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  1. Senescence of the neurons is believed to be a focal factor in the development of age-related neurodegenerative diseases such as Alzheimer’s disease. Diminutions in the levels of nerve growth factor (NGF) lead ...

    Authors: Syntyche Ling-Sing Seow, Murali Naidu, Pamela David, Kah-Hui Wong and Vikineswary Sabaratnam
    Citation: BMC Complementary and Alternative Medicine 2013 13:157
  2. Registered dietitians (RDs) play a key role in disseminating information about nutrition and intervening in nutrition-related disorders in the Canadian context. Natural health products (NHPs) are increasingly ...

    Authors: Kristine Hirschkorn, Rishma Walji and Heather Boon
    Citation: BMC Complementary and Alternative Medicine 2013 13:156
  3. The present study was carried out to assess the phytochemical and anti-dermatophytic effect of the leaf and bark extracts of Xylosma longifolium Clos. The leaf and stem bark are used by the indigenous people of M...

    Authors: Wangkheirakpam Radhapiyari Devi, S Brojendro Singh and Chingakham B Singh
    Citation: BMC Complementary and Alternative Medicine 2013 13:155
  4. Arecae semen, the dried slice of areca nuts, is a traditional Chinese medicine used to treat intestinal parasitosis, rectal tenesmus and diarrhea. Areca nuts contain a rich amount of polyphenols that have been s...

    Authors: Chia-Chi Wang, Yu-Ru Lin, Mei-Hsiu Liao and Tong-Rong Jan
    Citation: BMC Complementary and Alternative Medicine 2013 13:154
  5. There are few studies of the prevalence and patterns of herbal and dietary supplement (HDS) use in patients with chronic kidney disease (CKD), although many researchers and health professionals worldwide have ...

    Authors: Mayuree Tangkiatkumjai, Helen Boardman, Kearkiat Praditpornsilpa and Dawn M Walker
    Citation: BMC Complementary and Alternative Medicine 2013 13:153
  6. Formaldehyde can induce misfolding and aggregation of Tau protein and β amyloid protein, which are characteristic pathological features of Alzheimer’s disease (AD). An increase in endogenous formaldehyde conce...

    Authors: Ping Sun, Jin-yan Chen, Jiao Li, Meng-ru Sun, Wei-chuan Mo, Kai-li Liu, Yan-yan Meng, Ying Liu, Feng Wang, Rong-qiao He and Qian Hua
    Citation: BMC Complementary and Alternative Medicine 2013 13:152
  7. Honey has been identified as a potential alternative to the widespread use of antibiotics, which are of significant concern considering the emergence of resistant bacteria. In this context, this study aimed to...

    Authors: Renah Boanerges de Queiroz Pimentel, Cristovão Alves da Costa, Patrícia Melchionna Albuquerque and Sergio Duvoisin Junior
    Citation: BMC Complementary and Alternative Medicine 2013 13:151
  8. Angiogenesis is closely related to the growth, invasion and metastasis of tumors, also considered as the key target of anticancer therapy. Scutellaria barbata D. Don (S. barbata), a traditional Chinese medicine, ...

    Authors: Zhi-Jun Dai, Wang-Feng Lu, Jie Gao, Hua-Feng Kang, Yu-Guang Ma, Shu-Qun Zhang, Yan Diao, Shuai Lin, Xi-Jing Wang and Wen-Ying Wu
    Citation: BMC Complementary and Alternative Medicine 2013 13:150
  9. Extracts of leaves from Clerodendrum have been used for centuries to treat a variety of medicinal problems in tropical Africa. However, little is known about the high-molecular weight active components conferring...

    Authors: Koffi Kouakou, Igor A Schepetkin, SangMu Jun, Liliya N Kirpotina, Ahoua Yapi, Daria S Khramova, David W Pascual, Yury S Ovodov, Mark A Jutila and Mark T Quinn
    Citation: BMC Complementary and Alternative Medicine 2013 13:149
  10. Limited study on the use of complementary alternative medicine (CAM) among patients with diabetes mellitus (DM), particularly in primary -care settings. This study seeks to understand the prevalence, types, ex...

    Authors: Siew Mooi Ching, Zainul Amiruddin Zakaria, Fuziah Paimin and Mehrdad Jalalian
    Citation: BMC Complementary and Alternative Medicine 2013 13:148
  11. In Cameroon herbs are traditionally used to meet health care needs and plans are on the way to integrate traditional medicine in the health care system, even though the plans have not been put into action yet....

    Authors: Fidele Ntie-Kang, Lydia Likowo Lifongo, Luc Meva’a Mbaze, Nnange Ekwelle, Luc C Owono Owono, Eugene Megnassan, Philip N Judson, Wolfgang Sippl and Simon M N Efange
    Citation: BMC Complementary and Alternative Medicine 2013 13:147
  12. Chronic pain affects nearly 116 million American adults at an estimated cost of up to $635 billion annually and is the No. 1 condition for which patients seek care at integrative medicine clinics. In our Study...

    Authors: Donald I Abrams, Rowena Dolor, Rhonda Roberts, Constance Pechura, Jeffery Dusek, Sandi Amoils, Steven Amoils, Kevin Barrows, Joel S Edman, Joyce Frye, Erminia Guarneri, Ben Kligler, Daniel Monti, Myles Spar and Ruth Q Wolever
    Citation: BMC Complementary and Alternative Medicine 2013 13:146
  13. Rhaphidophora korthalsii (Araceae) is a root-climber plant which has been widely used in Chinese traditional medicine for cancer and skin disease treatment. Previous reports have recorded its immunomodulatory ef...

    Authors: Swee Keong Yeap, Abdul Rahman Omar, Wan Yong Ho, Boon Kee Beh, Abdul Manaf Ali and Noorjahan Banu Alitheen
    Citation: BMC Complementary and Alternative Medicine 2013 13:145
  14. Constitutive activation of STAT3 is one of the major oncogenic pathways involved in the development of various types of malignancies including colorectal cancer (CRC); and thus becomes a promising therapeutic ...

    Authors: Wei Lin, Liangpu Zheng, Qunchuan Zhuang, Jinyan Zhao, Zhiyun Cao, Jianwei Zeng, Shan Lin, Wei Xu and Jun Peng
    Citation: BMC Complementary and Alternative Medicine 2013 13:144
  15. Maytenus royleanus is traditionally used in gastro-intestinal disorders. The aim of this study was to evaluate the methanol extract of leaves and its derived fractions for various antioxidant assays and for its ...

    Authors: Maria Shabbir, Muhammad Rashid Khan and Naima Saeed
    Citation: BMC Complementary and Alternative Medicine 2013 13:143
  16. The use of plants and their derived substances increases day by day for the discovery of therapeutic agents owing to their versatile applications. Current research is directed towards finding naturally-occurri...

    Authors: Shafiqul Islam, Samima Nasrin, Muhammad Ali Khan, ASM Sakhawat Hossain, Farhadul Islam, Proma Khandokhar, M Nurul Haque Mollah, Mamunur Rashid, Golam Sadik, Md Aziz Abdur Rahman and AHM Khurshid Alam
    Citation: BMC Complementary and Alternative Medicine 2013 13:142
  17. Growing evidence shows that herb medicines have some anti-osteoporotic effects, the mechanism underlying is unknown. This study aims to investigate the therapeutic effect of Chinese herb supplements on rats th...

    Authors: Meijie Liu, Gary Guishan Xiao, Peijing Rong, Jiazi Dong, Zhiguo Zhang, Hongyan Zhao, Jingru Teng, Hongxia Zhao, Jinghua Pan, Yan Li, Qinglin Zha, Ying Zhang and Dahong Ju
    Citation: BMC Complementary and Alternative Medicine 2013 13:141
  18. Stress caused by free radicals accumulation result into many hazardous diseases. A number of investigations are focusing to find out the plant oriented natural antioxidant moieties. The basic aim of this resea...

    Authors: Bushra Ahmad, Muhammad Rashid Khan, Naseer Ali Shah and Rahmat Ali Khan
    Citation: BMC Complementary and Alternative Medicine 2013 13:140
  19. The purpose of this investigation was to determine if black tea extract (BTE), consisting primarily of flavanol compounds called theaflavins, could inhibit herpes simplex virus type-1 (HSV-1) infection in cult...

    Authors: Anthony Cantatore, Sade D Randall, Daniel Traum and Sandra D Adams
    Citation: BMC Complementary and Alternative Medicine 2013 13:139
  20. Rubus fruticosus is used in tribal medicine as anthelmintic and an antispasmodic. In the current work, we investigated the anthelmintic and antispasmodic activities of crude methanol extract of fruits of R. frut...

    Authors: Niaz Ali, Umer Aleem, Syed Wadood Ali Shah, Ismail Shah, Muhammad Junaid, Ghayour Ahmed, Waqar Ali and Mehreen Ghias
    Citation: BMC Complementary and Alternative Medicine 2013 13:138
  21. Soshiho-tang (SH; Chinese name, Xiao-Chai-Hu-Tang; Japanese name, Shosaiko-to) is a traditional Korean, Chinese, and Japanese medicine, which has been used to treat various conditions, including hepatitis, liv...

    Authors: Jung-Jin Lee, Taesoo Kim, Won-Kyung Cho and Jin Yeul Ma
    Citation: BMC Complementary and Alternative Medicine 2013 13:137
  22. High-cholesterol diet (HCD) increases the oxidative stress in different tissues leading to many diseases. Rutin (RT) is a natural flavonoid (vitamin p), which possesses an antioxidant activity with protective ...

    Authors: Salem S Al-Rejaie, Abdulaziz M Aleisa, Mohamed M Sayed-Ahmed, Othman A AL-Shabanah, Hatem M Abuohashish, Mohammed M Ahmed, Khaled A Al-Hosaini and Mohamed M Hafez
    Citation: BMC Complementary and Alternative Medicine 2013 13:136
  23. We have previously reported that aerial parts of Tylophora hirsuta have antispasmodic profile. The current work is an attempt for isolation of pharmacologically active compound(s) that contribute for its antispas...

    Authors: Niaz Ali
    Citation: BMC Complementary and Alternative Medicine 2013 13:135
  24. Transcutaneous electrical nerve stimulation (TENS) is a non-pharmacologic treatment for pain relief. In previous animal studies, TENS effectively alleviated Complete Freund’s Adjuvant (CFA)- or carrageenan-ind...

    Authors: Jun-Fan Fang, Yi Liang, Jun-Ying Du and Jian-Qiao Fang
    Citation: BMC Complementary and Alternative Medicine 2013 13:134
  25. The plant genus Fallopia is well-known in Chinese traditional medicine and includes many species that contain bioactive compounds, namely phytoestrogens. Consumption of phytoestrogens may be linked to decreased i...

    Authors: Jennifer C Brennan, Michael S Denison, Dirk M Holstege, Prokopios Magiatis, Jerry L Dallas, Elisa G Gutierrez, Anatoly A Soshilov and James R Millam
    Citation: BMC Complementary and Alternative Medicine 2013 13:133
  26. Traditional Chinese medicine (TCM) is an integral part of mainstream medicine in China. Due to its worldwide use, potential impact on healthcare and opportunities for new drug development, TCM is also of great...

    Authors: Qihe Xu, Rudolf Bauer, Bruce M Hendry, Tai-Ping Fan, Zhongzhen Zhao, Pierre Duez, Monique SJ Simmonds, Claudia M Witt, Aiping Lu, Nicola Robinson, De-an Guo and Peter J Hylands
    Citation: BMC Complementary and Alternative Medicine 2013 13:132
  27. Women with polycystic ovary syndrome (PCOS) have symptoms of depression and anxiety and impaired health related quality of life (HRQoL). Here we test the post-hoc hypothesis that acupuncture and exercise impro...

    Authors: Elisabet Stener-Victorin, Göran Holm, Per Olof Janson, Deborah Gustafson and Margda Waern
    Citation: BMC Complementary and Alternative Medicine 2013 13:131
  28. Antibacterial activity of honey is mainly dependent on a combination of its peroxide activity and non-peroxide components. This study aims to investigate antibacterial activity of five varieties of Malaysian h...

    Authors: Mohd Izwan Zainol, Kamaruddin Mohd Yusoff and Mohd Yasim Mohd Yusof
    Citation: BMC Complementary and Alternative Medicine 2013 13:129
  29. Colorectal cancer remains one of the leading causes of cancer death worldwide. Traditional Chinese Medicine (TCM) has played a positive role in colorectal cancer treatment. There is a great need to establish e...

    Authors: Shan Deng, Bing Hu, Hong-Mei An, Qin Du, Ling Xu, Ke-Ping Shen, Xiu-Feng Shi, Meng-Meng Wei and Yang Wu
    Citation: BMC Complementary and Alternative Medicine 2013 13:128
  30. Based on the reported antioxidant and anti-inflammatory potential of Terminalia paniculata, the bark aqueous extract (TPW) was investigated against liver damage.

    Authors: Sahil Talwar, Hitesh V Jagani, Pawan G Nayak, Nitesh Kumar, Anoop Kishore, Punit Bansal, Rekha R Shenoy and Krishnadas Nandakumar
    Citation: BMC Complementary and Alternative Medicine 2013 13:127
  31. The TRAMIL program aims to understand, validate and expand health practices based on the use of medicinal plants in the Caribbean, which is a “biodiversity hotspot” due to high species endemism, intense develo...

    Authors: Claribel Luciano-Montalvo, Isabelle Boulogne and Jannette Gavillán-Suárez
    Citation: BMC Complementary and Alternative Medicine 2013 13:126
  32. The aim of this publication is to present a case study of how to locate and appraise qualitative studies for the conduct of a meta-ethnography in the field of complementary and alternative medicine (CAM). CAM ...

    Authors: Brigitte Franzel, Martina Schwiegershausen, Peter Heusser and Bettina Berger
    Citation: BMC Complementary and Alternative Medicine 2013 13:125
  33. Personalised (or individualised) medicine in the days of genetic researchrefers to molecular biologic specifications in individuals and not to aresponse to individual patient needs in the sense of person-centr...

    Authors: Brigitte Franzel, Martina Schwiegershausen, Peter Heusser and Bettina Berger
    Citation: BMC Complementary and Alternative Medicine 2013 13:124
  34. Yi Guan Jian Decoction (YGJD), a famous Chinese prescription, has long been employed clinically to treat liver fibrosis. However, as of date, there is no report on the effects of YGJD from a metabonomic approa...

    Authors: Xiaojun Gou, Qing Tao, Qin Feng, Jinghua Peng, Yu Zhao, Jianye Dai, Wenyu Wang, Yongyu Zhang, Yiyang Hu and Ping Liu
    Citation: BMC Complementary and Alternative Medicine 2013 13:123
  35. Patients’ expectations of osteopathic care have been little researched. The aim of this study was to quantify the most important expectations of patients in private UK osteopathic practices, and the extent to ...

    Authors: CM Janine Leach, Anne Mandy, Matthew Hankins, Laura M Bottomley, Vinette Cross, Carol A Fawkes, Adam Fiske and Ann P Moore
    Citation: BMC Complementary and Alternative Medicine 2013 13:122
  36. Egyptians recognized the healing power of herbs and used them in their medicinal formulations. Nowadays, “Attarin” drug shops and the public use mainly the Unani medicinal system for treatment of their health ...

    Authors: Shereen K Ali, Ahmed R Hamed, Maha M Soltan, Usama M Hegazy, Esameldin E Elgorashi, Ibrahim A El-Garf and Ahmed A Hussein
    Citation: BMC Complementary and Alternative Medicine 2013 13:121
  37. Parthenium hysterophorus L. (Asteraceae) is a common weed occurring throughout the globe. In traditional medicine its decoction has been used for treatment of many infectious and degenerative diseases. This work...

    Authors: Shashank Kumar, Amita Mishra and Abhay K Pandey
    Citation: BMC Complementary and Alternative Medicine 2013 13:120
  38. A traditional Chinese Medicine (TCM) formula, HZJW, has been applied in clinics in China for gastrointestinal disorders. However, the therapeutic mechanism underlying its efficacy and safety remained to be def...

    Authors: Jian-Hui Xie, Yun-Long Chen, Qing-He Wu, Jun Wu, Ji-Yan Su, Hong-Yin Cao, Yu-Cui Li, Yi-Sheng Li, Jin-Bin Liao, Xiao-Ping Lai, Ping Huang and Zi-Ren Su
    Citation: BMC Complementary and Alternative Medicine 2013 13:119
  39. Diabetes is a serious metabolic disorder affecting the metabolism of carbohydrate, protein and fat. A number of studies have shown that diabetes mellitus is associated with oxidative stress, leading to an incr...

    Authors: Hasni Misbah, Azlina Abdul Aziz and Norhaniza Aminudin
    Citation: BMC Complementary and Alternative Medicine 2013 13:118
  40. Dental caries is an infectious disease which results from the acidic demineralisation of the tooth enamel and dentine as a consequence of the dental plaque (a microbial biofilm) accumulation. Research showed t...

    Authors: Caterina Signoretto, Anna Marchi, Anna Bertoncelli, Gloria Burlacchini, Alberto Milli, Francesco Tessarolo, Iole Caola, Adele Papetti, Carla Pruzzo, Egija Zaura, Peter Lingström, Itzhak Ofek, David A Spratt, Jonathan Pratten, Michael Wilson and Pietro Canepari
    Citation: BMC Complementary and Alternative Medicine 2013 13:117
  41. Oxidative stress has been implicated in the progression of various diseases, which may result in the depletion of endogenous antioxidants. Exogenous supplementation with antioxidants could result in increased ...

    Authors: Werner Cordier, Mary Gulumian, Allan Duncan Cromarty and Vanessa Steenkamp
    Citation: BMC Complementary and Alternative Medicine 2013 13:116
  42. Chromatin, residing in the nuclei of eukaryotic cells, comprises DNA and histones to make up chromosomes. Chromatin condenses to compact the chromosomes and loosens to facilitate gene transcription and DNA rep...

    Authors: Hsin-Ying Hsieh, Pei-Hsun Chiu and Sun-Chong Wang
    Citation: BMC Complementary and Alternative Medicine 2013 13:115
  43. Reflexology is an alternative medical practice that produces beneficial effects by applying pressure to specific reflex areas. Our previous study suggested that reflexological stimulation induced cortical acti...

    Authors: Naoki Miura, Yuko Akitsuki, Atsushi Sekiguchi and Ryuta Kawashima
    Citation: BMC Complementary and Alternative Medicine 2013 13:114
  44. Distressed individuals in Korea may benefit from the practice of mind–body exercises such as Qigong. However, the effectiveness of such techniques needs to be investigated.

    Authors: Eun-Young Hwang, Sun-Yong Chung, Jae-Heung Cho, Mi-Yeon Song, Sehyun Kim and Jong-Woo Kim
    Citation: BMC Complementary and Alternative Medicine 2013 13:113
  45. Osteoclasts are primarily responsible for bone resorption. In many pathological bone diseases including osteoporosis and rheumatoid arthritis, osteoclasts are excessively activated. Thus, controlling of osteoc...

    Authors: Hyunil Ha, Ki-Shuk Shim, Hyosun An, Taesoo Kim and Jin Yeul Ma
    Citation: BMC Complementary and Alternative Medicine 2013 13:112
  46. Plants of the genus Maytenus belong to the family Celastraceae and are widely used in folk medicine as anti-tumour, anti-asthmatic, analgesic, anti-inflammatory, antimicrobial and anti-ulcer agents, and as a trea...

    Authors: Tsholofelo Abednego Mokoka, Lyndy Joy McGaw, Ladislaus Kakore Mdee, Victor Patrick Bagla, Ezekiel Olugbenga Iwalewa and Jacobus Nicolaas Eloff
    Citation: BMC Complementary and Alternative Medicine 2013 13:111
  47. Persea americana seeds are widely used in traditional Mexican medicine to treat rheumatism, asthma, infectious processes as well as diarrhea and dysentery caused by intestinal parasites.

    Authors: Adelina Jiménez-Arellanes, Julieta Luna-Herrera, Ricardo Ruiz-Nicolás, Jorge Cornejo-Garrido, Amparo Tapia and Lilián Yépez-Mulia
    Citation: BMC Complementary and Alternative Medicine 2013 13:109
  48. Hwangryun-haedok-tang (HRT) is traditional herbal medicine used to treat inflammatory-related diseases in Asia. However, its effect on osteoclastogenesis and bone loss is still unknown. In this study, we evalu...

    Authors: Ki-Shuk Shim, Taesoo Kim, Hyunil Ha, Kwang Jin Lee, Chang-Won Cho, Han Sung Kim, Dong-Hyun Seo and Jin Yeul Ma
    Citation: BMC Complementary and Alternative Medicine 2013 13:106