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  1. Atherosclerosis (AS) is the primary cause of cardiovascular disease and the incidence is extremely common; however, there are currently few drugs that can effectively treat AS. Although oridonin has been widel...

    Authors: Zhipeng Chen, Heqian Liu, Xiaoqi Zhao, Subinur Mamateli, Cheng Liu, Lei Wang, Jing Yu, Yutong Liu, Jing Cai and Tong Qiao
    Citation: BMC Complementary Medicine and Therapies 2022 22:180
    Content type: Research Published on:

  2. Cisplatin (CisPT) is a chemotherapeutic that outcome in adverse effects including neurotoxicity. We examined the efficacy of hydaspica ethyl acetate extract (AHE) against CisPT-prompted neurotoxicity.

    Authors: Tayyaba Afsar, Suhail Razak and Ali Almajwal
    Citation: BMC Complementary Medicine and Therapies 2022 22:179
    Content type: Research Published on:

  3. Tetrapleura tetraptera is a medicinal spice traditionally used to treat cancer, diabetes, and several other ailments. This study analyzed the cytotoxicity of the dichloromethane methanol extract of T. tetraptera ...

    Authors: Idrios N. Bonsou, Armelle T. Mbaveng, Gaëlle S. Nguenang, Godloves F. Chi, Victor Kuete and Thomas Efferth
    Citation: BMC Complementary Medicine and Therapies 2022 22:178
    Content type: Research Published on:

  4. As a traditional herbal medicine, Dracaena angustifolia Roxb has been used as an anti-inflammatory agent by the Li people in Hainan, China. In preliminary phytochemical studies conducted in our lab, its fractions...

    Authors: Jiling Yi, Ting Zhao, Yuanlin Zhang, Yanxing Tan, Xiao Han, Yulin Tang and Guangying Chen
    Citation: BMC Complementary Medicine and Therapies 2022 22:177
    Content type: Research Published on:

  5. Luteolin, a flavonoid compound with anti-inflammatory activity, has been reported to alleviate cerebral ischemia/reperfusion (I/R) injury. However, its potential mechanism remains unclear.

    Authors: Lu Li, Guanghua Pan, Rong Fan, Dalei Li, Lei Guo, Lili Ma, Hui Liang and Jiaoxue Qiu
    Citation: BMC Complementary Medicine and Therapies 2022 22:176
    Content type: Research Published on:

  6. Traditional Korean Medicine (TKM) is highly integrated with the modern health care system of South Korea and is actively used in the public health field. Since 2014, the Ministry of Health and Welfare of South...

    Authors: Eunhye Hyun, Jiseon Ryu, Kibong Kim, Sangjae Lee, Seungtae Kim and Byungmook Lim
    Citation: BMC Complementary Medicine and Therapies 2022 22:175
    Content type: Research Published on:

  7. Polysaccharides from wampee have been reported to process various biological activities, while the relationship between structure and bioactivities has been barely addressed. Pectin, an abundant water-soluble ...

    Authors: Weiyu Fu, Xuehua Liao, Qian Zhang, Yuzhen Zhu, Si Mei, Qian Li, Xin Zhou, Xiaojun Li, Hui Luo, Hua Ye and Kefeng Wu
    Citation: BMC Complementary Medicine and Therapies 2022 22:174
    Content type: Research Published on:

  8. Conventional cancer treatments, such as chemotherapy, radiation therapy, and surgery, often affect the patients’ quality of life due to their serious side effects, indicating the urgent need to develop less to...

    Authors: Mahla Amirzadeh, Sara Soltanian and Neda Mohamadi
    Citation: BMC Complementary Medicine and Therapies 2022 22:173
    Content type: Research Published on:

  9. Globally, ischemic stroke is a major health threat to humans that causes lifelong disability and death. Mentha arvensis (MA) has been used in traditional medicine to alleviate oxidative stress and inflammation-re...

    Authors: Md Sadikul Islam, Ha-Young Shin, Yeo-Jin Yoo, Eui-Yong Lee, Ryunhee Kim, Young-Jin Jang, Md Rashedunnabi Akanda, Hyun-Jin Tae, In-Shik Kim, Dongchoon Ahn and Byung-Yong Park
    Citation: BMC Complementary Medicine and Therapies 2022 22:172
    Content type: Research Published on:

  10. Psychologists, and their clients, are engaging with complementary medicine (CM). Increasing evidence for CM approaches, such as improved nutrition and St John’s wort, has led to their inclusion in the Royal Au...

    Authors: Carrie Thomson-Casey, Jon Adams and Erica McIntyre
    Citation: BMC Complementary Medicine and Therapies 2022 22:171
    Content type: Research Published on:

  11. Busulfan is an antineoplastic medication that is broadly utilized for cancer treatment. It affects the testicular function and leads to sterility. The present study aimed to evaluate the effects of ellagic aci...

    Authors: Amirabbas Rostami, Sina Vakili, Farhad Koohpeyma, Bahia Namavar Jahromi, Ziba Afshari Aghajari, Fatemeh Mahmoudikohani, Forough Saki, Marzieh Mahmoodi, Khojaste Rahimi Jaberi, Ahmad Movahedpour, Majid Jafari Khorchani and Saam Noroozi
    Citation: BMC Complementary Medicine and Therapies 2022 22:170
    Content type: Research Published on:

  12. Pithecellobium dulce (Roxb.), an evergreen medium-sized, spiny tree which have vast nutritional values and widely used in ayurvedic medicines and home remedies. The plant has also been a rich source of biological...

    Authors: Masuma Akter, Mst. Shahnaj Parvin, Md. Mahadi Hasan, Md. Aziz Abdur Rahman and Md. Ekramul Islam
    Citation: BMC Complementary Medicine and Therapies 2022 22:169
    Content type: Research Published on:

  13. Current therapies for alcohol-induced liver injury are of limited efficacy and associated with significant side effects. With the proposed pathophysiology of alcohol-induced liver injury to be related to deran...

    Authors: Maneerat Chayanupatkul, Kanjana Somanawat, Natthaya Chuaypen, Naruemon Klaikeaw, Natcha Wanpiyarat, Prasong Siriviriyakul, Somying Tumwasorn and Duangporn Werawatganon
    Citation: BMC Complementary Medicine and Therapies 2022 22:168
    Content type: Research Published on:

  14. Vascular damage, autoimmune abnormalities, and fibrosis are the three pathological features of systemic sclerosis (SSc).However, pulmonary vascular damage is the main factor affecting the progression and progn...

    Authors: Kai Li, Qian Wang, Qin Lv, Kelei Guo, Li Han, Peipei Duan, Yongzheng Deng and Hua Bian
    Citation: BMC Complementary Medicine and Therapies 2022 22:167
    Content type: Research Published on:

  15. Ginsenoside Rg-1 (Rg-1), a triterpenoid saponin abundantly present in Panax ginseng, is a type of naturally occurring steroid with known anti-diabetic and anti-inflammatory effects. In this study, we sought to co...

    Authors: A Young Han, Su Min Ha, You Kyoung Shin and Geun Hee Seol
    Citation: BMC Complementary Medicine and Therapies 2022 22:166
    Content type: Research Published on:

  16. Vitamin D (Vit D) supplementation and Aerobic Training (AT) exert several beneficial effects such as antioxidant and anti-inflammatory actions. The literature on the effects of AT and Vit D supplementation on ...

    Authors: Rastegar Hoseini, Hiwa Ahmed Rahim and Jalal Khdhr Ahmed
    Citation: BMC Complementary Medicine and Therapies 2022 22:165
    Content type: Research Published on:

  17. Influenza A virus infection due to drug resistance and side effects of the conventional antiviral drugs yet remains a serious public health threat for humans and animals. Forsythiaside A is an effective ingred...

    Authors: Xiao Zheng, Ziqi Chen, Shanshan Shi, Huijun Yan, Junmei Zhou, Lifang Jiang, Hongli Wang, Guanghui Hou and Zhenyou Jiang
    Citation: BMC Complementary Medicine and Therapies 2022 22:164
    Content type: Research Published on:

  18. Previous studies in our laboratory in ex vivo assays have demonstrated H. hemerocallidea extract as potential antidiabetic agent through increased insulin release from pancreatic beta cells. Thus, for this study ...

    Authors: N. M. Mkolo, O. O. Olaokun, P. H. King, I. Janse van Rensburg, J. N. Eloff and V. Naidoo
    Citation: BMC Complementary Medicine and Therapies 2022 22:163
    Content type: Research Published on:

  19. In Korea, conventional medicine (CM) and traditional Korean medicine (KM) are run as a dual healthcare system; however, the backgrounds and characteristics of the users of both medical services have not yet be...

    Authors: Yui Sasaki, Jeong-Su Park, Sunju Park, Chunhoo Cheon, Yong-Cheol Shin, Seong-Gyu Ko and Bo-Hyoung Jang
    Citation: BMC Complementary Medicine and Therapies 2022 22:162
    Content type: Research Published on:

  20. In 2019, investigators from China, South Korea and the United States of America initiated a coordinated multinational trial. The trial included three parallel randomized studies with a planned pooled analysis ...

    Authors: Sylvia Baedorf Kassis, Weidong Lu, Sarah A. White, Im Hee Shin, Sung Hwan Park, Young Ju Jeong, Chang Yao, Jennifer Ligibel and Barbara E. Bierer
    Citation: BMC Complementary Medicine and Therapies 2022 22:161
    Content type: Research Published on:

  21. The present study aimed to determine the protective effects of hypaconitine (HA) and glycyrrhetinic acid (GA) against chronic heart failure (CHF) in the rats and to explore the underlying molecular mechanisms.

    Authors: Liqin Wang, Haiming Deng, Tengyu Wang, Yun Qiao, Jianbing Zhu and Mingfeng Xiong
    Citation: BMC Complementary Medicine and Therapies 2022 22:160
    Content type: Research Published on:

  22. Croton macrostachyus is an important plant in traditional African medicine, widely utilized to treat a variety of diseases. In Kenya, HIV-infected patients use leaf and root decoctions of the plant as a cure for...

    Authors: Ermias Mergia Terefe, Faith A. Okalebo, Solomon Derese, Moses K. Langat, Eduard Mas-Claret, Nada H. Aljarba, Saad Alkahtani, Gaber El-Saber Batiha, Arabinda Ghosh, Eman A. El-Masry and Joseph Muriuki
    Citation: BMC Complementary Medicine and Therapies 2022 22:159
    Content type: Research Published on:

  23. The 7β-(3-ethyl-cis-crotonoyloxy)-1α-(2-methylbutyryloxy)-3,14-dehydro-Z-notonipetranone (ECN), a sesquiterpenoid isolated from the Tussilago farfara Linneaus (Asteraceae), was evaluated against acute Carrageenan...

    Authors: Amna Khan, Li Zhang, Chang Hu Li, Ashraf Ullah Khan, Bushra Shal, Adnan Khan, Sajjad Ahmad, Fakhar ud Din, Zia ur rehman, Feng Wang and Salman Khan
    Citation: BMC Complementary Medicine and Therapies 2022 22:158
    Content type: Research Published on:

  24. Hypertension and its associated dysfunction of the blood-brain barrier (BBB) are considered to contribute to cerebral small vessel disease (cSVD). Angiotensin II (Ang II), as an important vasoactive peptide of...

    Authors: Yu Yan Xie, Yun Wei Lu and Gu Ran Yu
    Citation: BMC Complementary Medicine and Therapies 2022 22:157
    Content type: Research Published on:

  25. Despite the number of deaths and the significant economic and social costs associated with Chagas, Leishmaniasis and Malaria diseases worldwide, available drugs are limited and have serious side effects and hi...

    Authors: Camila M. Clemente, Sara M. Robledo and Soledad Ravetti
    Citation: BMC Complementary Medicine and Therapies 2022 22:156
    Content type: Research Published on:

  26. Individual acupuncture (AP) is a safe and effective treatment for cancer-related pain and other symptoms in cancer survivors. However, access to individual AP is limited, and costs can be prohibitive. Group AP...

    Authors: Devesh Oberoi, Erica N. Reed, Katherine-Ann Piedalue, Jessa Landmann and Linda E. Carlson
    Citation: BMC Complementary Medicine and Therapies 2022 22:155
    Content type: Research article Published on:

  27. The study was planned to investigate the phytochemicals, antidiabetic and antioxidant studies of A. consanguineum.

    Authors: Mater H. Mahnashi, Yahya S. Alqahtani, Ali O. Alqarni, Bandar A. Alyami, Omaish S. Alqahtani, Muhammad Saeed Jan, Fida Hussain, Zia Ul Islam, Farhat Ullah, Muhammad Ayaz, Muhammad Abbas, Umer Rashid and Abdul Sadiq
    Citation: BMC Complementary Medicine and Therapies 2022 22:154
    Content type: Research Published on:

  29. Gout is a common disease with high incidence due to unhealthy diet and living habits. Simiao Powder, as a classic formula consisted of four common herbs, has been widely used in clinical practice since ancient...

    Authors: Huachong Xu, Jialin Wu, Shiqi Wang, Lu Xu, Pei Liu, Yucong Shi, Sizhi Wu, Li Deng and Xiaoyin Chen
    Citation: BMC Complementary Medicine and Therapies 2022 22:152
    Content type: Research Published on:

  30. Asthma and idiopathic pulmonary fibrosis (IPF) are common chronic diseases of the respiratory system in clinical practice. However, the relationship and molecular links remain unclear, and the current treatmen...

    Authors: Yuanyuan Zhong, Lingli Hu, Wenjing Chen, Bin Wang, Jing Sun and Jingcheng Dong
    Citation: BMC Complementary Medicine and Therapies 2022 22:151
    Content type: Research Published on:

  31. Endometrial carcinoma is one of the two cancers with rising mortality and morbidity in recent years. In the light of many controversies about its treatment, it is urgent to construct a new prognostic model and...

    Authors: Zhiheng Lin, Xiaohui Sui, Wenjian Jiao, Ying Wang and Junde Zhao
    Citation: BMC Complementary Medicine and Therapies 2022 22:150
    Content type: Research Published on:

  32. Antimicrobial peptides (AMPs) are important effectors of the innate defense system. Cathelicidins, (CRAMP in mouse/rat, LL-37 in human) is one of the two major classes of AMPs in humans. The upregulation of LL...

    Authors: Nagat Siednamohammeddeen, Rehab Badi, Tahane Mohammeddeen, Khalid Enan and AmalSaeed
    Citation: BMC Complementary Medicine and Therapies 2022 22:149
    Content type: Research Published on:

  33. Massage is a widely acceptable and popular form of complementary medicine (CM) among Australian women. While there is some research that reports on massage use in younger women, there is minimal research explo...

    Authors: Suzy Ladanyi, Jon Adams and David Sibbritt
    Citation: BMC Complementary Medicine and Therapies 2022 22:148
    Content type: Research Published on:

  34. Gao-Zi-Yao has long been a unique way for treating various diseases. The present study is to explore the effect of Gao-Zi-Yao on learning and memory function in old spontaneous hypertensive rats (SHR) and its ...

    Authors: Meng-Xiao Han, Wen-Yi Jiang, Yan Jiang, Lin-Hui Wang, Rong Xue, Guo-Xing Zhang and Jing-Wei Chen
    Citation: BMC Complementary Medicine and Therapies 2022 22:147
    Content type: Research Published on:

  35. Herbal medicines are widely used in the world especially in developing countries. Pregnant women use herbal products to treat pregnancy related illnesses due to prior experience of herbal medicine use and easy...

    Authors: Yaschilal Muche Belayneh, Tewodros Yoseph and Solomon Ahmed
    Citation: BMC Complementary Medicine and Therapies 2022 22:146
    Content type: Research article Published on:

  36. Use of natural products has been proposed as an efficient method in modulation of immune system and treatment of cancers. The aim of this study was to investigate the potential of cryptotanshinone (CPT), narin...

    Authors: Shokoofe Noori, Mitra Nourbakhsh, Hossein Imani, Niloofar Deravi, Niloufar Salehi and Zohreh Abdolvahabi
    Citation: BMC Complementary Medicine and Therapies 2022 22:145
    Content type: Research Published on:

  37. Chronic exposure to ultraviolet B (UVB) causes a series of adverse skin reactions, such as erythema, sunburn, photoaging, and cancer, by altering signaling pathways related to inflammation, oxidative stress, a...

    Authors: Bei Chen, Honghong Chen, Haidong Qu, Kun Qiao, Min Xu, Jingna Wu, Yongchang Su, Yan Shi, Zhiyu Liu and Qin Wang
    Citation: BMC Complementary Medicine and Therapies 2022 22:144
    Content type: Research Published on:

  38. Cinnamon (Cinnamomum zeylanicum) and Clove (Syzygium aromaticum) essential oils are two medicinally important plant-derived substances with a wide range of biological properties. Besides, nanoemulsion-based gels ...

    Authors: Fariba Esmaeili, Masoumeh Zahmatkeshan, Yaser Yousefpoor, Hiva Alipanah, Ehsan Safari and Mahmoud Osanloo
    Citation: BMC Complementary Medicine and Therapies 2022 22:143
    Content type: Research Published on:

  39. The potential of essential oils (EOs) and of their principal constituents for eradication of biofilm and at the same time the research of new potential acetylcholinesterase inhibitors is gaining increasing int...

    Authors: Lucia Caputo, Francesca Capozzolo, Giuseppe Amato, Vincenzo De Feo, Florinda Fratianni, Giovanni Vivenzio and Filomena Nazzaro
    Citation: BMC Complementary Medicine and Therapies 2022 22:142
    Content type: Research Published on:

  40. Diabetic retinopathy (DR), one of the most common and severe microvascular complication of diabetes mellitus (DM), is mainly caused by diabetic metabolic disorder. So far, there is no effective treatment for D...

    Authors: Yao Chen, Jiaojiao Sun, Zhiyun Zhang, Xiaotong Liu, Qiaozhi Wang and Yang Yu
    Citation: BMC Complementary Medicine and Therapies 2022 22:141
    Content type: Research Published on:

    The Correction to this article has been published in BMC Complementary Medicine and Therapies 2022 22:153

  41. Mosquito-borne diseases such as malaria and encephalitis are still the cause of several hundred thousand deaths annually. The excessive use of chemical insecticides for transmission control has led to environm...

    Authors: Alireza Sanei-Dehkordi, Mohammad Djaefar Moemenbellah-Fard, Mostafa Saffari, Elham Zarenezhad and Mahmoud Osanloo
    Citation: BMC Complementary Medicine and Therapies 2022 22:140
    Content type: Research Published on:

  42. Crinum latifolium L. (Amaryllidaceae) has been used in Southeast Asian traditional medicine to alleviate the symptoms of benign prostatic hyperplasia (BPH). The pathological mechanism of BPH is associated with th...

    Authors: Wisuwat Thongphichai, Tamonwan Uttarawichien, Pithi Chanvorachote, Supaporn Pitiporn, Todsaphol Charoen-ame, Pakakrong Kwankhao, Pasarapa Towiwat and Suchada Sukrong
    Citation: BMC Complementary Medicine and Therapies 2022 22:139
    Content type: Research Published on:

  43. Alleviating suffering and improving quality of life are universally shared goals. In this context, we implemented a pilot study to assess the feasibility and acceptability of a mindfulness intervention in the ...

    Authors: Virginie Prevost, Sophie Lefevre-Arbogast, Alexandra Leconte, Claire Delorme, Sandrine Benoit, Titi Tran and Bénédicte Clarisse
    Citation: BMC Complementary Medicine and Therapies 2022 22:138
    Content type: Research Published on:

  44. Cancer-related incidence and mortality rates are rapidly increasing worldwide. However, no studies have examined the effect of cancer as a single factor on the use of traditional, complementary, and alternativ...

    Authors: Dongsu Kim, Soo-Hyun Sung, Seungwon Shin and Minjung Park
    Citation: BMC Complementary Medicine and Therapies 2022 22:137
    Content type: Research Published on:

  45. Authors: Hei-Jen Huang, Jie-Ling Chen, Jian-Fu Liao, Yu-Hsin Chen, Min-Wei Chieu, Ya-Yun Ke, Chih-Chieh Hsu, Ying-Chieh Tsai and Hsiu Mei Hsieh-Li
    Citation: BMC Complementary Medicine and Therapies 2022 22:136
    Content type: Correction Published on:

    The original article was published in BMC Complementary Medicine and Therapies 2021 21:259

  46. Trachyspermum ammi, commonly known as Ajwain, is a member of the Apiaceae family. It is a therapeutic herbal spice with diverse pharmacological properties, used in traditional medicine for various ailments. Howev...

    Authors: Saud O. Alshammari, Taibah Aldakhil, Qamar A. Alshammari, David Salehi and Aftab Ahmed
    Citation: BMC Complementary Medicine and Therapies 2022 22:135
    Content type: Research Published on:

  47. The genus Eryngium is a member of the Apiaceae family that has shown different pharmacological effects mainly including anti-inflammatory, analgesic, anti-cancer, hepatoprotective, and anti-oxidant. Previous r...

    Authors: Haleh Forouhandeh, Zahra Rezaei Param, Ommoleila Molavi, Parina Asgharian and Vahideh Tarhriz
    Citation: BMC Complementary Medicine and Therapies 2022 22:134
    Content type: Research Published on:

  48. The blood-testis barrier (BTB) is a physical barrier of the testis to prevent various exogenous substrates from entering apical compartments and provides immune privilege for spermatogenesis, which is essentia...

    Authors: Junjun Li, Yaodong You, Peihai Zhang, Xiaopeng Huang, Liang Dong, Fang Yang, Xujun Yu and Degui Chang
    Citation: BMC Complementary Medicine and Therapies 2022 22:133
    Content type: Research Published on:

  49. Cognitive health is of great interest to society, with neuroinflammation and systemic inflammation age-related risk factors that are linked to declines in cognitive performance. Several botanical ingredients h...

    Authors: Gemma Margetts, Sotirios Kleidonas, Nawel S. Zaibi, Mohamed S. Zaibi and Kieron D. Edwards
    Citation: BMC Complementary Medicine and Therapies 2022 22:131
    Content type: Research Published on:

  50. Medicinal plants have been successfully used as an alternative source of drugs for the treatment of microbial diseases. Finding a novel treatment for malaria is still challenging, and various extracts from dif...

    Authors: Ahmed M. Abdou, Abdel-latif S. Seddek, Noha Abdelmageed, Mohamed O. Badry and Yoshifumi Nishikawa
    Citation: BMC Complementary Medicine and Therapies 2022 22:130
    Content type: Research article Published on:
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ISSN: 2662-7671

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