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Table 6 In vivo antiplasmodial suppression of aqueous fruit extract of T. arjuna in ICR mice blood infected with P. berghei ANKA

From: Antimalarial efficacy and toxicological assessment of medicinal plant ingredients of Prabchompoothaweep remedy as a candidate for antimalarial drug development

Group

Dose (mg/ml)

% Parasitemia

% Suppression

MST (days)

Negative control

–

34.30 ± 2.52 b, c, d, e

–

8.60 ± 1.03

Artesunate

6

2.38 ± 0.35 a, c, d, e

93.07 ± 1.01 a, c, d, e

18.40 ± 0.98 a, c, d, e

T. arjuna extract (Treated groups)

200

24.58 ± 1.15 a, b, d, e

28.33 ± 3.01 a, b, d, e

13.00 ± 1.67 a, b, d, e

400

18.60 ± 1.64 a, b, c, e

45.77 ± 4.78 a, b, c, e

16.00 ± 1.05 a, b, c

600

10.99 ± 1.40 a, b, c, d

67.95 ± 4.09 a, b, c, d

17.40 ± 1.60 a, b, c

  1. Data represent mean ± SEM (n = 5 per group); MST: mean survival time; Negative control: 7% Tween 80 solution
  2. Values are significantly different at p < 0.05
  3. Significant differences (p < 0.01) are indicated by acompared to the negative control; bcompared to artesunate; ccompared to 200 mg/kg extract; dcompared to 400 mg/kg extract; ecompared to 600 mg/kg extract