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Fig. 7 | BMC Complementary Medicine and Therapies

Fig. 7

From: Diosmin ameliorates renal fibrosis through inhibition of inflammation by regulating SIRT3-mediated NF-κB p65 nuclear translocation

Fig. 7

Schema of the underlying mechanism anti-inflammatory effect of Diosmin in renal fibrosis. Diosmin performs promotes the expression and activity of SIRT3, then inhibits nuclear translocation of NF-κB p65 to reduce inflammatory cytokines (TNF-α, IL-6, and IL-1β) levels. Therefore, Diosmin exerts the anti-fibrotic effect. Altogether, Diosmin attenuates renal fibrosis mainly by suppressing NF-κB p65-inflammation pathway, which is dependent on induction of SIRT3 expression

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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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