Aruoma OI. Free radicals, antioxidants and international nutrition. Asia Pac J Clin Nutr. 1999;8:53–63.
Article
PubMed
CAS
Google Scholar
Gupta VK, Sharma SK. Plants as natural antioxidants. Nat Prod Rad. 2006;5:326–34.
Google Scholar
Magder S. Reactive oxygen species: toxic molecules or spark of life? Crit Care. 2006;10:208.
Article
PubMed
PubMed Central
Google Scholar
Brewer MS. Natural antioxidants: sources, compounds, mechanisms of action, and potential applications. Compr Rev Food Sci Food Saf. 2011;10:221–47.
Article
CAS
Google Scholar
Lu LY, Ou N, Lu Q-B. Antioxidant induces DNA damage, cell death and mutagenicity in human lung and skin normal cells. Sci Rep. 2013;3:3169.
Article
PubMed
PubMed Central
Google Scholar
Soobrattee MA, Neergheen VS, Luximon-Ramma A, Aruoma OI, Bahorun T. Phenolics as potential antioxidant therapeutic agents: mechanism and actions. Mutat Res. 2005;579:200–13.
Article
PubMed
CAS
Google Scholar
Chaudière J, Ferrari-Iliou R. Intracellular antioxidants: from chemical to biochemical mechanisms. Food Chem Toxicol. 1999;37:949–62.
Article
PubMed
Google Scholar
Fridovich I. Fundamental aspects of reactive oxygen species, or what's the matter with oxygen? Ann N Y Acad Sci. 1999;893:13–8.
Article
PubMed
CAS
Google Scholar
Hinneburg I, Damien Dorman HJ, Hiltunen R. Antioxidant activities of extracts from selected culinary herbs and spices. Food Chem. 2006;97:122–9.
Article
CAS
Google Scholar
Amin A, Hamza AA, Bajbouj K, Ashraf SS, Daoud S. Saffron: a potential candidate for a novel anticancer drug against hepatocellular carcinoma. Hepatology. 2011;54:857–67.
Article
PubMed
CAS
Google Scholar
Hamza AA, Ahmed MM, Elwey HM, Amin A. Melissa officinalis protects against doxorubicin-induced cardiotoxicity in rats and potentiates its anticancer activity on MCF-7 cells. PLoS One. 2016;11:e0167049.
Article
PubMed
PubMed Central
CAS
Google Scholar
Xue WL, Li XS, Zhang J, Liu YH, Wang ZL, Zhang RJ. Effect of Trigonella foenum-graecum (fenugreek) extract on blood glucose, blood lipid and hemorheological properties in streptozotocin-induced diabetic rats. Asia Pac J Clin Nutr. 2007;16(Suppl 1):422–6.
PubMed
CAS
Google Scholar
Amin A, Alkaabi A, Al-Falasi S, Daoud SA. Chemopreventive activities of Trigonella foenum graecum (fenugreek) against breast cancer. Cell Biol Int. 2005;29:687–94.
Article
PubMed
Google Scholar
El Bairi K, Ouzir M, Agnieszka N, Khalki L. Anticancer potential of Trigonella foenum graecum: cellular and molecular targets. Biomed Pharmacother. 2017;90:479–91.
Article
PubMed
CAS
Google Scholar
Seethapathy GS, Ganesh D, Kumar JUS, Senthilkumar U, Newmaster SG, Ragupathy S, et al. Assessing product adulteration in natural health products for laxative yielding plants, Cassia, Senna, and Chamaecrista, in southern India using DNA barcoding. Int J Legal Med. 2015;129:693–700.
Article
PubMed
Google Scholar
Elkady AI. Crude alkaloid extract of Rhazya stricta inhibits cell growth and sensitizes human lung cancer cells to cisplatin through induction of apoptosis. Genet Mol Biol. 2013;36:12–21.
Article
PubMed
PubMed Central
Google Scholar
Faqi AS. A comprehensive guide to toxicology in preclinical drug development: Academic Press; 2013.
Diplock AT, Charuleux JL, Crozier-Willi G, Kok FJ, Rice-Evans C, Roberfroid M, et al. Functional food science and defence against reactive oxidative species. Br J Nutr. 1998;80:S77–S112.
Article
PubMed
CAS
Google Scholar
Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol. 2007;39:44–84.
Article
PubMed
CAS
Google Scholar
Shigenaga MK, Ames BN. Oxidants and mitogenesis as causes of mutation and cancer: the influence of diet. Basic Life Sci. 1993;61:419–36.
PubMed
CAS
Google Scholar
Greenwell M, Rahman P. Medicinal plants: their use in anticancer treatment. Int J Pharm Sci Res. 2015;6:4103.
PubMed
PubMed Central
CAS
Google Scholar
Alam AHMK, Hossain ASMS, Khan MA, Kabir SR, Reza MA, Rahman MM, et al. The Antioxidative Fraction of White Mulberry Induces Apoptosis through Regulation of p53 and NFκB in EAC Cells. PLoS ONE. 2016;11:e0167536.
Article
PubMed
PubMed Central
CAS
Google Scholar
Islam S, Nasrin S, Khan MA, Hossain ASMS, Islam F, Khandokhar P, et al. Evaluation of antioxidant and anticancer properties of the seed extracts of Syzygium fruticosum Roxb. growing in Rajshahi, Bangladesh. BMC Complement Altern Med. 2013;13:142.
Article
PubMed
PubMed Central
Google Scholar
Carmeliet P. Angiogenesis in life, disease and medicine. Nature. 2005;438:932.
Article
PubMed
CAS
Google Scholar
Bar J, Goss GD. Tumor vasculature as a therapeutic target in non-small cell lung cancer. J Thorac Oncol. 2012;7:609–20.
Article
PubMed
CAS
Google Scholar
Keizer RJ, Funahashi Y, Semba T, Wanders J, Beijnen J, Schellens J, et al. Evaluation of α 2-integrin expression as a biomarker for tumor growth inhibition for the investigational integrin inhibitor E7820 in preclinical and clinical studies. AAPS J. 2011;13:230–9.
Article
PubMed
PubMed Central
CAS
Google Scholar
Mita M, Kelly KR, Mita A, Ricart AD, Romero O, Tolcher A, et al. Phase I study of E7820, an oral inhibitor of integrin α-2 expression with antiangiogenic properties, in patients with advanced malignancies. Clin Cancer Res. 2011;17:193–200.
Article
PubMed
CAS
Google Scholar
Senger DR, Perruzzi CA, Streit M, Koteliansky VE, de Fougerolles AR, Detmar M. The α1β1 and α2β1 integrins provide critical support for vascular endothelial growth factor signaling, endothelial cell migration, and tumor angiogenesis. Am J Pathol. 2002;160:195–204.
Article
PubMed
PubMed Central
CAS
Google Scholar
Senger DR, Claffey KP, Benes JE, Perruzzi CA, Sergiou AP, Detmar M. Angiogenesis promoted by vascular endothelial growth factor: regulation through α1β1 and α2β1 integrins. Proc Natl Acad Sci U S A. 1997;94:13612–7.
Article
PubMed
PubMed Central
CAS
Google Scholar
Amzad Hossain M, Shah MD. A study on the total phenols content and antioxidant activity of essential oil and different solvent extracts of endemic plant Merremia borneensis. Arab J Chem. 2015;8:66–71.
Article
CAS
Google Scholar
Singleton VL, Orthofer R, Lamuela-Raventós RM. Analysis of total phenols and other oxidation substrates and antioxidants by means of folin-ciocalteu reagent: Methods Enzymol Academic Press; 1999. p. 152–78.
Lim YY, Quah EPL. Antioxidant properties of different cultivars of Portulaca oleracea. Food Chem. 2007;103:734–40.
Article
CAS
Google Scholar
Chang C-C, Yang M-H, Wen H-M, Chern J-C. Estimation of total flavonoid content in propolis by two complementary colorimetric methods. J Food Drug Anal. 2002;10:178–82.
CAS
Google Scholar
Guzmán C, Bagga M, Kaur A, Westermarck J, Abankwa D. ColonyArea: an ImageJ plugin to automatically quantify Colony formation in Clonogenic assays. PLoS One. 2014;9:e92444.
Article
PubMed
PubMed Central
CAS
Google Scholar
Saleh E, El-Awady R, Anis N. Predictive markers for the response to 5-fluorouracil therapy in cancer cells: constant-field gel electrophoresis as a tool for prediction of response to 5-fluorouracil-based chemotherapy. Oncol Lett. 2013;5:321–7.
Article
PubMed
CAS
Google Scholar
Khan MA, Rahman AA, Islam S, Khandokhar P, Parvin S, Islam MB, et al. A comparative study on the antioxidant activity of methanolic extracts from different parts of Morus alba L. (Moraceae). BMC Res Notes. 2013;6:24.
Article
PubMed
PubMed Central
Google Scholar
Robbins RJ. Phenolic acids in foods: an overview of analytical methodology. J Agric Food Chem. 2003;51:2866–87.
Article
PubMed
CAS
Google Scholar
Wojdyło A, Oszmiański J, Czemerys R. Antioxidant activity and phenolic compounds in 32 selected herbs. Food Chem. 2007;105:940–9.
Article
CAS
Google Scholar
Pontis JA, LAMAd C, SJRd S, Flach A. Color, phenolic and flavonoid content, and antioxidant activity of honey from Roraima, Brazil. Food Sci. Technol (Campinas). 2014;34:69–73.
Article
Google Scholar
Belguith-Hadriche O, Bouaziz M, Jamoussi K, Simmonds MS, El Feki A, Makni-Ayedi F. Comparative study on hypocholesterolemic and antioxidant activities of various extracts of fenugreek seeds. Food Chem. 2013;138:1448–53.
Article
PubMed
CAS
Google Scholar
Bukhari NA, Al-Otaibi RA, Ibhrahim MM. Phytochemical and taxonomic evaluation of Rhazya stricta in Saudi Arabia. Saudi J Biol Sci. 2017;24:1513–21.
Article
CAS
Google Scholar
Robards K, Prenzler PD, Tucker G, Swatsitang P, Glover W. Phenolic compounds and their role in oxidative processes in fruits. Food Chem. 1999;66:401–36.
Article
CAS
Google Scholar
Kitts DD, Wijewickreme AN, Hu C. Antioxidant properties of a north American ginseng extract. Mol Cell Biochem. 2000;203:1–10.
Article
PubMed
CAS
Google Scholar
Shan B, Cai YZ, Sun M, Corke H. Antioxidant capacity of 26 spice extracts and characterization of their phenolic constituents. J Agric Food Chem. 2005;53:7749–59.
Article
PubMed
CAS
Google Scholar
Amin A, Mousa M. Merits of anti-cancer plants from the Arabian gulf region. Cancer Ther. 2007;5:55–66.
Google Scholar
Popova M, Bankova V, Butovska D, Petkov V, Nikolova-Damyanova B, Sabatini AG, et al. Validated methods for the quantification of biologically active constituents of poplar-type propolis. Phytochem Anal. 2004;15:235–40.
Article
PubMed
CAS
Google Scholar
Amin A, Hamza AA, Daoud S, Khazanehdari K, Hrout AA, Baig B, et al. Saffron-based Crocin prevents early lesions of liver Cancer: in vivo, in vitro and network analyses. Recent Pat Anticancer Drug Discov. 2016;11:121–33.
Article
PubMed
CAS
Google Scholar
Wu C-T, Tsai Y-T, Lai J-N. Demographic and medication characteristics of traditional Chinese medicine users among colorectal cancer survivors: a nationwide database study in Taiwan. J Tradit Complement Med. 2016;7:188–94.
Article
PubMed
PubMed Central
Google Scholar
Pereira RM, Ferreira-Silva GA, Pivatto M, Santos Lde A, Bolzani Vda S, Chagas de Paula DA, et al. Alkaloids derived from flowers of Senna spectabilis, (−)-cassine and (−)-spectaline, have antiproliferative activity on HepG2 cells for inducing cell cycle arrest in G1/S transition through ERK inactivation and downregulation of cyclin D1 expression. Toxicol In Vitro. 2016;31:86–92.
Article
PubMed
CAS
Google Scholar
Newman DJ, Cragg GM. Natural products as sources of new drugs from 1981 to 2014. J Nat Prod. 2016;79:629–61.
Article
PubMed
CAS
Google Scholar
Block KI, Gyllenhaal C, Lowe L, Amedei A, Amin ARMR, Amin A, et al. Designing a broad-spectrum integrative approach for cancer prevention and treatment. Semin Cancer Biol. 2015;35(Supplement):S276–304.
Article
PubMed
PubMed Central
CAS
Google Scholar
Devasena T, Venugopal MP. Fenugreek seeds modulate 1,2-dimethylhydrazine-induced hepatic oxidative stress during colon carcinogenesis. Ital J Biochem. 2007;56:28–34.
PubMed
CAS
Google Scholar
Li F, Fernandez PP, Rajendran P, Hui KM, Sethi G. Diosgenin: a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells. Cancer Lett. 2010;292:197–207.
Article
PubMed
CAS
Google Scholar
Chandra P, Pandey R, Kumar B, Srivastva M, Pandey P, Sarkar J, et al. Quantification of multianalyte by UPLC–QqQLIT–MS/MS and in-vitro anti-proliferative screening in Cassia species. Ind Crop Prod. 2015;76:1133–41.
Article
CAS
Google Scholar
Nehdi IA, Sbihi HM, Tan CP, Al-Resayes SI. Seed oil from Harmal (Rhazya stricta Decne) grown in Riyadh (Saudi Arabia): a potential source of δ-tocopherol. J Saudi Chem Soc. 2016;20:107–13.
Article
CAS
Google Scholar
El Gendy MAM, Ali BH, Michail K, Siraki AG, El-Kadi AOS. Induction of quinone oxidoreductase 1 enzyme by Rhazya stricta through Nrf2-dependent mechanism. J Ethnopharmacol. 2012;144:416–24.
Article
PubMed
CAS
Google Scholar
Brown NR, Noble ME, Endicott JA, Johnson LN. The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases. Nat Cell Biol. 1999;1:438–43.
Article
PubMed
CAS
Google Scholar
McGowan CH, Russell P. Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyr15. EMBO J. 1993;12:75.
Article
PubMed
PubMed Central
CAS
Google Scholar
Wells NJ, Watanabe N, Tokusumi T, Jiang W, Verdecia MA, Hunter T. The C-terminal domain of the Cdc2 inhibitory kinase Myt1 interacts with Cdc2 complexes and is required for inhibition of G (2)/M progression. J Cell Sci. 1999;112:3361–71.
PubMed
CAS
Google Scholar
Enserink JM, Kolodner RD. An overview of Cdk1-controlled targets and processes. Cell Div. 2010;5:11–52.
Article
PubMed
PubMed Central
CAS
Google Scholar
Gach K, Grądzka I, Wasyk I, Męczyńska-Wielgosz S, Iwaneńko T, Szymański J, et al. Anticancer activity and radiosensitization effect of methyleneisoxazolidin-5-ones in hepatocellular carcinoma HepG2 cells. Chem Biol Interact. 2016;248:68–73.
Article
PubMed
CAS
Google Scholar
Rafehi H, Orlowski C, Georgiadis GT, Ververis K, El-Osta A, Karagiannis TC. Clonogenic assay: adherent cells. J Vis Exp. 2011;49:2573.
Google Scholar
Jiang WG, Sanders AJ, Katoh M, Ungefroren H, Gieseler F, Prince M, et al. Molecular, biological and clinical perspectives. Semin Cancer Biol. 2015;35(Supplement):S244–75.
Article
PubMed
CAS
Google Scholar
Baeshen NA, Elkady AI, Abuzinadah OA, Mutwakil MH. Potential anticancer activity of the medicinal herb, Rhazya stricta, against human breast cancer. Afr J Biotechnol. 2012;11:8960–72.
Article
Google Scholar
Bozzuto G, Ruggieri P, Molinari A. Molecular aspects of tumor cell migration and invasion. Ann Ist Super Sanita. 2010;46:66–80.
PubMed
CAS
Google Scholar
Alur I, Dodurga Y, Secme M, Elmas L, Bagci G, Goksin I, et al. Anti-tumor effects of bemiparin in HepG2 and MIA PaCa-2 cells. Gene. 2016;585:241–6.
Article
PubMed
CAS
Google Scholar
Lavictoire SJ, Parolin DA, Klimowicz AC, Kelly JF, Lorimer IA. Interaction of Hsp90 with the nascent form of the mutant epidermal growth factor receptor EGFRvIII. J Biol Chem. 2003;278:5292–9.
Article
PubMed
CAS
Google Scholar
Hocman G. Chemoprevention of cancer: phenolic antioxidants (BHT, BHA). Int J BioChemiPhysics. 1988;20:639–51.
Article
CAS
Google Scholar