Fig. 6

Diosmin ameliorates renal fibrosis by regulating SIRT3-mediated NF-κB p65 nuclear translocation. A The enrichment plot of NF-κB signaling pathway. B Representative western blot analysis of the expression of total NF-κB P65 and nuclear NF-κB p65 in HK-2 cells. C Quantitative analysis of total NF-κB p65 and (D) nuclear NF-κB p65. ^***p < 0.001 versus the control (DMSO) group; ^&&&p < 0.001 versus the TGF-β1 alone group; ^###p < 0.001 versus the Dios + TGF-β1 group; ns = no significance; WCL = whole cell; NE = nucleus; t-NF-κB p65 = total NF-κB p65