Mendola P, Selevan SG, Gutter S, Rice D. Environmental factors associated with a spectrum of neurodevelopmental deficits. Ment Retard Dev Disabil. 2002;8:188–97.
Article
Google Scholar
MacFabe DF, Cain DP, Rodriguez-Capote K, Franklin AE, Hoffman JE, Boon F, Taylor AR, Kavaliers M, Ossenkopp KP. Neurobiological effects of intraventricular propionic acid in rats: possible role of short chain fatty acids on the pathogenesis and characteristics of autism spectrum disorders. Behav Brain Res. 2007;176(1):149–69.
El-Ansary AK, Ben Bacha A, Kotb M. Etiology of autistic features: the persisting neurotoxic effects of propionic acid. J Neuroinflammation. 2012;9.
Veenstra-VanderWeele J, Muller CL, Iwamoto H, Sauer JE, Owens WA, Shah CR, Cohen J, Mannangatti P, Jessen T, Thompson BJ, Ye R, Kerr TM, Carneiro AM, Crawley JN, Sanders-Bush E, McMahon DG, Ramamoorthy S, Daws LC, Sutcliffe JS, Blakely RD. Autism gene variant causes hyperserotonemia, serotonin receptor hypersensitivity, social impairment and repetitive behavior. Proc Natl Acad Sci U S A. 2012;109(14):5469–74.
Ashwood P, Krakowiak P, Hertz-Picciotto I, Hansen R, Pessah I, Van de Water J. Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome. Brain Behav Immun. 2011;25:40–5.
Article
CAS
PubMed
Google Scholar
El-Ansary AK, Ben Bacha AG, Al-Ayadhi LY. Pro-inflammatory and pro-apoptotic markers in relation to mono and di-cations in plasma of autistic patients from Saudi Arabia. J Neuroinflammation. 2011;8:142.
Article
CAS
PubMed
PubMed Central
Google Scholar
Goines PE, Ashwood P. Cytokine dysregulation in autism spectrum disorders (ASD): possible role of the environment. Neurotoxicol Teratol. 2013;36:67–81.
Article
CAS
PubMed
Google Scholar
Ricci S, Businaro R, Ippoliti F, Vasco VL, Massoni F, Onofri E, Troili G, Pontecorvi V, Morelli M, Ricciardi MR. Altered cytokine and BDNF levels in Autism spectrum disorder. Neurotoxicity Res. 2013;24:491–501.
Shultz SR, MacFabe DF, Ossenkopp KP, Scratch S, Whelan J, Taylor R, Cain DP. Intracerebroventricular injection of propionic acid, an enteric bacterial metabolic end-product, impairs social behavior in the rat: implications for an animal model of autism. Neuropharmacology. 2008;54(6):901–11.
Narita N, Kato M, Tazoe M, Miyazaki K, Narita M, Okado N. Increased monoamine concentration in the brain and blood of fetal thalidomideandvalproic acid-exposed rat: putative animal models for autism. Pediatr Res. 2002;52:576.
CAS
PubMed
Google Scholar
Ossenkopp KP, Kelly A, Foley KA, Gibson J, Fudge MA, Kavaliers M, Cain DP, MacFabe DF . Systemic treatment with the enteric bacterial fermentation product, propionic acid, produces both conditioned taste avoidance and conditioned place avoidance in rats. Behav Brain Res. 2012;227:134.
Almaraz-Abarca N, Campos MDG, Ávila-Reyes JA, Naranjo-Jiménez N, Herrera-Corral J, González-Valdez LS. Variability of antioxidant activity among honeybee-collected pollen of different botanical origin. Interciencia. 2004;29(10):574–8.
Google Scholar
Kroyer H. Evaluation of bioactive properties of pollen extracts as functional dietary food supplement. Innovative Food Sci Emerg Technol. 2001;2(3):171–4.
Article
CAS
Google Scholar
Eraslan G, Kanbur M, Silici S, Liman B, Altinordulu S, Sarica ZS. Evaluation of protective effect of bee pollen against propoxur toxicity in rat. Ecotoxicol Environ Saf. 2009;72(3):931–7.
Article
CAS
PubMed
Google Scholar
Pascoal A, Rodrigues S, Teixeira A, Feas X, Estev-inho LM. Biological activities of commercial bee pollens: antimicrobial, antimutagenic, antioxidant and anti-inflammatory. Food Chem Toxicol. 2014;63:233–9.
Article
CAS
PubMed
Google Scholar
Komosinska-Vassev K, Olczyk P, Kaźmierczak J, Mencner L, Olczyk K. Bee pollen: chemical composition and therapeutic application. Evid Based Complement Alternat Med. 2015;2015:297425.
Article
PubMed
PubMed Central
Google Scholar
Baltrusayt V, Venskmonis PR, Ceksteryte V. Antibacterial activity of honey and beebread of different origin against Saureus and S-epidermidis. Food Technol Biotechnol. 2007;45(2):201–8.
Google Scholar
Erkmen O, Ozcan MM. Antimicrobial effects of Turkishpropolis pollen, and laurel on spoilage and pathogenic foodrelated microorganisms. J Med Food. 2008;11(3):587–92.
Article
CAS
PubMed
Google Scholar
Smaga I, Niedzielska E, Gawlik M, Moniczewski A, Krzek J, Przegaliński E, Pera J, Filip M.. Oxidativestress as an etiologicalfactor and a potentialtreatmenttarget of psychiatricdisorders. Part2. Depression, anxiety, schizophrenia and autism. Pharmacol Rep. 2015;67(3):569–80.
Zagrodzka J, Romaniuk A, Wieczorek M, Boguszewski P. Bicuculline administration into ventromedial hypothalamus: effects on fear and regional brain monoamines and GABA concentrations in rats. Acta Neurobiol Exp. 2000;60(3):333–43.
CAS
Google Scholar
Theophine CO, Peter AA, Adaobi CE, Maureen OO, Collins AO, Frankline N, et al. Evaluation of the acute and sub-acute toxicity of Annonasenegalensis root bark extracts. Asian Pac J Trop Med. 2012;5:277–82.
Article
Google Scholar
Hashioka S, Klegeris A, Qing H, McGeer PL. STAT3 inhibitors attenuate interferon-ϒ-induced neurotoxicity and inflammatory molecule production by human astrocytes. Neurobiol Dis. 2011;41(2):299–307.
Article
CAS
PubMed
Google Scholar
Ha SK, Lee P, Park JA, Oh HR, Lee SY, Park JH, Lee EH, Ryu JH, Lee KR, Kim SY. Apigenin inhibits the production of NO and PGE2 in microglia and inhibits neuronal cell death in a middle cerebral artery occlusion-induced focal ischemia mice model. Neurochem Int. 2008;52(4–5):878–86.
Raso GM, Meli R, Di Carlo G, Pacilio M, Di Carlo R. Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids in macrophages J774. Life Sci. 2001;496:12–8.
Google Scholar
Vauzour D, Martinsen A, Layé S. Neuroinflammatory processes in cognitive disorders: Is there a role for flavonoids and n-3 polyunsaturated fatty acids in counteracting their detrimental effects? Neurochem Int. 2015;89:63–74.
Article
CAS
PubMed
Google Scholar
Young AM, Campbell E, Lynch S, Suckling J, Powis SJ. Aberrant NF-kappaB expression in autism spectrum condition: a mechanism for neuroinflammation. Front Psychiatry. 2011;2:27.
Article
CAS
PubMed
PubMed Central
Google Scholar
Yui K, Imataka G, Nakamura H, Ohara N, Naito Y. Eicosanoids derived from arachidonic acid and their family prostaglandins and cyclooxygenase in psychiatric disorders. CurrNeuropharmacol. 2015;13(6):776–85.
CAS
Google Scholar
Sweeten TL, Posey DJ, Shankar S, Mc Dougle CJ. High nitric oxide production in autistic disorder: a possible role for interferon-gamma. Biol Psychiatry. 2004;55(4):434–7.
Article
CAS
PubMed
Google Scholar
Mehraj V, Routy JP. Tryptophan catabolism in chronic viral infections: handling uninvited guests. Int J Tryptophan Res. 2015;8:41–8.
Article
PubMed
PubMed Central
Google Scholar
Fernstrom JD, Wurtman RJ. Brain serotonin content: increase following ingestion of carbohydrate diet. Science. 1971;174(4013):1023–5.
Article
CAS
PubMed
Google Scholar
Wurtman RJ. Nutrients affecting brain composition and behavior. Integr Psychiatry. 1987;5(4):226–38.
CAS
PubMed
Google Scholar
DetDegrandi-hoffman G, Eckholm BJ, Huang MH. A comparison of bee bread made by Africanized and European honey bees (Apismellifera) and its effects on hemolymph protein titers. Apidologie. 2013;44:52–63.
Article
Google Scholar
Rubin DH, Althoff RR, Ehli EA, Davies GE, Rettew DC, Crehan ET, Walkup JT, Hudziak JJ. Candidate gene associations with withdrawn behavior. J Child Psychol Psychiatry. 2013;54:1337–45.
Yang CJ, Tan HP, Du YJ. The developmental disruptions of serotonin signaling may be involved in autism during early brain development. Neuroscience. 2014;267C:1e10.
Google Scholar
Zhang WQ, Smolik CM, Barba-Escobedo PA, Gamez M, Sanchez JJ, Javors MA, Daws LC, Gould GG. Acute dietary tryptophan manipulation differentially alters social behavior, brain serotonin and plasmacorticosterone in three inbred mouse strains. Neuropharmacology. 2015;90:1–8.
Thornberry NA, Lazebnik Y. Caspases: enemies within. Science. 1998;281:1312–6.
Article
CAS
PubMed
Google Scholar
Nicholson DW, Ali A, Thornberry NA, Vaillancourt JP, Ding CK, Gallant M, Gareau Y, Griffin PR, Labelle M,Lazebnik YA, Munday NA, Raju SM, Smulson ME, Yamin T, Yu VL, Miller D. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature. 1995;376:37–43.
Al-Ayadhi LY, Ben Bacha AG, Kotb M, El-Ansary AK. A novel study on amyloid β peptide 40, 42 and 40/42 ratio in Saudi autistics. Behav Brain Funct. 2012;8:4.
Article
CAS
PubMed
PubMed Central
Google Scholar
Frackowiak J, Mazur-Kolecka B, Kuchna I, Nowicki K, Brown WT, Wegiel J. Accumulation of amyloid-beta peptide species in four brain structures in children with autism. San Diego: International Meeting for Autism Research; 2011.
Google Scholar
Guo M, Suo Y, Gao Q, Du H, WenyunZeng W, Wang Y, Hu X, Jiang X. The protective mechanism of Ginkgolides and Ginkgo flavonoids on the TNF-α induced apoptosis of rat hippocampal neurons and its mechanisms in vitro. Heliyon. 2015;1(1), e00020.
Al-Abdali A, Al-Ayadhi L, El-Ansary A. Association of social and cognitive impairment and biomarkers in autism spectrum disorders. J Neuroinflammation. 2014;11:4.
Article
Google Scholar
El-Ansary A, Al-Ayadhi L. Neuroinflammation in autism spectrum disorders. J Neuroinflammation. 2012;9.
El-Ansary A, Al-Ayadhi L. Lipid mediators in plasma of autism spectrum disorders. Lipids Health Dis. 2012;11:160.
Article
CAS
PubMed
PubMed Central
Google Scholar
Tomova A, Husarova V, Lakatosova S, Bakos J, Vlkova B, Babinska K, Ostatnikova D. Gastrointestinal microbiota in children with autism in Slovakia. Physiol Behav. 2015;138:179–87.
Cheng N, Ren N, Gao H, Lei XS, Zheng J, Cao W. Antioxidant and hepatoprotectiveeffectsofSchisandrachinensis pollen extract on CCl4-induced acute liver damage in mice. Food Chem Toxicol. 2013;55:234–40.
Article
CAS
PubMed
Google Scholar
Eraslan G, Kanbu M, Silici S, Liman B, Altinordulu S, Sarica SZ. Evaluation of protective effect of bee pollen against propoxur toxicity in rat. Ecotoxicol Environ Saf. 2009;7(23):931–7.
Article
Google Scholar
Choi EM. Antinociceptive and antiinflammatory activities of pine (Pinusdensiflora) pollen extract. Phytother Res. 2007;21(5):471–5.
Article
PubMed
Google Scholar
Lopez-Ramirez MA, Fischer R, Torres-Badillo CC, Davies HA, Logan K, Pfizenmaier K, Male DK, Sharrack B, Romero IA. Role of caspases in cytokine-induced barrier breakdown in human brain endothelial cells. J Immunol. 2012;189(6):3130–9.
Zweig MH, Campbell G. Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. Clin Chem. 1993;39:561–77.
CAS
PubMed
Google Scholar