Table 1 Overview of bioinformatic tools used in this article

Prediction of potential targets for Calycosin

Similarity Ensemble Approach (SEA)

http://sea.bkslab.org/

Pharm Mapper

http://lilab-ecust.cn/pharmmapper/

STITCH

http://stitch.embl.de/

Traditional Chinese Medicine Systems Pharmacology (TCMSP)

http://lsp.nwu.edu.cn/tcmsp.php

Collection of Gene Targets for OA

therapeutic target database (TTD)

https://db.idrblab.org/ttd/, September 29th, 2021

Drug Bank

http://www.drugbank.ca/

Online Mendelian Inheritance in Man (OMIM)

https://www.ncbi.nlm.nih.gov/omim/

Gene Cards

http://www.genecards.org/

Construction of PPI

Search Tool for Recurring Instances of Neighboring Genes (STRING)

http://string905.embl.de/, version11.0b

GO and KEGG Pathway Analysis

Database for Annotation, Visualization, and Integrated Discovery (DAVID)

https://davidd.ncifcrf.gov/

Molecular Docking

PubChem

https://pubchem.ncbi.nlm.nih.gov/

Universal Protein Resource (UniProt)

https://www.uniprot.org/

Protein Data Bank (PDB)

http://www.rcsb.org/pdb