Figure 3

Glucose metabolism in the brain changed during the CUS procedure and after curcumin treatment. ( A) Parts of the brain that showed significant changes in glucose metabolism induced by chronic unpredictable stress (CUS) relative to the control group. (B) Changes induced by CUS and the administration of curcumin compared with CUS group. (C) Changes in glucose metabolism in the brain. *Values differ significantly between model and control groups, # Values differ significantly between treatment and model groups, according to Mann–Whitney U (*P < 0.05 and ^# P < 0.05). Au1, primary auditory cortex (ML: -6.0 mm, AP: -4.0 mm, DV: -5.0 mm); AHiAL (L), left amygdalohippocampal area, anterolateral part (ML: -4.0 mm, AP: -9.0 mm, DV: -4.0 mm); AHiAL(R), right amygdalohippocampal area, anterolateral part (ML: +4.0 mm, AP: -9.0 mm, DV: -4.0 mm).