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Table 8 Packed cell volume, rectal temperature and body weight of infected mice treated with solvent fractions of the leaves of Olea europaea in the 4-day suppressive test

From: Evaluation of the anti-malarial activity of crude extract and solvent fractions of the leaves of Olea europaea (Oleaceae) in mice

Groups Packed cell volume Rectal temperature Body weight
D 0 D4 % change D0 D4 % change D0 D4 % change
2% TW80 59.51 ± 0.41 54.24 ± 0.51 −8.86 36.71 ± 0.08 34.83 ± 0.17 −5.12 28.57 ± 0.26 27.26 ± 0.22 −4.58
CQ25 mg/kg 60.32 ± 0.52 60.03 ± 0.52 −0.48a3 35.67 ± 0.28 35.68 ± 0.24 0.03a3 28.27 ± 0.21 28.61 ± 0.24 1.20a3
200 mg/kg CF 59.7 ± 0.70 56.11 ± 0.68 −5.85a3b3e1 36.50 ± 0.22 35.18 ± 0.21 −3.61a1b3 28.33 ± 0.15 27.15 ± 0.15 −4.17b3
400 mg/kg CF 60.18 ± 0.49 56.99 ± 0.44 −5.14a3b3 36.39 ± 0.17 35.53 ± 0.19 −3.46a2b3 28.16 ± 0.25 27.17 ± 0.28 −3.52a1b3
600 mg/kg CF 60.88 ± 0.34 57.99 ± 0.40 −4.75a3b3 35.92 ± 0.18 35.30 ± 0.16 −3.12a2b3 28.35 ± 0.73 27.4 ± 70 −3.35a2b3
2% TW80 59.51 ± 0.41 54.21 ± 0.51 −8.91 36.71 ± 0.08 34.78 ± 0.17 −5.26 28.59 ± 0.26 27.26 ± 0.37 −4.65
CQ25 mg/kg 60.32 ± 0.52 60.03 ± 0.51 −0.48a3 35.68 ± 0.29 35.68 ± 0.24 0.00a3 28.29 ± 0.22 28.61 ± 0.24 1.13a3
200 mg/kg BF 59.63 ± 0.70 56.47 ± 0.75 −5.30a3b3d1e2 36.55 ± 0.22 35.25 ± 0.20 −3.52 a1b3e2 28.20 ± 0.2 27.04 ± 0.18 −4.11b3
400 mg/kg BF 60.23 ± 0.49 57.73 ± 0.44 −4.15a3b3 36.44 ± 0.17 35.62 ± 0.20 −2.25a3b3 28.16 ± 0.32 27.21 ± 0.35 −3.37a1b3
600 mg/kg BF 60.93 ± 0.34 58.69 ± 0.40 −3.68a3b3 35.97 ± 0.18 35.5 ± 0.16 −1.31a3 27.85 ± 0.73 26.99 ± 0.71 −3.09a2b3
2% TW80 59.44 ± 0.41 54.22 ± 0.51 −8.78 36.69 ± 0.10 34.78 ± 0.14 −5.21 28.59 ± 0.26 27.26 ± 0.22 −4.65
CQ25 mg/kg 60.30 ± 0.51 60.03 ± 0.51 -.45a3 35.68 ± 0.28 35.67 ± 0.24 −0.03a3 28.29 ± 0.22 28.61 ± 0.24 1.13a3
200 mg/kg AF 59.75 ± 0.70 55.18 ± 0.68 −5.98a3b3 36.57 ± 0.22 35.14 ± 0.20 −3.90a1b3 28.36 ± 0.15 27.16 ± 0.16 −4.33b3
400 mg/kg AF 60.22 ± 0.49 55.87 ± 0.43 −5.57a3b3 36.43 ± 0.17 35.23 ± 0.19 −3.61a2b3 28.2 ± 0.25 27.01 ± 0.28 −4.22 b3
600 mg/kg AF 60.86 ± 0.35 56.69 ± 0.40 −5.22a3b3 36.02 ± 0.18 35.10 ± 0.16 −3.43a2b3 28.42 ± 0.73 27.31 ± 0.69 −3.91 b3
  1. Data are expressed as mean ± SEM; n = 6; CF, chloroform fraction; BF, butanol fraction; AF, aqueous fraction; a, compared to negative control; b, to CQ25mg/kg; c, to 200 mg/kg; d, to 400 mg/kg; e, to 600 mg/kg; 1, p < 0.05; 2, p < 0.01; 3, p < 0.001; 2% TW80, 2% Tween80; CQ chloroquine, D0 pre -treatment value on day 0, D4 post- treatment value on day 4