Skip to main content

Table 2 Urinary (24 h) excretions and serum analysis of kidney stone-forming electrolytes and kidney function markers in experimental male Wistar rats treated with selected plant extracts at 200 mg/kg dose on 28th day post-treatment. The mixed extract = the combination of A. aspera, S. punctata and R. abyssinicus extracts (1:1:1 ratio), Aqueous (aq.), Ethyl acetate (EtOAc), Butanol (BuOH), Chloroform (Chl), and Petroleum ether (PET). The data were presented the mean ± SD for 6 rats in each group (n = 6). Comparisons between means were made against Group I (vehicle control) and Group II (lithiatic control). *p < 0.05, **p < 0.01, ***p < 0.001 indicate significant changes in comparison with Group I (vehicle control), #p < 0.05, ##p < 0.01, ###p < 0.001 indicate a significant change in comparison with Group II (lithiatic control)

From: Evaluations of the curative efficacy of G. fruticosus solvent extracts in experimentally induced nephrolithiatic Wistar male rats

Groups Treatments Electrolytes (mg/dl) Kidney Function Test (mg/dl)
Sodium Potassium Chloride Creatinine Total protein Uric acid
Urine
 I. Normal control (DH2O) 135 ± 33.85 25.33 ± 6.44 142.56 ± 17.71 1.11 ± 0.09 3.50 ± 0.74 2.14 ± 0.33
 II. Lithiatic control 213 ± 48.14 43.00 ± 11.91 189.30 ± 21.65 5.11 ± 2.53 12.13 ± 5.35 5.13 ± 1.71
 III. K-Cit (2.5 g/kg) 154 ± 32.32# 35.75 ± 7.03 145.20 ± 15.25# 2.51 ± 0.76# 7.66 ± 2.90*# 3.05 ± 0.98
 IV. Cystone (750 mg/kg) 163 ± 18.14# 38.03 ± 5.19 157.58 ± 16.51 3.13 ± 1.03* 8.50 ± 1.57** 3.12 ± 1.07
 V. G. fruticosus PET extracts 204 ± 34.05** 43.98 ± 7.11* 166.03 ± 15.12* 4.15 ± 0.33** 9.15 ± 1.87** 5.11 ± 0.33*
 VI. G. fruticosus Chl. extracts 213 ± 33.71** 39.83 ± 6.45 164.50 ± 15.73* 3.68 ± 0.66* 8.98 ± 3.32** 5.30 ± 1.20*
 VII. G. fruticosus EtOAc extra 128.5 ± 10.19### 31.08 ± 4.50 144.21 ± 20.06# 3.41 ± 0.47* 4.66 ± 1.09## 4.83 ± 0.71
 VIII. G. fruticosus BuOH extracts 133 ± 15.04## 21.41 ± 3.82## 143.78 ± 14.37# 3.36 ± 0.87* 4.97 ± 0.75## 3.91 ± 0. 67#
 IX. G. fruticosus aq. fraction 148 ± 17.03# 27.50 ± 6.73# 148.00 ± 18.00# 3.35 ± 0.12* 8.90 ± 2.15*# 3.79 ± 2.11
Serum
 I. Normal control (DH2O) 157 ± 6.25 5.17 ± 1.25 82 ± 4.33 1.03 ± 0.05 3.50 ± 0.74 0.97 ± 0.08
 II. Lithiatic control 219 ± 13.24 9. 14 ± 2.31 113. ± 7.25 5.29 ± 0.89 13.19 ± 3.02 6.74 ± 2.34
 III. K-Cit (2.5 g/kg) 16*.5 ± 6.19# 7.3 ± 1.77 93 ± 6.19 2.68 ± 0.50# 5.63 ± 1.34## 2.50 ± 1.05##
 IV. Cystone (750 mg/kg) 175 ± 10.32# 6.1 ± 2.03 88 ± 6.22 3.19 ± 0.39 7.85 ± 2.55*# 4.21 ± 0.89#
 V. G. fruticosus PET extract 203 ± 17.16** 8.20 ± 2.13* 129 ± 6.51* 5.93 ± 0.16** 7.82 ± 1.20*# 4.18 ± 0.78*
 VI. G. fruticosus Chl. extract 193 ± 12.50* 9.50 ± 2.17* 122 ± 9.54* 4.03 ± 0.39* 6.93 ± 1.54*# 5.40 ± 1.33**
 VII. G. fruticosus EtOAc extract 169 ± 8.34# 4.85 ± 0.93## 94 ± 5.78 3.67 ± 0.04 5.04 ± 1.43## 2.76 ± 0.61##
 VIII. G. fruticosus BuOH extract 174 ± 11.23# 8.22 ± 2.07* 79 ± 4.13# 3.19 ± 0.07 7.98 ± 2.17*# 5.22 ± 1.27*
 IX. G. fruticosus aq. fraction 185 ± 8.37* 5.16 ± 1.64# 87 ± 4.84# 3.18 ± 0.60 6.23 ± 2.17*# 4.93 ± 0.44*