Table 5 Effect of plant extracts on kidney homogenate constituents of phosphate, oxalate and calcium following the administrations of curative test on the 28th day at 200 mg/kg dose. The mixed extract = the combination of A. aspera, S. punctata and R. abyssinicus extracts (1: 1:1 ratio). Data were presented as mean ± SD for 6 rats in each group (n = 6). Comparisons between means were made against Group I (vehicle control) and Group II (lithiatic control). *p < 0.05, **p < 0.01,***p < 0.001 indicate significant changes in comparison with the group I (vehicle control), #p < 0.05, ##p < 0.01, ###p < 0.001 indicate significant changes in comparison with group II (lithiatic control)
Groups | Treatments | Kidney homogenates (mg/dl) | ||
|---|---|---|---|---|
Phosphate | Oxalate | Calcium | ||
I. | Normal control (DH2O) | 3.84 ± 1.02 | 1.45 ± 0.30 | 2.12 ± 1.30 |
II. | Lithiatic control | 9.44 ± 2.31 | 7.67 ± 2.25 | 9.50 ± 2.47 |
III. | K-Cit (2.5 g/kg) | 5.13 ± 1.33# | 3.33 ± 0.87*# | 3.33 ± 2.24# |
IV. | Cystone (750 mg/kg) | 7.05 ± 2.00 | 5.27 ± 1.42** | 4.22 ± 2.10# |
V. | G. fruticosus PET extract | 8.23 ± 2.70* | 4.52 ± 0.56*# | 5.03 ± 1.98 |
VI. | G. fruticosus Chl. extract | 7.50 ± 2.08 | 4.09 ± 0.78*# | 5.11 ± 1.69 |
VII. | G. fruticosus EtOAc extract | 3.89 ± 0.42# | 2.10 ± 0.87## | 7.05 ± 2.56* |
VIII. | G. fruticosus BuOH extract | 6.11 ± 1.55 | 3.31 ± 0.32*# | 7.21 ± 2.37* |
IX. | G. fruticosus aq. fraction | 4.52 ± 0.63# | 5.43 ± 1.05** | 5.53 ± 1.88* |