Wu W, Liu P, Li J: Necroptosis: an emerging form of programmed cell death. Crit Rev Oncol Hematol. 2012, 82 (3): 249-258. 10.1016/j.critrevonc.2011.08.004.
Article
PubMed
Google Scholar
Han J, Zhong CQ, Zhang DW: Programmed necrosis: backup to and competitor with apoptosis in the immune system. Nat Immunol. 2011, 12 (12): 1143-1149. 10.1038/ni.2159.
Article
CAS
PubMed
Google Scholar
Bonnet MC, Preukschat D, Welz PS, van Loo G, Ermolaeva MA, Bloch W, Haase I, Pasparakis M: The adaptor protein FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation. Immunity. 2011, 35 (4): 572-582. 10.1016/j.immuni.2011.08.014.
Article
CAS
PubMed
Google Scholar
Song KJ, Jang YS, Lee YA, Kim KA, Lee SK, Shin MH: Reactive oxygen species-dependent necroptosis in Jurkat T cells induced by pathogenic free-living Naegleria fowleri. Parasite Immunol. 2011, 33 (7): 390-400. 10.1111/j.1365-3024.2011.01297.x.
Article
CAS
PubMed
Google Scholar
Wu YT, Tan HL, Huang Q, Sun XJ, Zhu X, Shen HM: zVAD-induced necroptosis in L929 cells depends on autocrine production of TNFalpha mediated by the PKC-MAPKs-AP-1 pathway. Cell Death Differ. 2011, 18 (1): 26-37. 10.1038/cdd.2010.72.
Article
CAS
PubMed
Google Scholar
Vanlangenakker N, Bertrand MJ, Bogaert P, Vandenabeele P, Vanden Berghe T: TNF-induced necroptosis in L929 cells is tightly regulated by multiple TNFR1 complex I and II members. Cell Death Dis. 2011, 2: e230-10.1038/cddis.2011.111.
Article
CAS
PubMed
PubMed Central
Google Scholar
Jouan-Lanhouet S, Arshad MI, Piquet-Pellorce C, Martin-Chouly C, Le Moigne-Muller G, Van Herreweghe F, Takahashi N, Sergent O, Lagadic-Gossmann D, Vandenabeele P, Samson M, Dimanche-Boitrel MT: TRAIL induces necroptosis involving RIPK1/RIPK3-dependent PARP-1 activation. Cell Death Differ. 2012, 19 (12): 2003-2014. 10.1038/cdd.2012.90.
Article
CAS
PubMed
PubMed Central
Google Scholar
Vieira M, Fernandes J, Carreto L, Anuncibay-Soto B, Santos M, Han J, Fernandez-Lopez A, Duarte CB, Carvalho AL, Santos AE: Ischemic insults induce necroptotic cell death in hippocampal neurons through the up-regulation of endogenous RIP3. Neurobiol Dis. 2014, 68C: 26-36.
Article
Google Scholar
Chen WW, Yu H, Fan HB, Zhang CC, Zhang M, Zhang C, Cheng Y, Kong J, Liu CF, Geng D, Xu X: RIP1 mediates the protection of geldanamycin on neuronal injury induced by oxygen-glucose deprivation combined with zVAD in primary cortical neurons. J Neurochem. 2012, 120 (1): 70-77. 10.1111/j.1471-4159.2011.07526.x.
Article
CAS
PubMed
Google Scholar
Viringipurampeer IA, Shan X, Gregory-Evans K, Zhang JP, Mohammadi Z, Gregory-Evans CY: Rip3 knockdown rescues photoreceptor cell death in blind pde6c zebrafish. Cell Death Differ. 2014, 21 (5): 665-675. 10.1038/cdd.2013.191.
Article
CAS
PubMed
PubMed Central
Google Scholar
Rosenbaum DM, Degterev A, David J, Rosenbaum PS, Roth S, Grotta JC, Cuny GD, Yuan J, Savitz SI: Necroptosis, a novel form of caspase-independent cell death, contributes to neuronal damage in a retinal ischemia-reperfusion injury model. J Neurosci Res. 2010, 88 (7): 1569-1576.
CAS
PubMed
Google Scholar
Dvoriantchikova G, Degterev A, Ivanov D: Retinal ganglion cell (RGC) programmed necrosis contributes to ischemia-reperfusion-induced retinal damage. Exp Eye Res. 2014, 123C: 1-7.
Article
Google Scholar
Huang JF, Shang L, Zhang MQ, Wang H, Chen D, Tong JB, Huang H, Yan XX, Zeng LP, Xiong K: Differential neuronal expression of receptor interacting protein 3 in rat retina: involvement in ischemic stress response. BMC Neurosci. 2013, 14: 16-10.1186/1471-2202-14-16.
Article
CAS
PubMed
PubMed Central
Google Scholar
Shang L, Huang J-F, Ding W, Chen S, Xue L-X, Ma R-F, Xiong K: Calpain: a molecule to induce AIF-mediated necroptosis in RGC-5 following elevated hydrostatic pressure. BMC Neurosci. 2014, 15 (1): 63-10.1186/1471-2202-15-63.
Article
PubMed
PubMed Central
Google Scholar
Daoud A, Song J, Xiao F, Shang J: B-9-3, a novel beta-carboline derivative exhibits anti-cancer activity via induction of apoptosis and inhibition of cell migration in vitro. Eur J Pharmacol. 2014, 724: 219-230.
Article
CAS
PubMed
Google Scholar
Choi S, Keys H, Staples RJ, Yuan J, Degterev A, Cuny GD: Optimization of tricyclic Nec-3 necroptosis inhibitors for in vitro liver microsomal stability. Bioorg Med Chem Lett. 2012, 22 (17): 5685-5688. 10.1016/j.bmcl.2012.06.098.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wang K, Li J, Degterev A, Hsu E, Yuan J, Yuan C: Structure-activity relationship analysis of a novel necroptosis inhibitor, Necrostatin-5. Bioorg Med Chem Lett. 2007, 17 (5): 1455-1465. 10.1016/j.bmcl.2006.11.056.
Article
CAS
PubMed
Google Scholar
Zheng W, Degterev A, Hsu E, Yuan J, Yuan C: Structure-activity relationship study of a novel necroptosis inhibitor, necrostatin-7. Bioorg Med Chem Lett. 2008, 18 (18): 4932-4935. 10.1016/j.bmcl.2008.08.058.
Article
CAS
PubMed
Google Scholar
Wu Z, Li Y, Cai Y, Yuan J, Yuan C: A novel necroptosis inhibitor-necrostatin-21 and its SAR study. Bioorg Med Chem Lett. 2013, 23 (17): 4903-4906. 10.1016/j.bmcl.2013.06.073.
Article
CAS
PubMed
Google Scholar
Xing J, Yi-fan F: Advances in studies on saponins in Anemarrhena asphodeloides. Chinese Tradit Herbal Drugs. 2010, 41 (4): supl12-15-
Google Scholar
Li TJ, Qiu Y, Yang PY, Rui YC, Chen WS: Timosaponin B-II improves memory and learning dysfunction induced by cerebral ischemia in rats. Neurosci Lett. 2007, 421 (2): 147-151. 10.1016/j.neulet.2007.04.082.
Article
CAS
PubMed
Google Scholar
Kim JY, Shin JS, Ryu JH, Kim SY, Cho YW, Choi JH, Lee KT: Anti-inflammatory effect of anemarsaponin B isolated from the rhizomes of Anemarrhena asphodeloides in LPS-induced RAW 264.7 macrophages is mediated by negative regulation of the nuclear factor-kappaB and p38 pathways. Food Chem Toxicol. 2009, 47 (7): 1610-1617. 10.1016/j.fct.2009.04.009.
Article
PubMed
Google Scholar
Zhang J, Zhang M, Sugahara K, Sagara Y, Meng Z, Xu S, Kodama H: Effect of steroidal saponins of Anemarrhenae rhizoma on superoxide generation in human neutrophils. Biochem Biophys Res Commun. 1999, 259 (3): 636-639. 10.1006/bbrc.1999.0831.
Article
CAS
PubMed
Google Scholar
Kaname N, Zhang J, Meng Z, Xu S, Sugahara K, Doi Y, Kodama H: Effect of timosaponin E1 and E2 on superoxide generation induced by various stimuli in human neutrophils and on platelet aggregation in human blood. Clin Chim Acta. 2000, 295 (1–2): 129-140.
Article
CAS
PubMed
Google Scholar
Yun D, Bai-ping M, Yu-wen C, Yu-xian S, Jing-jing Z, Yu-jun S: Protective effects of timosaponin BII on primary neurons against beta amyloid peptide 25–35. Chinese Pharmacol Bull. 2009, 02: 244-247.
Google Scholar
Yun D, Qiuping X, Zhenquan L, Baiping M, Chengqi X, Yang Z: Protective effects of saponin compound from anemarrhena asphodeloides on rat undergone cerebral ischemia/ reperfusion. J Beijing Univ Tradit Chinese Med. 2005, 02: 33-35.
Google Scholar
Huang JF, Shang L, Liu P, Zhang MQ, Chen S, Chen D, Fan CL, Wang H, Xiong K: Timosaponin-BII inhibits the up-regulation of BACE1 induced by ferric chloride in rat retina. BMC Complement Altern Med. 2012, 12: 189-10.1186/1472-6882-12-189.
Article
CAS
PubMed
PubMed Central
Google Scholar
Li GY, Li T, Fan B, Zheng YC, Ma TH: The D(1) dopamine receptor agonist, SKF83959, attenuates hydrogen peroxide-induced injury in RGC-5 cells involving the extracellular signal-regulated kinase/p38 pathways. Mol Vis. 2012, 18: 2882-2895.
CAS
PubMed
PubMed Central
Google Scholar
Zhang F, Zhan Q, Gao S, Dong X, Jiang B, Sun L, Tao X, Chen WS: Chemical profile- and pharmacokinetics-based investigation of the synergistic property of platycodonis radix in traditional Chinese medicine formula Shengxian decoction. J Ethnopharmacol. 2014, 152 (3): 497-507. 10.1016/j.jep.2014.01.033.
Article
CAS
PubMed
Google Scholar
Tsai CH, Yang CW, Wang JY, Tsai YF, Tseng LM, King KL, Chen WS, Chiu JH, Shyr YM: Timosaponin AIII Suppresses Hepatocyte Growth Factor-Induced Invasive Activity through Sustained ERK Activation in Breast Cancer MDA-MB-231 Cells. Evid Based Complement Alternat Med. 2013, 2013: 421051-
PubMed
PubMed Central
Google Scholar
Laster SM, Wood JG, Gooding LR: Tumor necrosis factor can induce both apoptic and necrotic forms of cell lysis. J Immunol. 1988, 141 (8): 2629-2634.
CAS
PubMed
Google Scholar
Liang X, Chen Y, Zhang L, Jiang F, Wang W, Ye Z, Liu S, Yu C, Shi W: Necroptosis, a novel form of caspase-independent cell death, contributes to renal epithelial cell damage in an ATP-depleted renal ischemia model. Mol Med Rep. 2014, 10 (2): 719-724.
CAS
PubMed
Google Scholar
Lin W, Tongyi S: Role of Bax/Bcl-2 family members in green tea polyphenol induced necroptosis of p53-deficient Hep3B cells. Tumour Biol. 2014, 35 (8): 8065-8075. 10.1007/s13277-014-2064-0.
Article
CAS
PubMed
Google Scholar
Sawai H: Characterization of TNF-induced caspase-independent necroptosis. Leuk Res. 2014, 38 (6): 706-713. 10.1016/j.leukres.2014.02.002.
Article
CAS
PubMed
Google Scholar
Lu WQ, Qiu Y, Li TJ, Tao X, Sun LN, Chen WS: Timosaponin B-II inhibits pro-inflammatory cytokine induction by lipopolysaccharide in BV2 cells. Arch Pharm Res. 2009, 32 (9): 1301-1308. 10.1007/s12272-009-1916-4.
Article
CAS
PubMed
Google Scholar
Miura T, Ichiki H, Iwamoto N, Kato M, Kubo M, Sasaki H, Okada M, Ishida T, Seino Y, Tanigawa K: Antidiabetic activity of the rhizoma of Anemarrhena asphodeloides and active components, mangiferin and its glucoside. Biol Pharm Bull. 2001, 24 (9): 1009-1011. 10.1248/bpb.24.1009.
Article
CAS
PubMed
Google Scholar
Li Y: The protective effects of TSA after cerebral ischemia in rats. Master Degree. 2010, Beijing: Beijing University of Chinese Medicine
Google Scholar
Guo C, Li L, Yang X, Meng Z, Li F, Zhang C, Yang Z: Protective effects of timosaponin B-II on high glucose-induced apoptosis in human umbilical vein endothelial cells. Environ Toxicol Pharmacol. 2014, 37 (1): 37-44. 10.1016/j.etap.2013.11.009.
Article
CAS
PubMed
Google Scholar
Vandenabeele P, Declercq W, Van Herreweghe F, Vanden Berghe T: The role of the kinases RIP1 and RIP3 in TNF-induced necrosis. Sci Signal. 2010, 3 (115): re4-
Article
PubMed
Google Scholar
Zhang DW, Zheng M, Zhao J, Li YY, Huang Z, Li Z, Han J: Multiple death pathways in TNF-treated fibroblasts: RIP3- and RIP1-dependent and independent routes. Cell Res. 2011, 21 (2): 368-371. 10.1038/cr.2011.3.
Article
CAS
PubMed
PubMed Central
Google Scholar
King FW, Fong S, Griffin C, Shoemaker M, Staub R, Zhang YL, Cohen I, Shtivelman E: Timosaponin AIII is preferentially cytotoxic to tumor cells through inhibition of mTOR and induction of ER stress. PLoS One. 2009, 4 (9): e7283-10.1371/journal.pone.0007283.
Article
PubMed
PubMed Central
Google Scholar
Wang N, Feng Y, Zhu M, Siu FM, Ng KM, Che CM: A novel mechanism of XIAP degradation induced by timosaponin AIII in hepatocellular carcinoma. Biochim Biophys Acta. 2013, 1833 (12): 2890-2899. 10.1016/j.bbamcr.2013.07.018.
Article
CAS
PubMed
Google Scholar
Sy LK, Yan SC, Lok CN, Man RY, Che CM: Timosaponin A-III induces autophagy preceding mitochondria-mediated apoptosis in HeLa cancer cells. Cancer Res. 2008, 68 (24): 10229-10237. 10.1158/0008-5472.CAN-08-1983.
Article
CAS
PubMed
Google Scholar
Cabon L, Galan-Malo P, Bouharrour A, Delavallee L, Brunelle-Navas MN, Lorenzo HK, Gross A, Susin SA: BID regulates AIF-mediated caspase-independent necroptosis by promoting BAX activation. Cell Death Differ. 2012, 19 (2): 245-256. 10.1038/cdd.2011.91.
Article
CAS
PubMed
Google Scholar
Shulga N, Pastorino JG: Mitoneet mediates TNFalpha-induced necroptosis promoted by exposure to fructose and ethanol. J Cell Sci. 2014, 127 (Pt 4): 896-907.
Article
CAS
PubMed
PubMed Central
Google Scholar
Sosna J, Voigt S, Mathieu S, Kabelitz D, Trad A, Janssen O, Meyer-Schwesinger C, Schutze S, Adam D: The proteases HtrA2/Omi and UCH-L1 regulate TNF-induced necroptosis. Cell Commun Signal. 2013, 11: 76-10.1186/1478-811X-11-76.
Article
CAS
PubMed
PubMed Central
Google Scholar