Fig. 8

Effect of AS III on inhibition of the MAPK and AKT/mTOR signaling pathway. (A-B) Expression of the MAPKs and AKT/mTOR signaling pathway proteins in the presence and absence of AS III (250µM). (C) The ratios of p-P38/P38 and p-ERK/ERK were quantified from the Western blot data in (A). (D) The ratios of p-AKT/AKT and p-mTOR/mTOR were quantified from the western blot data in (B). Values are expressed as mean ± S.E.M. *P < 0.05, **P < 0.01, ***P < 0.001, compared untreated (0µM AS III) group