Fig. 5

Tan IIA attenuated tumor growth with a high level of safety in vivo. (A) Representative images of tumor from the control group and the Tan IIA (10 mg/kg) group; scale bars: 1 cm, (n = 5). (B) The tumor width and length were measured every other day (n = 5). (C) The subcutaneous tumors were weighed immediately at the end of the study. (D) Body weight was not obviously altered after treatment with Tan IIA (n = 5). (E) Immunohistochemical analysis of the expression of E-cadherin, vimentin, PI3K and p-Akt; scale bar: 50 μm. Compared with control (n = 3), * P < 0.05, ** P < 0.01, *** P < 0.001