Skip to main content

Table 3 Effects of plant extracts at 200 mg/kg dose on changes in urinary excretion (24 h) and serum crystal inhibitors and promoters in male Wistar rats on the 28th day post-treatment. The mixed extract = the combination of A. aspera, S. punctata and R. abyssinicus extracts (1: 1:1 ratio). The data were presented as mean ± SD for 6 rats in each group (n = 6). Comparisons between means were made against Group I (vehicle control) and Group II (lithiatic control). *p < 0.05, **p < 0.01,***p < 0.001 indicate significant changes in comparison with Group-I (vehicle control), #p < 0.05, ##p < 0.01, ###p < 0.001 indicate significant changes in comparison with Group II (lithiatic control)

From: Evaluations of the curative efficacy of G. fruticosus solvent extracts in experimentally induced nephrolithiatic Wistar male rats

Groups Treatments Crystal inhibitors (mg/dl) Crystal promoters (mg/dl)
Magnesium Citrate Calcium Phosphate Oxalate
Urine
 I. Normal control (DH2O) 2.88 ± 0.63 3.46 ± 0.78 2.60 ± 0.48 5.35 ± 1.12 3.81 ± 0.43
 II. Lithiatic control 0.96 ± 0.14 1.83 ± 0.51 11.40 ± 3.14 9.71 ± 2.89 12.76 ± 3.62
 II. K-Cit (2.5 g/kg) 1.52 ± 0.42 4.32 ± 1.43## 6.28 ± 1.15*# 6.73 ± 1.34 7.53 ± 2.02*#
 IV. Cystone (750 mg/kg) 1.70 ± 0.34 2.21 ± 0.46 5.84 ± 1.23*# 5.31 ± 1.29# 8.29 ± 2.11**
 V. G. fruticosus PET extract 1.87 ± 0.65 1.98 ± 0.23* 8.11 ± 1.29* 7.04 ± 2.17 7.32 ± 0.91*#
 VI. G. fruticosus Chl. extract 1.57 ± 0.28 2.37 ± 0.04 7.07 ± 1.16* 8.3 ± 2.62* 7.35 ± 1.40*#
 VII. G. fruticosus EtOAc extract 3.30 ± 1.21## 3.02 ± 1.12## 6.24 ± 1.35# 5.12 ± 0.98# 4.25 ± 0.53###
 VIII. G. fruticosus BuOH extract 2.61 ± 0.74# 2.43 ± 0.91 4.17 ± 0.85## 4.10 ± 0.65## 4.39 ± 0.33##
 IX. G. fruticosus aq. fraction 2.50 ± 0.88# 2.95 ± 0.66# 5.16 ± 0.71# 5.41 ± 1.02# 6.51 ± 1.03*##
Serum
 I. Normal control (DH2O) 3.07 ± 0.51 5.11 ± 1.33 3.17 ± 0.97 1.78 ± 0.64 1.24 ± 0.21
 II. Lithiatic control 0.98 ± 0.07 1.20 ± 0.07 11.6 ± 2.13 5.14 ± 1.45 11.32 ± 2.27
 III. K-Cit (2.5 g/kg) 1.72 ± 0.12 5.41 ± 1.13### 6.11 ± 1.75*# 3.61 ± 0.61* 4.06 ± 0.83*##
 IV. Cystone (750 mg/kg) 1.50 ± 0.30* 3.00 ± 0.32# 8.24 ± 2.88** 3.33 ± 1.14* 3.57 ± 0.67*###
 V. G. fruticosus PET extract 0.79 ± 0.08** 2.43 ± 0.79*# 7.44 ± 2.50** 6.78 ± 1.14* 6.75 ± 1.29**#
 VI. G. fruticosus Chl. extract 1.44 ± 0.19* 0.93 ± 1.19*** 8.30 ± 2.11** 4.39 ± 0.87* 7.92 ± 2.31**
 VII. G. fruticosus EtOAc extract 2.47 ± 0.11# 1.68 ± 1.27** 5.25 ± 1.62# 3.06 ± 0.32* 4.72 ± 0.68**##
 VIII. G. fruticosus BuOH extract 1.04 ± 0.31** 4.58 ± 1.54## 5.14 ± 0.82# 4.48 ± 1.89* 5.86 ± 2.14**##
 IX. G. fruticosus aq. fraction 1.87 ± 0.15 2.50 ± 0.92*# 3.42 ± 0.84### 6.03 ± 1.57* 7.10 ± 2.05**