Table 1 Antiprotozoal activity of the PFs and NPFs of I. confusa, I. pseudacorus and I. germanica and their cytotoxicity against MRC-5 and PMM cells

μg/mL

CC₅₀

Sc

CC₅₀

Sc

IC₅₀

SI^a

Sc

IC₅₀

SI^a

Sc

IC₅₀

SI^a

Sc

IC₅₀

SI^a

Sc

IC₅₀

SI^a

SI^b

Sc

I. confusa

PF

10.84^a

3

 > 64.00^a

1

Nc

Nc

Nc

 > 64.00^a

0.17

1

 > 64.00^a

0.17

1

 > 64.00^a

0.17

1

 > 64.00^a

0.17

0.99

1

NPF

28.15^b

2

32.00^b

1

1.08^a

26.11

5

32.69^b

0.86

1

16.00^b

1.76

2

8.83^b

3.19

3

12.70^c

2.22

1.00

2

I. pseudacorus

PF

 > 64.00^e

1

 > 64.00^a

1

30.64^c

2.09

1

62.14^c

1.03

1

 > 64.00^a

1.00

1

 > 64.00^a

1.00

1

 > 64.00^a

1.00

5.04

1

NPF

29.96^c

2

32.00^b

1

1.61^b

18.64

4

30.99^d

0.97

1

8.17^c

3.67

3

8.14^b

3.68

3

32.46^b

0.92

1.00

1

I. germanica

PF

 > 64.00^e

1

 > 64.00^a

1

23.97^d

2.67

2

 > 64.00^a

1.00

1

 > 64.00^a

1.00

1

 > 64.00^a

1.00

1

 > 64.00^a

1.00

1.00

1

NPF

32.00^d

2

32.00^b

1

2.59^b

12.34

4

33.45^b

0.96

1

23.35^d

1.37

2

10.30^c

3.11

3

32.46^b

0.99

0.99

1

Reference drugs

10.88^a

5.80^c

0.09^a

0.05^e

0.05^e

1.72^d

6.35^d