popular. However, licorice can increase blood pressure, and the content of glycyrrhizin - the major active constituents of licorice - can also decrease platelet aggregation  making it a key problem that several candy products with licorice is increasingly being consumed during pregnancy.
As a systematic report of the current use of licorice, alternative medicines and other herbal supplements among pregnant Danish women has never been reported, the aim of this study was to assess the prevalence and characteristics of alternative medicine, ginger and licorice use among Danish pregnant women.
In this prospective cohort study, we included participants seen at the Department of Obstetrics and Gynecology, Randers Regional Hospital, Denmark between June 2016 and December 2016. The inclusion criteria was attendance at a routine ultrasound examination in gestational week 10–16, which is accepted by more than 95% of the pregnant women in the recruitment area where this scan is not offered elsewhere. Exclusion criteria included an age below 18 years and poor language skills.
The study was approved by the Regional Scientific Ethical Committee (VEK 1–10–72-75-16) and followed the Helsinki guidelines of informed consent. Due to additional obligations, we could only recruit participants 2–3 days a week. On these days all eligible women were invited in correlation with their random given times at the ultrasound unit (Table 1).
The participants answered a questionnaire at recruitment or during a phone call within 1–2 weeks regarding the following information: age, parity, Body Mass Index (BMI), smoking, alcohol, licorice intake, socio-economic status, educational level, use of prescription and over the counter medicine (OTC), supplemental vitamins, and intake of alternative medications including herbal supplements (e.g., teas). If the women used any health supplements or followed a specific nutritional lifestyle, they were asked to specify the amount and duration of the various intakes. After delivery, we obtained information regarding outcomes from the women’s electronic medical records (Additional file 1: Table S2).
Continuous variables were compared between groups using Student’s tests or Mann-Whitney testing based on the testing of normal distribution of the data. Two-tailed comparisons were performed unless otherwise noted. Data are summarized as the means ± SD. GraphPad Prism version 7.03 Software (GraphPad Software, Inc., San Diego, CA, USA) was used to analyse the Student’s t-test and Mann-Whitney test results as well as confidence intervals presented in the relevant Tables. A level of significance at or below 0.05 was considered statistically significant for all analyses.
Among 297 eligible Danish women attending a routine first trimester ultrasound scan during our presence, we included 225 (75.8%) women who accepted to participate in the study, corresponding to a prevalence of 23.1% of all birth at Randers Regional Hospital in the inclusion period. Lack of time was the most common reason given for non-participation.
All women were interviewed, all but one returned the completed questionnaire living a study population for this study of 224.
The vast majority 71.8% (n = 158) had a spontaneous vaginal delivery (for details on birth complications and new born Apgar score see Additional file 1: Table S2). Of the 224 women from whom questionnaire data were available, data on birth weight and infant health was available from 217 participants. Of the seven missing individuals, four had a spontaneous abortion (1.8%), and three (1.3%) were lost to follow up at birth, because they had moved to another district (Additional file 2: Figure S1). Information regarding the correspondence between exposures and outcome was based on the 217 women that gave birth at Randers Regional Hospital. (For details on parity and lifestyle see Additional file 3: Table S1).
Up to 22.7% (n = 51) reported consumption of at least one type of alternative medicine, 14.7% (n = 33) reported doing so daily, and 4.9% (n = 11) took more than one remedy regularly. This intake was associated with chronic health issues (31.3%; 20 of 64), of which the majority reported a daily use (20.0%; 13 of 65), and a high household income (32.3%; 10 of 31; Table 2).
Ginger products were the most frequently used form of alternative medicine (11.1%, n = 25), such as through shots (7.1%; n = 16), tea, tablets, and oil. Among these, 3.1% (n = 7) reported taking them alongside prescription or OTC medicine. Only 2.7% (n = 6) used ginger for nausea and vomiting. The intake of ginger products was associated with chronic health issues (17.2%; 11 of 64), mean maternal age 31.8 years (95% CI: 29.9–33.6) among users vs. 29.5 years (95% CI: 28.6–30.1) among non-users (p = 0.02), mean birthweight 3572 g (95% CI: 3316-3827 g) among exposed vs. 3440 g (95% CI: 3355-3525 g) among unexposed (p = 0.28). Additionally, the consumption rate of ginger increased with higher levels of education, lowest among women with an upper secondary school education (5.9%; 1 of 17) and highest among women with a master’s degree (14.8%; 4 of 27).
Other frequently used products included peppermint tea for nausea (1.8%; n = 4), Psyllium Husk Fiber® for obstipation (6.7%; n = 15), and Kräuterblut® as an herbal substitute for iron supplements (2.7%; n = 6), see Table 3 and Table 4.
No less than 87.1% (n = 196) reported consuming licorice, 38.2% (n = 86) reported licorice consumption at least “a couple of times a week,” and 7.1% (n = 16) reported daily use. On each occasion of consumption, 33.8% (n = 76) ate at least a handful of licorice candies, and 4.4% (n = 10) reported consuming an entire bag of licorice. All participants with hypertension (1.3%; n = 3) reported a weekly consumption of licorice. Moreover, the frequency of licorice intake was also associated, albeit not significantly, with reduced birthweight (see Fig. 1). Differences in mean blood pressures between women reporting a mean daily intake of licorice (123 mmHg, 95% CI: 116–130 mmHg) and women reporting rare or no intake of licorice (119 mmHg, 95% CI: 117–121 mmHg) were significantly associated with increased maternal systolic blood pressure (p = 0.04), estimated via one-tailed Mann-Whitney testing based on the known effects of licorice on blood pressure (see Table 5).
The main finding of this cohort study of Danish pregnant women was that 23% reported using alternative medicines, with ginger products being by far the most popular item. Furthermore, 87% reported consuming licorice, with 7% reporting daily use.
Performing the study in an unbiased manner where the eligible population was representative of the entire population in the geographic area, and achieving an overall participation rate of 76%, strengthen the value and validity of the findings. Notably, we cannot exclude that selection bias occurred, as the women had to accept participation. However, ultra-performance liquid chromatography with high-resolution time-of-flight mass spectrometry (UPLC-HR-TOFMS) analysis of the pharmacological content of the blood samples from the same cohort (Volqvartz and Vestergaard et al. in prep) indicates a high degree of consistence between results from this cohort and a similar UPLC-HR-TOFMS analysis of unselected, unbiased pregnant women from the same region performed by Aagaard and co-workers . Also, the organisation of the maternal care system supports that all women from all parts of society attends the same, free-of-charge prenatal diagnostic system. On the other hand, limiting our study to one single interview means we did not assess all exposures occurring in pregnancy and, the size of the cohort limits the power to demonstrate possible associations between exposure and adverse obstetric outcomes in particular if the exposures are rare. However, by asking the women specifically if ginger or other substances were used do to pregnancy related nausea or for other reasons we obtained indication of the duration of the use.
Finally, we did not specifically inquire regarding the intake of red-clover-containing pregnancy tonics, which might explain why this was not mentioned by any participant. Notably, red clover is rich in phytoestrogens , and prenatal exposure is suspected to have deleterious effects on the developing male reproductive system; knowledge of the red-clover use among our subjects would thus be valuable. Analysis of 7928 boys in the cohort of “The Avon Longitudinal Study of Parents and Children” (ALSPAC) found that a maternal vegetarian diet rich in phytoestrogens in pregnancy was associated with an increased risk of hypospadias .
The fraction (23%) of pregnant women taking alternative medicines in this Danish study is relatively high compared to previous studies in Sweden (4%), Finland (9%), Norway (17%), and Iceland (35%) , but not compared to a number of non-Nordic countries (29%) . However, the fraction appears lower than that among non-pregnant Danish pre-surgical patients of both genders (50%) . The comparison of these studies is limited to some extent by different study designs and different definitions of alternative medicine. However, the positive associations with household income and education level is consistent across several studies . With the size of this study, assessing specific adverse effects on fetal development might not be possible even with our focus on the time of organogenesis. However, studies of the Danish National Birth Cohort have found a higher risk for malformations after prenatal exposure to St. John’s wort . This herbal medicine is a “natural anti-depressant” known to affect the serotonin system in ways similar to conventional antidepressants, which is a potential safety concern in pregnancy. With the high prevalence of users of alternative medicines identified in this study, further studies into the teratogenic effects of other exposures are warranted.
In particular, it appears important to focus on the use of ginger products among pregnant women. In Denmark, supermarkets expect to double the selling of ginger shots in coming years , even though 77% of the ginger consumers in our study did not declare their intake to be caused by a need to relieve symptoms. Ginger, or its active compound 6-gingerol (see Fig. 2) interacts with the cytochrome P450 system (e.g., CYP3A4, CYP2C9)  and fetal testosterone metabolism , thus serving as a potential teratogenic item. Furthermore, a cohort study from Korea showed 4 stillbirths among 159 singleton-pregnancy women receiving dried ginger (OR = 7.8; 95% CI 2.9–21) compared to the general population . In addition, ginger decreases platelet aggregation, which may increase the risk of post-partum bleeding.
Additionally, the high use of licorice among pregnant women in Denmark deserves further attention. Regular consumption of licorice – and hence the active compound glycyrrhizin (see Fig. 3) - inhibits the 11-β-hydroxysteroid dehydrogenase type 2 (11-β-HSD2) enzyme, thereby activating cortisol and generating hypokalaemic hypertension . Notably, we observed a minor increase in maternal systolic blood pressure (p = 0.04) and lower birthweights among children exposed to frequent maternal intake of licorice. The downregulation of 11-β-HSD2 in the placenta may contribute to several of the pathways leading to an increased risk of preeclampsia , miscarriage , preterm birth , toxicological effects , and lower intelligence quotient, poor memory and increased risk of attention deficit in the child . Furthermore, the phytoestrogen found in licorice, glabridin, might explain the pubertal advancement seen in girls prenatally exposed to licorice [25, 26].
In this study, we characterized lifestyle habits at the end of the first trimester of pregnancy, which is a very critical period of organogenesis . Notably, several studies into the Developmental Origins of Health and Disease Hypothesis (DOHaD) have shown that different effect occur in responds to reprogramming at different part of the pregnancy (for a review see Roseboom and coworkers ). Further studies should be aimed at including additional information of the habits in later pregnancy and expand the number of participants as it cannot be excluded that changes in habits occur during pregnancy which could also affect offspring health.
In a Danish context, ginger and liquorice are commonly ingested by pregnant women as are alternative medications. Based on our results and the discussion above, we recommend that health providers actively seek to increase their knowledge of the eating habits and alternative medicine use of pregnant women to avoid unnecessary health risk in pregnancy.
Body Mass Index
Developmental Origins of Health and Disease Hypothesis
Ultra-Performance Liquid Chromatography with High-Resolution Time-Of-Flight Mass Spectrometry Analysis
Hall HG, Griffiths DL, McKenna LG. The use of complementary and alternative medicine by pregnant women: a literature review. Midwifery. 2011;27(6):817–24.
Kennedy DA, Lupattelli A, Koren G, Nordeng H. Safety classification of herbal medicines used in pregnancy in a multinational study. BMC Complement Altern Med. 2016;16:102.
Kennedy DA, Lupattelli A, Koren G, Nordeng H. Herbal medicine use in pregnancy: results of a multinational study. BMC Complement Altern Med. 2013;13(1):355.
Danish Medicines Agency. Guidance on marketing authorization for herbal remedies (Markedsføringstilladelse til naturlægemidler) [Internet]. Lægemiddelstyrelsen. [cited 2017 Nov 30]. Available from: https://laegemiddelstyrelsen.dk/da/godkendelse/godkendelse-af-medicin/markedsfoeringstilladelse/ansoegning-om-markedsfoeringstilladelse/markedsfoeringstilladelse-til-naturlaegemidler/
Mills E, Dugoua J-J, Perri D. Herbal medicines in pregnancy and lactation: an evidence-based approach. 1st edition. United Kingdom: CRC Press. Taylor & Francis Group; 2006.
McLay JS, Izzati N, Pallivalapila AR, Shetty A, Pande B, Rore C, et al. Pregnancy, prescription medicines and the potential risk of herb-drug interactions: a cross-sectional survey. BMC Complement Altern Med. 2017;17(1):543.
Frawley J, Adams J, Steel A, Broom A, Gallois C, Sibbritt D. Women’s use and self-prescription of herbal medicine during pregnancy: an examination of 1,835 pregnant women. Womens Health Issues Off Publ Jacobs Inst Womens Health. 2015;25(4):396–402.
Heitmann K, Nordeng H, Holst L. Safety of ginger use in pregnancy: results from a large population-based cohort study. Eur J Clin Pharmacol. 2013;69(2):269–77.
Marx W, McKavanagh D, McCarthy AL, Bird R, Ried K, Chan A, et al. The Effect of Ginger (Zingiber officinale) on Platelet Aggregation: A Systematic Literature Review. PLoS ONE [Internet]. 2015 [cited 2017 Nov 23];10(10). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619316/
Choi JS, Han JY, Ahn HK, Lee SW, Koong MK, Velazquez-Armenta EY, et al. Assessment of fetal and neonatal outcomes in the offspring of women who had been treated with dried ginger (Zingiberis rhizoma siccus) for a variety of illnesses during pregnancy. J Obstet Gynaecol J Inst Obstet Gynaecol. 2015;35(2):125–30.
Raveendra KR, Jayachandra, Srinivasa V, Sushma KR, Allan JJ, Goudar KS, et al. An Extract of Glycyrrhiza glabra (GutGard) Alleviates Symptoms of Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled Study. Evid-Based Complement Altern Med ECAM [Internet]. 2012 [cited 2018 Nov 6];2012. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3123991/
Okuda-Tanino A, Sugawara D, Tashiro T, Iwashita M, Obara Y, Moriya T, et al. Licochalcones extracted from Glycyrrhiza inflata inhibit platelet aggregation accompanied by inhibition of COX-1 activity. PLoS One. 2017;12(3):e0173628.
Aagaard SK, Larsen A, Andreasen MF, Lesnikova I, Telving R, Vestergaard AL, et al. Prevalence of xenobiotic substances in first-trimester blood samples from Danish pregnant women: a cross-sectional study. BMJ Open. 2018;8(3):e018390.
Humfrey CD. Phytoestrogens and human health effects: weighing up the current evidence. Nat Toxins. 1998;6(2):51–9.
North K, Golding J. A maternal vegetarian diet in pregnancy is associated with hypospadias. The ALSPAC study team. Avon longitudinal study of pregnancy and childhood. BJU Int. 2000;85(1):107–13.
Vaabengaard P, Clausen LM. Surgery patients’ intake of herbal preparations and dietary supplements. Ugeskr Laeger. 2003;165(35):3320–3.
Kolding L, Pedersen LH, Henriksen TB, Olsen J, Grzeskowiak LE. Hypericum perforatum use during pregnancy and pregnancy outcome. Reprod Toxicol Elmsford N. 2015;58:234–7.
Bleeg MT. Danskerne drikker ingefærshots som aldrig før: Det er unødvendigt - TV 2. livsstil.tv2.dk [Internet]. 2016 [cited 2017 Nov 23]; Available from: http://livsstil.tv2.dk/sundhed/2016-04-19-danskerne-drikker-ingefaershots-som-aldrig-foer-det-er-unoedvendigt
Qiu J-X, Zhou Z-W, He Z-X, Zhang X, Zhou S-F, Zhu S. Estimation of the binding modes with important human cytochrome P450 enzymes, drug interaction potential, pharmacokinetics, and hepatotoxicity of ginger components using molecular docking, computational, and pharmacokinetic modeling studies. Drug Des Devel Ther. 2015;9:841–66.
Søndergaard K. [Ginger, pregnancy nausea and possible fetal injuries (testosterone effect)]. Ugeskr Laeger. 2008;170(5):359; author reply 359.
Räikkönen K, Pesonen A-K, Heinonen K, Lahti J, Komsi N, Eriksson JG, et al. Maternal licorice consumption and detrimental cognitive and psychiatric outcomes in children. Am J Epidemiol. 2009;170(9):1137–46.
Cuzzolin L, Francini-Pesenti F, Verlato G, Joppi M, Baldelli P, Benoni G. Use of herbal products among 392 Italian pregnant women: focus on pregnancy outcome. Pharmacoepidemiol Drug Saf. 2010;19(11):1151–8.
Strandberg TE, Järvenpää AL, Vanhanen H, McKeigue PM. Birth outcome in relation to licorice consumption during pregnancy. Am J Epidemiol. 2001;153(11):1085–8.
Nazari S, Rameshrad M, Hosseinzadeh H. Toxicological effects of Glycyrrhiza glabra (licorice): a review. Phytother Res PTR. 2017;31(11):1635–50.
Räikkönen K, Martikainen S, Pesonen A-K, Lahti J, Heinonen K, Pyhälä R, et al. Maternal licorice consumption during pregnancy and pubertal, cognitive, and psychiatric outcomes in children. Am J Epidemiol. 2017;185(5):317–28.
Simmler C, Pauli GF, Chen S-N. Phytochemistry and biological properties of glabridin. Fitoterapia. 2013;90:160–84.
Roseboom TJ, van der Meulen JH, Ravelli AC, Osmond C, Barker DJ, Bleker OP. Effects of prenatal exposure to the Dutch famine on adult disease in later life: an overview. Mol Cell Endocrinol. 2001;185(1–2):93–8.
Roseboom TJ, Painter RC, van Abeelen AFM, Veenendaal MVE, de Rooij SR. Hungry in the womb: what are the consequences? Lessons from the Dutch famine. Maturitas. 2011;70(2):141–5.
Li J, Cao H, Liu P, Cheng G, Sun M. Glycyrrhizic Acid in the Treatment of Liver Diseases: Literature Review. BioMed Res Int [Internet]. 2014 [cited 2018 Nov 30];2014. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052927/
Fleming T, editor. PDR for herbal medicines. 2., rev. ed. Montvale, N.J: Medical Economics Co; 2000.
Dante G, Bellei G, Neri I, Facchinetti F. Herbal therapies in pregnancy: what works? Curr Opin Obstet Gynecol. 2014;26(2):83–91.
Holst L, Nordeng H, Haavik S. Use of herbal drugs during early pregnancy in relation to maternal characteristics and pregnancy outcome. Pharmacoepidemiol Drug Saf. 2008;17(2):151–9.
de Boer HJ, Cotingting C. Medicinal plants for women’s healthcare in Southeast Asia: a meta-analysis of their traditional use, chemical constituents, and pharmacology. J Ethnopharmacol. 2014;151(2):747–67.
Huang F-J, Lan K-C, Kang H-Y, Liu Y-C, Hsuuw Y-D, Chan W-H, et al. Effect of curcumin on in vitro early post-implantation stages of mouse embryo development. Eur J Obstet Gynecol Reprod Biol. 2013;166(1):47–51.
National Center for Complementary and Integrative Health. Cranberry [Internet]. NCCIH. 2011 [cited 2018 Nov 13]. Available from: https://nccih.nih.gov/health/cranberry
Abat JK, Kumar S, Mohanty A. Ethnomedicinal, Phytochemical and Ethnopharmacological Aspects of Four Medicinal Plants of Malvaceae Used in Indian Traditional Medicines: A Review. Medicines [Internet]. 2017 [cited 2018 Nov 13];4(4). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750599/
Serban C, Sahebkar A, Ursoniu S, Andrica F, Banach M. Effect of sour tea (Hibiscus sabdariffa L.) on arterial hypertension: a systematic review and meta-analysis of randomized controlled trials. J Hypertens. 2015;33(6):1119–27.
Teoh AL, Heard G, Cox J. Yeast ecology of Kombucha fermentation. Int J Food Microbiol. 2004;95(2):119–26.
National Center for Complementary and Integrative Health. Probiotics: In Depth [Internet]. NCCIH. 2011 [cited 2018 Nov 13]. Available from: https://nccih.nih.gov/health/probiotics/introduction.htm
El Haouari M, Rosado JA. Phytochemical, Anti-Diabetic And Cardiovascular Properties Of Urtica dioica L. (Urticaceae): A Review. Mini Rev Med Chem. 2019;19(1):63–71. Epub ahead of print
We would like to thank all doctors, midwives, health care workers and secretaries for their collaboration, financial support and for taking the time to help with the completion of this study at the Department of Obstetrics and Gynecology and the Research Unit, Randers Regional Hospital.
This study was financially funded by the A.P. Møller Foundation, the Grosserer L. F. Foghts Foundation, the Foundation of the 1870s and the Linex Foundation. These Foundations had no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.
Availability of data and materials
The datasets used and analyzed during the current study are available from the corresponding author on reasonable request.
Ethics approval and consent to participate
All participants gave oral and written informed consent before participating. The study was approved by the Regional Scientific Ethical Committee (VEK 1–10–72-75-16).
Consent for publication
The authors declare that they have no competing interests.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Tabia Volqvartz and Anna-Louise Vestergaard shared first authorship
About this article
Cite this article
Volqvartz, T., Vestergaard, A., Aagaard, S.K. et al. Use of alternative medicine, ginger and licorice among Danish pregnant women – a prospective cohort study. BMC Complement Altern Med 19, 5 (2019). https://doi.org/10.1186/s12906-018-2419-y
- Alternative medicine
- First trimester pregnancy
- Herbal medicine