Table 3 Information of the 14 critical targets for treating osteosarcoma with TGT

1

Epidermal growth factor receptor

EGFR

P00533

36

0.15100513

0.79032258

2

Vascular endothelial growth factor A

VEGFA

P15692

35

0.15552886

0.77777778

3

Transcription factor Jun

JUN

P05412

29

0.07098548

0.71014493

4

Signal transducer and activator of transcription 3

STAT3

P40763

28

0.04977055

0.7

5

Heat shock protein HSP 90-α

HSP90AA1

P07900

26

0.0566902

0.68055556

6

Estrogen receptor

ESR1

P03372

24

0.03879833

0.66216216

7

Prostaglandin/H synthase 2

PTGS2

P35354

22

0.02259439

0.62025316

8

Androgen receptor

AR

P10275

21

0.03327999

0.63636364

9

Histone deacetylase 1

HDAC1

Q13547

17

0.03491079

0.60493827

10

Cyclin-dependent kinase 1

CDK1

P06493

17

0.06077285

0.59036145

11

Glucocorticoid receptor

NR3C1

P04150

16

0.0463535

0.57647059

12

CREB-binding protein

CREBBP

Q92793

15

0.03937816

0.56976744

13

DNA topoisomerase 1

TOP1

P11387

12

0.02337865

0.55681818

14

Thymidylate synthase

TYMS

P04818

12

0.0278047

0.54444444