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Table 1 Inhibitory activity of T. tipu flowers methanolic extract (ME) against NO, NF-KB, and TNF-R2 production in LPS stimulated RAW 264.7 macrophages

From: LC-MS/MS profiling of Tipuana tipu flower, HPLC-DAD quantification of its bioactive components, and interrelationships with antioxidant, and anti-inflammatory activity: in vitro and in silico approaches

Tested sample

Inhibition (IC50)

TNF-R2 (ng/mL)

NO (µg/mL)

NF-KB (pg/mL)

Methanol extract

8.51 ± 0.21*

9.33 ± 0.03*

7.63 ± 0.03 *

Reference drug

A3.5 ± 0.3

C7.53 ± 0.03

B6.81 ± 0.21

  1. Values are represented as mean ± SD; A: parthenolide; B: Certolizumab; C: curcumin; NF-KB: nuclear factorkappa B; NO: nitric oxide; TNF-R2: tumor necrosis factor-receptor 2; *Significantly different (P < 0.05) compared to reference drug using sample t-test.
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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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