Fig. 7

The histopathologic findings of (A) normal group showed normal liver lobule including hepatocytes and associated with portal tract, (B) EE-induced intrahepatic cholestasis group showed different histopathologic changes including marked hyperemia (red arrow), ductular reaction (proliferation) (black arrow), increase of Kupffer cells (yellow arrow), sinusoidal inflammatory cells infiltrating (green arrow), feathery change (black arrow), portal inflammation (blue arrow), (C) UDCA-treated group showed mild hyperaemia (red arrow), bile duct (black arrow), scanty portal inflammation (yellow arrow), (D) SM-treated group showed moderate hyperemia (red arrow), ductular reaction (proliferation) (black arrow), increase of Kupffer cells (yellow arrow), moderate portal inflammation (green arrow), (E) nano-SM-treated group showed almost normal liver lobule with hepatocytes arranged in thin plate (red arrow), normal sinusoids (red arrow) and associated with portal tract (yellow arrow) (H & E, x400)