Armstrong VW, Oellerich M. New developments in the immunosuppressive drug monitoring of cyclosporine, tacrolimus, and azathioprine. Clin Biochem. 2001;34(1):9–16.
Article
CAS
Google Scholar
Ferjani H, El Arem A, Bouraoui A, Achour A, Abid S, Bacha H, Boussema-Ayed I. Protective effect of mycophenolate mofetil against nephrotoxicity and hepatotoxicity induced by tacrolimus in Wistar rats. J Physiol Biochem. 2016;72(2):133–44.
Article
CAS
Google Scholar
Campistol JM, Sacks SH. Mechanisms of nephrotoxicity. Transplantation. 2000;69(12 Suppl):S5–10.
Google Scholar
Křen V, Walterova D. Silybin and silymarin-new effects and applications. Biomedical Papers. 2005;149(1):29–41.
Article
Google Scholar
Naesens M, Kuypers DR, Sarwal M. Calcineurin inhibitor nephrotoxicity. Clin J Am Soc Nephrol. 2009;4(2):481–508.
Article
CAS
Google Scholar
Busauschina A, Schnuelle P, van der Woude FJ. Cyclosporine nephrotoxicity. Transplant Proc. 2004;36(2 Suppl):229S-233S.
Article
CAS
Google Scholar
Miyata S, Ohkubo Y, Mutoh S. A review of the action of tacrolimus (FK506) on experimental models of rheumatoid arthritis. Inflamm Res. 2005;54(1):1–9.
Article
CAS
Google Scholar
Liu JFK. 506 and ciclosporin: molecular probes for studying intracellular signal transduction. Trends Pharmacol Sci. 1993;14(5):182–8.
Article
CAS
Google Scholar
Busauschina A, Schnuelle P, van der Woude FJ. Cyclosporine nephrotoxicity. Transpl Proc. 2004;36(2):229–33.
Article
Google Scholar
Vicari-Christensen M, Repper S, Basile S, Young D. Tacrolimus: review of pharmacokinetics, pharmacodynamics, and pharmacogenetics to facilitate practitioners’ understanding and offer strategies for educating patients and promoting adherence. Prog Transpl. 2009;19(3):277–84.
Article
Google Scholar
Scott LJ, McKeage K, Keam SJ, Plosker GL. Tacrolimus. Drugs. 2003;63(12):1247–97.
Article
CAS
Google Scholar
Nash A, Samoylova M, Leuthner T, Zhu M, Lin L, Meyer JN. Brennan TV.Effects of immunosuppressive medications on mitochondrial function. J Surg Res. 2020;249:50–7.
Article
CAS
Google Scholar
Karimi G, Ramezani M, Tahoonian Z. Cisplatin nephrotoxicity and protection by milk thistle extract in rats. Evid -based Complement Altern Med. 2005;2(3):383–6.
Article
Google Scholar
Finaud J, Lac G, Filaire E. Oxidative stress. Sports Med. 2006;36(4):327–58.
Article
Google Scholar
Yoshikawa T, Naito Y. What is oxidative stress? Jpn Med Assoc J. 2002;45(7):271–6.
Google Scholar
Fu R, Tajima S, Shigematsu T, Zhang M, Tsuchimoto A, Egashira N, Ieiri I, Masuda S. Establishment of an experimental rat model of tacrolimus-induced kidney injury accompanied by interstitial fibrosis. Toxicol Lett. 2021;341:43–50.
Article
CAS
Google Scholar
Mitamura T, Yamada A, Ishida H, Fujihira S, Ohara K, Noguchi H, Mine Y. Tacrolimus (FK506)-induced nephrotoxicity in spontaneous hypertensive rats. J Toxicol Sci. 1994;19(4):219–26.
Article
CAS
Google Scholar
Klein IHHT, Abrahams A, van Ede T, Hené RJ, Koomans HA, Ligtenberg G. Different effects of tacrolimus and cyclosporine on renal hemodynamics and blood pressure in healthy subjects. Transplantation. 2002;73(5):732-6.
Nankivell BJ, Chapman JR, Bonovas G, Gruenewald SM.Oral cyclosporine but not tacrolimus reduces renal transplant blood flow. Transplantation. 2004;77(9):1457-459.
Kihm LP, Blume C, Seckinger J, Hankel V, Stoffler D, Morath C, Zeier M, Schwenger V. Acute effects of calcineurin inhibitors on kidney allograft microperfusion visualized by contrast-enhanced sonography. Transplantation. 2012;93(11):1125-9.
O’grady J, Hardy P, Burroughs A, Elbourne D, Group UK. Randomized controlled trial of tacrolimus versus microemulsified cyclosporin (TMC) in liver transplantation: poststudy surveillance to 3 years. Am J Transplant. 2007;7(1):137–41.
Article
Google Scholar
O’Grady JG, Burroughs A, Hardy P, Elbourne D, Truesdale A. Tacrolimus versus microemulsified ciclosporin in liver transplantation: the TMC randomised controlled trial. Lancet. 2002;360(9340):1119–25.
Article
Google Scholar
Sanchez-Campos S, Lopez-Acebo R, Gonzalez P, Culebras JM, Tunon MJ, Gonzalez-Gallego J. Cholestasis and alterations of glutathione metabolism induced by tacrolimus (FK506) in the rat. Transplantation. 1998;66(1):84–8.
Article
CAS
Google Scholar
Taniai N, Akimaru K, Ishikawa Y, Kanada T, Kakinuma D, Mizuguchi Y, Mamada Y, Yoshida H. Tajiri T.Hepatotoxicity caused by both tacrolimus and cyclosporine after living donor liver transplantation. J Nippon Med School. 2008;75(3):187–91.
Article
Google Scholar
Yadav DK, Gera DN, Gumber MR, Kute VB, Patel MP, Vanikar AV. Trivedi HL.Tacrolimus-induced severe cholestasis complicating renal transplantation. Ren Fail. 2013;35(5):735–7.
Article
Google Scholar
Akar Y, Yucel G, Durukan A, Yucel I, Arici G. Systemic toxicity of tacrolimus given by various routes and the response to dose reduction. Clin Exp Ophthalmol. 2005;33(1):53–9.
Article
Google Scholar
Heim KE, Tagliaferro AR, Bobilya DJ. Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships. J Nutr Biochem. 2002;13(10):572–84.
Article
CAS
Google Scholar
Abenavoli AL, Capasso R, Milic N, Capasso F. Milk thistle in liver diseases: past, present, future. Phytother Res. 2010;24(10):1423–32.
Article
CAS
Google Scholar
Kvasnička F, Bíba B, Ševčík R, Voldřich M. Krátká J.Analysis of the active components of silymarin. J Chromatogr A. 2003;990(1):239–45.
Article
Google Scholar
Surai PF. Silymarin as a natural antioxidant: an overview of the current evidence and perspectives. Antioxidants. 2015;4(1):204–47.
Article
CAS
Google Scholar
Vargas-Mendoza N, Madrigal-Santillán E, Morales-González Á, Esquivel-Soto J, Esquivel-Chirino C, y González-Rubio MG-L, Gayosso-de-Lucio JA, Morales-González JA. Hepatoprotective effect of silymarin. World J Hepatol. 2014;6(3):144.
Article
Google Scholar
Gazak R, Walterova D, Kren V. Silybin and silymarin-new and emerging applications in medicine. Curr Med Chem. 2007;14(3):315–38.
Article
CAS
Google Scholar
Dehmlow C, Erhard J, de Groot H. Inhibition of Kupffer cell functions as an explanation for the hepatoprotective properties of silibinin. Hepatology. 1996;23(4):749–54.
Article
CAS
Google Scholar
Farghali H, Kamenikova L, Hynie S, Kmonickova E. Silymarin effects on intracellular calcuim and cytotoxicity: a study in perfused rat hepatocytes after oxidative stress injury. Pharmacol Res. 2000;41(2):231–7.
Article
CAS
Google Scholar
Subir Kumar Das SMaDV. Medicinal properties of milk thistle with special reference to silymarin an overview. Nat Prod Radiance. 2008;7(2):182–92.
Google Scholar
Radko L, Cybulski W. Application of silymarin in human and animal medicine. J Pre-Clinical Clin Res. 2007;1(1):022–6.
Google Scholar
Aboshanab MHA, El-Nabarawi MA, Teaima MH, El-Nekeety AA, Abdel-Aziem SH, Hassan NS, Abdel-Wahhab MA. Fabrication, characterization and biological evaluation of silymarin nanoparticles against carbon tetrachloride-induced oxidative stress and genotoxicity in rats. Int J Pharm. 2020;587:119639.
Article
CAS
Google Scholar
Heidarian E, Nouri A. Hepatoprotective effects of silymarin against diclofenac-induced liver toxicity in male rats based on biochemical parameters and histological study. Arch Physiol Biochem. 2021;127(2):112–8.
Article
CAS
Google Scholar
Ahmad MM, Rezk NA, Fawzy A, Sabry M. Protective effects of curcumin and silymarin against paracetamol induced hepatotoxicity in adult male albino rats. Gene. 2019;712:143966.
Article
CAS
Google Scholar
Keshavarz-Maleki R, Shalmani AA, Gholami M, Sabzevari S, Rahimzadegan M, Jeivad F, Sabzevari O. The ameliorative effect of monomethyl fumarate and silymarin against valproic acid induced hepatotoxicity in rats. Pharm Chem J. 2021;55(3):240–5.
Article
CAS
Google Scholar
Sonnenbichler J, Scalera F, Sonnenbichler I, Weyhenmeyer R. Stimulatory effects of silibinin and silicristin from the milk thistle Silybum marianum on kidney cells. J Pharmacol Exp Ther. 1999;290(3):1375–83.
CAS
Google Scholar
Nouri A, Heidarian E. Nephroprotective effect of silymarin against diclofenacinduced renal damage and oxidative stress in male rats. J Herbmed Pharmacol. 2019;8(2):146-52.
Guzel S, Sahinogullari ZU, Canacankatan N, Antmen SE, Kibar D, Coskun Yilmaz B. Potential renoprotective effects of silymarin against vancomycin-induced nephrotoxicity in rats. Drug Chem Toxicol. 2020;43(6):630–6.
Article
CAS
Google Scholar
Dumludag B, Derici MK, Sutcuoglu O, Ogut B, Pasaoglu OT, Gonul II, Derici U. Role of silymarin (Silybum marianum) in the prevention of colistin-induced acute nephrotoxicity in rats. Drug Chem Toxicol. 2022;45(2):568–75.
Article
CAS
Google Scholar
Erel O. A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clin Biochem. 2004;37(4):277–85.
Article
CAS
Google Scholar
Erel O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem. 2005;38(12):1103–11.
Article
CAS
Google Scholar
Karabulut AB, Ara C. Melatonin ameliorates tacrolimus (FK-506)’s induced immunosupressive effect in rat liver. Transpl Proc. 2009;41(5):1875–7.
Article
CAS
Google Scholar
Mollison KW, Fey TA, Krause RA, Andrews JM, Bretheim PT, Cusick PK, Hsieh GC, Luly JR. Nephrotoxicity studies of the immunosuppressants tacrolimus (FK506) and ascomycin in rat models. Toxicology. 1998;125(2–3):169–81.
Article
CAS
Google Scholar
Butani L, Afshinnik A, Johnson J, Javaheri D, Peck S, German JB, Perez RV. Amelioration of tacrolimus-induced nephrotoxicity in rats using juniper oil. Transplantation. 2003;76(2):306–11.
Article
Google Scholar
Al-Harbi NO, Imam F, Al-Harbi MM, Iqbal M, Nadeem A, Al-Shahrah OA, Korashy HM, Al-Hosaini KA, Ahmed M, Bahashwar S. Treatment with aliskiren ameliorates tacrolimus-induced nephrotoxicity in rats. J Renin-Angiotensin-Aldosterone Syst. 2015;16(4):1329–36.
Article
CAS
Google Scholar
Kedzierska K, Sporniak-Tutak K, Bober J, Safranow K, Olszewska M, Jakubowska K, Domański L, Gołembiewska E, Kwiatkowska E, Laszczyńska M. Oxidative stress indices in rats under immunosuppression. In: Transplantation proceedings: 2011: Elsevier; 2011: 3939–3945.
Zheng H-L, Zhang H-Y, Zhu C-L, Li H-Y, Cui S, Jin J, Piao S-G, Jiang Y-J, Xuan M-Y, Jin J-Z. L-Carnitine protects against tacrolimus-induced renal injury by attenuating programmed cell death via PI3K/AKT/PTEN signaling. Acta Pharmacol Sin. 2021;42(1):77–87.
Article
CAS
Google Scholar
Randhawa PS, Starzl TE, Demetris AJ. Tacrolimus (FK506)-associated renal pathology. Adv Anat Pathol. 1997;4(4):265.
Article
Google Scholar
Chen Y, Liang Y, Chen L, Liang J, Zhang J, Qiu J, Li W, Hu J, Xie K, Zhong W. Prevention of diltiazem in tacrolimus-induced nephrotoxicity: experiment with rats. Zhonghua Yi Xue Za Zhi. 2007;87(32):2235–7.
CAS
Google Scholar
McLaughlin GE, Schober M, Perez M, Ruiz P, Steele BW, Abitbol C. Benefit of theophylline administration in tacrolimus-induced nephrotoxicity in rats. Pediatr Nephrol. 2003;18(9):860–4.
Article
Google Scholar
Abdelmeguid NE, Chmaisse HN, Zeinab NSA. Protective effect of silymarin on cisplatin-induced nephrotoxicity in rats. Pak J Nutr. 2010;9(7):624–36.
Article
CAS
Google Scholar
El-Shitany NA, El-Haggar S, El-Desoky K. Silymarin prevents adriamycin-induced cardiotoxicity and nephrotoxicity in rats. Food Chem Toxicol. 2008;46(7):2422–8.
Article
CAS
Google Scholar
Cengiz M. Renoprotective effects of Silybum marianum (L.) Gaertn (silymarin) on thioacetamide-induced renal injury: biochemical and histopathological approach. Pakistan J Pharmaceut Sci. 2018;31(5):2137-41.
Amien AI, Fahmy SR, Abd-Elgleel FM, Elaskalany SM. Renoprotective effect of Mangifera indica polysaccharides and silymarin against cyclophosphamide toxicity in rats. J Basic Appl Zool. 2015;72:154–62.
Article
CAS
Google Scholar
Mohammed IA, Shaban KA, Albadrany YM. Hepato-renal and hematological effects of flunixin and silymarin coadministration in rats. Iraqi J Vet Sci. 2022;36(2):367–73.
Google Scholar
Demetris A, Fung J, Todo S, Banner B, Zerbe T, Sysyn G, Starzl T. Pathologic observations in human allograft recipients treated with FK 506. Transpl Proc. 1990;22(1):25–34.
CAS
Google Scholar
Khettry U, Backer A, Ayata G, Lewis WD, Jenkins RL. Gordon FD.Centrilobular histopathologic changes in liver transplant biopsies. Hum Pathol. 2002;33(3):270–6.
Article
Google Scholar
Whitfield J. Gamma glutamyl transferase. Crit Rev Clin Lab Sci. 2001;38(4):263–355.
Article
CAS
Google Scholar
Palomero J, Galán AI, Muñoz MaE, Tuñón Ma J, González-Gallego J, Jiménez R. Effects of aging on the susceptibility to the toxic effects of cyclosporin A in rats. Changes in liver glutathione and antioxidant enzymes. Free Radic Biol Med. 2001;30(8):836–45.
Article
CAS
Google Scholar
Khanna AK, Pieper GM. NADPH oxidase subunits (NOX-1, p22phox, Rac-1) and tacrolimus-induced nephrotoxicity in a rat renal transplant model. Nephrol Dialysis Transpl. 2006;22(2):376–85.
Article
Google Scholar
Koçarslan A, Koçarslan S, Aydin MS, Gunay Ş, Karahan MA, Taşkın A, Üstunel M, Aksoy N. Intraperitoneal administration of silymarin protects end organs from multivisceral ischemia/reperfusion injury in a rat model. Brazilian J Cardiovasc Surg. 2016;31:434–9.
Google Scholar
Turgut F, Bayrak O, Catal F, Bayrak R, Atmaca AF, Koc A, Akbas A, Akcay A, Unal D. Antioxidant and protective effects of silymarin on ischemia and reperfusion injury in the kidney tissues of rats. Int Urol Nephrol. 2008;40(2):453–60.
Article
CAS
Google Scholar
Kim HS, Lim SW, Jin L, Jin J, Chung BH, Yang CW. The protective effect of febuxostat on chronic tacrolimus-induced nephrotoxicity in rats. Nephron. 2017;135(1):61–71.
Article
CAS
Google Scholar
Choi S, You H, Chung S: Tacrolimus-induced apoptotic signal transduction pathway. In: Transplantation proceedings: 2008: Elsevier; 2008: 2734–2736.
Kochi S, Takanaga H, Matsuo H, Ohtani H, Naito M, Tsuruo T, Sawada Y. Induction of apoptosis in mouse brain capillary endothelial cells by cyclosporin A and tacrolimus. Life Sci. 2000;66(23):2255–60.
Article
CAS
Google Scholar
Dabak DO, Kocaman N. Effects of silymarin on methotrexate-induced nephrotoxicity in rats. Ren Fail. 2015;37(4):734–9.
Article
CAS
Google Scholar
Sozmen M, Devrim AK, Tunca R, Bayezit M, Dag S, Essiz D. Protective effects of silymarin on fumonisin B1-induced hepatotoxicity in mice. J Vet Sci. 2014;15(1):51–60.
Article
Google Scholar
Doehmer J, Tewes B, Klein K-U, Gritzko K, Muschick H. Mengs U.Assessment of drug–drug interaction for silymarin. Toxicol In Vitro. 2008;22(3):610–7.
Article
CAS
Google Scholar
Brantley SJ, Graf TN, Oberlies NH, Paine MF. A systematic approach to evaluate herb-drug interaction mechanisms: investigation of milk thistle extracts and eight isolated constituents as CYP3A inhibitors. Drug Metab Dispos. 2013;41(9):1662–70.
Article
CAS
Google Scholar
Kim C-S, Choi S-J, Park C-Y, Li C, Choi J-S. .Effects of silybinin on the pharmacokinetics of tamoxifen and its active metabolite, 4-hydroxytamoxifen in rats. Anticancer Res. 2010;30(1):79–85.
CAS
Google Scholar
Sridar C, Goosen TC, Kent UM, Williams JA, Hollenberg PF. Silybin inactivates cytochromes P450 3A4 and 2C9 and inhibits major hepatic glucuronosyltransferases. Drug Metab Dispos. 2004;32(6):587–94.
Article
CAS
Google Scholar
Qi Y, Li G, Zhou Y, Wang M, Bi K, Dai R. Determination of FK506 in rat blood by LC-MS/MS and effect of silymarin on its pharmacokinetics. J Liq Chromatogr Relat Technol. 2012;35(15):2217–27.
Article
CAS
Google Scholar
Gaston RS, Cecka JM, Kasiske BL, Fieberg AM, Leduc R, Cosio FC, Gourishankar S, Grande J, Halloran P, Hunsicker L, et al. Evidence for antibody-mediated Injury as a major determinant of late kidney allograft failure. Transplantation. 2010;90(1):68-74.