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  1. Identifying what therapies constitute complementary, alternative, and/or integrative medicine (CAIM) is complex for a multitude of reasons. An operational definition is dynamic, and changes based on both histo...

    Authors: Jeremy Y. Ng, Tushar Dhawan, Ekaterina Dogadova, Zhala Taghi-Zada, Alexandra Vacca, L. Susan Wieland and David Moher
    Citation: BMC Complementary Medicine and Therapies 2022 22:104
  2. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Shalini Mohan, Kalaivani Thiagarajan, Balaji Sundaramoorthy, Vivek Gurung, Manas Barpande, Shilpi Agrawal and Rajasekaran Chandrasekaran
    Citation: BMC Complementary Medicine and Therapies 2022 22:102

    The original article was published in BMC Complementary Medicine and Therapies 2016 16:229

  3. Disordered endothelial cell activation plays an important role in the pathophysiology of atherosclerosis, cancer, sepsis, viral infections, and inflammatory responses. There is interest in developing novel the...

    Authors: Yaritza Inostroza-Nieves, Shirley Valentin-Berrios, Christopher Vega, Gregory N. Prado, Claribel Luciano-Montalvo, José R. Romero and Alicia Rivera
    Citation: BMC Complementary Medicine and Therapies 2022 22:101
  4. Chronic myeloid leukemia (CML) is a myeloproliferative tumor originating from hematopoietic stem cells, and resistance to tyrosine kinase inhibitors (TKI) has become a major cause of treatment failure. Alterna...

    Authors: Xiang Qin, Xi Chen, Ling Guo, Jing Liu, You Yang, Yan Zeng, Cheng Li, Wenjun Liu and Wenzhe Ma
    Citation: BMC Complementary Medicine and Therapies 2022 22:100
  5. Hepatitis C virus infection is the main cause of liver ailments across the globe. Several HCV genotypes have been identified in different parts of the world. Effective drugs for combating HCV infections are av...

    Authors: Mahim Khan, Waqar Rauf, Fazal-e- Habib, Moazur Rahman, Shoaib Iqbal, Aamir Shehzad and Mazhar Iqbal
    Citation: BMC Complementary Medicine and Therapies 2022 22:98
  6. Dealing with the symptom burden of cancer diagnosis and treatment has led parents to seek different self-management strategies including Alternative and Complementary Medicine (CAM). The aim of this study was ...

    Authors: Dana C. Mora, Grete Overvåg, Miek C. Jong, Agnete E. Kristoffersen, Debbie C. Stavleu, Jianping Liu and Trine Stub
    Citation: BMC Complementary Medicine and Therapies 2022 22:97
  7. Cigarette smoke is a major risk factor for various lung diseases, such as chronic obstructive pulmonary disease (COPD). Ninjinyoeito (NYT), a traditional Chinese medicine, has been prescribed for patients with po...

    Authors: Kenta Murata, Nina Fujita and Ryuji Takahashi
    Citation: BMC Complementary Medicine and Therapies 2022 22:96
  8. Various pathogenic bacterial infections caused by acupuncture have raised widespread concern, but paravertebral abscesses and bloodstream infections of Burkholderia pseudomallei (B.pseudomallei) after acupuncture...

    Authors: Lingyan Xiao, Tong Zhou, Jun Chen, Yanqing Hu and Yishan Zheng
    Citation: BMC Complementary Medicine and Therapies 2022 22:95
  9. Acupuncture is a popular treatment for women’s health. Several trials and meta-analysis have been published in recent years on key women’s health conditions but it is unclear if this has led to any changes in ...

    Authors: Sandro Graca, Debra Betts, Kate Roberts, Caroline A. Smith and Mike Armour
    Citation: BMC Complementary Medicine and Therapies 2022 22:94
  10. Sini Decoction (SND), a classic Chinese medicine prescription, has been proved to have a good effect on heart failure (HF), whereas its underlying mechanism is still unclear. In order to explore the therapeuti...

    Authors: Zhenyu Zhao, Jiahao Liu, Yanzhi Hu, Xining Zhang, Liqin Cao, Zhenhua Dong, Lin Li and Zhixi Hu
    Citation: BMC Complementary Medicine and Therapies 2022 22:93
  11. Pyroptosis is a highly programmed inflammatory cell death process that represents an innate immune response. In this study, the occurrence of pyroptosis in rat mesangial cells (RMCs) and the effect of Huaier (...

    Authors: Wenjia Geng, Can Tu, Dahao Chen, Zhaoyu Lu, Wei Mao and Hanyu Zhu
    Citation: BMC Complementary Medicine and Therapies 2022 22:92
  12. The use of complementary and alternative medicine (CAM) therapies has increased in recent years throughout the world and in Iran. Nonetheless, there are limited data about the prevalence of their use. This stu...

    Authors: Niloofar Karimianfard and Azita Jaberi
    Citation: BMC Complementary Medicine and Therapies 2022 22:91

    The Correction to this article has been published in BMC Complementary Medicine and Therapies 2022 22:111

  13. Euphorbia grandicornis is widely utilized in traditional medicine for the treatment of microbial infections including sexually transmitted diseases such as syphilis, gonorrhoea and for healing of wounds.

    Authors: Douglas Kemboi, Moses K. Langat, Xavier Siwe-Noundou, Rui W. M. Krause, Michelle Louise Isaacs and Vuyelwa Jacqueline Tembu
    Citation: BMC Complementary Medicine and Therapies 2022 22:90
  14. Rehmanniae Radix (RR), an herb with numerous pharmacological effects, is widely used in traditional Chinese medicine for the treatment of blood deficiency syndrome, either alone or in combination with other herbs...

    Authors: Yang-yang Wang, Ning Zhou, Zeng-fu Shan, Ying-ying Ke, Zhen Liu, Zhen-hui Liu, Wei-sheng Feng and Xiao-ke Zheng
    Citation: BMC Complementary Medicine and Therapies 2022 22:89
  15. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12906-022-03569-2.

    Authors: Xiaocheng Cao, Hui Zou, Jianguo Cao, Yinghong Cui, Shuwen Sun, Kaiqun Ren, Zhenwei Song, Duo Li and Meifang Quan
    Citation: BMC Complementary Medicine and Therapies 2022 22:88
  16. Auricular acupressure (AA) has been viewed as a promising approach to managing chemotherapy-induced nausea and vomiting (CINV) but relevant research evidence has been inconclusive. This study aimed to examine ...

    Authors: Jing-Yu Tan, Alex Molassiotis, Lorna K. P. Suen, Jian Liu, Tao Wang and Hui-Rong Huang
    Citation: BMC Complementary Medicine and Therapies 2022 22:87
  17. Various mind-body practices are used by people living with HIV to promote their general well-being. Among these is autogenic training (AT), a self-guided relaxation technique requiring regular practice for obs...

    Authors: Maria Pilar Ramirez Garcia, Jérôme Leclerc-Loiselle, José Côté, Marie-Josée Brouillette and Réjean Thomas
    Citation: BMC Complementary Medicine and Therapies 2022 22:86
  18. The leaves of the plant Ilex latifolia Thunb. can be made into Kuding tea, which is a drink rich in polyphenols. This study aimed to observe the effect of Ilex latifolia Thunb. polyphenols (ILTPs) on human lung c...

    Authors: Jing Chen, Yesheng Du, Yanyan Long, Dan Tao, Mengyu Hu, Yong Jiang, Yue Wan and Dingyi Yang
    Citation: BMC Complementary Medicine and Therapies 2022 22:85
  19. The oxidized low density lipoprotein (ox-LDL) contributes to inflammation and oxidative stress through the activation of macrophages under hyperglycemia contributing to the development of diabetes mellitus and...

    Authors: Ignacio Peralta, Carla Marrassini, Malen Saint Martin, Laura Cogoi, María Rosario Alonso, Alejandro Gugliucci and Claudia Anesini
    Citation: BMC Complementary Medicine and Therapies 2022 22:84

    The Correction to this article has been published in BMC Complementary Medicine and Therapies 2022 22:182

  20. Paraquat (PQ) has been reported to have a high mortality rate. The major target organ of PQ poisoning is the lungs. The pathogenesis of PQ-induced lung injury involves oxidative stress and inflammation. Unfort...

    Authors: Sarawoot Palipoch, Chuchard Punsawad, Phanit Koomhin, Prasit Na-Ek, Wasinee Poonsawat, Rungruedi Kimseng, Potiga Chotipong, Kingkan Bunluepuech, Gorawit Yusakul and Prasit Suwannalert
    Citation: BMC Complementary Medicine and Therapies 2022 22:83
  21. Pharbitidis Semen (the seeds of Pharbitis nil), traditionally used as a purgative in Japan, China and Korea, contains a resin glycoside fraction named pharbitin, which is known as a purgative ingredient. Due to t...

    Authors: Jian-Rong Zhou, Naofumi Tokutomi, Yuusuke Satou, Shin Yasuda, Hideki Kinoshita, Toshihiro Nohara, Kazumi Yokomizo and Masateru Ono
    Citation: BMC Complementary Medicine and Therapies 2022 22:82
  22. Convulsive status epilepticus (CSE) prevention is critical for pediatric patients with epilepsy. Immediate intervention before CSE reduce severity. Despite its wide usage as an anticonvulsant, valproic acid (V...

    Authors: Chung-Min Tsai, Shwu-Fen Chang and Hsi Chang
    Citation: BMC Complementary Medicine and Therapies 2022 22:81
  23. Holarrhena floribunda (G.Don) T.Durand & Schinz stem bark has anecdotal use in Ghanaian folk medicine for the management of inflammatory conditions. This study was conducted to investigate the in vivo anti-inflam...

    Authors: Stephen Antwi, Daniel Oduro-Mensah, David Darko Obiri, Newman Osafo, Aaron Opoku Antwi, Helena Owusu Ansah, Augustine Ocloo and Laud K. N.-A. Okine
    Citation: BMC Complementary Medicine and Therapies 2022 22:80
  24. Chronic hyperglycemic triggers the non-enzymatic glycation of biomolecules, resulting in the production of advanced glycation endproducts, that lead to several micro- and macrovascular complications. Therefore...

    Authors: Hafiz Nadeem Khan, Saima Rasheed, M. Iqbal Choudhary, Nessar Ahmed and Abdu Adem
    Citation: BMC Complementary Medicine and Therapies 2022 22:79
  25. Multi-drug resistant bacteria hazards to the health of humans could be an agent in the destruction of human generation. Natural products of Bacillus species are the main source to access progressive antibiotics t...

    Authors: Somayeh Hallaj-Nezhadi, Rasoul Hamdipour, Mohamad Shahrvirani, Roya Zare tin, Florence Chapeland-leclerc, Gwenael Ruprich-Robert, Solmaz Esnaashari, Babak Elyasi Far and Azita Dilmaghani
    Citation: BMC Complementary Medicine and Therapies 2022 22:78
  26. Insomnia is one of the most frequent symptoms in people with cancer. Electroacupuncture has been widely used in people with cancer or insomnia. We explored the feasibility and preliminary effectiveness of elec...

    Authors: Boram Lee, Bo-Kyung Kim, Mikyung Kim, Ae-Ran Kim, Hyo-Ju Park, O-Jin Kwon, Jun-Hwan Lee and Joo-Hee Kim
    Citation: BMC Complementary Medicine and Therapies 2022 22:77
  27. The aim of the present study was to investigate the protective effect of the Sophora pachycarpa (S. pachycarpa) seed extract against carbon tetrachloride-induced toxicity on body organs, blood, and biochemical fa...

    Authors: Hamed Aramjoo, Pouria Mohammadparast-Tabas, Tahereh Farkhondeh, Mahmoud Zardast, Marzieh Makhdoumi, Saeed Samarghandian and Zahra Kiani
    Citation: BMC Complementary Medicine and Therapies 2022 22:76
  28. Platelets play an important role in the progression of atherosclerosis and cardiovascular events. The inhibition of platelet function is a main strategy to reduce risk of cardiovascular events. Some studies ha...

    Authors: Huilian Chen, Shenghao Zhang, Hui Wang, Li Bao, Wei Wu and Ruomei Qi
    Citation: BMC Complementary Medicine and Therapies 2022 22:75
  29. The aim of this study was to evaluate the antioxidant potential, antimicrobial activity, the in vitro anticancer effect (tested on MCF-7 breast cancer cell line), as well as the antiangiogenic and immunomodula...

    Authors: Brigitta Kis, Ioana Zinuca Pavel, Stefana Avram, Elena Alina Moaca, Martina Herrero San Juan, Anja Schwiebs, Heinfried H. Radeke, Delia Muntean, Zorita Diaconeasa, Daliana Minda, Camelia Oprean, Florina Bojin, Cristina Adriana Dehelean, Codruta Soica and Corina Danciu
    Citation: BMC Complementary Medicine and Therapies 2022 22:74
  30. Fibroblast-like synoviocytes (FLS) have cancer cell-like characteristics, such as abnormal proliferation and resistance to apoptosis, and play a pathogenic role in rheumatoid arthritis (RA). Hyperproliferation...

    Authors: Jia-Ying Wu, Ying-Jie Chen, Xiu-Qiong Fu, Jun-Kui Li, Ji-Yao Chou, Cheng-Le Yin, Jing-Xuan Bai, Ying Wu, Xiao-Qi Wang, Amy Sze-man Li, Lut Yi Wong and Zhi-Ling Yu
    Citation: BMC Complementary Medicine and Therapies 2022 22:73
  31. In response to the persistent problem of malaria resistance, medicinal herbal plants can be used as a source of potential novel antimalarial agents. Therefore, the aim of this study was to evaluate the in vivo...

    Authors: Prapaporn Chaniad, Arisara Phuwajaroanpong, Walaiporn Plirat, Tachpon Techarang, Arnon Chukaew and Chuchard Punsawad
    Citation: BMC Complementary Medicine and Therapies 2022 22:72
  32. Disturbance of the intestinal flora is a pathogenic factor for chronic atrophic gastritis (CAG). Hua-Zhuo-Jie-Du (HZJD) has been shown to be an effective Chinese herbal preparation for treating CAG. However, t...

    Authors: Pingping Zhou, Tianxiao Yang, Miaochan Xu, Yuejia Zhao, Pengpeng Shen and Yangang Wang
    Citation: BMC Complementary Medicine and Therapies 2022 22:71
  33. Traditional and complementary medicine (T&CM) is commonly used in South Asian countries such as Nepal. There are various causes and contributing factors for patients with cancer to consider using T&CM. However...

    Authors: Soo Jeung Choi, Sangita Karki Kunwor, Hyea Bin Im, Jung Hye Hwang, Dain Choi and Dongwoon Han
    Citation: BMC Complementary Medicine and Therapies 2022 22:70
  34. Candidiasis infection is associated with high morbidity and mortality. Fungicidal resistance of some commercially used fungicides ascended the need for a naturally effective alternative. The current study aime...

    Authors: Fatima O. Al-Otibi, Ghaida I. Alrumaizan and Raedah I. Alharbi
    Citation: BMC Complementary Medicine and Therapies 2022 22:69
  35. Phoenix dactylifera L. has a diverse set of pharmacological properties due to its distinct phytochemical profile. The purpose of this study was to investigate the anticancer potential of Phoenix dactylifera seed ...

    Authors: Mohsin Ali Khan, Romila Singh, Sahabjada Siddiqui, Imran Ahmad, Rumana Ahmad, Shivbrat Upadhyay, Md. Abul Barkat, Ahmed Mahmoud Abdelhaleem Ali, Qamar Zia, Aditi Srivastava, Anchal Trivedi, Ishrat Husain, Anand Narain Srivastava and Durga Prasad Mishra
    Citation: BMC Complementary Medicine and Therapies 2022 22:68
  36. Yoga is becoming an increasingly popular holistic approach in the West to manage long-term health conditions. This study presents the evaluation of a pilot yoga intervention, Yoga4Health, that was developed fo...

    Authors: Anna Cheshire, Rebecca Richards and Tina Cartwright
    Citation: BMC Complementary Medicine and Therapies 2022 22:67
  37. Prevention is a preliminary focus of periodontitis treatment. Rather than giving complicated treatment to a periodontitis patient, a variety of toothpastes have been suggested to prevent periodontal disease pr...

    Authors: La-ongthong Vajrabhaya, Suwanna Korsuwannawong, Nisarat Ruangsawasdi, Chareerut Phruksaniyom and Ratchaporn Srichan
    Citation: BMC Complementary Medicine and Therapies 2022 22:66
  38. Mica drugs, a group of herbo-metallic traditional preparations comprising biotite mica as the major mineral ingredient, are prescribed for skin disorders and respiratory ailments and other chronic conditions i...

    Authors: Apsara Wijenayake, Charmalie Abayasekara, Amarasooriya Pitawala and B. M. Ratnayake Bandara
    Citation: BMC Complementary Medicine and Therapies 2022 22:65
  39. The incidence of inflammatory bowel disease (IBD), an inflammatory disorder of the gastrointestinal system has increased. IBD, characterized by aberrant immune responses against antigens, is thought to be caus...

    Authors: Ji Min Shin, Yang-Ju Son, In Jin Ha, Saruul Erdenebileg, Da Seul Jung, Dae-geun Song, Young Sik Kim, Sang Min Kim and Chu Won Nho
    Citation: BMC Complementary Medicine and Therapies 2022 22:64
  40. Icariin (ICA) can promote the migration and bone formation of bone marrow mesenchymal stem cells. This study explored a potential role of ICA in recruiting stem cell niches (SCNs) within the intervertebral dis...

    Authors: Zhaofei Zhang, Fengwei Qin, Yonghui Feng, Sineng Zhang, Chunliang Xie, He Huang, Chaohui Sang, Shaoyu Hu, Feng Jiao, Jie Jiang and Yi Qin
    Citation: BMC Complementary Medicine and Therapies 2022 22:63
  41. The objective of this in vivo study is to evaluate in five rat models the pharmacologic effects and toxicity of a commercial hydro-alcoholic extract, GlucoMedix®, derived from Stevia rebaudiana and the pentacycli...

    Authors: León F. Villegas Vílchez, Julio Hidalgo Ascencios and Thomas P. Dooley
    Citation: BMC Complementary Medicine and Therapies 2022 22:62

    The Correction to this article has been published in BMC Complementary Medicine and Therapies 2022 22:230

  42. Gynura segetum (GS) is widely used in medical care and in community settings in China as the herbal remedy. It is widely thought to have antiphlogistic properties and pain relief in traditional Chinese medicin...

    Authors: Zilong Zhang, Haibo Zou, Zonglin Dai, Jin Shang, Shining Sure, Chunyou Lai, Ying Shi, Qinyan Yang, Guangming Xiang, Yutong Yao, Tianhang Feng, Deyuan Zhong and Xiaolun Huang
    Citation: BMC Complementary Medicine and Therapies 2022 22:61
  43. Over 2 million people in Europe are affected by ulcerative colitis, which often severely impacts the quality of life of those concerned. Among other factors, lifestyle and psychosocial factors seem to play an ...

    Authors: Christoph Schlee, Christine Uecker, Nina Bauer, Anna K. Koch and Jost Langhorst
    Citation: BMC Complementary Medicine and Therapies 2022 22:60
  44. Despite significant advances in the management of cardiovascular disease (CVDs), there is still a large burden of CVD in the world. The inclusion of functional foods in the diet may provide beneficial effects ...

    Authors: Hadi Emamat, Ali Zahedmehr, Sanaz Asadian and Javad Nasrollahzadeh
    Citation: BMC Complementary Medicine and Therapies 2022 22:59
  45. Gastric signet ring cell carcinoma (SRCC) is an aggressive gastric adenocarcinoma with a poor prognosis when diagnosed at an advanced stage. As alternative medicine, two natural supplements (ascorbate (AA) and...

    Authors: Weiyu Chen, Lingyun Xu, Edwin Chang, Gayatri Gowrishankar, Katherine W. Ferrara and Sanjiv Sam Gambhir
    Citation: BMC Complementary Medicine and Therapies 2022 22:58
  46. Alzheimer’s disease (AD) is one of the most common neurodegenerative disorders in the world, but still lack of effective drug treatment. Gynostemma Pentaphyllum (Thunb.) Makino (GpM), a Chinese medicinal herb, pl...

    Authors: Jiahao Wang, Jiamiao Shi, Ning Jia and Qinru Sun
    Citation: BMC Complementary Medicine and Therapies 2022 22:57
  47. Novel Corona Virus Disease 2019 (COVID-19) is closely associated with cytokines storms. The Chinese medicinal herb Artemisia annua L. (A. annua) has been traditionally used to control many inflammatory diseases, ...

    Authors: Yexiao Tang, Xiaobo Li, Yueming Yuan, Hongying Zhang, Yuanyuan Zou, Zhiyong Xu, Qin Xu, Jianping Song, Changsheng Deng and Qi Wang
    Citation: BMC Complementary Medicine and Therapies 2022 22:56
  48. The flower of Hosta plantaginea (Lam.) Aschers has traditionally been used in China as an important Mongolian medicine for the treatment of inflammatory diseases with limited scientific evidence. In previous stud...

    Authors: Li Yang and Junwei He
    Citation: BMC Complementary Medicine and Therapies 2022 22:55
  49. Compound Kushen Injection (CKI) is a Chinese patent drug that exerts curative effects in the clinical treatment of hepatocellular carcinoma (HCC). This study aimed to explore the targets and potential pharmaco...

    Authors: Shan Lu, Ziqi Meng, Yingying Tan, Chao Wu, Zhihong Huang, Jiaqi Huang, Changgeng Fu, Antony Stalin, Siyu Guo, Xinkui Liu, Leiming You, Xiaojiaoyang Li, Jingyuan Zhang, Wei Zhou, Xiaomeng Zhang, Miaomiao Wang…
    Citation: BMC Complementary Medicine and Therapies 2022 22:54