Schun Y, Cordell GA: Cytotoxic steroids of Gelsemium sempervirens. J Nat Prod. 1987, 50: 195-198. 10.1021/np50050a012.
Article
CAS
PubMed
Google Scholar
Dutt V, Thakur S, Dhar VJ, Sharma A: The genus Gelsemium: an update. Pharmacogn Rev. 2010, 4: 185-194. 10.4103/0973-7847.70916.
Article
CAS
PubMed
PubMed Central
Google Scholar
Jin GL, Su YP, Liu M, Xu Y, Yang J, Liao KJ, Yu CX: Medicinal plants of the genus Gelsemium (Gelsemiaceae, Gentianales)-a review of their phytochemistry, pharmacology, toxicology and traditional use. J Ethnopharmacol. 2014, doi:10.1016/j.jep.2014.01.003
Google Scholar
Valnet J: Phytothérapie. 1992, Paris: Maloine
Google Scholar
Peredery O, Persinger MA: Herbal treatment following post-seizure induction in rat by lithium pilocarpine: Scutellaria lateriflora (Skullcap), Gelsemium sempervirens (Gelsemium) and Datura stramonium (Jimson Weed) may prevent development of spontaneous seizures. Phytother Res. 2004, 18: 700-705. 10.1002/ptr.1511.
Article
PubMed
Google Scholar
Boericke W: Materia Medica with Repertory. 1927, Philadelphia: Boericke & Tafel, Inc
Google Scholar
Binsard AM, Guillemain J, Platel A, Savini EC, Tetau M: Etude psycho-pharmacologique de dilutions homéopathiques de Gelsemium et d’Ignatia. Ann Homeop Fr. 1980, 22: 35-50.
Google Scholar
Guillemain J, Rousseau A, Dorfman P, Tetau M: Recherche en psychopharmacologie. Cah Biother. 1989, 103: 53-66.
Google Scholar
Guermonprez M: Homéopathie, Principles - Clinique - Techniques. 2006, Paris: CEDH
Google Scholar
Bellavite P, Magnani P, Marzotto M, Conforti A: Assays of homeopathic remedies in rodent behavioural and psychopathological models. Homeopathy. 2009, 98: 208-227. 10.1016/j.homp.2009.09.005.
Article
PubMed
Google Scholar
Gahlot K, Abid M, Sharma A: Pharmacological evaluation of Gelsemium sempervirens roots for CNS depressant activity. Int J Pharm Tech Res. 2012, 3: 693-697.
Google Scholar
Dutt V, Dhar VJ, Sharma A: Antianxiety activity of Gelsemium sempervirens. Pharm Biol. 2010, 48: 1091-1096. 10.3109/13880200903490521.
Article
PubMed
Google Scholar
Liu M, Shen J, Liu H, Xu Y, Su YP, Yang J, Yu CX: Gelsenicine from Gelsemium elegans attenuates neuropathic and inflammatory pain in mice. Biol Pharm Bull. 2011, 34: 1877-1880. 10.1248/bpb.34.1877.
Article
CAS
PubMed
Google Scholar
Liu M, Huang HH, Yang J, Su YP, Lin HW, Lin LQ, Liao WJ, Yu CX: The active alkaloids of Gelsemium elegans Benth. are potent anxiolytics. Psychopharmacology (Berl). 2013, 225: 839-851. 10.1007/s00213-012-2867-x.
Article
CAS
Google Scholar
Zhang JY, Gong N, Huang JL, Guo LC, Wang YX: Gelsemine, a principal alkaloid from Gelsemium sempervirens Ait., exhibits potent and specific antinociception in chronic pain by acting at spinal alpha3 glycine receptors. Pain. 2013, 154: 2452-2462. 10.1016/j.pain.2013.07.027.
Article
CAS
PubMed
Google Scholar
Meyer L, Boujedaini N, Patte-Mensah C, Mensah-Nyagan AG: Pharmacological effect of gelsemine on anxiety-like behavior in rat. Behav Brain Res. 2013, 253: 90-94.
Article
CAS
PubMed
Google Scholar
Bhattacharyya SS, Mandal SK, Biswas R, Paul S, Pathak S, Boujedaini N, Belon P, Khuda-Bukhsh AR: In vitro studies demonstrate anticancer activity of an alkaloid of the plant Gelsemium sempervirens. Exp Biol Med (Maywood). 2008, 233: 1591-1601. 10.3181/0805-RM-181.
Article
CAS
Google Scholar
Zhao QC, Hua W, Zhang L, Guo T, Zhao MH, Yan M, Shi GB, Wu LJ: Antitumor activity of two gelsemine metabolites in rat liver microsomes. J Asian Nat Prod Res. 2010, 12: 731-739. 10.1080/10286020.2010.492951.
Article
CAS
PubMed
Google Scholar
Rammal H, Soulimani R: Effects of high doses of Gelsemium sempervirens L. on GABA receptor and on the cellular and humoral immunity in mice. J Med Med Sci. 2010, 1: 40-44.
Google Scholar
Xu YK, Liao SG, Na Z, Hu HB, Li Y, Luo HR: Gelsemium alkaloids, immunosuppressive agents from Gelsemium elegans. Fitoterapia. 2012, 83: 1120-1124. 10.1016/j.fitote.2012.04.023.
Article
CAS
PubMed
Google Scholar
Roy R, Tiller W, Bell IR, Hoover MR: The structure of liquid water. Novel insights from materials research; potential relevance to homeopathy. Mat Res Innovat. 2005, 9: 98-103.
Google Scholar
Yinnon TA, Yinnon CA: Electric dipole aggregates in very diluted polar liquids: theory and experimental evidence. Int J Mod Phys B. 2011, 25: 3707-3743. 10.1142/S0217979211101624.
Article
CAS
Google Scholar
Bell IR, Koithan M: A model for homeopathic remedy effects: low dose nanoparticles, allostatic cross-adaptation, and time-dependent sensitization in a complex adaptive system. BMC Complement Altern Med. 2012, 12: 191-10.1186/1472-6882-12-191.
Article
PubMed
PubMed Central
Google Scholar
Endler P, Thieves K, Reich C, Matthiessen P, Bonamin L, Scherr C, Baumgartner S: Repetitions of fundamental research models for homeopathically prepared dilutions beyond 10(-23): a bibliometric study. Homeopathy. 2010, 99: 25-36. 10.1016/j.homp.2009.11.008.
Article
PubMed
Google Scholar
Stock-Schroer B, Albrecht H, Betti L, Dobos G, Endler C, Linde K, Lüdtke R, Musial F, van Wijk R, Witt C, Baumgartner S: Reporting experiments in homeopathic basic research-description of the checklist development. Evid Based Complement Alternat Med. 2011, 2011: 639260-
Article
CAS
PubMed
PubMed Central
Google Scholar
Magnani P, Conforti A, Zanolin E, Marzotto M, Bellavite P: Dose-effect study of Gelsemium sempervirens in high dilutions on anxiety-related responses in mice. Psychopharmacology (Berl). 2010, 210: 533-545. 10.1007/s00213-010-1855-2.
Article
CAS
Google Scholar
Bellavite P, Conforti A, Marzotto M, Magnani P, Cristofoletti M, Olioso D, Zanolin ME: Testing homeopathy in mouse emotional response models: pooled data analysis of two series of studies. Evid Based Complement Alternat Med. 2012, 2012: 954374-
Article
PubMed
PubMed Central
Google Scholar
Sukul NC, Bala SK, Bhattacharyya B: Prolonged cataleptogenic effects of potentized homoeopathic drugs. Psychopharmacology (Berl). 1986, 89: 338-339.
Article
CAS
Google Scholar
Bousta D, Soulimani R, Jarmouni I, Belon P, Falla J, Foment N, Younos C: Neurotropic, immunological and gastric effects of low doses of Atropa belladonna L., Gelsemium sempervirens L. and Poumon histamine in stressed mice. J Ethnopharmacol. 2001, 74: 205-215. 10.1016/S0378-8741(00)00346-9.
Article
CAS
PubMed
Google Scholar
Venard C, Boujedaini N, Mensah-Nyagan AG, Patte-Mensah C: Comparative analysis of gelsemine and Gelsemium sempervirens activity on neurosteroid allopregnanolone formation in the spinal cord and limbic system. Evid Based Complement Alternat Med. 2011, 407617-doi:10.1093/ecam/nep083
Google Scholar
Seo JJ, Lee SH, Lee YS, Kwon BM, Ma Y, Hwang BY, Hong JT, Oh KW: Anxiolytic-like effects of obovatol isolated from Magnolia obovata: involvement of GABA/benzodiazepine receptors complex. Prog Neuropsychopharmacol Biol Psychiatry. 2007, 31: 1363-1369. 10.1016/j.pnpbp.2007.05.009.
Article
CAS
PubMed
Google Scholar
Donnici L, Tiraboschi E, Tardito D, Musazzi L, Racagni G, Popoli M: Time-dependent biphasic modulation of human BDNF by antidepressants in neuroblastoma cells. BMC Neurosci. 2008, 9: 61-10.1186/1471-2202-9-61.
Article
PubMed
PubMed Central
Google Scholar
Park SW, Seo MK, Cho HY, Lee JG, Lee BJ, Seol W, Kim YH: Differential effects of amisulpride and haloperidol on dopamine D2 receptor-mediated signaling in SH-SY5Y cells. Neuropharmacology. 2011, 61: 761-769. 10.1016/j.neuropharm.2011.05.022.
Article
CAS
PubMed
Google Scholar
Fisher P: What is homeopathy? An introduction. Front Biosci (Elite Ed). 2012, 4: 1669-1682.
Article
Google Scholar
Anonymous: Pharmacopée Homéopathique Française - X édition. 2002, Saint-Denis Cedex (FR): Agence Française de Sécurité Sanitaire de Produits de Santé
Google Scholar
Kohl RL, Perez-Polo JR, Quay WB: Effect of methionine, glycine and serine on serine hydroxymethyltransferase activity in rat glioma and human neuroblastoma cells. J Neurosci Res. 1980, 5: 271-280. 10.1002/jnr.490050403.
Article
CAS
PubMed
Google Scholar
Chakravarthy B, Gaudet C, Menard M, Atkinson T, Brown L, Laferla FM, Armato U, Whitfield J: Amyloid-beta peptides stimulate the expression of the p75(NTR) neurotrophin receptor in SHSY5Y human neuroblastoma cells and AD transgenic mice. J Alzheimers Dis. 2010, 19: 915-925.
CAS
PubMed
Google Scholar
Ishiyama M, Tominaga H, Shiga M, Sasamoto K, Ohkura Y, Ueno K: A combined assay of cell viability and in vitro cytotoxicity with a highly water-soluble tetrazolium salt, neutral red and crystal violet. Biol Pharm Bull. 1996, 19: 1518-1520. 10.1248/bpb.19.1518.
Article
CAS
PubMed
Google Scholar
Irizarry RA, Hobbs B, Collin F, Beazer-Barclay YD, Antonellis KJ, Scherf U, Speed TP: Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics. 2003, 4: 249-264. 10.1093/biostatistics/4.2.249.
Article
PubMed
Google Scholar
Bolstad BM, Irizarry RA, Astrand M, Speed TP: A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics. 2003, 19: 185-193. 10.1093/bioinformatics/19.2.185.
Article
CAS
PubMed
Google Scholar
Edgar R, Domrachev M, Lash AE: Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res. 2002, 30: 207-210. 10.1093/nar/30.1.207.
Article
CAS
PubMed
PubMed Central
Google Scholar
Smyth GK, Michaud J, Scott HS: Use of within-array replicate spots for assessing differential expression in microarray experiments. Bioinformatics. 2005, 21: 2067-2075. 10.1093/bioinformatics/bti270.
Article
CAS
PubMed
Google Scholar
Benjamini Y, Hochberg Y: Controlling the false discovery rate: a practical and powerful approach to multiple testing. J Royal Statistical Soc Series B (Methodological). 1995, 57: 289-300.
Google Scholar
Saeed AI, Bhagabati NK, Braisted JC, Liang W, Sharov V, Howe EA, Li J, Thiagarajan M, White JA, Quackenbush J: TM4 microarray software suite. Methods Enzymol. 2006, 411: 134-193.
Article
CAS
PubMed
Google Scholar
Brock G, Datta S, Pihur V, Datta S: clValid: an R package for cluster validation. J Stat Softw. 2008, 25: 1-22.
Article
Google Scholar
Huang dW, Sherman BT, Lempicki RA: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 2009, 4: 44-57.
Article
CAS
Google Scholar
Franco MI, Turin L, Mershin A, Skoulakis EM: Molecular vibration-sensing component in Drosophila melanogaster olfaction. Proc Natl Acad Sci USA. 2011, 108: 3797-3802. 10.1073/pnas.1012293108.
Article
CAS
PubMed
PubMed Central
Google Scholar
Tran AH, Berger A, Wu GE, Kee BL, Paige CJ: Early B-cell factor regulates the expression of Hemokinin-1 in the olfactory epithelium and differentiating B lymphocytes. J Neuroimmunol. 2011, 232: 41-50. 10.1016/j.jneuroim.2010.09.027.
Article
CAS
PubMed
Google Scholar
Cunin P, Caillon A, Corvaisier M, Garo E, Scotet M, Blanchard S, Delneste Y, Jeannin P: The tachykinins substance P and hemokinin-1 favor the generation of human memory Th17 cells by inducing IL-1beta, IL-23, and TNF-like 1A expression by monocytes. J Immunol. 2011, 186: 4175-4182. 10.4049/jimmunol.1002535.
Article
CAS
PubMed
Google Scholar
Madaan V, Wilson DR: Neuropeptides: relevance in treatment of depression and anxiety disorders. Drug News Perspect. 2009, 22: 319-324. 10.1358/dnp.2009.22.6.1395255.
Article
CAS
PubMed
Google Scholar
Alherbish A, Charrois TL, Ackman ML, Tsuyuki RT, Ezekowitz JA: The prevalence of natural health product use in patients with acute cardiovascular disease. PLoS ONE. 2011, 6: e19623-10.1371/journal.pone.0019623.
Article
CAS
PubMed
PubMed Central
Google Scholar
Barbancey J: Pratique Homéopathique en psycho-pathologie, Tome II. 1987, Paris: Editions Similia
Google Scholar
Danno K, Colas A, Masson JL, Bordet MF: Homeopathic treatment of migraine in children: results of a prospective, multicenter, observational study. J Altern Complement Med. 2012, 19: 119-123.
Article
PubMed
Google Scholar
Paris A, Gonnet N, Chaussard C, Belon P, Rocourt F, Saragaglia D, Cracowski JL: Effect of homeopathy on analgesic intake following knee ligament reconstruction: a phase III monocentre randomized placebo controlled study. Br J Clin Pharmacol. 2008, 65: 180-187. 10.1111/j.1365-2125.2007.03008.x.
Article
CAS
PubMed
Google Scholar
Bellavite P, Conforti A, Piasere V, Ortolani R: Immunology and homeopathy. 1. Historical background. eCAM. 2005, 2: 441-452.
PubMed
PubMed Central
Google Scholar
Shang A, Huwiler-Müntener K, Nartey L, Jüni P, Dörig S, Sterne JAC, Pewsner D, Egger M: Are the clinical effects of homoeopathy placebo effects? Comparative study of placebo-controlled trials of homoeopathy and allopathy. Lancet. 2005, 366: 726-732. 10.1016/S0140-6736(05)67177-2.
Article
PubMed
Google Scholar
Jonas WB, Kaptchuk TJ, Linde K: A critical overview of homeopathy. Ann Intern Med. 2003, 138: 393-399. 10.7326/0003-4819-138-5-200303040-00009.
Article
PubMed
Google Scholar
Calabrese EJ, Jonas WB: Evaluating homeopathic drugs within a biomedical framework. Hum Exp Toxicol. 2010, 29: 545-549. 10.1177/0960327110369775.
Article
CAS
PubMed
Google Scholar
Plant KE, Anderson E, Simecek N, Brown R, Forster S, Spinks J, Toms N, Gibson GG, Lyon J, Plant N: The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1. Toxicol Appl Pharmacol. 2009, 235: 124-134. 10.1016/j.taap.2008.10.019.
Article
CAS
PubMed
Google Scholar
Lai CK, Chan YW: Confirmation of Gelsemium poisoning by targeted analysis of toxic Gelsemium alkaloids in urine. J Anal Toxicol. 2009, 33: 56-61. 10.1093/jat/33.1.56.
Article
CAS
PubMed
Google Scholar
Calabrese EJ, Jonas WB: Homeopathy: clarifying its relationship to hormesis. Hum Exp Toxicol. 2010, 29: 531-536. 10.1177/0960327110369857.
Article
CAS
PubMed
Google Scholar
Iavicoli I, Calabrese EJ, Nascarella MA: Exposure to nanoparticles and hormesis. Dose Response. 2010, 8: 501-517. 10.2203/dose-response.10-016.Iavicoli.
Article
CAS
PubMed
PubMed Central
Google Scholar
Van Wijk R, Wiegant FA: Postconditioning hormesis and the homeopathic Similia principle: molecular aspects. Hum Exp Toxicol. 2010, 29: 561-565. 10.1177/0960327110369860.
Article
CAS
PubMed
Google Scholar
Bell IR, Schwartz GE: Adaptive network nanomedicine: an integrated model for homeopathic medicine. Front Biosci (Schol Ed). 2013, 5: 685-708.
Article
Google Scholar
Venard C, Boujedaini N, Belon P, Mensah-Nyagan AG, Patte-Mensah C: Regulation of neurosteroid allopregnanolone biosynthesis in the rat spinal cord by glycine and the alkaloidal analogs strychnine and gelsemine. Neuroscience. 2008, 153: 154-161. 10.1016/j.neuroscience.2008.02.009.
Article
CAS
PubMed
Google Scholar
Bellavite P, Conforti A, Pontarollo F, Ortolani R: Immunology and homeopathy. 2. Cells of the immune system and inflammation. eCAM. 2006, 3: 13-24.
PubMed
PubMed Central
Google Scholar
Witt CM, Bluth M, Albrecht H, Weisshuhn TE, Baumgartner S, Willich SN: The in vitro evidence for an effect of high homeopathic potencies–a systematic review of the literature. Complement Ther Med. 2007, 15: 128-138. 10.1016/j.ctim.2007.01.011.
Article
PubMed
Google Scholar
Sainte-Laudy J, Belon P: Inhibition of basophil activation by histamine: a sensitive and reproducible model for the study of the biological activity of high dilutions. Homeopathy. 2009, 98: 186-197. 10.1016/j.homp.2009.09.009.
Article
CAS
PubMed
Google Scholar
Majewsky V, Arlt S, Shah D, Scherr C, Jager T, Betti L, Trebbi G, Bonamin L, Klocke P, Baumgartner S: Use of homeopathic preparations in experimental studies with healthy plants. Homeopathy. 2009, 98: 228-243. 10.1016/j.homp.2009.09.012.
Article
PubMed
Google Scholar
Bellavite P, Marzotto M, Olioso D, Moratti E, Conforti A: High-dilution effects revisited. 1. Physicochemical aspects. Homeopathy. 2014, 103: 4-21. 10.1016/j.homp.2013.08.003.
Article
PubMed
Google Scholar
Anick DJ, Ives JA: The silica hypothesis for homeopathy: physical chemistry. Homeopathy. 2007, 96: 189-195. 10.1016/j.homp.2007.03.005.
Article
PubMed
Google Scholar
Chikramane PS, Suresh AK, Bellare JR, Kane SG: Extreme homeopathic dilutions retain starting materials: A nanoparticulate perspective. Homeopathy. 2010, 99: 231-242. 10.1016/j.homp.2010.05.006.
Article
PubMed
Google Scholar
Relaix S, Leheny RL, Reven L, Sutton M: Memory effect in composites of liquid crystal and silica aerosil. Phys Rev E Stat Nonlin Soft Matter Phys. 2011, 84: 061705-
Article
PubMed
Google Scholar
Baier G, Costa C, Zeller A, Baumann D, Sayer C, Araujo PH, Mailänder V, Musyanovych A, Landfester K: BSA adsorption on differently charged polystyrene nanoparticles using isothermal titration calorimetry and the influence on cellular uptake. Macromol Biosci. 2011, 11: 628-638. 10.1002/mabi.201000395.
Article
CAS
PubMed
Google Scholar
Bel HS, Magnin A, Petrier C, Boufi S: Starch nanoparticles formation via high power ultrasonication. Carbohydr Polym. 2013, 92: 1625-1632. 10.1016/j.carbpol.2012.11.022.
Article
Google Scholar
Upadhyay RP, Nayak C: Homeopathy emerging as nano medicine. Int J High Dilution Res. 2011, 10: 299-310.
Google Scholar
Das S, Das J, Samadder A, Bhattacharyya SS, Das D, Khuda-Bukhsh AR: Biosynthesized silver nanoparticles by ethanolic extracts of Phytolacca decandra, Gelsemium sempervirens, Hydrastis canadensis and Thuja occidentalis induce differential cytotoxicity through G2/M arrest in A375 cells. Colloids Surf B Biointerfaces. 2013, 101: 325-336.
Article
CAS
PubMed
Google Scholar
Prakash DJ, Arulkumar S, Sabesan M: Effect of nanohypericum (Hypericum perforatum gold nanoparticles) treatment on restraint stressinduced behavioral and biochemical alteration in male albino mice. Pharmacognosy Res. 2010, 2: 330-334. 10.4103/0974-8490.75450.
Article
PubMed
PubMed Central
Google Scholar
Bhattacharyya SS, Paul S, Khuda-Bukhsh AR: Encapsulated plant extract (Gelsemium sempervirens) poly (lactide-co-glycolide) nanoparticles enhance cellular uptake and increase bioactivity in vitro. Exp Biol Med (Maywood ). 2010, 235: 678-688. 10.1258/ebm.2010.009338.
Article
CAS
Google Scholar
Schwartz GE, Russek LG, Bell IR, Riley D: Plausibility of homeopathy and conventional chemical therapy: the systemic memory resonance hypothesis. Med Hypotheses. 2000, 54: 634-637. 10.1054/mehy.1999.0913.
Article
CAS
PubMed
Google Scholar
Bellavite P: Complexity science and homeopathy. A synthetic overview. Homeopathy. 2003, 92: 203-212. 10.1016/j.homp.2003.08.002.
Article
CAS
PubMed
Google Scholar
Bellavite P, Olioso D, Marzotto M, Moratti E, Conforti A: A dynamic network model of the similia principle. Complement Ther Med. 2013, 21: 750-761. 10.1016/j.ctim.2013.09.001.
Article
PubMed
Google Scholar
Bellavite P, Marzotto M, Olioso D, Moratti E, Conforti A: High-dilution effects revisited. 2. Pharmacodynamic mechanisms. Homeopathy. 2014, 103: 22-43. 10.1016/j.homp.2013.08.002.
Article
PubMed
Google Scholar
Ramo P, Kesseli J, Yli-Harja O: Perturbation avalanches and criticality in gene regulatory networks. J Theor Biol. 2006, 242: 164-170. 10.1016/j.jtbi.2006.02.011.
Article
CAS
PubMed
Google Scholar
Likhoshvai VA, Fadeev SI, Kogai VV, Khlebodarova TM: On the chaos in gene networks. J Bioinform Comput Biol. 2013, 11: 1340009-10.1142/S021972001340009X.
Article
PubMed
Google Scholar
Morita K, Tsumoto K, Aihara K: Possible effects of depolarizing GABAA conductance on the neuronal input–output relationship: a modeling study. J Neurophysiol. 2005, 93: 3504-3523. 10.1152/jn.00988.2004.
Article
CAS
PubMed
Google Scholar
Gupta K, Singh HP, Biswal B, Ramaswamy R: Adaptive targeting of chaotic response in periodically stimulated neural systems. Chaos. 2006, 16: 023116-10.1063/1.2204749.
Article
PubMed
Google Scholar
Qi Y, Watts AL, Kim JW, Robinson PA: Firing patterns in a conductance-based neuron model: bifurcation, phase diagram, and chaos. Biol Cybern. 2013, 107: 15-24. 10.1007/s00422-012-0520-8.
Article
CAS
PubMed
Google Scholar
Szolnoki Z: A dynamically changing intracellular water network serves as a universal regulator of the cell: the water-governed cycle. Biochem Biophys Res Commun. 2007, 357: 331-334. 10.1016/j.bbrc.2007.03.161.
Article
CAS
PubMed
Google Scholar