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Table 4 Top enriched annotation terms associated with the 56 genes differentially expressed upon exposure to Gelsemium s. 2c in SH-SY5Y cells

From: Extreme sensitivity of gene expression in human SH-SY5Y neurocytes to ultra-low doses of Gelsemium sempervirens

Category

Annotation term

P value

Genes

Fold enrichment

SP_PIR_KEYW

receptor

8.32E-11

AIPL1, OR4X1, CASR, OR5C1, GPR25, GALR2, OR7C2, MRGPRF, CLEC7A, TREM2

3.68

GOTERM_BP_FAT

GO:0007186 ~ G-protein coupled receptor protein signalling pathway

6.60E-11

OR4X1, CASR, OR5C1, CCL23, GPR25, GALR2, OR7C2, MRGPRF, TAC4

4.17

GOTERM_BP_FAT

GO:0007166 ~ cell surface receptor linked signal transduction

0.001

OR4X1, CASR, OR5C1, CCL23, DOK5, GPR25, GALR2, OR7C2, MRGPRF, CLEC7A, TAC4

0.08

GOTERM_BP_FAT

GO:0051606 ~ detection of stimulus

0.02

AIPL1, CASR, CLEC7A

13.23

INTERPRO

IPR017452:GPCR, rhodopsin-like superfamily

0.009

OR4X1, OR5C1, GPR25, GALR2, OR7C2, MRGPRF

4.44

KEGG_PATHWAY

hsa04740:Olfactory transduction

0.09

OR4X1, OR5C1, OR7C2

5.31

GOTERM_BP_FAT

GO:0006954 ~ inflammatory response

0.02

C8B, CCL23, CLEC7A, CD163

6.40

GOTERM_BP_FAT

GO:0006952 ~ defense response

0.02

C8B, CCL23, MPO, CLEC7A, CD163

4.23

GOTERM_BP_FAT

GO:0006955 ~ immune response

0.03

C8B, CCL23, LST1, CLEC7A, TREM2

3.77

GOTERM_BP_FAT

GO:0006874 ~ cellular calcium ion homeostasis

0.04

CASR, CCL23, GALR2

8.53

GOTERM_BP_FAT

GO:0030182 ~ neuron differentiation

0.04

LST1, NKX6-2, GALR2, EN2

4.75

GOTERM_CC_FAT

GO:0005886 ~ plasma membrane

0.02

CASR, OR5C1, SLC7A9, MRGPRF, CDHR5, CD163, C8B, OR4X1, ADAP2, GALR2, GPR25, OR7C2, CLEC7A, TREM2

1.65

GOTERM_CC_FAT

GO:0005576 ~ extracellular region

0.071

KLKBL4, C8B, CCL23, MPO, TAC4, TREM2, CSN1S1, CD163

2.03

SP_PIR_ KEYW

Disulfide bond

1.06E-12

KLKBL4, OR5C1, ALPK3, SLC7A9, GALNTL1, CSN1S1, CD163, C8B, OR4X1, CCL23, GALR2, OR7C2, MPO, CLEC7A, TREM2

2.99

SP_PIR_ KEYW

Glycoprotein

0.06

KLKBL4, CASR, OR5C1, MRGPRF, CDHR5, CD163, C8B, OR4X1, GALR2, OR7C2, MPO, CLEC7A, TREM2

1.75

  1. The analysis was performed by DAVID Bioinformatics Resources 6.7 (http://david.abcc.ncifcrf.gov). The genes associated with annotation terms with enrichment p < 0.1 are reported here.