Table 2 The 79 core targets in PPI network of SH003 in NSCLC

1

TP53

162

0.10566

0.54523

2

JUN

138

0.07476

0.53846

3

AKT1

138

0.05411

0.53056

4

STAT3

130

0.03249

0.51544

5

MAPK3

130

0.04915

0.52670

6

HSP90AA1

118

0.04699

0.51300

7

MAPK1

118

0.03560

0.51059

8

SRC

116

0.03600

0.50820

9

MYC

110

0.02469

0.49543

10

IL6

100

0.03790

0.49206

11

EGFR

100

0.04443

0.50115

12

CASP3

96

0.02424

0.48984

13

RELA

94

0.02887

0.49206

14

KRAS

92

0.01626

0.46667

15

ESR1

92

0.04012

0.49543

16

VEGFA

84

0.01507

0.48009

17

CCND1

84

0.00941

0.46269

18

MAPK8

78

0.01431

0.47903

19

IL1B

76

0.02354

0.46767

20

MAPK14

74

0.00708

0.45975

21

INS

74

0.02426

0.47797

22

FOS

72

0.01245

0.45877

23

NFKBIA

72

0.01884

0.48009

24

NFKB1

68

0.00743

0.45021

25

MTOR

66

0.00600

0.45493

26

FN1

64

0.01797

0.42970

27

STAT1

62

0.00371

0.45975

28

IGF1

62

0.00898

0.44286

29

CDK1

58

0.01181

0.43927

30

CDK2

58

0.00870

0.43313

31

FOXO1

58

0.00980

0.45114

32

PPARG

58

0.01106

0.46567

33

ERBB2

56

0.01331

0.46467

34

IRS1

56

0.00310

0.44016

35

TLR4

54

0.00806

0.44835

36

MMP9

54

0.01797

0.45781

37

PTGS2

54

0.05750

0.47797

38

BCL2L1

54

0.00259

0.43056

39

CDH1

54

0.01497

0.43662

40

RB1

52

0.00502

0.44650

41

PRKCD

50

0.00157

0.42801

42

NOTCH1

50

0.00650

0.44376

43

MAP2K1

50

0.00621

0.43487

44

RXRA

50

0.05300

0.46368

45

PTK2

48

0.00349

0.42970

46

PRKCA

48

0.01431

0.44467

47

CDK4

48

0.00353

0.42136

48

CASP8

48

0.00297

0.43141

49

GSK3B

48

0.00250

0.43227

50

CCL2

48

0.01312

0.42717

51

IGF1R

46

0.00169

0.43400

52

CHUK

46

0.00306

0.42633

53

CCNB1

46

0.00326

0.40185

54

APP

46

0.02875

0.43056

55

NOS3

44

0.01364

0.44106

56

SMAD2

42

0.00729

0.43662

57

PDPK1

40

0.00211

0.41333

58

NOS2

40

0.00419

0.44650

59

CCNA2

40

0.00202

0.39599

60

CDK6

38

0.00225

0.41333

61

H2AFX

38

0.00236

0.40789

62

CDK5

38

0.00274

0.41333

63

ESR2

38

0.00615

0.44742

64

ATM

38

0.00176

0.41176

65

MMP2

38

0.00342

0.41098

66

PPARA

38

0.03269

0.45877

67

NFATC1

36

0.00232

0.40561

68

HMOX1

36

0.01348

0.43141

69

PARP1

34

0.01929

0.41333

70

CAT

34

0.01341

0.43056

71

EZH2

30

0.00241

0.43487

72

HSPA8

30

0.00507

0.43662

73

NFE2L2

28

0.00473

0.42300

74

KEAP1

26

0.00424

0.42136

75

AHR

26

0.01433

0.42218

76

AURKA

24

0.00195

0.39599

77

GSTP1

24

0.02367

0.40789

78

NR1I2

24

0.02153

0.43056

79

HMGB1

22

0.00158

0.41021