Cinnamomum verum J. Presl. Bark essential oil: in vitro investigation of anti-cholinesterase, anti-BACE1, and neuroprotective activity

Table 3 Chemical composition of C. verum bark EO

Entry	Compounds ¹	RT (min) ²	Percent (%) ³	RI ⁴
Entry	Compounds ¹	RT (min) ²	Percent (%) ³	Calculated	Literature ⁵
1	α-Pinene^a	7.56	0.11	950	956
2	Camphene^a	7.85	0.09	973	981
3	Benzaldehyde^b	8.08	0.49	992	995
4	3-Phenylpropanal^b	10.98	0.77	1157	1163
5	Isoborneol^c	11.05	0.20	1162	1164
6	(E)-Cinnamaldehyde^b	12.41	68.23	1262	1268
7	Cyclosativene^d	13.15	0.45	1338	1344
8	α-Copaene^d	13.23	4.25	1343	1349
9	Cinnamaldehyde dimethyl acetal^e	13.39	4.21	1389	-
10	Isosativene^d	13.57	0.25	1407	-
11	(E)-Cinnamic acid^f	13.74	1.50	1420	1428
12	Aromadendrene^d	13.82	0.26	1431	1439
13	(Z)-α-Bisabolene^d	13.94	0.23	1469	1476
14	α-Muurolene^d	14.30	3.18	1471	1479
15	δ-Cadinene^d	14.49	5.53	1497	1503
16	β-Oplopenone^g	14.88	0.28	1580	1585
17	δ-Cadinol^g	15.21	0.64	1637	1644
18	t-Cadinol^g	15.46	1.26	1645	1649
19	t-Muurolol^g	15.57	0.36	1650	1650
20	Cadalene^d	15.72	0.63	1662	1665
21	Octadecane^h	16.42	0.16	1796	1800
22	Dibutyl phthalate^i,6	16.99	0.18	1897	1906
	Total (%) identified		93.26

¹ The chemical composition was identified based on the MS spectra and Kovats retention indices. Compounds belong to different classes including monoterpenes ^a, aldehydes ^b, monoterpenoids ^c, sesquiterpenes ^d, styrenes ^e, carboxylic acids ^f, sesquiterpenoids ^g, alkane hydrocarbons ^h, and aromatic esters ⁱ
² Retention time
³ Detected based on the GC (FID)
⁴ Kovats retention index
⁵ All calculated RI values were compared with those reported in the literature at the same conditions, cited in PubChem and NIST (National Institute of Standards and Technology)
⁶It may be associated with the presence of plasticizers

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