Fig. 1
Whole-cell current responses of AMPA receptor subunits following exposure to C. citratus water extract. Panel (a) illustrates the whole-cell current responses (in pA) of AMPA receptor subunits expressed in HEK293t cells, both in the presence of glutamate alone (black) and after the administration of 800 µg/ml of C. citratus extract (white). To provide a comprehensive view of the impact, Figures (b, c, d), and (e) present the A/AI ratio, where ‘A’ represents the current response to glutamate alone, and ‘A.I.’ signifies the current response following the introduction of the C. citratus water extract. Notably, all whole-cell current measurements were obtained at -60 mV, under pH 7.4, and at a temperature of 22 °C. Statistical comparisons were conducted using one-way analysis of variance (ANOVA), with ‘ns’ indicating non-significance. Each experimental dataset is based on evaluating 6 cells, and all data are presented as means ± SEM. The dots plotted above each column depict the current generated by each cell of the 6 cells examined following the extract’s application