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  1. The chemical composition and biological activity of Eucalyptus essential oils have been studied extensively (EOs). A few of them were tested for antibacterial effectiveness against otitis strains. The chemical...

    Authors: Elaissi Ameur, Moumni Sarra, Derbali Yosra, Khouja Mariem, Abid Nabil, Frederic Lynen and Khouja Mohamed Larbi
    Citation: BMC Complementary Medicine and Therapies 2021 21:209
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Complementary Medicine and Therapies 2021 21:241

  2. Integrating systems biology is an approach for investigating metabolic diseases in humans. However, few studies use this approach to investigate the mechanism by which Rhizoma coptidis (RC) reduces the effect of ...

    Authors: Yanhua Ji, Kexin Luo, Jiri Mutu Zhang, Peng Ni, Wangping Xiong, Xiaoquan Luo, Guoliang Xu, Hongning Liu and Zhijun Zeng
    Citation: BMC Complementary Medicine and Therapies 2021 21:208
    Content type: Research article Published on:

  3. Bupi Yishen Formula (BYF), a patent traditional Chinese medicine (TCM) formulation, has been used in the clinical treatment of chronic kidney disease (CKD). However, the mechanism of action of BYF has not been...

    Authors: Yenan Mo, Xina Jie, Lixin Wang, Chunlan Ji, Yueyu Gu, Zhaoyu Lu and Xusheng Liu
    Citation: BMC Complementary Medicine and Therapies 2021 21:207
    Content type: Research article Published on:

  4. Alzheimer’s disease (AD) is one of the most common neurodegenerative disorders, but there is still no effective way to stop or slow its progression. Our previous studies demonstrated that extract of Cynomorium so...

    Authors: Dan Cheng, Lei Su, Xu Wang, Xinjie Li, Lingling Li, Mengyuan Hu and Yi Lu
    Citation: BMC Complementary Medicine and Therapies 2021 21:206
    Content type: Research article Published on:

  5. The contemporary evidence-based practice model acknowledges the importance of patient preferences and clinician experience when applying evidence within a clinical setting. Knowledge mobilisation (KM) acknowle...

    Authors: Amie Steel, Matthew Leach, Caragh Brosnan, Vicky Ward and Iva Lloyd
    Citation: BMC Complementary Medicine and Therapies 2021 21:205
    Content type: Research Published on:

  6. Wedelia chinensis has been reported as a folk medicine for the treatment of different diseases including neurodegenerative disease. Although the plant has been studied well for diverse biological activities, the ...

    Authors: Md. Aminul Islam, Shahed Zaman, Kushal Biswas, Md. Yusuf Al-Amin, Md. Kamrul Hasan, A. H. M. K. Alam, Toshihisa Tanaka and Golam Sadik
    Citation: BMC Complementary Medicine and Therapies 2021 21:204
    Content type: Research Published on:

  7. Saffron or stigmas of Crocus sativus L. is one of the most valuable food products with interesting health-promoting properties. C. sativus has been widely used as a coloring and flavoring agent. Stigmas secondary...

    Authors: Olha Mykhailenko, Vilma Petrikaitė, Michal Korinek, Mohamed El-Shazly, Bing-Hung Chen, Chia-Hung Yen, Chung-Fan Hsieh, Ivan Bezruk, Asta Dabrišiūtė, Liudas Ivanauskas, Victoriya Georgiyants and Tsong-Long Hwang
    Citation: BMC Complementary Medicine and Therapies 2021 21:203
    Content type: Research Published on:

  8. Gout is initiated by the precipitation of monosodium urate (MSU) crystals within the joints and soft tissues, and it can eventually cause acute or chronic arthritis. MSU crystals trigger, amplify, and maintain...

    Authors: Hao-fei Fan, Xing-yue Fang, Hao-lin Wu, Yi-qian Xu, Li-chong Gong, Dao-rui Yu, Hao Jia, Xiao-liang Tang and Qi-bing Liu
    Citation: BMC Complementary Medicine and Therapies 2021 21:202
    Content type: Research article Published on:

  9. Over the past few decades, the popularity of complementary and alternative medicine (CAM) has grown considerably and along with it, scrutiny regarding its evidence base. While this is to be expected, and is in...

    Authors: Yasamin Veziari, Saravana Kumar and Matthew Leach
    Citation: BMC Complementary Medicine and Therapies 2021 21:201
    Content type: Research article Published on:

  10. In response to the World Health Organization’s recommendation, policy makers have been adopting evidence-based healthcare approach to promote the development of traditional, complementary and integrative medic...

    Authors: Charlene Hoi Lam Wong, Jeffrey Van Ho Tse, Per Nilsen, Leonard Ho, Irene Xin Yin Wu and Vincent Chi Ho Chung
    Citation: BMC Complementary Medicine and Therapies 2021 21:200
    Content type: Research Published on:

  11. Our current study aimed to evaluate the effect of an Glechoma hederacea extract (Hitrechol®) in normal rats and gallstone diseased mice to explore its underlying mechanisms. Normal rats and C57BL/6 mice with/with...

    Authors: Min Xiao, Mengbi Yang, Xiaoyu Ji, Dan Li, Yuning Xie, Yuanfeng Lyu and Zhong Zuo
    Citation: BMC Complementary Medicine and Therapies 2021 21:199
    Content type: Research Published on:

  12. Degenerative kidney diseases are mostly associated with oxidative stress. Natural products are considered as the antioxidants enrich food that can restrict the progress of oxidative stress induced disorders. T...

    Authors: Samiullah Burki, Zeba Gul Burki, Muhammad Arif Asghar, Imdad Ali and Saba Zafar
    Citation: BMC Complementary Medicine and Therapies 2021 21:198
    Content type: Research Published on:

  13. Dryopteris ramosa has numerous potentials uses in the treatment of different maladies as old traditional medication. The fronds of D. ramose are edible and orally administered for producing antibiotic effect. The...

    Authors: Fiaz Alam, Syed Hurmat Ali Khan and Mohammad Hassham Hassan Bin Asad
    Citation: BMC Complementary Medicine and Therapies 2021 21:197
    Content type: Research Published on:

  15. Metastatic castration-resistant prostate cancer (CRPC) is the leading cause of death among men diagnosed with prostate cancer. Piperlongumine (PL) is a novel potential anticancer agent that has been demonstrat...

    Authors: Ding-fang Zhang, Zhi-chun Yang, Jian-qiang Chen, Xiang-xiang Jin, Yin-da Qiu, Xiao-jing Chen, Hong-yi Shi, Zhi-guo Liu, Min-shan Wang, Guang Liang and Xiao-hui Zheng
    Citation: BMC Complementary Medicine and Therapies 2021 21:195
    Content type: Research article Published on:

  16. Hepatocellular carcinoma (HCC) represents a serious public health problem worldwide and has high morbidity and mortality. Dihydromyricetin (DHM) exhibits anticancer effect on a variety of malignancies, but its...

    Authors: Lianggui Jiang, Wen-Chu Ye, Zuobiao Li, Yongguang Yang, Wei Dai and Mingyi Li
    Citation: BMC Complementary Medicine and Therapies 2021 21:194
    Content type: Research Published on:

  17. Psoriasis is an autoimmune inflammatory skin disease that affects 0.5–3% of the world’s population and current treatment options are posed with limitations. The reduced risk of failure in clinical trials for r...

    Authors: Akachukwu Ibezim, Emmanuel Onah, Ebubechukwu N. Dim and Fidele Ntie-Kang
    Citation: BMC Complementary Medicine and Therapies 2021 21:193
    Content type: Research Published on:

  18. Lippia javanica (lemon bush) is commonly used in the treatment of respiratory ailments, including asthma in southern African countries but there is no scientific evidence to support this claim. This study investi...

    Authors: Mvuyisi O. M. Mfengu, Mathulo Shauli, Godwill A. Engwa, Hannibal T. Musarurwa and Constance R. Sewani-Rusike
    Citation: BMC Complementary Medicine and Therapies 2021 21:192
    Content type: Research Published on:

  19. Metastasis is the leading cause of death among breast cancer patients. MicroRNA-134 has been reported to have a tumor-suppressive role in breast cancer. Ruyiping (RYP), a traditional Chinese formula, has been ...

    Authors: Ziwei Jiang, Lixia Pei, Ying Xie, Qun Ye, Xiaoqiang Liang, Yiyi Ye and Sheng Liu
    Citation: BMC Complementary Medicine and Therapies 2021 21:191
    Content type: Research article Published on:

  20. Obesity is a common medical condition. Among all the classifications of obesity, central obesity is considered to be a significant threat on the health of individuals. Scientific researches have demonstrated t...

    Authors: Linda L. D. Zhong, Xingyao Wu, Tsz Fung Lam, Ying Ping Wong, Peihua Cao, Emily Yen Wong, Shipping Zhang and Zhaoxiang Bian
    Citation: BMC Complementary Medicine and Therapies 2021 21:190
    Content type: Study protocol Published on:

  21. Radioresistance can pose a significant obstacle to the effective treatment of breast cancers. Epithelial–mesenchymal transition (EMT) is a critical step in the acquisition of stem cell traits and radioresistan...

    Authors: Jiraporn Kantapan, Siwaphon Paksee, Aphidet Duangya, Padchanee Sangthong, Sittiruk Roytrakul, Sucheewin Krobthong, Wipob Suttana and Nathupakorn Dechsupa
    Citation: BMC Complementary Medicine and Therapies 2021 21:189
    Content type: Research article Published on:

  22. Flavonoids are compounds of interest in the search for new anti-cancer therapies. We have previously isolated the methoxyflavones 5,4′-dihydroxy-6,7,8,3′-tetramethoxyflavone (8-methoxycirsilineol), 5,4′-dihydr...

    Authors: Wendy Soria Sotillo, Santiago Tarqui, Xiaoli Huang, Giovanna Almanza and Stina Oredsson
    Citation: BMC Complementary Medicine and Therapies 2021 21:188
    Content type: Research article Published on:

  23. Parasite persistence, exacerbated and sustained immune response, and continuous oxidative stress have been described to contribute to the development of the cardiac manifestations in Chronic Chagas Disease. Ne...

    Authors: Wendy Lorena Quintero, Erika Marcela Moreno, Sandra Milena Leal Pinto, Sandra Milena Sanabria, Elena Stashenko and Liliana Torcoroma García
    Citation: BMC Complementary Medicine and Therapies 2021 21:187
    Content type: Research Published on:

  24. Melanoma and breast cancers are two common cancers worldwide. Due to the side effects of chemotherapy drugs and the occurring resistance against them, the development of green drugs has been received more atte...

    Authors: Hiva Alipanah, Mojtaba Farjam, Elham Zarenezhad, Ghazaal Roozitalab and Mahmoud Osanloo
    Citation: BMC Complementary Medicine and Therapies 2021 21:186
    Content type: Research Published on:

  25. Traditional, complementary, alternative and integrative medicine (TCAIM) can be described as diverse medical and healthcare interventions, practices, products, or disciplines that are not considered as part of...

    Authors: Jeremy Y. Ng
    Citation: BMC Complementary Medicine and Therapies 2021 21:185
    Content type: Research Published on:

  26. In order to find a new natural resource for pain-relief, the analgesic effects of Ilex dipyrena crude extract, fractions, and subfractions were evaluated in in-vivo mouse models with possible mechanism of action.

    Authors: Amjad Ali, Abdul Nasir, Syed Wadood Ali Shah, Atif Ali Khan Khalil, Mi-jeong Ahn, Syed Muhammad Mukarram Shah, Fazli Subhan, Muhammad Faheem, Wasim Sajjad, Mohammad Shoaib, Saeed Ahmad, Nausheen Nazir and Mohammad Nisar
    Citation: BMC Complementary Medicine and Therapies 2021 21:184
    Content type: Research article Published on:

  27. In recent years, researchers are interested in the discovery of active compounds from traditional remedies and natural sources, as they reveal higher therapeutic efficacies and improved toxicological profiles....

    Authors: Muganti Rajah Kumar, Swee Keong Yeap, Nurul Elyani Mohamad, Janna Ong Abdullah, Mas Jaffri Masarudin, Melati Khalid, Adam Thean Chor Leow and Noorjahan Banu Alitheen
    Citation: BMC Complementary Medicine and Therapies 2021 21:183
    Content type: Research Published on:

  28. Herbal medicine administration in conventional health care services is gaining popularity lately. Much has not been documented on the perceived enhancers and challenges to herbal medicine administration at the...

    Authors: Comfort Asare, Lydia Aziato and Daniel Boamah
    Citation: BMC Complementary Medicine and Therapies 2021 21:182
    Content type: Research Published on:

  29. Narrow spectrum of action through limited molecular targets and unforeseen drug-related toxicities have been the main reasons for drug failures at the phase I clinical trials in complex diseases. Most plant-de...

    Authors: Regan Odongo, Asuman Demiroglu-Zergeroglu and Tunahan Çakır
    Citation: BMC Complementary Medicine and Therapies 2021 21:181
    Content type: Research article Published on:

  30. Endodesmia calophylloides and Hymenostegia afzelii belong to the Guttiferae and Caesalpiniaceae plant families with known uses in African ethno-medicine to treat malaria and several other diseases. This study aim...

    Authors: Rodrigue Keumoe, Jean Garba Koffi, Darline Dize, Patrick Valère Tsouh Fokou, Joseph Tchamgoue, Lawrence Ayong, Bruno Lenta Ndjakou, Norbert Sewald, Bathelemy Ngameni and Fabrice Fekam Boyom
    Citation: BMC Complementary Medicine and Therapies 2021 21:180
    Content type: Research article Published on:

  31. Elevated lipid profiles and impaired glucose homeostasis are risk factors for several cardiovascular diseases (CVDs), which, subsequently, represent a leading cause of early mortality, worldwide. The aim of th...

    Authors: Amir Hadi, Makan Pourmasoumi, Ameneh Najafgholizadeh, Cain C. T. Clark and Ahmad Esmaillzadeh
    Citation: BMC Complementary Medicine and Therapies 2021 21:179
    Content type: Review Published on:

  32. Acacia senegal is a plant traditionally used for its various properties, including the treatment of infectious diseases. Recently, our team has demonstrated the ability of the hydroethanolic extract of the leaves...

    Authors: René Dofini Magnini, Mathieu Nitiéma, Geoffroy G. Ouédraogo, Sylvain Ilboudo, Alimata Bancé, Hassanata Millogo-Koné, Carole Di Giorgio, Jean-Marie Pagès, Adama Hilou and Anne Davin-Regli
    Citation: BMC Complementary Medicine and Therapies 2021 21:178
    Content type: Research article Published on:

  33. β-lactam antibiotics are a class of broad-spectrum antibiotics consisting of all antibiotic agents that contain a β-lactam ring in their molecular structures. β-lactam antibiotics are only known to be isolated...

    Authors: Tiffany Turner, Guillermo Ruiz, Johanne Gerstel and Jeffrey Langland
    Citation: BMC Complementary Medicine and Therapies 2021 21:177
    Content type: Research article Published on:

  34. Ardisia crispa (Thunb.) A.DC (Primulaceae), is a medicinal herb traditionally used by Asian people as remedies to cure inflammatory related diseases, including rheumatism. The plant roots possess various pharmaco...

    Authors: Joan Anak Blin, Roslida Abdul Hamid and Huzwah Khaza’ai
    Citation: BMC Complementary Medicine and Therapies 2021 21:176
    Content type: Research article Published on:

  35. Plantaginis Semen has been widely used as folk medicine and health care food against hyperuricemia (HUA) and gout, but its pharmacological mechanism remains unclear. This study investigated the therapeutic mec...

    Authors: Fei Yang, Wenjun Shi, Liting Wang, Nankun Qin, Chengxiang Wang, Yuying Guo, Guang Xu, Jie Fang, Xue Yu and Qun Ma
    Citation: BMC Complementary Medicine and Therapies 2021 21:175
    Content type: Research article Published on:

  36. Chronic pelvic pain (CPP) in women is persistent, intermittent cyclical and non-cyclical lower abdominal pain, lasting for more than 6 months. Traditional Chinese Medicine (TCM) is a popular treatment option f...

    Authors: Susan Arentz, Caroline Smith, Rebecca Redmond, Jason Abbott and Mike Armour
    Citation: BMC Complementary Medicine and Therapies 2021 21:174
    Content type: Research Published on:

  37. An emerging body of evidence indicates that puerarin (PUE) plays an important role in the treatment of angina pectoris, myocardial ischemia-reperfusion injury, hypertension and other cardiovascular diseases, b...

    Authors: Xiaoxia Fang, Sheng Dong, Yun Wu, Yun He, Min Lu, Dandan Shi, Na Feng, Songhe Yin, Yan Jiang, Anhua Zhang, Yan Ding, Qiufang Zhang, Junming Tang, Wenjun Zhang and Xiju He
    Citation: BMC Complementary Medicine and Therapies 2021 21:173
    Content type: Research Published on:

  38. Mulberry leaf as a traditional Chinese medicine is able to treat obesity, diabetes, and dyslipidemia. It is well known that diabetes leads to intestinal microbiota dysbiosis. It is also recently discovered tha...

    Authors: Zhan-Zhong Liu, Qing-Hua Liu, Zhao Liu, Jia-Wei Tang, Eng-Guan Chua, Fen Li, Xue-Song Xiong, Meng-Meng Wang, Peng-Bo Wen, Xin-Yi Shi, Xiang-Yu Xi, Xiao Zhang and Liang Wang
    Citation: BMC Complementary Medicine and Therapies 2021 21:172
    Content type: Research article Published on:

  39. The prevalence rates of the use of Complementary and Alternative Medicine (CAM) in allergy patients range from 42% in the United States up to 50% in Europe. In the Czech Republic, no such data exists. Our aim ...

    Authors: Jitka Pokladnikova, A-La Park, Jan Draessler, Anna Lukacisinova and Irena Krcmova
    Citation: BMC Complementary Medicine and Therapies 2021 21:171
    Content type: Research article Published on:

  40. Facial abscess caused by Candida albicans infection is a rare condition even in immunocompromised patients, and only a few cases have been reported. To our knowledge, this is the first case of multiple facial can...

    Authors: Jae Yun Sung, Ju Mi Kim, Jong Uk Lee, Yeon Hee Lee and Sung Bok Lee
    Citation: BMC Complementary Medicine and Therapies 2021 21:170
    Content type: Case report Published on:

  41. Non-small-cell lung cancer (NSCLC) accounts more than 80% of the lung cancer cases. Polysaccharides in rice bran and its fermentation products have been proven to suppress many cancers. However, the report on ...

    Authors: Wei Han, Hongjuan Chen, Lin Zhou, Haijie Zou, Xiaohong Luo, Bo Sun and Xuhui Zhuang
    Citation: BMC Complementary Medicine and Therapies 2021 21:169
    Content type: Research article Published on:

  42. The standardized herbal preparation, STW 5, is effective clinically in functional gastrointestinal disorders and experimentally in ulcerative colitis (UC). The present study explores whether the beneficial eff...

    Authors: Sarah S. Mohamed, Nourtan F. Abdeltawab, Walaa Wadie, Lamiaa A. Ahmed, Ramy M. Ammar, Sabine Rabini, Heba Abdel-Aziz and Mohamed T. Khayyal
    Citation: BMC Complementary Medicine and Therapies 2021 21:168
    Content type: Research Published on:

  43. The use of complementary and alternative medicine (CAM) is common among cancer patients and it may reflect the individual and societal beliefs on cancer therapy. Our study aimed to evaluate the trends of CAM u...

    Authors: Abdul Rahman Jazieh, Khadega A. Abuelgasim, Husam I. Ardah, Mohammad Alkaiyat and Omar B. Da’ar
    Citation: BMC Complementary Medicine and Therapies 2021 21:167
    Content type: Research article Published on:

  44. The pain and discomfort caused by episiotomy affect the quality of life of the mothers, so rapid and complete repair of the episiotomy is very important. Due to the effective ingredients of Verbascum Thapsus, it ...

    Authors: Sahar Taleb and Maryam Saeedi
    Citation: BMC Complementary Medicine and Therapies 2021 21:166
    Content type: Research Published on:

  45. Himalayan Columbine (Aquilegia pubiflora Wall. Ex Royle) is a medicinal plant and have been used as traditional treatments for various human diseases including skin burns, jaundice, hepatitis, wound healing, card...

    Authors: Hasnain Jan, Hazrat Usman, Muzamil Shah, Gouhar Zaman, Sadaf Mushtaq, Samantha Drouet, Christophe Hano and Bilal Haider Abbasi
    Citation: BMC Complementary Medicine and Therapies 2021 21:165
    Content type: Research article Published on:

  46. Antibiotic resistance has contributed to the burden of infectious diseases both in the hospital and community setting, and represents a great threat to public health. Previous studies have revealed the role of...

    Authors: Irene Chinda Kengne, Léonel Donald Tsamo Feugap, Abdel Jélil Njouendou, Claudia Darille Jouogo Ngnokam, Mahamat Djamalladine Djamalladine, David Ngnokam, Laurence Voutquenne-Nazabadioko and Jean-De-Dieu Tamokou
    Citation: BMC Complementary Medicine and Therapies 2021 21:164
    Content type: Research article Published on:

  47. C-Myc aberrations confer a more aggressive clinic behavior in diffuse large B-cell lymphoma (DLBCL). Matrine is an alkaloid extracted from Sophora flavescens Ait. It possesses anti-cancer property through inhibit...

    Authors: Jianyou Gu, Xiao Wang, Ling Zhang, Jingjing Xiang, Jingya Li, Zheng Chen, Yu Zhang, Junfa Chen and Jianping Shen
    Citation: BMC Complementary Medicine and Therapies 2021 21:163
    Content type: Research Published on:

  48. Recent experimental studies using herbal extracts have shown the possibility of peripheral nerve regeneration. This study aimed to investigate the effects of herbal extracts on peripheral nerve regeneration in...

    Authors: Young Jun Kim, Kyu Jin Kim, Jae Hoon Lee, Seong-Uk Park and Seung-Yeon Cho
    Citation: BMC Complementary Medicine and Therapies 2021 21:162
    Content type: Research article Published on:

  49. Diverse signalling pathways are involved in carcinogenesis and one of such pathways implicated in many cancers is the interleukin 6/signal transducer and activator of transcription 3 (IL-6/STAT3) signalling pa...

    Authors: Seth A. Domfeh, Patrick W. Narkwa, Osbourne Quaye, Kwadwo A. Kusi, Gordon A. Awandare, Charles Ansah, Alimatu Salam and Mohamed Mutocheluh
    Citation: BMC Complementary Medicine and Therapies 2021 21:161
    Content type: Research Published on:

  50. Silibinin, as a chemopreventive agent, has shown anti-cancer efficacy against different types of cancers. In the present study, we investigated the anti-cancer activities of silibinin on CT26 mouse colon cell ...

    Authors: Saba Sameri, Chiman Mohammadi, Mehrnaz Mehrabani and Rezvan Najafi
    Citation: BMC Complementary Medicine and Therapies 2021 21:160
    Content type: Research Published on:
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ISSN: 2662-7671

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