Koppel BS, Brust JC, Fife T, Bronstein J, Youssof S, Gronseth G, et al. Systematic review: efficacy and safety of medical marijuana in selected neurologic disorders: report of the Guideline Development Subcommittee of the American Academy of Neurology. Neurology. 2014;82(17):1556–63.
Article
PubMed
PubMed Central
Google Scholar
Sharkey KA, Darmani NA, Parker LA. Regulation of nausea and vomiting by cannabinoids and the endocannabinoid system. Eur J Pharmacol. 2014;722:134–46.
Article
CAS
PubMed
Google Scholar
Lowe H, Steele B, Bryant J, Toyang N, Ngwa W. Non-Cannabinoid Metabolites of Cannabis sativa L. with Therapeutic Potential. Plants (Basel). 2021;10(2):400.
Article
CAS
Google Scholar
Shanahan, M. Assessing the economic consequences of two cannabis policy options. New South Wales, Sydney. Retrieved from http://www.unsworks.unsw.edu.au/primo_library/libweb/action/dlDisplay.do. 2011.
Bari M, Battista N, Pirazzi V, Maccarrone M. The manifold actions of endocannabinoids on female and male reproductive events. Front Biosci (Landmark Ed). 2011;16(16):498–516.
Article
CAS
Google Scholar
Hishika R, Shastry S, Shinde S, Guptal S. Preliminary phytochemical and anti-inflammatory activity of seeds of Mucuna pruriens. Indian J pharmacol. 1981;13(1):97–8.
Google Scholar
Silva BM, Andrade PB, Valentão P, Ferreres F, Seabra RM, Ferreira MA. Quince (Cydonia oblonga Miller) fruit (pulp, peel, and seed) and Jam: antioxidant activity. J Agric Food Chem. 2004;52(15):4705–12.
Article
CAS
PubMed
Google Scholar
Hampl R, Kubatova J, Starka L. Steroids and endocrine disruptors–History, recent state of art and open questions. J Steroid Biochem Mol Biol. 2016;155(Pt B):217–23.
Article
CAS
PubMed
Google Scholar
Nwonuma CO, Favours GO, Rotimi DE, Alejolowo OO, Ojo OA, Afolabi BL,
et al. Comparative Modulatory Assessment of the Sperm Quality and TesticularFunction by
Solvent Fractions of the Cannabis Extract in Rats. Pharmacogn J. 2021;13(6)Suppl:1678-1687.
Indumathi C, Durgadevi G, Nithyavani S, Gayathri P. Estimation of terpenoid content and its antimicrobial property in Enicostemma litorrale. Int J ChemTech Res. 2014;6(9):4264–7.
CAS
Google Scholar
Van Buren JP, Robinson WB. Formation of complexes between protein and tannic acid. J Agric Food Chem. 2002;17(4):772–7.
Article
Google Scholar
El-Olemyl MM, Al-Muhtadi FJ, Afifi AA. Experimental Phyto-chemistry: A laboratory Manual for College of Pharmacy. Saudi University Press, 1994.
Bohn B, Kocipai-Abyazan R. Flavonoids and condensed tannins from leaves of Hawaiian Vaccinium reticulatum and V. calycynium. Pacific Sci. 1994;48:458–63.
Google Scholar
Kumar S, Pandey AK. Phenolic content, reducing power and membrane protective activities of Solanum xanthocarpum root extracts. Vegetos. 2013;26(1):301–7.
Article
Google Scholar
Ejikeme C, Ezeonu CS, Eboatu AN. Determination of Physical and Phytochemical Constituents of some Tropical Timbers Indigenous to nigerdelta area of nigeria. Eur Sci J. 2014;10(18):247–70.
Google Scholar
Alagbonsi IA, Olayaki LA, Salman TM. Melatonin and vitamin C exacerbate Cannabis sativa-induced testicular damage when administered separately but ameliorate it when combined in rats. J Basic Clin Physiol Pharmacol. 2016;27(3):277–87.
Article
CAS
PubMed
Google Scholar
Grandin T. Recommended animal handling guidelines and audit guide. USA: A systematic approach to animal welfare. American Industry Foundation; 2010.
Google Scholar
Cooper TG, Noonan E, von Eckardstein S, Auger J, Baker HW, Behre HM, et al. World Health Organization reference values for human semen characteristics. Hum Reprod Update. 2010;16(3):231–45.
Article
PubMed
Google Scholar
Yokoi K, Mayi Z. Organ apoptosis with cytotoxic drugs. Toxicology. 2004;290:78–85.
Google Scholar
Sönmez M, Türk G, Yüce A. The effect of ascorbic acid supplementation on sperm quality, lipid peroxidation and testosterone levels of male Wistar rats. Theriogenology. 2005;63(7):2063–72.
Article
PubMed
Google Scholar
Kemp A, Van Heijningen AJ. A colorimetric micro-method for the determination of glycogen in tissues. Biochem J. 1954;56(4):646–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ilavarasan R, Mallika M, Venkataraman S. Anti-inflammatory and free radical scavenging activity of Ricinus communis root extract. J Ethnopharmacol. 2006;103(3):478–80.
Article
PubMed
Google Scholar
Ramakrishnan S, Rao AV. Indirect Assessment of Hydroxymethylglutaryl-CoA Reductase (NADPH) Activity in Liver Tissue. Clin Chem. 1975;21(10):1523–5.
Article
PubMed
Google Scholar
Misra HP, Fridovich I. Superoxide dismutase: “Positive” spectrophotometric assays. Anal Biochem. 1977;79(1–2):553–60.
Article
CAS
PubMed
Google Scholar
Jollow DJ, Mitchell JR, Zampaglione N, Gillette JR, Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite. Pharmacology. 1974;11(3):151–69.
Article
CAS
PubMed
Google Scholar
Catalase AH. Methods of Enzymatic Analysis. New York: New York Academic Press; 1974.
Google Scholar
Satoh K. Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method. Clin Chim Acta. 1978;90(1):37–43.
Article
CAS
PubMed
Google Scholar
Gornall AG, Bardawill CJ, David MM. Determination of serum proteins by means of the biuret reaction. J Biol Chem. 1949;177(2):751–66.
Article
CAS
PubMed
Google Scholar
Wright P, Leathwood P, Plummer D. Enzymes in rat urine: alkaline phosphatase. Enzymologia. 1972;42(4):317–27.
CAS
PubMed
Google Scholar
Folch J, Lees M, Sloane Stanley G. A simple method for the isolation and purification of total lipides from animal tissues. J biol Chem. 1957;226(1):497–509.
Article
CAS
PubMed
Google Scholar
Eder K, Kirchgessner M. The effect of zinc deficiency on erythrocyte membrane lipids of force-fed rats receiving a diet containing coconut oil or fish oil. J Trace Elem Electrolytes Health Dis. 1994;8(2):63–73.
CAS
PubMed
Google Scholar
Kriketos AD, Furler SM, Gan SK, Poynten AM, Chisholm DJ, Campbell LV. Multiple indexes of lipid availability are independently related to whole body insulin action in healthy humans. J Clin Endocrinol Metab. 2003;88(2):793–8.
Article
CAS
PubMed
Google Scholar
Sanner MF. Python: a programming language for software integration and development. J Mol Graph Model. 1999;17(1):57–61.
CAS
PubMed
Google Scholar
Pamidighantam S, Nakandala S, Abeysinghe E, Wimalasena C, Yodage SR, Marru S, et al. Community science exemplars in seagrid science gateway: apache airavata based implementation of advanced infrastructure. Procedia Comput Sci. 2016;80:1927–39.
Article
Google Scholar
Trott O, Olson AJ. AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. J Comput Chem. 2010;31(2):455–61.
CAS
PubMed
PubMed Central
Google Scholar
Ciumărnean L, Milaciu MV, Runcan O, Vesa SC, Răchisan AL, Negrean V, et al. The effects of flavonoids in cardiovascular diseases. Molecules. 2020;25(18):4320.
Article
PubMed Central
Google Scholar
Alahmar AT. The effects of oral antioxidants on the semen of men with idiopathic oligoasthenoteratozoospermia. Clin Exp Reprod Med. 2018;45(2):57.
Article
PubMed
PubMed Central
Google Scholar
Adewoyin M, Ibrahim M, Roszaman R, Isa MLM, Alewi NAM, Rafa AAA, et al. Male infertility: the effect of natural antioxidants and phytocompounds on seminal oxidative stress. Diseases. 2017;5(1):9.
Article
PubMed Central
Google Scholar
Gupta R, Kachhawa J, Khushalani V, Tanwar K, Joshi Y, Effect of Cressacretica. Methanol extract on testicular function of albino rats. Pharmaceutical Biol. 2006;44(5):382–8.
Article
Google Scholar
Jamalan M, Ghaffari MA, Hoseinzadeh P, Hashemitabar M, Zeinali M. Human sperm quality and metal toxicants: protective effects of some flavonoids on male reproductive function. Int J Fertil Steril. 2016;10(2):215–23.
CAS
PubMed
PubMed Central
Google Scholar
Remya M, Sharma R, Shoaib H, Asad RJU, Swati S. In vitro effect of Aegle marmelos on human sperm motility. J Medi Plant Res. 2009;3(12):1137–9.
Google Scholar
López G, Lafuente R, Checa MA, Carreras R, Brassesco M. Diagnostic value of sperm DNA fragmentation and sperm high-magnification for predicting outcome of assisted reproduction treatment. Asian J Androl. 2013;15(6):790–4.
Article
PubMed
PubMed Central
Google Scholar
Kangasniemi M, Kaipia A, Toppari J, Perheentupa A, Huhtaniemi I, Parvinen M. Cellular regulation of follicle-stimulating hormone (FSH) binding in rat seminiferous tubules. J Androl. 1990;11(4):336–43.
CAS
PubMed
Google Scholar
Schubert M, Pérez Lanuza L, Gromoll J. Pharmacogenetics of FSH Action in the Male. Front Endocrinol (Lausanne). 2019;10:47.
Article
Google Scholar
Louei Monfared A. Correlation of Serum Lipid P rofile with Histological and Seminal Parameters of Testis in The Goat. Int J Fertil Steril. 2013;7(2):122–9.
PubMed
PubMed Central
Google Scholar
Masaki H, Kim N, Nakamura H, Kumasawa K, Kamata E, Hirano KI, et al. Long-chain fatty acid triglyceride (TG) metabolism disorder impairs male fertility: a study using adipose triglyceride lipase deficient mice. Mol Hum Reprod. 2017;23(7):452–60.
Article
CAS
PubMed
Google Scholar
Vijaykumar B, Sangamma I, Sharanabasappa A, Patil SB. Antispermatogenic and hormonal effects of Crotalaria juncea Linn. seed extracts in male mice. Asian J Androl. 2004;6(1):67–70.
CAS
PubMed
Google Scholar
Yu Q, Li T, Li J, Zhong L, Mao X. 2017. Nitric oxide synthase in male urological and andrologic functions, in Nitric oxide synthase-simple enzyme-complex roles. IntechOpen.
Romeo C, Santoro G. Free radicals in adolescent varicocele testis. Oxid Med Cell Longev. 2014;2014:912878.
Article
PubMed
PubMed Central
Google Scholar
Sadik NA. Effects of diallyl sulfide and zinc on testicular steroidogenesis in cadmium-treated male rats. J Biochem Mol Toxicol. 2008;22(5):345–53.
Article
CAS
PubMed
Google Scholar
Welch C, Watson ME, Poth M, Hong T, Francis GL. Evidence to suggest nitric oxide is an interstitial regulator of Leydig cell steroidogenesis. Metabolism. 1995;44(2):234–8.
Article
CAS
PubMed
Google Scholar
Dacheux JL, Castella S, Gatti JL, Dacheux F. Epididymal cell secretory activities and the role of proteins in boar sperm maturation. Theriogenology. 2005;63(2):319–41.
Article
CAS
PubMed
Google Scholar
Vanha-Perttula T, Nikkanen V. Acid phosphatases of the rat testis in experimental conditions. Acta Endocrinol (Copenh). 1973;72(2):376–90.
Article
CAS
Google Scholar
Johnson KJ. Testicular histopathology associated with disruption of the Sertoli cell cytoskeleton. Spermatogenesis. 2014;4(2):e979106.
Article
PubMed
Google Scholar
Nwonuma CO, Osemwegie OO, Irokanulo EO, Alejolowo OO, Kayode OT, Olaolu TD, et al. Comparative effects of combined use of alcohol with cannabis and tobacco on testicular function in rats. Toxicol Res (Camb). 2021;10(4):761–70.
Article
Google Scholar
Rasoulpour T, DiPalma K, Kolvek B, Hixon M. Akt1 suppresses radiation-induced germ cell apoptosis in vivo. Endocrinology. 2006;147(9):4213–21.
Article
CAS
PubMed
Google Scholar
Richburg JH, Johnson KJ, Schoenfeld HA, Meistrich ML, Dix DJ. Defining the cellular and molecular mechanisms of toxicant action in the testis. Toxicol Lett. 2002;135(3):167–83.
Article
CAS
PubMed
Google Scholar
Vornberger W, Prins G, Musto NA, Suarez-Quian CA. Androgen receptor distribution in rat testis: new implications for androgen regulation of spermatogenesis. Endocrinology. 1994;134(5):2307–16.
Article
CAS
PubMed
Google Scholar
O’Hara L, Smith LB. Androgen receptor roles in spermatogenesis and infertility. Best Pract Res Clin Endocrinol Metab. 2015;29(4):595–605.
Article
CAS
PubMed
Google Scholar
Bai X, Tang Y, Li Q, Liu D, Liu G, Fan X, et al. An Integrated analysis of network pharmacology, molecular docking, and experiment validation to explore the new candidate active component and mechanism of cuscutae semen-mori fructus coupled-herbs in treating oligoasthenozoospermia. Drug Des Devel Ther. 2021;15:2059–89.
Article
PubMed
PubMed Central
Google Scholar