Fig. 1

Relative expression of Nrf2 (a, b) and FOXO3a (c, d) in HEK-293T, HT-29, and PC-3 after treatment with ErSE and EpSH extracts. Cells were treated with the ErSE or EpsH extracts for 12 and 18 h (25 µg*mL^− 1). Data were expressed as mean values ± standard deviation (n = 3). *# Different symbols correspond to significant differences between treatments concerning the negative control (C) per cell line (p < 0,05). C = Negative Control; ErSE = ethyl acetate extract made from stems of E. rubra, selective for PC-3; EpSH = hexane extract made from stems of E. pulverulenta, selective for HT-29; C + = 5-Fluorouracil (6.5 µg*mL^− 1, 50 µM)