Gibbs JB: Mechanism-based target identification and drug discovery in cancer research. Science. 2000, 287 (5460): 1969-1973. 10.1126/science.287.5460.1969.
Article
CAS
PubMed
Google Scholar
Richardson ME, Siemann DW: Tumor cell heterogeneity: impact on mechanisms of therapeutic drug resistance. Int J Radiat Oncol Biol Phys. 1997, 39 (4): 789-795. 10.1016/S0360-3016(97)00469-0.
Article
CAS
PubMed
Google Scholar
Balunas MJ, Kinghorn AD: Drug discovery from medicinal plants. Life Sci. 2005, 78 (5): 431-441. 10.1016/j.lfs.2005.09.012.
Article
CAS
PubMed
Google Scholar
Pezzuto JM: Plant-derived anticancer agents. Biochem Pharmacol. 1997, 53 (2): 121-133. 10.1016/S0006-2952(96)00654-5.
Article
CAS
PubMed
Google Scholar
Abdel-Hamid NM, Nazmy MH, Mahmoud AW, Fawzy MA, Youssof M: A survey on herbal management of hepatocellular carcinoma. World J Hepatol. 2011, 3 (7): 175-183. 10.4254/wjh.v3.i7.175.
Article
PubMed
PubMed Central
Google Scholar
Aune D, Chan DS, Lau R, Vieira R, Greenwood DC, Kampman E, Norat T: Dietary fibre, whole grains, and risk of colorectal cancer: systematic review and dose-response meta-analysis of prospective studies. BMJ. 2011, 343: d6617-10.1136/bmj.d6617.
Article
PubMed
PubMed Central
Google Scholar
Steinmetz KA, Potter JD: Vegetables, fruit, and cancer prevention: a review. J Am Diet Assoc. 1996, 96 (10): 1027-1039. 10.1016/S0002-8223(96)00273-8.
Article
CAS
PubMed
Google Scholar
Van Duyn MA, Pivonka E: Overview of the health benefits of fruit and vegetable consumption for the dietetics professional: selected literature. J Am Diet Assoc. 2000, 100 (12): 1511-1521. 10.1016/S0002-8223(00)00420-X.
Article
CAS
PubMed
Google Scholar
Aggarwal BB, Van Kuiken ME, Iyer LH, Harikumar KB, Sung B: Molecular targets of nutraceuticals derived from dietary spices: potential role in suppression of inflammation and tumorigenesis. Exp Biol Med (Maywood). 2009, 234 (8): 825-849. 10.3181/0902-MR-78.
Article
CAS
Google Scholar
Haque N, Salma U, Nurunnabi TR, Haque AK, Mukti IJ, Pervin S, Nahar R: Lifestyle related causes of cancer and chemoprevention through phytonutrients. Pak J Biol Sci. 2010, 13 (19): 916-926.
Article
CAS
PubMed
Google Scholar
Guilford JM, Pezzuto JM: Natural products as inhibitors of carcinogenesis. Expert Opin Investig Drugs. 2008, 17 (9): 1341-1352. 10.1517/13543784.17.9.1341.
Article
CAS
PubMed
Google Scholar
Surh YJ: Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer. 2003, 3 (10): 768-780. 10.1038/nrc1189.
Article
CAS
PubMed
Google Scholar
Gupta SC, Kim JH, Prasad S, Aggarwal BB: Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals. Cancer Metastasis Rev. 2010, 29 (3): 405-434. 10.1007/s10555-010-9235-2.
Article
CAS
PubMed
PubMed Central
Google Scholar
Sung B, Prasad S, Yadav VR, Aggarwal BB: Cancer cell signaling pathways targeted by spice-derived nutraceuticals. Nutr Cancer. 2012, 64 (2): 173-197. 10.1080/01635581.2012.630551.
Article
CAS
PubMed
Google Scholar
Jagetia GC, Aggarwal BB: "Spicing up" of the immune system by curcumin. J Clin Immunol. 2007, 27 (1): 19-35. 10.1007/s10875-006-9066-7.
Article
CAS
PubMed
Google Scholar
Butler MS: Natural products to drugs: natural product-derived compounds in clinical trials. Nat Prod Rep. 2008, 25 (3): 475-516. 10.1039/b514294f.
Article
CAS
PubMed
Google Scholar
Dhillon RAW N, Abbruzzese JL, Hong DS, Camacho LH, Li L, Braiteh F, Kurzrock R: Phase II clinical trial of curcumin in patients with advanced pancreatic cancer. J Clin Oncol (Meeting Abstracts). 2006, 24 (18S): 14151-
Google Scholar
Sashidhara KV, White KN, Crews P: A selective account of effective paradigms and significant outcomes in the discovery of inspirational marine natural products. J Nat Prod. 2009, 72 (3): 588-603. 10.1021/np800817y.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ulbricht C, Basch E, Burke D, Cheung L, Ernst E, Giese N, Foppa I, Hammerness P, Hashmi S, Kuo G: Fenugreek (Trigonella foenum-graecum L. Leguminosae): an evidence-based systematic review by the natural standard research collaboration. J Herb Pharmacother. 2007, 7 (3-4): 143-177.
Article
PubMed
Google Scholar
Prabhakar PK, Doble M: Mechanism of action of natural products used in the treatment of diabetes mellitus. Chin J Integr Med. 2011, 17 (8): 563-574. 10.1007/s11655-011-0810-3.
Article
PubMed
Google Scholar
Haque N, Salma U, Nurunnabi TR, Uddin MJ, Jahangir MF, Islam SM, Kamruzzaman M: Management of type 2 diabetes mellitus by lifestyle, diet and medicinal plants. Pak J Biol Sci. 2011, 14 (1): 13-24.
Article
CAS
PubMed
Google Scholar
Hasani-Ranjbar S, Nayebi N, Moradi L, Mehri A, Larijani B, Abdollahi M: The efficacy and safety of herbal medicines used in the treatment of hyperlipidemia; a systematic review. Curr Pharm Des. 2010, 16 (26): 2935-2947. 10.2174/138161210793176464.
Article
CAS
PubMed
Google Scholar
Sirtori CR, Galli C, Anderson JW, Sirtori E, Arnoldi A: Functional foods for dyslipidaemia and cardiovascular risk prevention. Nutr Res Rev. 2009, 22 (2): 244-261. 10.1017/S0954422409990187.
Article
CAS
PubMed
Google Scholar
Dwivedi S, Aggarwal A: Indigenous drugs in ischemic heart disease in patients with diabetes. J Altern Complement Med. 2009, 15 (11): 1215-1221. 10.1089/acm.2009.0187.
Article
PubMed
Google Scholar
Shabbeer S, Sobolewski M, Anchoori RK, Kachhap S, Hidalgo M, Jimeno A, Davidson N, Carducci MA, Khan SR: Fenugreek: a naturally occurring edible spice as an anticancer agent. Cancer Biol Ther. 2009, 8 (3): 272-278. 10.4161/cbt.8.3.7443.
Article
CAS
PubMed
PubMed Central
Google Scholar
Raju J, Patlolla JM, Swamy MV, Rao CV: Diosgenin, a steroid saponin of Trigonella foenum graecum (Fenugreek), inhibits azoxymethane-induced aberrant crypt foci formation in F344 rats and induces apoptosis in HT-29 human colon cancer cells. Cancer Epidemiol Biomarkers Prev. 2004, 13 (8): 1392-1398.
CAS
PubMed
Google Scholar
Amin A, Alkaabi A, Al-Falasi S, Daoud SA: Chemopreventive activities of Trigonella foenum graecum (Fenugreek) against breast cancer. Cell Biol Int. 2005, 29 (8): 687-694. 10.1016/j.cellbi.2005.04.004.
Article
PubMed
Google Scholar
Bin-Hafeez B, Haque R, Parvez S, Pandey S, Sayeed I, Raisuddin S: Immunomodulatory effects of fenugreek (Trigonella foenum graecum L.) extract in mice. Int Immunopharmacol. 2003, 3 (2): 257-265. 10.1016/S1567-5769(02)00292-8.
Article
CAS
PubMed
Google Scholar
Corbiere C, Liagre B, Bianchi A, Bordji K, Dauca M, Netter P, Beneytout JL: Different contribution of apoptosis to the antiproliferative effects of diosgenin and other plant steroids, hecogenin and tigogenin, on human 1547 osteosarcoma cells. Int J Oncol. 2003, 22 (4): 899-905.
CAS
PubMed
Google Scholar
Liu MJ, Wang Z, Ju Y, Wong RN, Wu QY: Diosgenin induces cell cycle arrest and apoptosis in human leukemia K562 cells with the disruption of Ca2+ homeostasis. Cancer Chemother Pharmacol. 2005, 55 (1): 79-90. 10.1007/s00280-004-0849-3.
Article
CAS
PubMed
Google Scholar
Srinivasan S, Koduru S, Kumar R, Venguswamy G, Kyprianou N, Damodaran C: Diosgenin targets Akt-mediated prosurvival signaling in human breast cancer cells. Int J Cancer. 2009, 125 (4): 961-967. 10.1002/ijc.24419.
Article
CAS
PubMed
Google Scholar
Khoja KK, Shaf G, Hasan TN, Syed NA, Al-Khalifa AS, Al-Assaf AH, Alshatwi AA: Fenugreek, a naturally occurring edible spice, kills MCF-7 human breast cancer cells via an apoptotic pathway. Asian Pac J Cancer Prev. 2011, 12 (12): 3299-3304.
PubMed
Google Scholar
Li F, Fernandez PP, Rajendran P, Hui KM, Sethi G: Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells. Cancer Lett. 2010, 292 (2): 197-207. 10.1016/j.canlet.2009.12.003.
Article
CAS
PubMed
Google Scholar
Chen PS, Shih YW, Huang HC, Cheng HW: Diosgenin, a steroidal saponin, inhibits migration and invasion of human prostate cancer PC-3 cells by reducing matrix metalloproteinases expression. PLoS One. 2011, 6 (5): e20164-10.1371/journal.pone.0020164.
Article
CAS
PubMed
PubMed Central
Google Scholar
Varjas T, Nowrasteh G, Budan F, Horvath G, Cseh J, Gyongyi Z, Makai S, Ember I: The effect of fenugreek on the gene expression of arachidonic acid metabolizing enzymes. Phytother Res. 2011, 25 (2): 221-227.
PubMed
Google Scholar
Shishodia S, Aggarwal BB: Diosgenin inhibits osteoclastogenesis, invasion, and proliferation through the downregulation of Akt, I kappa B kinase activation and NF-kappa B-regulated gene expression. Oncogene. 2006, 25 (10): 1463-1473. 10.1038/sj.onc.1209194.
Article
CAS
PubMed
Google Scholar
Klionsky DJ, Emr SD: Autophagy as a regulated pathway of cellular degradation. Science. 2000, 290 (5497): 1717-1721.
Article
CAS
PubMed
PubMed Central
Google Scholar
Chen N, Debnath J: Autophagy and tumorigenesis. FEBS Lett. 2010, 584 (7): 1427-1435. 10.1016/j.febslet.2009.12.034.
Article
CAS
PubMed
Google Scholar
Clarke PG: Developmental cell death: morphological diversity and multiple mechanisms. Anat Embryol (Berl). 1990, 181 (3): 195-213.
Article
CAS
Google Scholar
Vicencio JM, Galluzzi L, Tajeddine N, Ortiz C, Criollo A, Tasdemir E, Morselli E, Ben Younes A, Maiuri MC, Lavandero S: Senescence, apoptosis or autophagy? When a damaged cell must decide its path--a mini-review. Gerontology. 2008, 54 (2): 92-99. 10.1159/000129697.
Article
PubMed
Google Scholar
Levine B, Kroemer G: Autophagy in the pathogenesis of disease. Cell. 2008, 132 (1): 27-42. 10.1016/j.cell.2007.12.018.
Article
CAS
PubMed
PubMed Central
Google Scholar
Mathew R, Karantza-Wadsworth V, White E: Role of autophagy in cancer. Nat Rev Cancer. 2007, 7 (12): 961-967. 10.1038/nrc2254.
Article
CAS
PubMed
PubMed Central
Google Scholar
Botti J, Djavaheri-Mergny M, Pilatte Y, Codogno P: Autophagy signaling and the cogwheels of cancer. Autophagy. 2006, 2 (2): 67-73.
Article
CAS
PubMed
Google Scholar
Tanida I, Ueno T, Kominami E: LC3 conjugation system in mammalian autophagy. Int J Biochem Cell Biol. 2004, 36 (12): 2503-2518. 10.1016/j.biocel.2004.05.009.
Article
CAS
PubMed
Google Scholar
Abe A, Yamada H, Moriya S, Miyazawa K: The beta-carboline alkaloid harmol induces cell death via autophagy but not apoptosis in human non-small cell lung cancer A549 cells. Biol Pharm Bull. 2011, 34 (8): 1264-1272. 10.1248/bpb.34.1264.
Article
CAS
PubMed
Google Scholar
Hannigan AM, Gorski SM: Macroautophagy: the key ingredient to a healthy diet?. Autophagy. 2009, 5 (2): 140-151. 10.4161/auto.5.2.7529.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hu YL, Delay M, Jahangiri A, Molinaro AM, Rose SD, Carbonell WS, Aghi MK: Hypoxia-induced autophagy promotes tumor cell survival and adaptation to antiangiogenic treatment in glioblastoma. Cancer Res. 2012, 72 (7): 1773-1783. 10.1158/0008-5472.CAN-11-3831.
Article
CAS
PubMed
PubMed Central
Google Scholar
Malkinson AM, Beer DS: Pharmacologic and genetic studies on the modulatory effects of butylated hydroxytoluene on mouse lung adenoma formation. J Natl Cancer Inst. 1984, 73 (4): 925-933.
CAS
PubMed
Google Scholar
Kundu JK, Na HK, Surh YJ: Ginger-derived phenolic substances with cancer preventive and therapeutic potential. Forum Nutr. 2009, 61: 182-192.
Article
CAS
PubMed
Google Scholar
Deb J, Dibra H, Shan S, Rajan S, Manneh J, Kankipati CS, Perry CJ, Nicholl ID: Activity of aspirin analogues and vanillin in a human colorectal cancer cell line. Oncol Rep. 2011, 26 (3): 557-565.
CAS
PubMed
Google Scholar
Vidhya N, Devaraj SN: Induction of apoptosis by eugenol in human breast cancer cells. Indian J Exp Biol. 2011, 49 (11): 871-878.
CAS
PubMed
Google Scholar
Jaganathan SK, Mazumdar A, Mondhe D, Mandal M: Apoptotic effect of eugenol in human colon cancer cell lines. Cell Biol Int. 2011, 35 (6): 607-615. 10.1042/CBI20100118.
Article
CAS
PubMed
Google Scholar
Manikandan P, Murugan RS, Priyadarsini RV, Vinothini G, Nagini S: Eugenol induces apoptosis and inhibits invasion and angiogenesis in a rat model of gastric carcinogenesis induced by MNNG. Life Sci. 2010, 86 (25–26): 936-941.
Article
CAS
PubMed
Google Scholar
Sakr SA, Abo-El-Yazid SM: Effect of fenugreek seed extract on adriamycin-induced hepatotoxicity and oxidative stress in albino rats. Toxicol Ind Health 0748233711425076. 2011, 10.1177/0748233711425076.
Google Scholar
Sushma N, Devasena T: Aqueous extract of Trigonella foenum graecum (fenugreek) prevents cypermethrin-induced hepatotoxicity and nephrotoxicity. Hum Exp Toxicol. 2010, 29 (4): 311-319. 10.1177/0960327110361502.
Article
PubMed
Google Scholar
Muraki E, Hayashi Y, Chiba H, Tsunoda N, Kasono K: Dose-dependent effects, safety and tolerability of fenugreek in diet-induced metabolic disorders in rats. Lipids Health Dis. 2011, 10: 240-10.1186/1476-511X-10-240.
Article
CAS
PubMed
PubMed Central
Google Scholar