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Table 4 Top 20 enriched KEGG pathways with 79 key targets of SH003 in NSCLC

From: Network pharmacology study to explore the multiple molecular mechanism of SH003 in the treatment of non-small cell lung cancer

ID

Pathway Name

Term PValue Corrected with Benjamini-Hochberg

Gene Count

KEGG:05200

Pathways in cancer

5.04E-62

53

KEGG:05417

Lipid and atherosclerosis

3.60E-44

34

KEGG:04933

PI3K-Akt signaling pathway

1.95E-35

33

KEGG:05167

Human cytomegalovirus infection

2.62E-38

31

KEGG:05163

Kaposi sarcoma-associated herpesvirus infection

1.46E-38

30

KEGG:05215

Hepatitis B

2.65E-37

28

KEGG:05161

Human papillomavirus infection

1.01E-28

28

KEGG:04151

Proteoglycans in cancer

9.96E-33

27

KEGG:05212

AGE-RAGE signaling pathway in diabetic complications

2.55E-39

26

KEGG:05205

Prostate cancer

9.13E-38

25

KEGG:04218

MAPK signaling pathway

1.12E-25

25

KEGG:05160

Cellular senescence

1.08E-30

24

KEGG:05162

Hepatitis C

1.22E-30

24

KEGG:04068

Human immunodeficiency virus 1 infection

1.70E-27

24

KEGG:05165

Human T-cell leukemia virus 1 infection

3.42E-27

24

KEGG:05418

Measles

3.77E-30

23

KEGG:05224

MicroRNAs in cancer

2.72E-22

23

KEGG:05219

Pancreatic cancer

1.74E-34

22

KEGG:05170

FoxO signaling pathway

5.74E-29

22

KEGG:04926

Fluid shear stress and atherosclerosis

2.17E-28

22