Paterson I, Anderson EA: Chemistry. The renaissance of natural products as drug candidates. Science. 2005, 310 (5747): 451-453. 10.1126/science.1116364.
Article
PubMed
Google Scholar
Efferth T, Benakis A, Romero MR, Tomicic M, Rauh R, Steinbach D, Hafer R, Stamminger T, Oesch F, Kaina B: Enhancement of cytotoxicity of artemisinins toward cancer cells by ferrous iron. Free Radic Biol Med. 2004, 37 (7): 998-1009. 10.1016/j.freeradbiomed.2004.06.023.
Article
CAS
PubMed
Google Scholar
Efferth T, Rucker G, Falkenberg M, Manns D, Olbrich A, Fabry U, Osieka R: Detection of apoptosis in KG-1a leukemic cells treated with investigational drugs. Arzneimittelforschung. 1996, 46 (2): 196-200.
CAS
PubMed
Google Scholar
Efferth T, Sauerbrey A, Olbrich A, Gebhart E, Rauch P, Weber HO, Hengstler JG, Halatsch ME, Volm M, Tew KD: Molecular modes of action of artesunate in tumor cell lines. Mol Pharmacol. 2003, 64 (2): 382-394. 10.1124/mol.64.2.382.
Article
CAS
PubMed
Google Scholar
Huang PR, Yeh YM, Wang TC: Potent inhibition of human telomerase by helenalin. Cancer Lett. 2005, 227 (2): 169-174. 10.1016/j.canlet.2004.11.045.
Article
CAS
PubMed
Google Scholar
Berges C, Fuchs D, Opelz G, Daniel V, Naujokat C: Helenalin suppresses essential immune functions of activated CD4+ T cells by multiple mechanisms. Mol Immunol. 2009, 46 (15): 2892-2901. 10.1016/j.molimm.2009.07.004.
Article
CAS
PubMed
Google Scholar
Lyss G, Knorre A, Schmidt TJ, Pahl HL, Merfort I: The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-kappaB by directly targeting p65. J Biol Chem. 1998, 273 (50): 33508-33516. 10.1074/jbc.273.50.33508.
Article
CAS
PubMed
Google Scholar
Zhao Y, Hamza MS, Leong HS, Lim CB, Pan YF, Cheung E, Soo KC, Iyer NG: Kruppel-like factor 5 modulates p53-independent apoptosis through Pim1 survival kinase in cancer cells. Oncogene. 2008, 27 (1): 1-8.
Article
PubMed
Google Scholar
Traganos F, Darzynkiewicz Z: Lysosomal proton pump activity: supravital cell staining with acridine orange differentiates leukocyte subpopulations. Methods Cell Biol. 1994, 41: 185-194.
Article
CAS
PubMed
Google Scholar
Nicoletti I, Migliorati G, Pagliacci MC, Grignani F, Riccardi C: A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods. 1991, 139 (2): 271-279. 10.1016/0022-1759(91)90198-O.
Article
CAS
PubMed
Google Scholar
Telford WG, King LE, Fraker PJ: Comparative evaluation of several DNA binding dyes in the detection of apoptosis-associated chromatin degradation by flow cytometry. Cytometry. 1992, 13 (2): 137-143. 10.1002/cyto.990130205.
Article
CAS
PubMed
Google Scholar
Hoffmann R, von Schwarzenberg K, Lopez-Anton N, Rudy A, Wanner G, Dirsch VM, Vollmar AM: Helenalin bypasses Bcl-2-mediated cell death resistance by inhibiting NF-kappaB and promoting reactive oxygen species generation. Biochem Pharmacol. 2011, 82 (5): 453-463. 10.1016/j.bcp.2011.05.029.
Article
CAS
PubMed
Google Scholar
Kim HP, Wang X, Chen ZH, Lee SJ, Huang MH, Wang Y, Ryter SW, Choi AM: Autophagic proteins regulate cigarette smoke-induced apoptosis: protective role of heme oxygenase-1. Autophagy. 2008, 4 (7): 887-895.
Article
CAS
PubMed
Google Scholar
Telleria CM, Goyeneche AA, Stocco CO, Gibori G: Involvement of nuclear factor kappa B in the regulation of rat luteal function: potential roles as survival factor and inhibitor of 20alpha-hydroxysteroid dehydrogenase. J Mol Endocrinol. 2004, 32 (2): 365-383. 10.1677/jme.0.0320365.
Article
CAS
PubMed
Google Scholar
Copetti T, Bertoli C, Dalla E, Demarchi F, Schneider C: p65/RelA modulates BECN1 transcription and autophagy. Mol Cell Biol. 2009, 29 (10): 2594-2608. 10.1128/MCB.01396-08.
Article
CAS
PubMed
PubMed Central
Google Scholar
Newman DJ, Cragg GM: Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007, 70 (3): 461-477. 10.1021/np068054v.
Article
CAS
PubMed
Google Scholar
Normile D: Asian medicine. The new face of traditional Chinese medicine. Science. 2003, 299 (5604): 188-190. 10.1126/science.299.5604.188.
Article
CAS
PubMed
Google Scholar
Wiseman N: Traditional Chinese medicine: a brief outline. J Chem Inf Comput Sci. 2002, 42 (3): 445-455. 10.1021/ci010107l.
Article
CAS
PubMed
Google Scholar
Yuan R, Lin Y: Traditional Chinese medicine: an approach to scientific proof and clinical validation. Pharmacol Ther. 2000, 86 (2): 191-198. 10.1016/S0163-7258(00)00039-5.
Article
CAS
PubMed
Google Scholar
Powis G, Gallegos A, Abraham RT, Ashendel CL, Zalkow LH, Grindey GB, Bonjouklian R: Increased intracellular Ca2+ signaling caused by the antitumor agent helenalin and its analogues. Cancer Chemother Pharmacol. 1994, 34 (4): 344-350. 10.1007/BF00686043.
Article
CAS
PubMed
Google Scholar
Boulanger D, Brouillette E, Jaspar F, Malouin F, Mainil J, Bureau F, Lekeux P: Helenalin reduces Staphylococcus aureus infection in vitro and in vivo. Vet Microbiol. 2007, 119 (2–4): 330-338.
Article
CAS
PubMed
Google Scholar
Francois G, Passreiter CM: Pseudoguaianolide sesquiterpene lactones with high activities against the human malaria parasite Plasmodium falciparum. Phytother Res. 2004, 18 (2): 184-186. 10.1002/ptr.1376.
Article
CAS
PubMed
Google Scholar
Shacka JJ, Klocke BJ, Roth KA: Autophagy, bafilomycin and cell death: the “a-B-cs” of plecomacrolide-induced neuroprotection. Autophagy. 2006, 2 (3): 228-230.
Article
CAS
PubMed
Google Scholar
Shacka JJ, Klocke BJ, Shibata M, Uchiyama Y, Datta G, Schmidt RE, Roth KA: Bafilomycin A1 inhibits chloroquine-induced death of cerebellar granule neurons. Mol Pharmacol. 2006, 69 (4): 1125-1136. 10.1124/mol.105.018408.
Article
CAS
PubMed
Google Scholar
Wu YC, Wu WK, Li Y, Yu L, Li ZJ, Wong CC, Li HT, Sung JJ, Cho CH: Inhibition of macroautophagy by bafilomycin A1 lowers proliferation and induces apoptosis in colon cancer cells. Biochem Biophys Res Commun. 2009, 382 (2): 451-456. 10.1016/j.bbrc.2009.03.051.
Article
CAS
PubMed
Google Scholar
Yamamoto A, Tagawa Y, Yoshimori T, Moriyama Y, Masaki R, Tashiro Y: Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells. Cell Struct Funct. 1998, 23 (1): 33-42. 10.1247/csf.23.33.
Article
CAS
PubMed
Google Scholar
Jin F, Liu X, Zhou Z, Yue P, Lotan R, Khuri FR, Chung LW, Sun SY: Activation of nuclear factor-kappaB contributes to induction of death receptors and apoptosis by the synthetic retinoid CD437 in DU145 human prostate cancer cells. Cancer Res. 2005, 65 (14): 6354-6363. 10.1158/0008-5472.CAN-04-4061.
Article
CAS
PubMed
Google Scholar
Buchele B, Zugmaier W, Lunov O, Syrovets T, Merfort I, Simmet T: Surface plasmon resonance analysis of nuclear factor-kappaB protein interactions with the sesquiterpene lactone helenalin. Anal Biochem. 2010, 401 (1): 30-7. 10.1016/j.ab.2010.02.020.
Article
PubMed
Google Scholar
Reikvam H, Olsnes AM, Gjertsen BT, Ersvar E, Bruserud O: Nuclear Factor-kappaB Signaling: A Contributor in Leukemogenesis and a Target for Pharmacological Intervention in Human Acute Myelogenous Leukemia. Crit Rev Oncog. 2009, 15 (1): 1-36. 10.1615/CritRevOncog.v15.i1-2.10.
Article
PubMed
Google Scholar
Fabre C, Carvalho G, Tasdemir E, Braun T, Ades L, Grosjean J, Boehrer S, Metivier D, Souquere S, Pierron G: NF-kappaB inhibition sensitizes to starvation-induced cell death in high-risk myelodysplastic syndrome and acute myeloid leukemia. Oncogene. 2007, 26 (28): 4071-4083. 10.1038/sj.onc.1210187.
Article
CAS
PubMed
Google Scholar
Djavaheri-Mergny M, Amelotti M, Mathieu J, Besancon F, Bauvy C, Codogno P: Regulation of autophagy by NFkappaB transcription factor and reactives oxygen species. Autophagy. 2007, 3 (4): 390-392.
Article
CAS
PubMed
Google Scholar
Nivon M, Richet E, Codogno P, Arrigo AP, Kretz-Remy C: Autophagy activation by NFkappaB is essential for cell survival after heat shock. Autophagy. 2009, 5 (6): 766-783.
Article
CAS
PubMed
Google Scholar
Xiao G: Autophagy and NF-kappaB: fight for fate. Cytokine Growth Factor Rev. 2007, 18 (3–4): 233-243.
Article
CAS
PubMed
PubMed Central
Google Scholar
Fan Y, Mao R, Zhao Y, Yu Y, Sun W, Song P, Shi Z, Zhang D, Yvon E, Zhang H: Tumor necrosis factor-alpha induces RelA degradation via ubiquitination at lysine 195 to prevent excessive nuclear factor-kappaB activation. J Biol Chem. 2009, 284 (43): 29290-29297. 10.1074/jbc.M109.018994.
Article
CAS
PubMed
PubMed Central
Google Scholar
Baumgartner B, Weber M, Quirling M, Fischer C, Page S, Adam M, Von Schilling C, Waterhouse C, Schmid C, Neumeier D: Increased IkappaB kinase activity is associated with activated NF-kappaB in acute myeloid blasts. Leukemia. 2002, 16 (10): 2062-2071. 10.1038/sj.leu.2402641.
Article
CAS
PubMed
Google Scholar
Braun T, Carvalho G, Coquelle A, Vozenin MC, Lepelley P, Hirsch F, Kiladjian JJ, Ribrag V, Fenaux P, Kroemer G: NF-kappaB constitutes a potential therapeutic target in high-risk myelodysplastic syndrome. Blood. 2006, 107 (3): 1156-1165.
Article
CAS
PubMed
Google Scholar
Cilloni D, Messa F, Rosso V, Arruga F, Defilippi I, Carturan S, Catalano R, Pautasso M, Panuzzo C, Nicoli P: Increase sensitivity to chemotherapeutical agents and cytoplasmatic interaction between NPM leukemic mutant and NF-kappaB in AML carrying NPM1 mutations. Leukemia. 2008, 22 (6): 1234-1240. 10.1038/leu.2008.68.
Article
CAS
PubMed
Google Scholar
Frelin C, Imbert V, Griessinger E, Peyron AC, Rochet N, Philip P, Dageville C, Sirvent A, Hummelsberger M, Berard E: Targeting NF-kappaB activation via pharmacologic inhibition of IKK2-induced apoptosis of human acute myeloid leukemia cells. Blood. 2005, 105 (2): 804-811. 10.1182/blood-2004-04-1463.
Article
CAS
PubMed
Google Scholar
Itoh M, Fu L, Tohda S: NF-kappaB activation induced by Notch ligand stimulation in acute myeloid leukemia cells. Oncol Rep. 2009, 22 (3): 631-634.
CAS
PubMed
Google Scholar