Table 1 SMA- LC intersection targets KEGG enrichment pathway and gene name

1

hsa05200: 21Pathways in cancer

10

9.90 × 10^–4

E2F1、AR、CCND1、HSP90AA1、BCR、RAC1、RARA、STK4、TRAF4、CDK2

2

hsa05215: Prostate cancer

5

3.50 × 10^–4

E2F1、AR、CCND1、HSP90AA1、CDK2

3

hsa00480: Glutathione metabolism

4

8.60 × 10^–4

ODC1、RRM1、IDH2、IDH1

4

hsa05223: Non-small cell lung cancer

4

1.30 × 10^–3

E2F1、CCND1、ALK、STK4

5

hsa04115: p53 signalling pathway

4

2.50 × 10^–3

CCND1、THBS1、CDK2、TP73

6

hsa05222: Small cell lung cancer

4

4.90 × 10^–3

E2F1、CCND1、TRAF4、CDK2

7

hsa04151: PI3K-Akt signaling pathway

6

9.10 × 10^–3

CCND1、HSP90AA1、RAC1、THBS1、INSR、CDK2

8

hsa05219: Bladder cancer

3

1.10 × 10^–2

E2F1、CCND1、THBS1

9

hsa04110: Cell cycle

4

1.20 × 10^–2

E2F1、CCND1、CCNA2、CDK2

10

hsa04068: FoxO signaling pathway

4

1.30 × 10^–2

CCND1、STK4、INSR、CDK2

11

hsa05161: Hepatitis B

4

2.00 × 10^–2

E2F1、CCND1、CCNA2、CDK2

12

hsa05212: Pancreatic cancer

3

2.80 × 10^–2

E2F1、CCND1、RAC1

13

hsa05220: Chronic myeloid leukemia

3

3.40 × 10^–2

E2F1、CCND1、BCR

14

hsa05205: Proteoglycans in cancer

4

4.20 × 10^–2

CCND1、RAC1、ESR1、THBS1

15

hsa05203: Viral carcinogenesis

4

4.20 × 10^–2

CCND1、RAC1、CCNA2、CDK2

16

hsa04914: Progesterone-mediated oocyte maturation

3

4.30 × 10^–2

HSP90AA1、CCNA2、CDK2

17

hsa01210: 2-Oxocarboxylic acid metabolism

2

6.00 × 10^–2

IDH2、IDH1

18

hsa04919: Thyroid hormone signaling pathway

3

7.30 × 10^–2

NOTCH1、CCND1、ESR1

19

hsa04152: AMPK signaling pathway

3

7.90 × 10^–2

CCND1、CCNA2、INSR

20

hsa05162: Measles

3

9.60 × 10^–2

CCND1、CDK2、TP73

21

hsa05206: MicroRNAs in cancer

4

8.00 × 10^–2

E2F1、NOTCH1、CCND1、THBS1