Reinhard KH. Uncaria tomentosa (Willd.) D.C.: Cat’s claw, uña de gato, or saventaro. J Altern Complement Med. 1999;5:143–51.
Article
CAS
PubMed
Google Scholar
Patidar A, Birla D, Patel V, Chaturvedi M, Manocha N. A review of on advantages of natural analgesics over conventional synthetic analgesics. Int J Pharm Life Sci. 2014;5:3534–9.
Google Scholar
Rojas-Durana R, Gonza’lez-Aspajoa G, Ruiz-Martel C, Bourdy G, Doroteo-Ortega VH, Alban-Castillo J, et al. Anti-inflammatory activity of Mitraphylline isolated from Uncaria tomentosa bark. J Ethnopharmacol. 2012;143:801–4.
Article
Google Scholar
Wagner H, Kreutzkamp B, Jurcic K. Die Alkaloide von Uncaria tomentosa ihre phagozytosesteigernde wirkung. Planta Med. 1985;51:419–23.
Article
CAS
PubMed
Google Scholar
Aquino R, De Simone F, Pizza C, Conti C, Stein ML. Plant Metabolites structure and in vitro antiviral activity of quinovic acid glycosides from Uncaria tomentosa and Guettarda platypoda. J Nat Prod. 1989;52:679–85.
Article
CAS
PubMed
Google Scholar
Aquino R, Vicenzo F, Francesco S. Plant Metabolites. New compounds and anti inflamatory activity of Uncaria tomentosa. J Nat Prod. 1991;52:679–85.
Article
Google Scholar
Yoshimoto K, Sato H, Ohtake M, Laus G, Brössner D, Keplinger K. Alkaloids of Peruvian Uncaria tomentosa. Phytochemistry. 1997;45:855–60.
Article
Google Scholar
Falkiewicz B, Łukasiak J. Vilcacora [Uncaria tomentosa (Willd.) DC. and Uncaria guianensis (Aublet) Gmell.]—a review of published scientific literature. Case Rep Clin Pract Rev. 2001;2:305–16.
Google Scholar
Choy EH, Panayi GS. Cytokine pathways and joint inflammation in rheumatoid arthritis. N Engl J Med. 2001;344:907–16.
Article
CAS
PubMed
Google Scholar
MacGregor AJ, Silman AJ. Rheumatoid arthritis and other synovial disorders: Classification and epidemiology. In: Hochberg MC et al., editors. Rheumatology, vol. 1. London: Mosby Publications; 2004.
Google Scholar
Bush KA, Kirkham BW, Walker JS. The in vivo effects of tumor necrosis factor blockade on the early cell mediated immune events and syndrome expression in rat adjuvant arthritis. Clin Exp Immunol. 2002;127:423–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hegen M, Keith Jr JC, Collins M, Nickerson-Nutter CL. Utility of animal models for identification of potential therapeutics for rheumatoid arthritis. Ann Rheum Dis. 2008;67:1505–15.
Article
CAS
PubMed
Google Scholar
Iain BM, Georg S. Cytokines in the pathogenesis of rheumatoid arthritis. Nat Rev Immunol. 2007;7:429–42.
Article
Google Scholar
Luttikhuizen DT, Harmsen MC, de Leij LFMH, van Luyn MJA. Expression of P2 receptors at site of chronic inflammation. Cell Tissue Res. 2004;317:289–98.
Article
CAS
PubMed
Google Scholar
Ralevic V, Burnstock G. Involvement of purinergic signaling in cardiovascular diseases. Drug News Perspect. 2003;16:133–40.
Article
CAS
PubMed
Google Scholar
Bours M, Swennen E, Di Virgilio F, Cronstein BN, Dagnelie PC. Adenosine 5′ triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol Ther. 2006;112:358–404.
Article
CAS
PubMed
Google Scholar
Langston H, Ke Y, Gewirtz A, Dombrowski K, Kapp J. Secretion of IL-2 and IFN-y, but not IL-4, by antigen-speci.c T cells requires extracellular ATP. J Immunol. 2003;170:2962–70.
Article
CAS
PubMed
Google Scholar
Robson SC, Sévigny J, Zimmermann H. The E-NTPDase family of ectonucleotidases: structure function relationships and pathophysiological significance. Purinergic Signal. 2006;2:409–30.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zimmermann H, Mishra S, Shukla V, Langer D, Gampe K, Grimm I, et al. Ecto-nucleotidases, molecular properties and functional impact. An R Acad Nac Farm. 2007;73:537–66.
CAS
Google Scholar
Yegutkin GG. Nucleotide and nucleoside converting ectoenzymes: important modulators of purinergic signalling cascade. Biochim Biophs Acta. 2008;1783:673–94.
Article
CAS
Google Scholar
Pulte E, Broekman M, Olson K, Drosopoulos JHF, Kizer JR, Islam N, et al. CD39/NTPDase-1 activity and expression in normal leucocytes. Thromb Res. 2007;121:309–17.
Article
CAS
PubMed
PubMed Central
Google Scholar
Barankiewicz J, Dosch HM, Cohen A. Extracellular nucleotide catabolism in human B and T lymphocytes. The source of adenosine production. J Biol Chem. 1988;263:7094–8.
CAS
PubMed
Google Scholar
Franco R, Casadó V, Ciruela F, Saura C, Canela EI, Lluis C. Cell surface adenosine deaminase: much more than an ectoenzyme. Prog Neurobiol. 1997;52:283–94.
Article
CAS
PubMed
Google Scholar
Bota A, Javier Gella F, Profilis C, Férard G, Hadjivassiliou AG, Hørder M, et al. Production and certification of an enzyme reference material for adenosine deaminase 1 (BCR 647). Clin Chim Acta. 2001;306:79–89.
Article
CAS
PubMed
Google Scholar
Antonioli L, Fornai M, Colucci R, Ghisu N, Tuccori M, Del Tacca M, et al. Pharmacological modulation of adenosine system: novel options for treatment of inflammatory bowel diseases. Inflamm Bowel Dis. 2008;14:566–74.
Article
PubMed
Google Scholar
SBCAL. Sociedade Brasileira de Ciências em Animais de Laboratório. Brasil: Cuidado e Manejo de Animais de Laboratório; 2009.
Google Scholar
Sauzem PD, Sant’Anna GS, Machado P, Duarte MM, Ferreira J, Mello CF, et al. Effect of 5-trifluoromethyl-4,5-dihydro-1H-pyrazoles on chronic inflammatory pain model in rats. Eur J Pharmacol. 2009;616:91–100.
Article
CAS
PubMed
Google Scholar
Bertol G, Franco L, Oliveira BH. HPLC Analysis of Oxindole Alkaloids in Uncaria tomentosa: Sample Preparation and Analysis Optimisation by Factorial Design. Phytochem Anal. 2012;23:143–51.
Article
CAS
PubMed
Google Scholar
Cao YQ, Mantyh PW, Carlson EJ, Gillespie A, Epstein CJ, Basbaum A. Primary afferent tachykinins are required to experience moderate to intense pain. Nature. 1998;392:390–3.
Article
CAS
PubMed
Google Scholar
Dixon WJ. Efficient analysis of experimental observations. Ann Rev Pharmacol Toxicol. 1980;20:441–62.
Article
CAS
Google Scholar
Suzuki K, Ota H, Sasagawa S, Sakatani T, Fujikura T. Assay method for myeloperoxidase in human polymorphonuclear leukocytes. Anal Biochem. 1983;132:345–52.
Article
CAS
PubMed
Google Scholar
Böyum A. Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. Scand J Clin Lab Invest Suppl. 1968;97:77–89.
PubMed
Google Scholar
Jaques JA, Peres Rezer JF, Ruchel JB, Gutierres J, Bairros AV, Gomes Farias IL, et al. A method for isolation of rat lymphocyte-rich mononuclear cells from lung tissue useful for determination of nucleoside triphosphate diphosphohydrolase activity. Anal Biochem. 2011;410:34–9.
Article
CAS
PubMed
Google Scholar
Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72:248–54.
Article
CAS
PubMed
Google Scholar
Leal DBR, Streher CA, Neu TN, Bitencourt FP, Leal CAM, Silva JEP, et al. Characterization of NTPDase (NTPDase1; ecto-apyrase; ecto-diphosphohydrolase; CD39; E.C. 3.6.1.5) activity in humans lymphocytes. Biochim Biophys Acta. 2005;1721:9–15.
Article
CAS
PubMed
Google Scholar
Chan KM, Delfert D, Junger KD. A direct colorimetric assay for Ca2+ stimulated ATPase activity. Anal Biochem. 1986;157:375–80.
Article
CAS
PubMed
Google Scholar
Giusti G, Galanti B. Colorimetric Method. In: Bergmeyer HU, editor. Methods of enzymatic analysis. Weinheim: Verlag Chemie; 1984. p. 315–23.
Google Scholar
Voelter W, Zech K, Arnold P, Ludwig G. Determination of selected pyrimidines, purines and their metabolites in serum and urine by reverse-phase ion-pair chromatography. J Chromatogr. 1980;199:345–54.
Article
CAS
PubMed
Google Scholar
Akesson C, Lindgren H, Pero RW, Leanderson T, Ivars F. Quinic acid is a biologically active component of the Uncaria tomentosa extract C-Med 100. Int Immunopharmacol. 2005;5:219–29.
Article
CAS
PubMed
Google Scholar
Jurgensen S, Dalbó S, Angers P, Santos AR, Ribeiro do Valle RM. Involvement of 5-HT2 receptors in the antinociceptive effect of Uncaria tomentosa. Pharmacol Biochem Behav. 2005;81:466–77.
Article
PubMed
Google Scholar
Pilarski R, Zieliński H, Ciesiołka D, Gulewicz K. Antioxidant activity of ethanolic and aqueous extracts of Uncaria tomentosa (Willd.) DC. J Ethnopharmacol. 2006;104:18–23.
Article
PubMed
Google Scholar
Aquino R, De Simone F, Pizza C, Vincieri F, Gacs BE. New polyhydroxylated triterpenes from Uncaria tomentosa. J Nat Prod. 1990;53:559–64.
Article
CAS
PubMed
Google Scholar
Laus G, Brossner D, Keplinger K. Alkaloids of peruvian Uncaria tomentosa. Phytochemistry. 1997;45:855–60.
Article
CAS
Google Scholar
Aguilar JL, Rojas P, Marcelo A, Plaza A, Bauer R, Reininger E, et al. Anti-inflamatory activity of two extracts of Uncaria tomentosa (Rubiaceae). J Ethnopharmacol. 2002;81:271–6.
Article
PubMed
Google Scholar
Joe B, Griffiths MM, Remmers EF, Wilder RL. Animal models of rheumatoid arthritis and related inflammation. Cur Rheumat R. 1999;1:139–48.
Article
CAS
Google Scholar
Keplinger K, Laus G, Wurm M, Dierich MP, Teppner H. Uncaria tomentosa (Wild). Ethnomedicinal Uses and new pharmacological, toxicological and botanical results. J Ethnopharmacol. 1999;64:23–34.
Article
CAS
PubMed
Google Scholar
Castañeda O, León G, León D, Calvoh A, Chávez J, Escalante J, et al. Uña de Gato en Artritis Reumatóide: Estúdio doble cego, en comparación com placebo. Rev Peru Reumatol. 1998;4:15–21.
Google Scholar
Piscoya J, Rodriguez Z, Bustamante SA, Okuhama NN, Miller MJ, Sandoval M. Efficacy and safety of freeze-dried cat’s claw in osteoarthritis knee: mechanism of actions of the species Uncaria guianensis. Inflamm Res. 2001;50:442–8.
Article
CAS
PubMed
Google Scholar
Mur E, Hartig F, Eibl G, Schirmer M. Randized double blind trial of an extract from the pentacyclic alkaloid-chemotype of Uncaria tomentosa for the treatment of rheumatoid arthritis. J Rheumatol. 2002;29:678–81.
CAS
PubMed
Google Scholar
Miyara M, Sakaguchi S. Natural regulatory T cells: mechanisms of suppression. Trends Mol Med. 2007;13:108–16.
Article
CAS
PubMed
Google Scholar
la Sala A, Ferrari D, Di Virgilio F, Idzko M, Norgauer J, Girolomoni G. Alerting and tuning the immune response by extracellular nucleotides. J Leukoc Biol. 2003;73:339–43.
Article
PubMed
Google Scholar
Gordon JL. Extracellular ATP: effects, sources and fate. Biochem J. 1986;233:309–19.
Article
CAS
PubMed
PubMed Central
Google Scholar
Becker LV, Rosa CS, Souza VCG, Bagatini MD, Casali EA, Leal CAM, et al. Activities of enzymes that hydrolyze adenine nucleotides in platelets from patients with rheumatoid arthritis. Clin Biochem. 2010;43:1096–100.
Article
CAS
PubMed
Google Scholar
Jaques JAS, Becker LV, Souza VCG, Leal CAM, Bertoldo TMD, Pinheiro KV, et al. Activities of enzymes that hydrolyze adenine nucleotides in lymphocytes from patients with rheumatoid arthritis. Cell Biochem Funct. 2013;31:395–9.
Article
Google Scholar
Loza MJ, Anderson AS, O’Rourke KS, Wood J, Khan IU. T-cell specific defect in expression of the NTPDase CD39 as a biomarker for lupus. Cell Immunol. 2011;271:110–7.
Article
CAS
PubMed
PubMed Central
Google Scholar
Schmatz R, Schetinger MR, Spanevello RM, Mazzanti CM, Stefanello N, Maldonado PA, et al. Effects of resveratrol on nucleotide degrading enzymes in streptozotocin-induced diabetic rats. Life Sci. 2009;84:345–50.
Article
CAS
PubMed
Google Scholar
Spanevello RM, Mazzanti CM, Schmatz R, Thome G, Bagatini M, Correa M, et al. The activity and expression of NTPDase is altered in lymphocytes of multiple sclerosis patients. Clin Chim Acta. 2010;411:210–4.
Article
CAS
PubMed
Google Scholar
Di Virgilio F. The P2Z purinoreceptor: intriguing role in immunity, inflammation and cell death. Immunol Today. 1995;16:524–8.
Article
PubMed
Google Scholar
Gessi S, Varani K, Merighi S, Fogli E, Sacchetto V, Benini A, et al. Adenosine and lymphocyte regulation. Purinergic Signal. 2007;3:109–16.
Article
CAS
PubMed
PubMed Central
Google Scholar
Di Virgilio F, Ferrari D, Idzko M, Panther E, Norgauer J, La Sala A, et al. P2 receptors, and inflammation. Drug Devel R. 2003;59:171–4.
Article
Google Scholar
Di Virgilio F, Boeynaems JM, Robson SC. Extracellular nucleotides as negative modulators of immunity. Cur Op Pharmacol. 2009;9:507–13.
Article
Google Scholar
Heitzman ME, Neto CC, Winiarz E, Vaisberg AJ, Hammond GB. Ethnobotany, phytochemistry and pharmacology of Uncaria (Rubiaceae). Phytochemistry. 2005;66:5.
Article
CAS
PubMed
Google Scholar
Erowele GI, Kalejaiye AO. Pharmacology and therapeutic uses of cat’s claw. Am J Health Syst Pharm. 2009;66:992–5.
Article
PubMed
Google Scholar
Urdanibia I, Estrada O, Ibarra C, Michelangeli F, Milano B, Taylor P. Anti-inflammatory and anti-tumour effects of two species of Cat’s claw (Uncaria). Planta Med. 2013;79:PF11.
Article
Google Scholar
Urdanibia I, Estrada O, Ibarra C, Michelangeli F, Ruiz MC, Taylor P. Anti-inflammatory effects of different preparations of cat’s claw. Planta Med. 2012;78:PI131.
Article
Google Scholar
Yegutkin GG, Henttinen T, Samburski SS, Spychala J, Jalkanen S. The evidence for two opposite, ATP-generating and ATP-consuming, extracellular pathways on endothelial and lymphoid cells. Biochem J. 2002;367:121–8.
Article
CAS
PubMed
PubMed Central
Google Scholar