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  1. Periodontitis is a chronic infection initiated by oral bacterial and their virulence factors, yet the severity of periodontitis is largely determined by the dysregulated host immuno-inflammatory response. Baic...

    Authors: Manman Ren, Ya Zhao, Zhiqi He, Jian Lin, Chuchu Xu, Fen Liu, Rongdang Hu, Hui Deng and Yi Wang

    Citation: BMC Complementary Medicine and Therapies 2021 21:43

    Content type: Research article

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  2. The sentence of “Danshen (Salvia Miltiorrhizae Radix et Rhizoma) and Siwu decoction are similar in function” was first recorded in an ancient Chinese medical book “Fu Ren Ming Li Lun”. This theory has far-reac...

    Authors: Yang Li, Li Qiao, Cong Chen, Zhenguo Wang and Xianjun Fu

    Citation: BMC Complementary Medicine and Therapies 2021 21:42

    Content type: Research article

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  3. The latest coronavirus SARS-CoV-2, discovered in China and rapidly spread Worldwide. COVID-19 affected millions of people and killed hundreds of thousands worldwide. There are many ongoing studies investigatin...

    Authors: Aslı Deniz Aydın, Faruk Altınel, Hüseyin Erdoğmuş and Çağdaş Devrim Son

    Citation: BMC Complementary Medicine and Therapies 2021 21:41

    Content type: Research article

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  4. There is preliminary evidence to suggest curcumin can alleviate digestive symptoms in adults with self-reported digestive complaints and irritable bowel syndrome. However, in all these trials, curcumin was use...

    Authors: Adrian L. Lopresti, Stephen J. Smith, Alethea Rea and Shavon Michel

    Citation: BMC Complementary Medicine and Therapies 2021 21:40

    Content type: Research article

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  5. Curcumin, a natural polyphenolic substance, has been known for more than two millennia as having strong anti-inflammatory activity towards multiple ailments, including arthritis. The main drawback of curcumin ...

    Authors: Ieva Rinkunaite, Egidijus Simoliunas, Milda Alksne, Dominyka Dapkute and Virginija Bukelskiene

    Citation: BMC Complementary Medicine and Therapies 2021 21:39

    Content type: Research article

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  6. Tripterygium hypoglaucum Hutch (THH) both has prominent efficacy and unwarranted toxicity in the treatment of autoimmune diseases. Nevertheless, its pharmacological and toxicological profiles still remain to be e...

    Authors: Dan Zhang, Yizhu Dong, Jintao Lv, Bing Zhang, Xiaomeng Zhang and Zhijian Lin

    Citation: BMC Complementary Medicine and Therapies 2021 21:38

    Content type: Research article

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  7. Considering the advantages of using medicinal herbs as supplementary treatments to sensitize conventional anti-cancer drugs, studying functional mechanisms and regulatory effects of Echinacea purpurea (as a non-c...

    Authors: Fatemeh Hosami, Azadeh Manayi, Vahid Salimi, Farshad Khodakhah, Mitra Nourbakhsh, Britt Nakstad and Masoumeh Tavakoli-Yaraki

    Citation: BMC Complementary Medicine and Therapies 2021 21:37

    Content type: Research article

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  8. During the fresh cycles of in vitro fertilization and embryo transfer, a disturbance in the reproductive endocrine environment following controlled ovarian hyperstimulation (COH) is closely related to compromi...

    Authors: Yufan Song, Fanru Zhou, Xiujuan Tan, Xia Liu, Jiahui Ding, Chu Zhang, Fan Li, Wenxin Zhu, Wenwen Ma, Runan Hu and Mingmin Zhang

    Citation: BMC Complementary Medicine and Therapies 2021 21:36

    Content type: Research article

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  9. Water-soluble, but not lipid-soluble, extract of Dicranopteris linearis leaves has been proven to possess hepatoprotective activity. The present study aimed to validate the hepatoprotective and antioxidant activi...

    Authors: Zainul Amiruddin Zakaria, Adibah Sahmat, Azfar Hizami Azmi, Amal Syahirah Nur Zainol, Maizatul Hasyima Omar, Tavamani Balan, Lilis Sulistyorini, R. Azizah and Muhammad Nazrul Hakim Abdullah

    Citation: BMC Complementary Medicine and Therapies 2021 21:35

    Content type: Research article

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  10. Panax notoginseng is one of the most valuable traditional Chinese medicines. Polysaccharides in P. notoginseng has been shown to significantly reduce the incidence of human diseases. However the application of fe...

    Authors: Shiquan You, Xiuqin Shi, Dan Yu, Dan Zhao, Quan An, Dongdong Wang, Jiachan Zhang, Meng Li and Changtao Wang

    Citation: BMC Complementary Medicine and Therapies 2021 21:34

    Content type: Research article

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  11. Microcirculatory disturbance is closely associated with multiple diseases such as ischemic and septic stroke. Luteolin (3,4,5,7-tetrahydroxyflavone) is a vascular protective flavonoid present in several dietar...

    Authors: Jie Su, Han-Ting Xu, Jing-Jing Yu, Mei-Qiu Yan, Ting Wang, Ya-Jun Wu, Bo Li, Wen-Jie Lu, Chuan Wang, Shan-Shan Lei, Si-Min Chen, Su-Hong Chen and Gui-Yuan Lv

    Citation: BMC Complementary Medicine and Therapies 2021 21:33

    Content type: Research article

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  12. The regeneration of nucleus pulposus (NP) cells is an effective method to prevent intervertebral disc degeneration (IVDD). In this study, we investigated the role of Asperosaponin VI (ASA VI), isolated from a ...

    Authors: Yong-tao Niu, Lin Xie, Rong-Rong Deng and Xiao-yu Zhang

    Citation: BMC Complementary Medicine and Therapies 2021 21:32

    Content type: Research article

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  13. Inflammation is the main key role in developing chronic diseases including cancer, cardiovascular diseases, diabetes, arthritis, and neurodegenerative diseases which possess a huge challenge for treatment. Wit...

    Authors: Yazan Ranneh, Abdah Md Akim, Hasiah Ab. Hamid, Huzwah Khazaai, Abdulmannan Fadel, Zainul Amiruddin Zakaria, Mohammed Albujja and Mohd Fadzelly Abu Bakar

    Citation: BMC Complementary Medicine and Therapies 2021 21:30

    Content type: Review

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  14. The dysfunction of the thyroid gland is a common medical condition. Nowadays, patients frequently use medicinal herbs as complementary or alternative options to conventional drug treatments. These patients may...

    Authors: Lubov V. Krepkova, Valentina V. Bortnikova, Aleksandra N. Babenko, Praskovya G. Mizina, Vladimir A. Mkhitarov, Kathleen M. Job, Catherine M. Sherwin and Elena Y. Enioutina

    Citation: BMC Complementary Medicine and Therapies 2021 21:31

    Content type: Research article

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  15. Little is known about factors associated with a clinically relevant reduction in menopausal symptoms through a brief acupuncture approach for women with moderate-to-severe menopausal symptoms.

    Authors: Frans Boch Waldorff, Christine Winther Bang, Volkert Siersma, John Brodersen and Kamma Sundgaard Lund

    Citation: BMC Complementary Medicine and Therapies 2021 21:29

    Content type: Research article

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  16. Ulcerative colitis is a gut inflammatory disorder due to altered immune response to gut microbiome, with interplay of environmental and genetic factors. TNF-α activates inflammatory response through a cascade ...

    Authors: Misbahuddin Rafeeq, Hussam Aly Sayed Murad, Hossam Mohammed Abdallah and Ali M. El-Halawany

    Citation: BMC Complementary Medicine and Therapies 2021 21:28

    Content type: Research article

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    The Correction to this article has been published in BMC Complementary Medicine and Therapies 2021 21:60

  17. New agents for developing alternative or complementary medicine to treat the hepatitis C virus (HCV) are still needed due to high rates of HCV infection globally and the current limitations of available treatm...

    Authors: Aty Widyawaruyanti, Mulyadi Tanjung, Adita Ayu Permanasari, Ratih Saputri, Lidya Tumewu, Myrna Adianti, Chie Aoki-Utsubo, Hak Hotta, Achmad Fuad Hafid and Tutik Sri Wahyuni

    Citation: BMC Complementary Medicine and Therapies 2021 21:27

    Content type: Research article

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  18. Pre-administration of probiotic Lactobacilli attenuates ethanol-induced gastric mucosal injury (GMI). The underpinning mechanisms remain to be elucidated. We speculated that lactate, the main metabolite of Lactob...

    Authors: Yingpeng Huang, Jiali Zhang, Renjie Dong, Xiawei Ji, Yusha Jiang, Jianke Cen, Zhihuai Bai, Kairui Hong, Huihui Li, Jiajing Chen, Jinhui Zhou, Fanyu Qian, Fangyan Wang, Yue Qu and Yan Zhou

    Citation: BMC Complementary Medicine and Therapies 2021 21:26

    Content type: Research article

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  19. Fucoidan, a water-soluble polysaccharide, exerts anticoagulant and antiviral functions. It was recently reported that fucoidan also exerts an antitumor function. Lung cancer is one of the most common cancers i...

    Authors: Xiaohan Chen, Li Sun, Xiaojuan Wei, Haijun Lu, Ye Tan, Zhanyi Sun and Jinju Jiang

    Citation: BMC Complementary Medicine and Therapies 2021 21:25

    Content type: Research article

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  20. Wrist-ankle acupuncture (WAA) as a kind of micro acupuncture therapy has been used to management cancer pain, however, the effects of WAA on cancer pain were controversial in the current studies. Therefore, th...

    Authors: Bei Dong, Lu Lin, Qiuyun Chen, Yishu Qi, Fen Wang, Keyan Qian and Li Tian

    Citation: BMC Complementary Medicine and Therapies 2021 21:24

    Content type: Research article

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  21. Evidence showed that Tai Chi may have beneficial effects among hypertensive individuals, although the results are not convincing. We aim to conduct a high-quality clinical trial with 24-h BP measurement to pro...

    Authors: Yuxi Li, Dongling Zhong, Chao Dong, Lihong Shi, Yaling Zheng, Yongguo Liu, Qiaoqin Li, Hui Zheng, Juan Li, Tianyu Liu and Rongjiang Jin

    Citation: BMC Complementary Medicine and Therapies 2021 21:23

    Content type: Study protocol

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  22. Nymphaea lotus L. (N. lotus) is an aquatic plant with anecdotal reports suggesting its use in the traditional management of cancer. However, there is a paucity of data on the antioxidant, anti-inflammatory and cy...

    Authors: Benoit Banga N’guessan, Adwoa Dede Asiamah, Nana Kwame Arthur, Samuel Frimpong-Manso, Patrick Amoateng, Seth Kwabena Amponsah, Kennedy Edem Kukuia, Joseph Adusei Sarkodie, Kwabena Frimpong-Manso Opuni, Isaac Julius Asiedu-Gyekye and Regina Appiah-Opong

    Citation: BMC Complementary Medicine and Therapies 2021 21:22

    Content type: Research article

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  23. Asthma is a chronic inflammatory disease characterized by airway remodeling and inflammation. Rhynchophylline is a kind of indole alkaloid isolated from Uncaria rhynchophylla. Here we investigated the effect of r...

    Authors: Hui Li, Qianyu Bi, Hongxia Cui, Chuanfeng Lv and Meng Wang

    Citation: BMC Complementary Medicine and Therapies 2021 21:21

    Content type: Research article

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  24. Cancer is a multifactorial disease caused by uncontrolled proliferation of cells. About 50–80% of cancer patients develop cachexia, a complex metabolic syndrome associated with an increase of mortality and mor...

    Authors: Henrique Jorge Novaes Morgan, Aislan Quintiliano Delgado, Luiz Leonardo Saldanha, Nathalia Aparecida De Paula Camaforte, Anne Lígia Dokkedal and José Roberto Bosqueiro

    Citation: BMC Complementary Medicine and Therapies 2021 21:20

    Content type: Research article

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  25. During the last few decades, patients worldwide have been interested in using alternative medicine in treating diseases to avoid the increased side effects of chemical medications. Green coffee is unroasted co...

    Authors: Haddad A. El Rabey, Samar M. Rezk, Mohamed I. Sakran, Ghena M. Mohammed, Omar Bahattab, Maha J. Balgoon, Mohamed A. Elbakry and Nadia Bakry

    Citation: BMC Complementary Medicine and Therapies 2021 21:19

    Content type: Research article

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  26. Norwogonin is a natural flavone with three phenolic hydroxyl groups in skeletal structure and has excellent antioxidant activity. However, the neuroprotective effect of norwogonin remains unclear. Here, we inv...

    Authors: Linlin Jing, Rongmin Gao, Jie Zhang, Dongmei Zhang, Jin Shao, Zhengping Jia and Huiping Ma

    Citation: BMC Complementary Medicine and Therapies 2021 21:18

    Content type: Research article

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  27. Drugs used for the treatment of diseases associated with chronic inflammation, such as cancer and rheumatoid arthritis have the potential to cause undesirable side-effects, which might result in patients endin...

    Authors: Nimsi Campos-Xolalpa, Ángel Josabad Alonso-Castro, Elizabeth Ortíz-Sanchez, Juan Ramon Zapata-Morales, Marco Martin González-Chávez and Salud Pérez

    Citation: BMC Complementary Medicine and Therapies 2021 21:17

    Content type: Research article

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  28. Traditional Chinese medicine (TCM) has gained increasing acceptance and popularity by the global community. The current study aimed to investigate self-reported evaluations of learning TCM and opinions about T...

    Authors: Fan Qu, Qing Zhang, Minchen Dai, Yijing He, Jiaqi Wu, Xian Zhang, Yuhang Zhu, Ying’er Gu, Fangfang Wang and Xiangrong Xu

    Citation: BMC Complementary Medicine and Therapies 2021 21:16

    Content type: Research article

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  29. Non-small cell lung cancer is a common type of lung cancer. Piperlongumine (PL), which is extracted from the roots of piperaceae plant, long pepper, and peppercorn, is an alkaloid amide that inhibits tumor gro...

    Authors: Xinhua Lu, Chenyang Xu, Zhexuan Xu, Chunya Lu, Rui Yang, Furui Zhang and Guojun Zhang

    Citation: BMC Complementary Medicine and Therapies 2021 21:15

    Content type: Research article

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  30. About 70% of Ghanaians depend on traditional, complementary and integrative medicine (TCIM) practices for primary healthcare needs. It was therefore integrated into mainstream healthcare delivery system by the...

    Authors: Angela Kenu, Ernest Kenu, Delia Akosua Bandoh and Moses Aikins

    Citation: BMC Complementary Medicine and Therapies 2021 21:14

    Content type: Research article

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  31. Alcohol abuse is a major problem worldwide and it affects people’s health and economy. There is a relapse in alcohol intake due to alcohol withdrawal. Alcohol withdrawal anxiety-like behavior is a symptom that...

    Authors: Lalit Sharma, Aditi Sharma, Ashutosh Kumar Dash, Gopal Singh Bisht and Girdhari Lal Gupta

    Citation: BMC Complementary Medicine and Therapies 2021 21:13

    Content type: Research article

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  32. Activation of renal fibroblasts is a critical mechanism in the process of renal fibrosis. As a commonly used herbal formula, Shenkang (SK) has been found to attenuate renal fibrosis and renal parenchyma destru...

    Authors: Tianyu Qin, You Wu, Tonghua Liu and Lili Wu

    Citation: BMC Complementary Medicine and Therapies 2021 21:12

    Content type: Research article

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  33. The traditional Chinese medicine formula Si-Jun-Zi-Tang (SJZT) has a long history of application in the treatment of functional dyspepsia (non-ulcer dyspepsia, FD)-like symptoms. SJZT-based therapies have been cl...

    Authors: Yaping Wang, Bin Liu, Xiuqiong Fu, Tiejun Tong and Zhiling Yu

    Citation: BMC Complementary Medicine and Therapies 2021 21:11

    Content type: Research article

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  34. Curcumin has been demonstrated to exert anti-oxidant, anti-fibrotic, anti-inflammatory, and anti-cancer activities. This study was conducted to observe the effect and inner mechanism of curcumin in rats with r...

    Authors: Wei Li, Liangjun Jiang, Xianzhou Lu, Xianrong Liu and Mingjiong Ling

    Citation: BMC Complementary Medicine and Therapies 2021 21:10

    Content type: Research article

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  35. Epilepsy, one of the most common neurological disorders, affects over 70 million people worldwide. Rhynchophylline displays a wide variety of pharmacologic actives. However, the pharmacologic effects of rhynch...

    Authors: Hua Geng, Xuqin Chen and Chengzhong Wang

    Citation: BMC Complementary Medicine and Therapies 2021 21:9

    Content type: Research article

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  36. The benefits of qigong for systolic and diastolic blood pressure (BP) reduction have been noted in previously published systematic reviews; however, the data on its effectiveness has been at best scarce. We ai...

    Authors: Siew Mooi Ching, Naidu Ragubathi Mokshashri, Maharajan Mari Kannan, Kai Wei Lee, Nurin Amalina Sallahuddin, Jun Xun Ng, Jie Lin Wong, Navin Kumar Devaraj, Fan Kee Hoo, Yee Shen Loo and Sajesh K. Veettil

    Citation: BMC Complementary Medicine and Therapies 2021 21:8

    Content type: Research article

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  37. Stroke causes lasting brain damage that has numerous impacts on the survivor’s physical, psychosocial, and spiritual well-being. Young survivors (< 65 years old) tend to suffer more because of their longer ove...

    Authors: Caitlin Kar Pui Chan, Temmy Lee Ting Lo, Adrian Ho Yin Wan, Pamela Pui Yu Leung, Marco Yiu Chung Pang and Rainbow Tin Hung Ho

    Citation: BMC Complementary Medicine and Therapies 2021 21:7

    Content type: Study protocol

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  38. Germacrone (GM) is a terpenoid compound which is reported to have anti-inflammatory and anti-oxidative effects. However, its role in treating traumatic brain injury (TBI) remains largely unknown.

    Authors: Sujing Zhuang, Baogui Liu, Shifeng Guo, Yanzhong Xue, Lin Wu, Shiqi Liu, Chunling Zhang and Xiuyan Ni

    Citation: BMC Complementary Medicine and Therapies 2021 21:6

    Content type: Research article

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  39. Correspondence from Yu et al. identify methodological issues with the systematic review of manual therapy for pediatric manuscript. Like any research study, limitations are important for readers to keep in con...

    Authors: Katherine A. Pohlman, Kristian Anderson, Beth Carleo and Brian Gleberzon

    Citation: BMC Complementary Medicine and Therapies 2021 21:5

    Content type: Correspondence

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    The original article was published in BMC Complementary Medicine and Therapies 2021 21:4

  40. Prevost et al. published a systematic review evaluating the use of manual therapy for clinical conditions in the pediatric population in 2019. However, several methodological flaws in the conduct of the review...

    Authors: Hainan Yu, Heather Shearer, Anne Taylor-Vaisey, Silvano Mior, Leslie Verville, Gaelan Connell and Pierre Côté

    Citation: BMC Complementary Medicine and Therapies 2021 21:4

    Content type: Correspondence

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    The Correspondence to this article has been published in BMC Complementary Medicine and Therapies 2021 21:5

  41. Generally, complementary and alternative therapies (CAT) are accepted methods of treatment by patients with various types of conditions. Their use is becoming especially prevalent among patients with eye probl...

    Authors: Dania Jaber, Rafat Abu Ghannam, Waleed Rashed, Mohammad Shehadeh and Sa’ed H. Zyoud

    Citation: BMC Complementary Medicine and Therapies 2021 21:3

    Content type: Research article

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  42. Patients with lymphoedema are at high risk of getting bacterial and fungal wound infections leading to acute inflammatory episodes associated with cellulitis and erysipelas. In Ethiopia, wound infections are t...

    Authors: Dereje Nigussie, Gail Davey, Belete Adefris Legesse, Abebaw Fekadu and Eyasu Makonnen

    Citation: BMC Complementary Medicine and Therapies 2021 21:2

    Content type: Research article

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  43. Hypercholesterolemia has posed a serious threat of heart diseases and stroke worldwide. Xanthine oxidase (XO), the rate-limiting enzyme in uric acid biosynthesis, is regarded as the root of reactive oxygen spe...

    Authors: Rishab Marahatha, Saroj Basnet, Bibek Raj Bhattarai, Prakriti Budhathoki, Babita Aryal, Bikash Adhikari, Ganesh Lamichhane, Darbin Kumar Poudel and Niranjan Parajuli

    Citation: BMC Complementary Medicine and Therapies 2021 21:1

    Content type: Research article

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  44. Rhinoviruses and influenza viruses cause millions of acute respiratory infections annually. Symptoms of mild acute respiratory infections are commonly treated with over-the-counter products like ambroxol, brom...

    Authors: Christin Walther, Kristin Döring and Michaela Schmidtke

    Citation: BMC Complementary Medicine and Therapies 2020 20:380

    Content type: Research article

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  45. Aloe’s reported bioactivities (anticancer, anti-inflammatory and wound healing) suggest they might inhibit a subgroup of matrix metalloproteinases (MMPs) called gelatinases (MMP-2 and MMP-9). The goal of the pres...

    Authors: Ana Lima, Paula Batista-Santos, Eduarda Veríssimo, Patrícia Rebelo and Ricardo Boavida Ferreira

    Citation: BMC Complementary Medicine and Therapies 2020 20:379

    Content type: Research article

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  46. Diabetic cardiomyopathy is a main cause of the increased morbidity in diabetic patients, no effective treatment is available so far. Polydatin, a resveratrol glucoside isolated from the Polygonum cuspidatum, was ...

    Authors: Ying-Ying Tan, Lei-Xin Chen, Ling Fang and Qi Zhang

    Citation: BMC Complementary Medicine and Therapies 2020 20:378

    Content type: Research article

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  47. Previous studies have found that Hugan Qingzhi tablet (HQT) has significant lipid-lowering and antioxidant effects on non-alcoholic fatty liver disease (NAFLD). Moreover, the results of proteomic analysis conf...

    Authors: Miaoting Yang, Zhijuan Chen, Shijian Xiang, Fan Xia, Waijiao Tang, Xiaorui Yao and Benjie Zhou

    Citation: BMC Complementary Medicine and Therapies 2020 20:377

    Content type: Research article

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  48. Obesity and its associated diseases have become a major world-wide health problem. Purple-leaf Tea (Camellia sinensis L.) (PLT), that is rich of anthocyanins, has been shown to have preventive effects on obesity ...

    Authors: Yu-Chun Lin, Hsu-Feng Lu, Jui-Chieh Chen, Hsiu-Chen Huang, Yu-Hsin Chen, Yen-Shuo Su, Chien-Yi Tung and Cheng Huang

    Citation: BMC Complementary Medicine and Therapies 2020 20:376

    Content type: Research article

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  49. Annona muricata L. was identified as a popular medicinal plant in treatment regimens among cancer patients in Jamaica by a previously conducted structured questionnaire. Ethnomedically used plant parts, were exam...

    Authors: Kimberley Foster, Omolola Oyenihi, Sunelle Rademan, Joseph Erhabor, Motlalepula Matsabisa, James Barker, Moses K. Langat, Amy Kendal-Smith, Helen Asemota and Rupika Delgoda

    Citation: BMC Complementary Medicine and Therapies 2020 20:375

    Content type: Research article

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  50. This study aimed to evaluate the effects of the Acorus tatarinowii Schott [Shi Chang Pu (SCP)] extract administered at the start of 2 h of middle cerebral artery occlusion (MCAo), followed by 3 d of reperfusion, ...

    Authors: Yu-Chen Lee, Shung-Te Kao and Chin-Yi Cheng

    Citation: BMC Complementary Medicine and Therapies 2020 20:374

    Content type: Research article

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