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  1. Breast cancer is still the most common malignant tumor that threatens the female’s life in the world, especially triple-negative breast cancer (TNBC), one of the most difficult subtypes. Lack of targeted thera...

    Authors: Mingjiang Yao, Xiaodi Fan, Bo Yuan, Norio Takagi, Sai Liu, Xiao Han, Junguo Ren and Jianxun Liu
    Citation: BMC Complementary and Alternative Medicine 2019 19:216
  2. Mounting evidence indicates that the cerebral cortex is an important physiological system of emotional activity, and its dysfunction may be the main cause of stress. Glutamate is the primary excitatory neurotr...

    Authors: Yan Liu, Xiu-fang Ding, Xin-xing Wang, Xiao-juan Zou, Xiao-juan Li, Yue-yun Liu, Jie Li, Xiu-yun Qian and Jia-xu Chen
    Citation: BMC Complementary and Alternative Medicine 2019 19:215
  3. The present study evaluated the antinociceptive effect of the bark of Artocarpus lacucha, which is used for the treatment of stomachache, headache and boils in the traditional system of medicine.

    Authors: Shanta Islam, Md. Shafiullah Shajib, Ridwan Bin Rashid, Mohammad Firoz Khan, Md. Abdullah Al-Mansur, Bidyut Kanti Datta and Mohammad Abdur Rashid
    Citation: BMC Complementary and Alternative Medicine 2019 19:214
  4. Various extracts of Centella asiatica (Apiaceae) and its active constituent, asiaticoside, have been reported to possess wound healing property when assessed using various in vivo and in vitro models. In an attem...

    Authors: Afnan Sh. Ahmed, Muhammad Taher, Uttam Kumar Mandal, Juliana Md Jaffri, Deny Susanti, Syed Mahmood and Zainul Amiruddin Zakaria
    Citation: BMC Complementary and Alternative Medicine 2019 19:213
  5. Recently, there has been an increasing tendency to go back to nature in search of new medicines. To facilitate this, a great deal of effort has been made to compile information on natural products worldwide, a...

    Authors: Lemessa Etana Bultum, Assefa Mussa Woyessa and Doheon Lee
    Citation: BMC Complementary and Alternative Medicine 2019 19:212
  6. Breast cancer is the leading cause of cancer-related death in women worldwide. Although traditional Chinese medicine (TCM) is commonly used by patients with breast cancer, little is known about TCM prescriptio...

    Authors: Yu-Te Liu, Chao-Hsiang Hsiao, Bor-Show Tzang and Tsai-Ching Hsu
    Citation: BMC Complementary and Alternative Medicine 2019 19:211
  7. Skin diseases are a major health concern especially in association with human immune deficiency syndrome and acquired an immune deficiency. The aim of this study was to document the ethnomedicinal information ...

    Authors: Khafsa Malik, Mushtaq Ahmad, Muhammad Zafar, Riaz Ullah, Hafiz Majid Mahmood, Bushra Parveen, Neelam Rashid, Shazia Sultana, Syed Nasar Shah and Lubna
    Citation: BMC Complementary and Alternative Medicine 2019 19:210
  8. The imbalance between the generation of free radicals and natural cellular antioxidant defenses, known as oxidative stress, can cause oxidation of biomolecules and further contribute to aging-associated diseas...

    Authors: Palika Wetchakul, Jo Aan Goon, Ademola Ezekiel Adekoya, Opeyemi Joshua Olatunji, Sutticha Ruangchuay, Patcharawalai Jaisamut, Acharaporn Issuriya, Nongluk Kunworarath, Surasak Limsuwan and Sasitorn Chusri
    Citation: BMC Complementary and Alternative Medicine 2019 19:209
  9. Acupuncture is widely used worldwide, and systematic reviews on acupuncture are increasingly being published. Although acupuncture systematic reviews share several essential elements with other systematic revi...

    Authors: Xiaoqin Wang, Yaolong Chen, Yali Liu, Liang Yao, Janne Estill, Zhaoxiang Bian, Taixiang Wu, Hongcai Shang, Myeong Soo Lee, Dang Wei, Jinhui Tian, Bin Ma, Yongfeng Wang, Guihua Tian and Kehu Yang
    Citation: BMC Complementary and Alternative Medicine 2019 19:208
  10. Cnidii Rhizoma is the dried root stem of Cnidium officinale Makino. Cnidii Rhizoma (CR) has been used to treat menstrual irregularity, menstrual pain, and menopause in Korea. However, the effects and mechanisms o...

    Authors: Ka-Yeon Lee, Jae-Hyun Kim, Eun-Young Kim, Mijung Yeom, Hyuk-Sang Jung and Youngjoo Sohn
    Citation: BMC Complementary and Alternative Medicine 2019 19:207
  11. About 425 million adults had diabetes mellitus globally in 2017. Type 2 diabetes accounts for the enormous majority of diabetes cases and it is gradually growing which is predicted to increase by 48% in 2045. ...

    Authors: Gebretsadkan Hintsa Tekulu, Ephrem Mebrahtu Araya and Hayelom Gebrekirstos Mengesha
    Citation: BMC Complementary and Alternative Medicine 2019 19:206
  12. Gastric ulcer is one of the most prevalent diseases worldwide. In Iranian folk medicine, Achillea wilhelmsii (AW) is used as a treatment for gastric ulcer. Previous reports also mentioned Antiulcerogenic properti...

    Authors: Mehdi Koushki, Reyhaneh Farrokhi Yekta, Nasrin Amiri-Dashatan, Masoumeh Dadpay and Fatemeh Goshadrou
    Citation: BMC Complementary and Alternative Medicine 2019 19:205
  13. Metastasis is the main cause of lung cancer death. As a seed of metastasis, circulating tumor cells are an important target for metastasis intervention. The traditional Chinese medicine, Jinfukang, has been cl...

    Authors: Zujun Que, Zhiyi Zhou, Bin Luo, Changsheng Dong, Yi Jiang, Hegen Li and Jianhui Tian
    Citation: BMC Complementary and Alternative Medicine 2019 19:204
  14. 5-Florouracil (5-FU) is a commonly used chemotherapeutic drug for cholangiocarcinoma, whereas it has unsatisfactory effect, and patients often have chemo-resistance to it. The combination of chemotherapeutic a...

    Authors: Zhaoyu Fu, Kexin Ma, Bing Dong, Chongyu Zhao, Chi Che, Chengyong Dong, Rixin Zhang, Haibo Wang, Xiang Wang and Rui Liang
    Citation: BMC Complementary and Alternative Medicine 2019 19:203
  15. Scientific studies have shown that the potential therapeutic efficacy of curcumin in several diseases is due to its potent antioxidant and anti-inflammatory properties. Consequently, curcumin supplementation s...

    Authors: Tatiane Andreza Lima Silva, Danielle Coutinho Medeiros, Gidyenne Christine Bandeira Silva Medeiros, Rafaela Catherine Silva Cunha Medeiros, Juliany de Souza Araújo, Jason Azevedo Medeiros, Marcela Abbott Galvao Ururahy, Ronaldo Vagner Thomatieli Santos, Radames Maciel Vitor Medeiros, Lucia Leite-Lais and Paulo Moreira Silva Dantas
    Citation: BMC Complementary and Alternative Medicine 2019 19:202
  16. Self-directed learning is a student-centered approach based on the students’ evaluation about their own learning needs. Self-directed practice is a component of the self-directed learning which focus on achiev...

    Authors: Giandomenico D’Alessandro, Giacomo Consorti and Francesco Cerritelli
    Citation: BMC Complementary and Alternative Medicine 2019 19:201
  17. Astilbe rivularis L. is an indigenous medicinal plant growing in high altitude of Darjeeling Himalayan region of India and Nepal. The plant rhizome has been used traditionally as medicine by local tribes to treat...

    Authors: Vijeta Rai, Anoop Kumar, Vaskar Das and Shilpi Ghosh
    Citation: BMC Complementary and Alternative Medicine 2019 19:200
  18. Triphala is an indigenous medical product used for a variety of diseases. This study was conducted to determine the effect of Triphala on antibiotic properties of gentamicin and oxacillin against multi-drug re...

    Authors: Amirthasingam Manoraj, Vasanthi Thevanesam, B. M. R. Bandara, Asela Ekanayake and Veranja Liyanapathirana
    Citation: BMC Complementary and Alternative Medicine 2019 19:199
  19. Endothelial cell inflammation is a central event in the pathogenesis of numerous cardiovascular diseases, including sepsis and atherosclerosis. Triptolide, a principal bioactive ingredient of Traditional Chine...

    Authors: Chundong Song, Youping Wang, Lin Cui, Fengna Yan and Si Shen
    Citation: BMC Complementary and Alternative Medicine 2019 19:198
  20. The present study was aimed to evaluate the molecular level anticaries effect of different medicinal plants against Streptococcus mutans (S.mutans) glucosyltransferases (gtf).

    Authors: Kiranmai Mandava, Uma Rajeswari Batchu, Shravya Kakulavaram, Shulamithi Repally, Ishwarya Chennuri, Srinivas Bedarakota and Namratha Sunkara
    Citation: BMC Complementary and Alternative Medicine 2019 19:197
  21. The rise in use of food supplements based on botanical ingredients (herbal supplements) is depicted as part of a trend empowering consumers to manage their day-to-day health needs, which presupposes access to ...

    Authors: Matthew Peacock, Mihaela Badea, Flavia Bruno, Lada Timotijevic, Martina Laccisaglia, Charo Hodgkins, Monique Raats and Bernadette Egan
    Citation: BMC Complementary and Alternative Medicine 2019 19:196
  22. Probiotics have been reported to be the active component used in the treatment of many functional gastrointestinal symptoms and syndromes. Lactobacillus and yeast culture are extensively used in probiotic supplem...

    Authors: Ki-Bae Hong, Hyeyoung Seo, Joong-su Lee and Yooheon Park
    Citation: BMC Complementary and Alternative Medicine 2019 19:195
  23. Infertility is considered one of the global public health problems and during human history, it is also considered one of the unsolved problems of the continuous human race. This study aimed to collect and doc...

    Authors: Nidal Jaradat and Abdel Naser Zaid
    Citation: BMC Complementary and Alternative Medicine 2019 19:194
  24. Wenshen Jianpi recipe (WSJPR), a blended traditional Chinese medicine, is considered to have the possible beneficial effect on the progression of diabetic nephropathy (DN). This present study was designed to e...

    Authors: Xiaodan Cao, Renxiong Wei, Jun Zhou, Xiaoxia Zhang, Wenbo Gong, Tinglong Jin and Xiabo Chen
    Citation: BMC Complementary and Alternative Medicine 2019 19:193
  25. Acute postoperative pain remains a major clinical problem that affects patient recovery. Distal acupoint and peri-incisional stimulation are both used for relieving acute postoperative pain in hospital. Our ob...

    Authors: Juan Zhu, Qian Xu, Rong Zou, Wenzhong Wu, Xiaoqiu Wang, Yanyi Wang, Fangbing Ji, Zhen Zheng and Man Zheng
    Citation: BMC Complementary and Alternative Medicine 2019 19:192
  26. Wnt/β-catenin signaling pathway is closely related to osteoarthritis. In our preliminary study, β-catenin conditional activation (cAct) mice that specifically over-express β-catenin gene in cartilage chondrocy...

    Authors: Wan-qing Xie, Yong-jian Zhao, Feng Li, Bing Shu, Shu-ru Lin, Li Sun, Yong-jun Wang and Hong-xin Zheng
    Citation: BMC Complementary and Alternative Medicine 2019 19:191
  27. While yoga is increasingly used for health purposes, its safety has been questioned. The aim of this cross-sectional survey was to analyze yoga-associated adverse effects and their correlates.

    Authors: Holger Cramer, Daniela Quinker, Dania Schumann, Jon Wardle, Gustav Dobos and Romy Lauche
    Citation: BMC Complementary and Alternative Medicine 2019 19:190
  28. The Atlantic Forest biome extends along the entire Brazilian coast and is home to approximately 20,000 plant species, many of which are endemic; it is considered one of the hotspot regions of the planet. Sever...

    Authors: Ayla das Chagas Almeida, Lais Azevedo Rodrigues, Graziela dos Santos Paulino, Ananda Pereira Aguilar, Alisson Andrade Almeida, Sukarno Olavo Ferreira, Geraldo Célio Brandão, João Paulo Viana Leite and Andréa de Oliveira Barros Ribon
    Citation: BMC Complementary and Alternative Medicine 2019 19:189
  29. Apiole was isolated from the leaves of various plants and vegetables and has been demonstrated to inhibit human colon cancer cell (COLO 205 cells) growth through induction of G0/G1 cell cycle arrest and apopto...

    Authors: Kuan-Hsun Wu, Wen-Jui Lee, Tzu-Chun Cheng, Hui-Wen Chang, Li-Ching Chen, Chia-Chang Chen, Hsiu-Man Lien, Teng-Nan Lin and Yuan-Soon Ho
    Citation: BMC Complementary and Alternative Medicine 2019 19:188
  30. One of the most important ways to cure hydatid cysts is surgery. Today, available chemical drugs have shown severe complications during hydatid cyst surgery. Here we investigated theefficacy and safety of Curcuma...

    Authors: Hossein Mahmoudvand, Mahbobeh Pakravanan, Mohammad Reza Aflatoonian, Amal Khudair Khalaf, Massumeh Niazi, Seyyed Reza Mirbadie, Amir Tavakoli Kareshk and Mehrdad Khatami
    Citation: BMC Complementary and Alternative Medicine 2019 19:187
  31. Oxidative stress and the inflammatory process are involved in ischemia–reperfusion (I/R) injury. Juglans mollis has been reported as having antioxidant activity, which could attenuate the damage caused by I/R. We...

    Authors: Jonathan Perez-Meseguer, Liliana Torres-González, Jorge Aurelio Gutiérrez-González, Gabriela Alarcón-Galván, Homero Zapata-Chavira, Noemi Waksman-de Torres, Diana Patricia Moreno-Peña, Linda Elsa Muñoz-Espinosa and Paula Cordero-Pérez
    Citation: BMC Complementary and Alternative Medicine 2019 19:186
  32. Honey has been increasingly recognized as a potential therapeutic agent for treatment of wound infections. There is an urgent need for assessment and evaluation of the antibacterial properties against wound pa...

    Authors: Muhammad Barkaat Hussain, Yasser Mahmoud Kamel, Zia Ullah, Asif Ahmad Mohamad Jiman-Fatani and Ansar Shafiq Ahmad
    Citation: BMC Complementary and Alternative Medicine 2019 19:185
  33. Bitter gourd (Momordica charantia) has attracted the focus of researchers owing to its excellent anti-diabetic action. The beneficial effect of Momordica charantia on heart has been reported by in vitro and in vi...

    Authors: Muhammad Farooq Khan, Nael Abutaha, Fahd A. Nasr, Ali S. Alqahtani, Omar M. Noman and Mohammad A. M. Wadaan
    Citation: BMC Complementary and Alternative Medicine 2019 19:184
  34. Cylicodiscus gabunensis Harms (Family Leguminosae) (CG) is an African medicinal plant used as a treatment of various ailments including malaria, liver diseases, and gastrointestinal disturbances. Its extracts sho...

    Authors: Omar Aldulaimi, Falko Drijfhout, Fidelia I. Uche, Paul Horrocks and Wen-Wu Li
    Citation: BMC Complementary and Alternative Medicine 2019 19:183
  35. Increase oxidative trauma is the main cause behind Cisplatin (CP) induced cardiotoxicity which restricts its clinical application as anti-neoplastic prescription. Acacia hydaspica is a natural shrub with diverse ...

    Authors: Tayyaba Afsar, Suhail Razak, Ali Almajwal, Maria Shabbir and Muhammad Rashid Khan
    Citation: BMC Complementary and Alternative Medicine 2019 19:182

    The Correction to this article has been published in BMC Complementary Medicine and Therapies 2020 20:326

  36. Study of phytochemicals and pharmacological properties of bryophytes has been neglected for a long time because of the three main reasons i.e. (i) difficulty in collection in large amount for analysis; (ii) th...

    Authors: Sumira Mukhia, Palash Mandal, D. K. Singh and Devendra Singh
    Citation: BMC Complementary and Alternative Medicine 2019 19:181
  37. Fruit, bark and leaves of Zanthoxylum armatum DC are popular remedies for gastrointestinal, cardiovascular and respiratory disorders in the subcontinent traditional practices. The aim of the study was to individu...

    Authors: Fiaz Alam and Abdul Jabbar Shah
    Citation: BMC Complementary and Alternative Medicine 2019 19:180
  38. Community-dwelling persons with dementia commonly use dietary supplements (DS), often without receiving help with the administration. Patient safety is a concern, as DS-drug interactions and adverse events are...

    Authors: Hilde Risvoll, Frauke Musial, Kjell H. Halvorsen, Trude Giverhaug and Marit Waaseth
    Citation: BMC Complementary and Alternative Medicine 2019 19:179
  39. To evaluate the effectiveness and safety of HuoXueHuaYu (HXHY) therapy in treating nonalcoholic fatty liver disease (NAFLD) through a systematic review and meta-analysis.

    Authors: Yunfei Cai, Qiuer Liang, Weihao Chen, Minghao Chen, Ruixue Chen, Yun Zhang, Ya Xiao and Liguo Chen
    Citation: BMC Complementary and Alternative Medicine 2019 19:178
  40. Quercus gall extracts’ ability to kill pathogens in vitro and even removal of chronic drug-resistant infections has been reported by several studies. The current investigation is focused on the action of extracts...

    Authors: Akhter Ahmed Ahmed and Fraidoon Abdulqadir Salih
    Citation: BMC Complementary and Alternative Medicine 2019 19:177
  41. Snake venoms contain various bioactive constituents which possess potential therapeutic effects. The aim of this work was to investigate the effect of the extract from Agkistrodon halys venom on lipopolysaccharid...

    Authors: Quan-Hai Wang, Wei Li, Yu-Xin Jiang, Xiao-Hua Lu and Guo-Guang Wang
    Citation: BMC Complementary and Alternative Medicine 2019 19:176
  42. Skin injury is inevitable in daily life. In recent years, with the increasing morbidity of diseases such as diabetes and metabolic disorders, chronic wounds have become a considerable challenge in clinical pra...

    Authors: Yan Lin, Qiqi Shao, Meng Zhang, Chenyue Lu, Joy Fleming and Songkun Su
    Citation: BMC Complementary and Alternative Medicine 2019 19:175
  43. The use of essential oils is growing in the United States, but clinician attitudes, experience, and beliefs regarding their use have not previously been studied.

    Authors: Amy C. S. Pearson, Susanne M. Cutshall, W. Michael Hooten, Nancy J. Rodgers, Brent A. Bauer and Anjali Bhagra
    Citation: BMC Complementary and Alternative Medicine 2019 19:174
  44. Health supplement (HS) products that are available in the Emirate of Dubai (United Arab Emirates; UAE) contain chemicals that may adversely affect human health. This study aimed to investigate the prevalence o...

    Authors: Naseem Mohammed Abdulla, Faisal Aziz, Iain Blair, Michal Grivna, Balazs Adam and Tom Loney
    Citation: BMC Complementary and Alternative Medicine 2019 19:172
  45. Drug resistance poses a challenge to malaria control measures. This calls for discovery & development of new chemotherapeutic agents. This study therefore was initiated to investigate the antimalarial activity...

    Authors: Desye Misganaw, Ephrem Engidawork and Teshome Nedi
    Citation: BMC Complementary and Alternative Medicine 2019 19:171
  46. The use of herbal medicine (HM) has become an essential form of treatment and it is more and more common around the world. Little is known about the reasons that drive people to initially use HM or to maintain...

    Authors: Alexandra N. Welz, Agnes Emberger-Klein and Klaus Menrad
    Citation: BMC Complementary and Alternative Medicine 2019 19:170
  47. Garcinia species contain bioactive compounds such as flavonoids, xanthones, triterpernoids, and benzophenones with antibacterial, antifungal, anti-inflammatory, and antioxidant activities. In addition, many of th...

    Authors: Aziera Adnan, Zeenathul Nazariah Allaudin, Homayoun Hani, Hwei-San Loh, Teng-Jin Khoo, Kang Nee Ting and Rasedee Abdullah
    Citation: BMC Complementary and Alternative Medicine 2019 19:169
  48. Several immunological pathways, particularly skin inflammation via various pro-inflammatory cytokines have been reported to be involved in the pathogenesis and clinical manifestations of psoriasis. The aim of ...

    Authors: Raksawan Deenonpoe, Pokpong Prayong, Nattakarn Thippamom, Jitlada Meephansan and Kesara Na-Bangchang
    Citation: BMC Complementary and Alternative Medicine 2019 19:168

    The Correction to this article has been published in BMC Complementary Medicine and Therapies 2023 23:113

  49. Centella asiatica (L.) Urban, known as Indian Pennywort, is a tropical medicinal plant from Apiaceae family native to Southeast Asian countries. It has been widely used as a nerve tonic in Ayuverdic medicine sinc...

    Authors: Norazzila Omar, Yogeswaran Lokanathan, Zainul Rashid Mohd Razi and Ruszymah Bt Haji Idrus
    Citation: BMC Complementary and Alternative Medicine 2019 19:167