Network pharmacology study to explore the multiple molecular mechanism of SH003 in the treatment of non-small cell lung cancer

Table 5 The 64 key targets in the PPI network for the validated four active compounds from SH003 in NSCLC

No	Name	Degree	Betweenness Centrality	Closeness Centrality
1	TP53	148	0.15135	0.59316
2	AKT1	114	0.06646	0.56934
3	JUN	108	0.05402	0.55714
4	IL6	104	0.05594	0.53793
5	STAT3	102	0.04319	0.54545
6	EGFR	100	0.04684	0.55319
7	ESR1	88	0.07330	0.54355
8	MAPK3	86	0.02919	0.52000
9	CASP3	84	0.02055	0.50814
10	IL1B	82	0.03133	0.51656
11	SRC	82	0.01311	0.51656
12	NFKB1	82	0.02687	0.52349
13	CCND1	82	0.03380	0.52525
14	HSP90AA1	82	0.03791	0.50000
15	FN1	78	0.04886	0.49057
16	MAPK1	76	0.02645	0.51148
17	MAPK8	72	0.01777	0.50649
18	INS	70	0.04570	0.50000
19	FOS	62	0.01344	0.48750
20	MAPK14	60	0.00913	0.48148
21	PPARG	60	0.02096	0.49057
22	ERBB2	58	0.03464	0.50323
23	MMP9	58	0.00992	0.48297
24	MTOR	58	0.00824	0.48148
25	PTGS2	58	0.03742	0.48148
26	GSK3B	56	0.00732	0.47273
27	FOXO1	56	0.01969	0.48750
28	IGF1	56	0.00684	0.47130
29	RELA	56	0.02063	0.48447
30	TLR4	52	0.01024	0.47706
31	BCL2L1	52	0.00407	0.46847
32	PARP1	48	0.02031	0.46018
33	CDK2	46	0.00983	0.44193
34	IRS1	44	0.00280	0.46988
35	CASP9	44	0.00367	0.45748
36	APP	44	0.04140	0.45882
37	CCNB1	42	0.00851	0.43575
38	CDH1	42	0.00204	0.45748
39	CDK1	42	0.00827	0.43454
40	MAPK9	42	0.00432	0.44571
41	NFE2L2	40	0.01331	0.46018
42	MMP2	38	0.00419	0.44193
43	CDK4	38	0.00434	0.44068
44	MCL1	34	0.01074	0.43454
45	MAP2K1	34	0.00177	0.44068
46	SMAD2	32	0.00761	0.45087
47	KDR	32	0.00333	0.43697
48	PTK2	32	0.00252	0.44571
49	ESR2	32	0.00523	0.45087
50	HMOX1	30	0.00648	0.44068
51	CCNA2	30	0.00192	0.41270
52	MMP3	28	0.00523	0.40206
53	AURKA	28	0.00435	0.43094
54	CYP1A1	28	0.04861	0.39898
55	NOS3	26	0.00416	0.42507
56	CYP19A1	26	0.06300	0.42276
57	HSPA8	26	0.01106	0.44699
58	CHEK1	26	0.00177	0.40206
59	AGT	24	0.00746	0.42391
60	CDK5	22	0.00507	0.42049
61	CDK6	22	0.00184	0.41711
62	KEAP1	20	0.00489	0.43213
63	GSTP1	20	0.02364	0.41935
64	NQO1	18	0.01164	0.43213

ISSN: 2662-7671