Fig. 10

BCA inhibits the RANKL-induced MAPK signaling pathway. A Representative western blotting images of the effects of BCA on JNK1/2 and ERK1/2 phosphorylation. BCA was used to pretreat BMMs for 1 h followed by 0, 10, 20, 30 and 60 min of RANKL (50 ng/mL) stimulation. B-C Quantitative analysis of the fold change in p-JNK and p-ERK expression after BCA (10µM) treatment. Data were presented as the means ± SD; *P < 0.05, and ***P < 0.001 relative to RANKL-induced controls