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Table 2 The effect of naringenin and CPT on DTH responses in Balb/c mice against red blood cells of sheep (sRBC)

From: Naringenin and cryptotanshinone shift the immune response towards Th1 and modulate T regulatory cells via JAK2/STAT3 pathway in breast cancer

 

treatment

% of footpad increase (DTH)

24 h

48 h

72 h

Group 1

sRBC + saline

45 Âħ 4.2

42 Âħ 8.2

35 Âħ 5.8

Group 2

sRBC + Naringenin (20 mg/Kg/day)

70 Âħ 8.9

65 Âħ 7.8

60 Âħ 6.3

Group 3

sRBC + Naringenin (50 mg/Kg/day)

93 Âħ 7.7a

76 Âħ 8.4

54 Âħ 2.3

Group 4

sRBC + CPT (20 mg/Kg/day)

75 Âħ 8.4

61 Âħ 8.4

59 Âħ 7.3

Group 5

sRBC + Naringenin (20 mg/Kg/day) + CPT (20 mg/Kg/day)

108 Âħ 5.4a

96 Âħ 6.4a

72 Âħ 5.3

  1. Results are presented as mean Âħ S.E.M. (standard error of the mean)
  2. DTH Delay type hypersensitivity, CPT Cryptotanshinone
  3. aSignificant difference (P < 0.05) in comparison with group 1 (control)